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1. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate
2. Adreson
3. Cortisone
4. Cortone Acetate
1. Cortisone 21-acetate
2. 50-04-4
3. Cortone Acetate
4. Incortin
5. Biocort Acetate
6. Artriona
7. Cortadren
8. Scheroson
9. Cortisyl
10. Adreson
11. Irisone Acetate
12. Cortelan
13. Cortistab
14. Ricortex
15. Cortogen Acetate
16. Compound E Acetate
17. Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-
18. Cortisone Monoacetate
19. Nsc 49420
20. Cortisone, 21-acetate
21. Cortilen
22. Cortisone Aceticum
23. 11-dehydro-17-hydroxycorticosterone-21-acetate
24. 11-dehydro-17-hydroxycorticosterone Acetate
25. 17,21-dihydroxypregn-4-ene-3,11,20-trione 21-acetate
26. Nsc-49420
27. 883wkn7w8x
28. Chebi:3897
29. Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate
30. Cortisone (acetate)
31. Ncgc00021191-07
32. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate
33. Dsstox_cid_2858
34. Dsstox_rid_76761
35. Dsstox_gsid_22858
36. 17,21-dihydroxypregn-4-ene-3,11,20-trione-21-acetate
37. 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione Acetate
38. Cas-50-04-4
39. [2-[(8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate
40. 2-((8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Acetate
41. Smr000059124
42. Ccris 3661
43. Cortisone Acetate (cortone)
44. Einecs 200-006-5
45. Unii-883wkn7w8x
46. Cortisoneacetate
47. Cortisone Acetate [usp:jan]
48. Acetate Cortisone
49. Cortisyl Artriona
50. Component Of Neosone
51. Mfcd00003609
52. Neosone (salt/mix)
53. 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione
54. Cortisone-21-acetate
55. 21-acetoxy-17,alpha-hydroxy-3,11,20-triketopregnene-4
56. 21-acetoxy-17,alpha-hydroxypregn-4-ene-3,11,20-trione
57. Cortone Acetate (tn)
58. 4-pregnene-17,alpha,21-diol-3,11,20-trione 21-acetate
59. Schembl4501
60. Chembl1650
61. Lopac0_000271
62. Mls000069478
63. Mls002207136
64. Mls002548859
65. 21-acetoxy-4-pregnen-17alpha-ol-3,11,20-trione
66. Cortisone Acetate [jan]
67. Cortisone Acetate (jp17/usp)
68. Dtxsid0022858
69. Cortisone 21-acetate, >=99%
70. Cortisone Acetate [vandf]
71. Cortisone Aceticum [hpus]
72. Cortisone Acetate [mart.]
73. 17alpha,21-dihydroxy-4-pregnene-3,11,20-trione 21-acetate
74. Hms2235d24
75. Hms3259n19
76. Hms3260h04
77. Cortisone Acetate [usp-rs]
78. Cortisone Acetate [who-dd]
79. Bcp08487
80. Cortisone 21-acetate [mi]
81. Nsc49420
82. Zinc3875334
83. Tox21_113482
84. Tox21_500271
85. Bdbm50455157
86. Hy-17461a
87. Lmst02030120
88. Akos005267225
89. Tox21_113482_1
90. Ac-6827
91. Ccg-204366
92. Cortisone Acetate [orange Book]
93. Cs-1742
94. Db01380
95. Lp00271
96. Nc00677
97. Sdccgsbi-0050259.p002
98. Cortisone Acetate [ep Monograph]
99. Cortisone Acetate [usp Monograph]
100. Ncgc00021191-03
101. Ncgc00021191-06
102. Ncgc00021191-08
103. Ncgc00021191-09
104. Ncgc00021191-16
105. Ncgc00260956-01
106. [2-[(8s,9s,10r,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] Acetate
107. 2-((1s,10s,11s,15s,2r,14r)-14-hydroxy-2,15-dimethyl-5,17-dioxotetracyclo[8.7.0 .0<2,7>.0<11,15>]heptadec-6-en-14-yl)-2-oxoethyl Acetate
108. As-13692
109. Cortisone Acetate 100 Microg/ml In Methanol
110. Eu-0100271
111. S2559
112. C08173
113. C90609
114. D00973
115. Ab00384283-08
116. Ab00384283_09
117. Cortisone Acetate 100 Microg/ml In Acetonitrile
118. 003c609
119. W-105993
120. Brd-k86161929-001-13-3
121. Hydrocortisone Acetate Impurity D [ep Impurity]
122. Pregn-4-ene-3,20-trione, 21-(acetyloxy)-17-hydroxy-
123. 17-hydroxy-3,11,20-trioxopregn-4-en-21-yl Acetate #
124. 21-acetoxy-17.alpha.-hydroxy-3,11,20-triketopregnene-4
125. 21-acetoxy-17.alpha.-hydroxypregn-4-ene-3,11,20-trione
126. 4-pregnen-17.alpha.,21-diol-3,11,20-trione 21-acetate
127. Pregn-4-ene-3,20-trione, 17,21-dihydroxy-, 21-acetate
128. 4-pregnene-17.alpha.,21-diol-3,11,20-trione 21-acetate
129. Cortisone Acetate, European Pharmacopoeia (ep) Reference Standard
130. Cortisone Acetate, United States Pharmacopeia (usp) Reference Standard
131. Cortisone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material
| Molecular Weight | 402.5 g/mol |
|---|---|
| Molecular Formula | C23H30O6 |
| XLogP3 | 2.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 402.20423867 g/mol |
| Monoisotopic Mass | 402.20423867 g/mol |
| Topological Polar Surface Area | 97.7 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 827 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 2 | |
|---|---|
| Drug Name | Cortisone acetate |
| PubMed Health | Cortisone Acetate (By mouth) |
| Drug Classes | Endocrine-Metabolic Agent, Immune Suppressant |
| Drug Label | Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Cortisone acetate is a white or practically white, odorless, crystalline powder. It is stable in air. It i... |
| Active Ingredient | Cortisone acetate |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | 25mg |
| Market Status | Prescription |
| Company | Hikma Pharms |
| 2 of 2 | |
|---|---|
| Drug Name | Cortisone acetate |
| PubMed Health | Cortisone Acetate (By mouth) |
| Drug Classes | Endocrine-Metabolic Agent, Immune Suppressant |
| Drug Label | Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.Cortisone acetate is a white or practically white, odorless, crystalline powder. It is stable in air. It i... |
| Active Ingredient | Cortisone acetate |
| Dosage Form | Tablet |
| Route | Oral |
| Strength | 25mg |
| Market Status | Prescription |
| Company | Hikma Pharms |
Cortisone acetate is indicated to treat a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.
Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. The duration of action is moderate as it is generally given once daily. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
Route of Elimination
Corticosteroids are eliminated predominantly in the urine.
Clearance
Data regarding the clearance of cortisone acetate is not readily available.
The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.
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ABOUT THIS PAGE
A Cortisone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cortisone, including repackagers and relabelers. The FDA regulates Cortisone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cortisone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Cortisone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Cortisone supplier is an individual or a company that provides Cortisone active pharmaceutical ingredient (API) or Cortisone finished formulations upon request. The Cortisone suppliers may include Cortisone API manufacturers, exporters, distributors and traders.
click here to find a list of Cortisone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Cortisone DMF (Drug Master File) is a document detailing the whole manufacturing process of Cortisone active pharmaceutical ingredient (API) in detail. Different forms of Cortisone DMFs exist exist since differing nations have different regulations, such as Cortisone USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Cortisone DMF submitted to regulatory agencies in the US is known as a USDMF. Cortisone USDMF includes data on Cortisone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cortisone USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Cortisone suppliers with USDMF on PharmaCompass.
The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.
The Cortisone Drug Master File in Japan (Cortisone JDMF) empowers Cortisone API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).
PMDA reviews the Cortisone JDMF during the approval evaluation for pharmaceutical products. At the time of Cortisone JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.
click here to find a list of Cortisone suppliers with JDMF on PharmaCompass.
A Cortisone CEP of the European Pharmacopoeia monograph is often referred to as a Cortisone Certificate of Suitability (COS). The purpose of a Cortisone CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Cortisone EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Cortisone to their clients by showing that a Cortisone CEP has been issued for it. The manufacturer submits a Cortisone CEP (COS) as part of the market authorization procedure, and it takes on the role of a Cortisone CEP holder for the record. Additionally, the data presented in the Cortisone CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Cortisone DMF.
A Cortisone CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Cortisone CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.
click here to find a list of Cortisone suppliers with CEP (COS) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Cortisone as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for Cortisone API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture Cortisone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain Cortisone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Cortisone NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of Cortisone suppliers with NDC on PharmaCompass.
Cortisone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Cortisone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cortisone GMP manufacturer or Cortisone GMP API supplier for your needs.
A Cortisone CoA (Certificate of Analysis) is a formal document that attests to Cortisone's compliance with Cortisone specifications and serves as a tool for batch-level quality control.
Cortisone CoA mostly includes findings from lab analyses of a specific batch. For each Cortisone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Cortisone may be tested according to a variety of international standards, such as European Pharmacopoeia (Cortisone EP), Cortisone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cortisone USP).
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