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Chemistry

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Also known as: Cortexolone, 11-deoxycortisol, 152-58-9, Reichstein's substance s, 11-desoxycortisol, 11-deoxyhydrocortisone
Molecular Formula
C21H30O4
Molecular Weight
346.5  g/mol
InChI Key
WHBHBVVOGNECLV-OBQKJFGGSA-N
FDA UNII
WDT5SLP0HQ

Cortodoxone
17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.
1 2D Structure

Cortodoxone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
2.1.2 InChI
InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
2.1.3 InChI Key
WHBHBVVOGNECLV-OBQKJFGGSA-N
2.1.4 Canonical SMILES
CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C
2.1.5 Isomeric SMILES
C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
2.2 Other Identifiers
2.2.1 UNII
WDT5SLP0HQ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 11 Deoxycortisol

2. 11 Desoxycortisol

3. 11 Desoxycortisone

4. 11-deoxycortisol

5. 11-desoxycortisol

6. 11-desoxycortisone

7. Cortexolone

8. Reichstein Substance S

9. Reichstein's Substance S

10. Reichsteins Substance S

11. Substance S, Reichstein's

2.3.2 Depositor-Supplied Synonyms

1. Cortexolone

2. 11-deoxycortisol

3. 152-58-9

4. Reichstein's Substance S

5. 11-desoxycortisol

6. 11-deoxyhydrocortisone

7. Substance S

8. 17,21-dihydroxyprogesterone

9. Cortisol, 11-deoxy-

10. Reichstein S

11. 17,21-dihydroxypregn-4-ene-3,20-dione

12. 11-desoxyhydrocortisone

13. 17alpha-hydroxycortexone

14. 11-deoxy-17-hydroxycorticosterone

15. 11-deoxycortisone

16. 11-dioxycortisol

17. Reichstein's Compound S

18. Pregn-4-ene-3,20-dione, 17,21-dihydroxy-

19. 17-hydroxy-11-deoxycorticosterone

20. Sk&f 3050

21. 11-deoxy Cortisol

22. 11-desoxy-17-hydroxycorticosterone

23. 4-pregnene-17alpha,21-diol-3,20-dione

24. Cortifen

25. 17-alpha-hydroxycortexone

26. Cortodoxonum [inn-latin]

27. 17,21-dihydroxy-4-pregnene-3,20-dione

28. 17.alpha.-hydroxycortexone

29. Cortodoxona [inn-spanish]

30. Skf 3050

31. 17,21-dihydroxy-pregn-4-ene-3,20-dione

32. Nsc-18317

33. Corticosterone, 11-deoxy-17-hydroxy-

34. Wdt5slp0hq

35. Skf-3050

36. Mls000069440

37. Mls001333071

38. Chebi:28324

39. Sk&f-3050

40. Cortodoxone (usan)

41. Ncgc00021222-03

42. Smr000059123

43. 11-desoxy-17.alpha.-hydroxycorticosterone

44. 17alpha,21-dihydroxy-4-pregnene-3,20-dione

45. 4-pregnene-17.alpha.,21-diol-3,20-dione

46. Cortodoxone [usan]

47. Dsstox_cid_25642

48. Dsstox_rid_81022

49. 17.alpha.,21-dihydroxypregn-4-ene-3,20-dione

50. Dsstox_gsid_45642

51. (8r,9s,10r,13s,14s,17r)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one

52. 11-desoxycortisone

53. Cortodoxona

54. Cortodoxonum

55. 17,21-dihydroxypregn-4-ene-3,20-dione (reichstein's Substance S)

56. 11 Deoxycortisol

57. Cas-152-58-9

58. Unii-wdt5slp0hq

59. Mfcd00003662

60. 17alpha,21-dihydroxypregna-4-ene-3,20-dione

61. Substance S, Reichstein's

62. 17-hydroxydesoxycorticosterone

63. Cortodoxone [usan:inn:ban]

64. Einecs 205-805-2

65. Brn 2511358

66. Opera_id_1433

67. Cortodoxone [inn]

68. 11-deoxycortisol Solution

69. Lopac0_001040

70. Schembl42590

71. 17a,21-dihydroxyprogesterone

72. 4-08-00-02913 (beilstein Handbook Reference)

73. Mls001333072

74. Chembl253144

75. Gtpl5100

76. Dtxsid8045642

77. Hms2234l16

78. Hms3263o21

79. (8r,9s,10r,13s,14s,17r)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3(2h)-one

80. Reichstein's Substance S, >=98%

81. Zinc3860956

82. Tox21_110867

83. Tox21_501040

84. Bdbm50423539

85. Cmc_13429

86. Lmst02030086

87. S4775

88. Akos015969740

89. Tox21_110867_1

90. Ccg-205117

91. Cs-5182

92. Lp01040

93. Sdccgsbi-0051010.p002

94. Ncgc00021222-04

95. Ncgc00021222-05

96. Ncgc00021222-06

97. Ncgc00021222-07

98. Ncgc00261725-01

99. As-56275

100. Hy-77839

101. 20-dione 17,21-dihydroxypregn-4-ene-3

102. 17.alpha.,21-dihydroxyprogesterone

103. Eu-0101040

104. C05488

105. C72891

106. D03595

107. Hydrocortisone Impurity F [ep Impurity]

108. R 0500

109. 11-desoxy-17-hydroxycorticosterone [mi]

110. 17alpha,21-dihydroxy-pregna-4-ene-3,20-dione

111. 152c589

112. A936328

113. Sr-01000076100

114. 4-pregnen-17.alpha.,21-diol-3,20-dione

115. Q2064915

116. Sr-01000076100-1

117. 17.alpha.,21-dihydroxy-4-pregnen-3,20-dione

118. .delta.4-pregnene-17.alpha.,21-diol-3,20-dione

119. 33bb233b-cc8f-413b-8901-3a73030bba68

120. 11-deoxycortisol (17,21-dihydroxypregn-4-ene-3,20-dione)

121. 17-(1-keto-2-hydroxyethyl)-4-androsten-17alpha, 21-ol-3-one

122. 17

123. A Inverted Exclamation Mark,21-dihydroxypregna-4-ene-3,20-dione

124. 11-deoxycortisol (17,21-dihydroxypregn-4-ene-3,20-dione) 1.0 Mg/ml In Methanol

125. (1s,2r,10r,11s,14r,15s)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

126. (8r,10r,13s,17r)-17-hydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

127. (8r,9s,10r,13s,14s,17r)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3h-cyclopenta[a]phenanthren-3-one

128. 11-deoxycortisol Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

129. 37-60-5

2.4 Create Date
2005-06-01
3 Chemical and Physical Properties
Molecular Weight 346.5 g/mol
Molecular Formula C21H30O4
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass346.21440943 g/mol
Monoisotopic Mass346.21440943 g/mol
Topological Polar Surface Area74.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity652
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

17Beta-21-dihydroxyprogesterone is a known human metabolite of 17alpha-hydroxy-progesterone.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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Cortodoxone Manufacturers

A Cortodoxone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cortodoxone, including repackagers and relabelers. The FDA regulates Cortodoxone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cortodoxone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cortodoxone Suppliers

A Cortodoxone supplier is an individual or a company that provides Cortodoxone active pharmaceutical ingredient (API) or Cortodoxone finished formulations upon request. The Cortodoxone suppliers may include Cortodoxone API manufacturers, exporters, distributors and traders.

Cortodoxone GMP

Cortodoxone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cortodoxone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cortodoxone GMP manufacturer or Cortodoxone GMP API supplier for your needs.

Cortodoxone CoA

A Cortodoxone CoA (Certificate of Analysis) is a formal document that attests to Cortodoxone's compliance with Cortodoxone specifications and serves as a tool for batch-level quality control.

Cortodoxone CoA mostly includes findings from lab analyses of a specific batch. For each Cortodoxone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cortodoxone may be tested according to a variety of international standards, such as European Pharmacopoeia (Cortodoxone EP), Cortodoxone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cortodoxone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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