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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Ssr 125543, Ssr125543, Ssr-125543, 752253-39-7, Nbi-74788, Crinecerfont [usan]
Molecular Formula
C27H28ClFN2OS
Molecular Weight
483.0  g/mol
InChI Key
IEAKXXNRGSLYTQ-DEOSSOPVSA-N
FDA UNII
MFT24BX55I

Crinecerfont
1 2D Structure

Crinecerfont

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine
2.1.2 InChI
InChI=1S/C27H28ClFN2OS/c1-6-11-31(24(13-19-8-9-19)20-10-7-16(2)23(29)14-20)27-30-26(18(4)33-27)21-12-17(3)25(32-5)15-22(21)28/h1,7,10,12,14-15,19,24H,8-9,11,13H2,2-5H3/t24-/m0/s1
2.1.3 InChI Key
IEAKXXNRGSLYTQ-DEOSSOPVSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F
2.1.5 Isomeric SMILES
CC1=C(C=C(C=C1)[C@H](CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F
2.2 Other Identifiers
2.2.1 UNII
MFT24BX55I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(2-chloro-4-methoxy-5-methylphenyl)-n-((1s)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine

2. Nbi 74788

3. Nbi-74788

2.3.2 Depositor-Supplied Synonyms

1. Ssr 125543

2. Ssr125543

3. Ssr-125543

4. 752253-39-7

5. Nbi-74788

6. Crinecerfont [usan]

7. 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine

8. Mft24bx55i

9. 06-rori

10. Chembl291657

11. Chebi:34969

12. Ssr125543a

13. 752253-39-7 (free Base)

14. Chembl1628268

15. (s)-4-(2-chloro-4-methoxy-5-methylphenyl)-n-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-n-(prop-2-yn-1-yl)thiazol-2-amine

16. Sr-125543a

17. Crinecerfont [inn]

18. Unii-mft24bx55i

19. Gtpl3533

20. Schembl5453205

21. Dtxsid10996687

22. Ssr-125543a

23. Zinc1550164

24. Bdbm50144192

25. Bdbm50348828

26. Pdsp1_000883

27. Pdsp2_000869

28. Who 10958

29. Ncgc00386642-01

30. Hy-106203

31. Cs-0025238

32. Q27088874

33. [4-(4-bromo-phenyl)-5,6-dimethyl-pyrimidin-2-yl]-dicyclopropylmethyl-propyl-amine

34. 2-thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-n-((1s)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-n-2-propynyl-

35. 2-thiazolamine, 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1s)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-2-propyn-1-yl

36. 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-(prop-2-yn-1-yl)-1,3-thiazol-2-amine

2.4 Create Date
2005-10-11
3 Chemical and Physical Properties
Molecular Weight 483.0 g/mol
Molecular Formula C27H28ClFN2OS
XLogP38
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass482.1594906 g/mol
Monoisotopic Mass482.1594906 g/mol
Topological Polar Surface Area53.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity699
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of atypical haemolytic uremic syndrome, Treatment of paroxysmal nocturnal haemoglobinuria


Treatment of congenital adrenal hyperplasia


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ABOUT THIS PAGE

Crinecerfont Manufacturers

A Crinecerfont manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Crinecerfont, including repackagers and relabelers. The FDA regulates Crinecerfont manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Crinecerfont API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Crinecerfont Suppliers

A Crinecerfont supplier is an individual or a company that provides Crinecerfont active pharmaceutical ingredient (API) or Crinecerfont finished formulations upon request. The Crinecerfont suppliers may include Crinecerfont API manufacturers, exporters, distributors and traders.

Crinecerfont GMP

Crinecerfont Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Crinecerfont GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Crinecerfont GMP manufacturer or Crinecerfont GMP API supplier for your needs.

Crinecerfont CoA

A Crinecerfont CoA (Certificate of Analysis) is a formal document that attests to Crinecerfont's compliance with Crinecerfont specifications and serves as a tool for batch-level quality control.

Crinecerfont CoA mostly includes findings from lab analyses of a specific batch. For each Crinecerfont CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Crinecerfont may be tested according to a variety of international standards, such as European Pharmacopoeia (Crinecerfont EP), Crinecerfont JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Crinecerfont USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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