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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 222400-20-6, Cs-023, Ro-4908463, R-1558, R-115685, R-1l5685
Molecular Formula
C23H35N7O6S
Molecular Weight
537.6  g/mol
InChI Key
KEDAXBWZURNCHS-GPODMPQUSA-N
FDA UNII
1654W9611T

Cs 023
Tomopenem is a 1-beta-methylcarbapenem antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria. Tomopenem has a longer half-life than imipenem-cilastatin or meropenem and shows activity against methicillin-resistant S. aureus.
1 2D Structure

Cs 023

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,5S,6S)-3-[(3S,5S)-5-[(3S)-3-[[2-(diaminomethylideneamino)acetyl]amino]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
2.1.2 InChI
InChI=1S/C23H35N7O6S/c1-10-17-16(11(2)31)21(34)30(17)18(22(35)36)19(10)37-13-6-14(28(3)9-13)20(33)29-5-4-12(8-29)27-15(32)7-26-23(24)25/h10-14,16-17,31H,4-9H2,1-3H3,(H,27,32)(H,35,36)(H4,24,25,26)/t10-,11-,12+,13+,14+,16-,17-/m1/s1
2.1.3 InChI Key
KEDAXBWZURNCHS-GPODMPQUSA-N
2.1.4 Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(N(C3)C)C(=O)N4CCC(C4)NC(=O)CN=C(N)N)C(=O)O)C(C)O
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](N(C3)C)C(=O)N4CC[C@@H](C4)NC(=O)CN=C(N)N)C(=O)O)[C@@H](C)O
2.2 Other Identifiers
2.2.1 UNII
1654W9611T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cs 023

2. Cs-023

3. Cs023 Cpd

4. R 115685

5. R-115685

6. R115685

7. Ro4908463

2.3.2 Depositor-Supplied Synonyms

1. 222400-20-6

2. Cs-023

3. Ro-4908463

4. R-1558

5. R-115685

6. R-1l5685

7. Ro4908463

8. Antibiotic Cs 023

9. 1654w9611t

10. R115685

11. (4r,5s,6s)-3-[(3s,5s)-5-[(3s)-3-[[2-(diaminomethylideneamino)acetyl]amino]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

12. 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 3-(((3s,5s)-5-(((3s)-3-((((aminoiminomethyl)amino)acetyl)amino)-1-pyrrolidinyl)carbonyl)-1-methyl-3-pyrrolidinyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-, (4r,5s,6s)-

13. Tomopenem [usan]

14. Tomopenem [usan:inn]

15. R 115685

16. Ro 4908463

17. R 1558

18. Unii-1654w9611t

19. (4r,5s,6s)-3-(((3s,5s)-5-((s)-3-(2-guanidinoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[

20. Cs 023

21. Tomopenem [inn]

22. Cs023 Cpd

23. Tomopenem (usan/inn)

24. Tomopenem [who-dd]

25. Schembl304829

26. Chembl389847

27. Gtpl10869

28. Dtxsid70873384

29. Cs023

30. Zinc3993831

31. Bdbm50483019

32. Hy-123022

33. Cs-0079886

34. D09022

35. Q15427876

36. (1r,5s,6s)-2-[(2s,4s)-2-[(3s)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-6-[(1r)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic Acid

37. (1r,5s,6s)-6-[(1r)-1-hydroxyethyl]-1-methyl-2-[(2s,4s)-2-[(3s)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic Acid

38. (4r,5s,6s)-3-(((3s,5s)-5-(((3s)-3-((2-guanidinoacetyl)amino)pyrrolidin-1-yl)carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

39. (4r,5s,6s)-3-(((3s,5s)-5-((3s)-3-(carbamimidamidoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)sulfanyl)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid

40. (4r,5s,6s)-3-(((3s,5s)-5-((s)-3-(2-guanidinoacetamido)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

41. (4r,5s,6s)-3-[(3s,5s)-5-[(3s)-3-[(2-guanidinoacetyl)amino]pyrrolidine-1-carbonyl]-1-methyl-pyrrolidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

42. (4r,5s,6s)-3-{[(3s,5s)-5-{[(3s)-3-{[n-(diaminomethylidene)glycyl]amino}pyrrolidin-1-yl]carbonyl}-1-methylpyrrolidin-3-yl]sulfanyl}-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 537.6 g/mol
Molecular Formula C23H35N7O6S
XLogP3-3.7
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass537.23695304 g/mol
Monoisotopic Mass537.23695304 g/mol
Topological Polar Surface Area220 Ų
Heavy Atom Count37
Formal Charge0
Complexity1050
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Cs 023 Manufacturers

A Cs 023 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cs 023, including repackagers and relabelers. The FDA regulates Cs 023 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cs 023 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cs 023 Suppliers

A Cs 023 supplier is an individual or a company that provides Cs 023 active pharmaceutical ingredient (API) or Cs 023 finished formulations upon request. The Cs 023 suppliers may include Cs 023 API manufacturers, exporters, distributors and traders.

click here to find a list of Cs 023 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Cs 023 USDMF

A Cs 023 DMF (Drug Master File) is a document detailing the whole manufacturing process of Cs 023 active pharmaceutical ingredient (API) in detail. Different forms of Cs 023 DMFs exist exist since differing nations have different regulations, such as Cs 023 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Cs 023 DMF submitted to regulatory agencies in the US is known as a USDMF. Cs 023 USDMF includes data on Cs 023's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Cs 023 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Cs 023 suppliers with USDMF on PharmaCompass.

Cs 023 GMP

Cs 023 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cs 023 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cs 023 GMP manufacturer or Cs 023 GMP API supplier for your needs.

Cs 023 CoA

A Cs 023 CoA (Certificate of Analysis) is a formal document that attests to Cs 023's compliance with Cs 023 specifications and serves as a tool for batch-level quality control.

Cs 023 CoA mostly includes findings from lab analyses of a specific batch. For each Cs 023 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cs 023 may be tested according to a variety of international standards, such as European Pharmacopoeia (Cs 023 EP), Cs 023 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cs 023 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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