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Cupric acetate
Also known as: Copper(ii) acetate, 142-71-2, Copper diacetate, Copper acetate, Copper(ii)acetate, Copper(2+) acetate
Molecular Formula
C4H6CuO4
Molecular Weight
181.63  g/mol
InChI Key
OPQARKPSCNTWTJ-UHFFFAOYSA-L
FDA UNII
39M11XPH03

1 2D Structure

Cupric acetate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
copper;diacetate
2.1.2 InChI
InChI=1S/2C2H4O2.Cu/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
2.1.3 InChI Key
OPQARKPSCNTWTJ-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC(=O)[O-].CC(=O)[O-].[Cu+2]
2.2 Other Identifiers
2.2.1 UNII
39M11XPH03
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Copper(i) Acetate

2. Copper(ii) Acetate

3. Copper(ii) Acetate Monohydrate

4. Cu(ii) Acetate

5. Hoganite

2.3.2 Depositor-Supplied Synonyms

1. Copper(ii) Acetate

2. 142-71-2

3. Copper Diacetate

4. Copper Acetate

5. Copper(ii)acetate

6. Copper(2+) Acetate

7. Copper(2+) Diacetate

8. Copper (ii) Acetate

9. Cupric Diacetate

10. Neutral Verdigris

11. Crystals Of Venus

12. Acetic Acid, Copper(2+) Salt

13. Copper Acetate (cu(c2h3o2)2)

14. Crystallized Verdigris

15. Acetic Acid, Copper(2+) Salt, Basic

16. Cupric Acetate,anhydrous

17. Copper Acetate (cu(oac)2)

18. Acetic Acid Copper(2+) Salt

19. 39m11xph03

20. Acetic Acid, Copper(ii) Salt (2:1)

21. 52503-64-7

22. Copper Di(acetate)

23. Acetic Acid, Copper(2+) Salt (2:1)

24. Venus Copper

25. Copper(ii)-acetate

26. Acetic Acid, Copper Salt

27. Octan Mednaty [czech]

28. Octan Mednaty

29. Acetic Acid, Cupric Salt

30. Mfcd00008690

31. Acetate De Cuivre

32. Acetate De Cuivre [french]

33. Cu(ii) Acetate

34. Ccris 5286

35. Hsdb 915

36. Cupric Acetate, Basic

37. Nsc-75796

38. 4180-12-5

39. Einecs 205-553-3

40. Nsc 75796

41. Diacetoxycopper

42. Bisacetoxycopper

43. Unii-39m11xph03

44. Copper;diacetate

45. Diacetoxy Copper

46. Ai3-01379

47. Acetic Acid, Copper (2+) Salt

48. Copper Acetate Salt

49. Copper(ii)diacetate

50. Copper (ii)acetate

51. Copper-(ii)acetate

52. Einecs 257-974-7

53. Copper(1i) Acetate

54. Copper(11) Acetate

55. Copper(ii) Diacetate

56. Copper-(ii) Acetate

57. Copper-(ii)-acetate

58. Cuprum Aceticum

59. Copper (ii) Diacetate

60. Diacetoxy Copper (ii)

61. Acetic Acid,copper Salt

62. Cu(oac)2

63. Ec 205-553-3

64. Schembl1080

65. Cupric Acetate [mi]

66. Acetic Acid Copper(ii) Salt

67. Copper,bis(acetato-ko,ko')-

68. Cupric Acetate [inci]

69. Cuprum Aceticum [hpus]

70. Copper Acetate [mart.]

71. Copper Acetate [who-dd]

72. Dtxsid2059720

73. Copper(ii) Acetate [hsdb]

74. Copper(ii) Acetate, Anhydrous

75. Akos015892699

76. Copper(ii) Acetate, Trace Metals Grade

77. Ft-0653868

78. D77909

79. Q421854

80. J-520114

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 181.63 g/mol
Molecular Formula C4H6CuO4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass180.956206 g/mol
Monoisotopic Mass180.956206 g/mol
Topological Polar Surface Area80.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity25.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Therapeutic Uses

Medication (VET): In hematinic mixtures (liquid or tablets) as source of copper.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 132


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

There are limited data concerning toxicity of copper in experimental animals. Heavy accumulation of copper was observed in the liver and kidneys of rats maintained for 16 mo on a diet supplemented with 5,000 ppm copper acetate. Similar depositions were seen in the liver and kidney as well as the brain and the large and small bowel in rats exposed to 1250 ppm cupric acetate monohydrate in the drinking water for up to 902 days.

USEPA; Health Issue Assessment: Copper p.33 (1987) EPA/600/8-87/001


5.2 Mechanism of Action

The effects of cadmium and copper on the sodium ion (Na(+)) glucose cotransport in the kidney cortical cells of 4 week old male C57B16-rats were studied. Different concentrations of cadmium chloride, zinc chloride, or cupric acetate were added to the culture media. The Na(+)-glucose cotransport was estimated from the uptake of radiolabeled alpha-methylglucoside using scintillation counting techniques. Metallothionein was measured by Sephadex-G-75 column chromatography and subsequent high performance liquid chromatography. For Cd(2+) and Cu(2+), an increase in concentration resulted in an increase in the extent of inhibition of the Na(+)-glucose cotransport with approximately 3 hour lag times for the induction of inhibition. Increases in metal ion concentration also resulted in slower increases of metallothionein protein, with the rapid induction of metallothionein messenger RNA after incubation with the ions. Pretreatment of the cells with zinc(2+) reduced the effects of Cd(2+) and Cu(2+) on the cotransport by delaying the onset and reducing the extent of the inhibition.

PMID:7992308 Blumenthal S et al; Toxicology and Applied Pharmacology 129 (2): 177-87 (1994)


Ascorbic acid incubation reduced the occurrence of copper acetate induced increases in methemoglobin, while not effecting changes in glutathione in rats.

PMID:6635265 Calabrese EJ et al; Regul Toxicol Pharmacol 3 (3): 179-83 (1983)


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