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Chemistry

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Also known as: Cx717, 867276-98-0, Cx-717, Unii-7i12yta3qm, 7i12yta3qm, Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone
Molecular Formula
C11H11N3O3
Molecular Weight
233.22  g/mol
InChI Key
KFRQROSRKSVROW-UHFFFAOYSA-N
FDA UNII
7I12YTA3QM

CX717
CX-717 is an ampakine compound previously investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.
1 2D Structure

CX717

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone
2.1.2 InChI
InChI=1S/C11H11N3O3/c15-11(14-3-5-16-6-4-14)8-1-2-9-10(7-8)13-17-12-9/h1-2,7H,3-6H2
2.1.3 InChI Key
KFRQROSRKSVROW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1COCCN1C(=O)C2=CC3=NON=C3C=C2
2.2 Other Identifiers
2.2.1 UNII
7I12YTA3QM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cx717

2.3.2 Depositor-Supplied Synonyms

1. Cx717

2. 867276-98-0

3. Cx-717

4. Unii-7i12yta3qm

5. 7i12yta3qm

6. Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone

7. 2,1,3-benzoxadiazol-5-yl-4-morpholinylmethanone

8. Cx 717

9. Morpholine, 4-(2,1,3-benzoxadiazol-5-ylcarbonyl)-

10. 211735-82-9

11. Starbld0003244

12. Cx 717 (pharmaceutical)

13. Oprea1_513346

14. Schembl243542

15. Chembl4791762

16. Dtxsid301241632

17. Ex-a6414

18. Db05047

19. Bs-47001

20. Cs-0256234

2.4 Create Date
2005-09-07
3 Chemical and Physical Properties
Molecular Weight 233.22 g/mol
Molecular Formula C11H11N3O3
XLogP30.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass233.08004122 g/mol
Monoisotopic Mass233.08004122 g/mol
Topological Polar Surface Area68.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity294
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

CX-717 is an ampakine compound. It is a positive allosteric modulator of AMPA receptors. Its action is theorized to be due to the facilitation of transmission at cortical synapses that use glutamate as a neurotransmitter. This in turn may promote plasticity at the synapse, which could translate into better cognitive performance. CX-717 works by allosterically binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. In addition, CX717 could potentially strongly impact the up-regulation of BDNF (brain-derived neurotrophic factor) or NGF (nerve growth factor), two growth factors known to stimulate the formation of new circuitry in the brain associated with forming memory and cognition.


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Looking for 867276-98-0 / CX717 API manufacturers, exporters & distributors?

CX717 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of CX717 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right CX717 manufacturer or CX717 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred CX717 manufacturer or CX717 supplier.

PharmaCompass also assists you with knowing the CX717 API Price utilized in the formulation of products. CX717 API Price is not always fixed or binding as the CX717 Price is obtained through a variety of data sources. The CX717 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

CX717

Synonyms

867276-98-0, Cx-717, Unii-7i12yta3qm, 7i12yta3qm, Benzo[c][1,2,5]oxadiazol-5-yl(morpholino)methanone, 2,1,3-benzoxadiazol-5-yl-4-morpholinylmethanone

Cas Number

867276-98-0

Unique Ingredient Identifier (UNII)

7I12YTA3QM

About CX717

CX-717 is an ampakine compound previously investigated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and Alzheimer's disease.

CX717 Manufacturers

A CX717 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of CX717, including repackagers and relabelers. The FDA regulates CX717 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. CX717 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

CX717 Suppliers

A CX717 supplier is an individual or a company that provides CX717 active pharmaceutical ingredient (API) or CX717 finished formulations upon request. The CX717 suppliers may include CX717 API manufacturers, exporters, distributors and traders.

CX717 GMP

CX717 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of CX717 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right CX717 GMP manufacturer or CX717 GMP API supplier for your needs.

CX717 CoA

A CX717 CoA (Certificate of Analysis) is a formal document that attests to CX717's compliance with CX717 specifications and serves as a tool for batch-level quality control.

CX717 CoA mostly includes findings from lab analyses of a specific batch. For each CX717 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

CX717 may be tested according to a variety of international standards, such as European Pharmacopoeia (CX717 EP), CX717 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (CX717 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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