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    Cyclizine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 3,466Xls

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    2D Structure
    Also known as: 303-25-3, Cyclizine hcl, Marezine hydrochloride, Echnatol, Fortravel, Marzine
    Molecular Formula
    C18H23ClN2
    Molecular Weight
    302.8  g/mol
    InChI Key
    UKPBEPCQTDRZSE-UHFFFAOYSA-N
    FDA UNII
    W0O1NHP4WE
    A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-benzhydryl-4-methylpiperazine;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
    2.1.3 InChI Key
    UKPBEPCQTDRZSE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    W0O1NHP4WE
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cyclizine

    2. Cyclizine Hcl

    3. Hcl, Cyclizine

    4. Hydrochloride, Cyclizine

    5. Marezine

    2.3.2 Depositor-Supplied Synonyms

    1. 303-25-3

    2. Cyclizine Hcl

    3. Marezine Hydrochloride

    4. Echnatol

    5. Fortravel

    6. Marzine

    7. Reis-fit

    8. Valoid

    9. 1-benzhydryl-4-methylpiperazine;hydrochloride

    10. 1-(diphenylmethyl)-4-methylpiperazine Monohydrochloride

    11. Cyclizine Monohydrochloride

    12. W0o1nhp4we

    13. Nsc-169102

    14. (+-)-1-diphenylmethyl-4-methylpiperazine Hydrochloride

    15. Dihydrochlorid

    16. Piperazine, 1-(diphenylmethyl)-4-methyl-, Monohydrochloride

    17. Chebi:51045

    18. Piperazine, 1-(diphenylmethyl)-4-methyl-, Hydrochloride (1:1)

    19. N-benzhydryl-n'-methylpiperazine Monohydrochloride

    20. 1-(diphenylmethyl)-4-methylpiperazine Hydrochloride

    21. Cyclizine Chloride

    22. 7380-29-2

    23. Piperazine,1-(diphenylmethyl)-4-methyl-,hydrochloride

    24. Collox

    25. Marezine;n-methyl-n'-benzhydrylpiperazine; Nsc 26608; Nautazine; Ne-devomit; Neo-devomit

    26. Cyclizini Hydrochloridum

    27. Unii-w0o1nhp4we

    28. Cyclizine Hydrochloride (usp)

    29. Sr-05000001595

    30. Cylizine Hcl

    31. Cyclizine Hydrochloride [usp:ban]

    32. Prestwick_789

    33. Einecs 206-136-9

    34. Component Of Diconal

    35. Nsc 169102

    36. 1-benzhydryl-4-methylpiperazine Hydrochloride

    37. N-benzhydryl-n'-methylpiperazine Hydrochloride

    38. Schembl97825

    39. Cyclizine-[d4] Hydrochloride

    40. Mls002153853

    41. Chembl1324714

    42. Hms1569f21

    43. Bcp30021

    44. Cyclizine Hcl;marezine Hydrochloride

    45. Cyclizine Hydrochloride [mi]

    46. Nsc169102

    47. Ccg-220510

    48. Cyclizine Hydrochloride [mart.]

    49. Cyclizine Hydrochloride [usp-rs]

    50. Cyclizine Hydrochloride [who-dd]

    51. Ncgc00180957-01

    52. As-80830

    53. Smr001233212

    54. Wln: T6n Dntj A1 Dyr & R & Gh

    55. A5580

    56. Cyclizine Hydrochloride [ep Impurity]

    57. Ft-0665335

    58. 1-benzhydryl-4-methylpiperazin-4-ium;chloride

    59. Cyclizine Hydrochloride [ep Monograph]

    60. Cyclizine Hydrochloride [usp Monograph]

    61. D03622

    62. J-017911

    63. Sr-05000001595-3

    64. Q27122290

    65. (.+-.)-1-diphenylmethyl-4-methylpiperazine Hydrochloride

    2.4 Create Date
    2006-04-14
    3 Chemical and Physical Properties
    Molecular Weight 302.8 g/mol
    Molecular Formula C18H23ClN2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass302.1549764 g/mol
    Monoisotopic Mass302.1549764 g/mol
    Topological Polar Surface Area6.5 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity253
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)