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    Cyclofenil

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    PharmaCompass
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    2D Structure
    Also known as: 2624-43-3, Ondogyne, Sexovid, Cyclofenyl, Cyclopenil, Cyclophenyl
    Molecular Formula
    C23H24O4
    Molecular Weight
    364.4  g/mol
    InChI Key
    GVOUFPWUYJWQSK-UHFFFAOYSA-N
    FDA UNII
    J468V64WZ1
    A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [4-[(4-acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] acetate
    2.1.2 InChI
    InChI=1S/C23H24O4/c1-16(24)26-21-12-8-19(9-13-21)23(18-6-4-3-5-7-18)20-10-14-22(15-11-20)27-17(2)25/h8-15H,3-7H2,1-2H3
    2.1.3 InChI Key
    GVOUFPWUYJWQSK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)OC1=CC=C(C=C1)C(=C2CCCCC2)C3=CC=C(C=C3)OC(=O)C
    2.2 Other Identifiers
    2.2.1 UNII
    J468V64WZ1
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate

    2. Cyclophenil

    3. F 6066

    4. F-6066

    5. F6066

    6. Ondogyne

    2.3.2 Depositor-Supplied Synonyms

    1. 2624-43-3

    2. Ondogyne

    3. Sexovid

    4. Cyclofenyl

    5. Cyclopenil

    6. Cyclophenyl

    7. Fertodur

    8. Ondonid

    9. Rehibin

    10. Sanocrisin

    11. Sexadieno

    12. Sexovar

    13. Oginex

    14. Neoclym

    15. Ici 48213

    16. (cyclohexylidenemethylene)bis(4,1-phenylene) Diacetate

    17. F 6066

    18. 4,4'-(cyclohexylidenemethylene)diphenol Diacetate Ester

    19. (cyclohexylidenemethylene)-bis(4,1-phenylene) Diacetate

    20. H 3452

    21. Cyclophenil

    22. F-6066

    23. Ici-48213

    24. Nsc-86464

    25. Bis(p-hydroxyphenyl)cyclohexyldienemethane Diacetate

    26. [4-[(4-acetyloxyphenyl)-cyclohexylidenemethyl]phenyl] Acetate

    27. J468v64wz1

    28. Cfn

    29. 4,4'-(cyclohexylidenemethylene)bisphenol 1,1'-diacetate

    30. Ncgc00165767-02

    31. Dsstox_cid_2866

    32. Dsstox_rid_76764

    33. Dsstox_gsid_22866

    34. (cyclohexylidenemethylene)bis(4,1-phenylene)diacetate

    35. Ciclofenilo

    36. Cyclofenilum

    37. Cyclofenilum [inn-latin]

    38. Ciclofenilo [inn-spanish]

    39. Nsc 86464

    40. Cas-2624-43-3

    41. Cyclofenil [inn:ban:dcf:jan]

    42. Einecs 220-089-1

    43. Brn 2014687

    44. Unii-j468v64wz1

    45. Ai3-52271

    46. Phenol, 4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-, Acetate

    47. Sexovid (tn)

    48. P-cresol, Diacetate

    49. Bis-(p-hydroxyphenyl)-cyclohexylidenemethane Diacetate

    50. Bis(p-acetoxyphenyl)cyclohexylidenemethane

    51. Cyclofenil [mi]

    52. Cyclofenil (jan/inn)

    53. Cyclofenil [inn]

    54. Cyclofenil [jan]

    55. F6066

    56. 4,4'-(cyclohexylidenmethylen)diphenyl Diacetat

    57. Cyclofenil [mart.]

    58. Cyclofenil [who-dd]

    59. Nciopen2_009345

    60. Schembl132246

    61. Chembl141305

    62. (cyclohexylidenemethanediyl)dibenzene-4,1-diyl Diacetate

    63. Dtxsid4022866

    64. Chebi:31446

    65. Zinc608288

    66. Bcp29796

    67. Nsc86464

    68. Tox21_112259

    69. Bdbm50523931

    70. S5393

    71. Akos015900207

    72. P-cresol, Alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-, Diacetate

    73. Tox21_112259_1

    74. Ccg-268218

    75. Cs-w011816

    76. Db13472

    77. Hy-w011100

    78. Ncgc00165767-01

    79. Ncgc00165767-03

    80. Ncgc00165767-04

    81. Ac-22576

    82. As-69834

    83. Cyclofenil, >=98% (hplc), White Solid

    84. Bis-(p-acetoxyphenyl)-cyclohexylidenemethane

    85. Db-046909

    86. B7564

    87. C74360

    88. D01281

    89. 624c433

    90. A877295

    91. Cyclophenil; F 6066; F6066;f-6066;ondogyne

    92. Q513583

    93. Sr-01000944933

    94. J-016345

    95. Sr-01000944933-1

    96. Brd-k68996996-001-01-7

    97. 4-{[4-(acetyloxy)phenyl](cyclohexylidene)methyl}phenyl Acetate

    98. Cyclofenil,4,4\'-(cyclohexylidenemethylene)bisphenol1,1\'-diacetate

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 364.4 g/mol
    Molecular Formula C23H24O4
    XLogP35.5
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass364.16745924 g/mol
    Monoisotopic Mass364.16745924 g/mol
    Topological Polar Surface Area52.6 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity503
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Fertility Agents, Female

    Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)

    4.2 ATC Code

    G - Genito urinary system and sex hormones

    G03 - Sex hormones and modulators of the genital system

    G03G - Gonadotropins and other ovulation stimulants

    G03GB - Ovulation stimulants, synthetic

    G03GB01 - Cyclofenil