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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

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DRUG PRODUCT COMPOSITIONS

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Chemistry

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Also known as: Doxo-emch, Inno-206, Aldoxorubicin, C28mv4im0b, 151038-96-9, Unii-c28mv4im0b
Molecular Formula
C37H42N4O13
Molecular Weight
750.7  g/mol
InChI Key
OBMJQRLIQQTJLR-FRTGXRTISA-N

D00CZL
Aldoxorubicin is a 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hypervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.
1 2D Structure

D00CZL

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide
2.1.2 InChI
InChI=1S/C37H42N4O13/c1-17-32(46)20(38)13-27(53-17)54-22-15-37(51,23(16-42)39-40-24(43)9-4-3-5-12-41-25(44)10-11-26(41)45)14-19-29(22)36(50)31-30(34(19)48)33(47)18-7-6-8-21(52-2)28(18)35(31)49/h6-8,10-11,17,20,22,27,32,42,46,48,50-51H,3-5,9,12-16,38H2,1-2H3,(H,40,43)/t17-,20-,22-,27-,32+,37-/m0/s1
2.1.3 InChI Key
OBMJQRLIQQTJLR-FRTGXRTISA-N
2.1.4 Canonical SMILES
CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=NNC(=O)CCCCCN6C(=O)C=CC6=O)CO)O)N)O
2.1.5 Isomeric SMILES
C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=NNC(=O)CCCCCN6C(=O)C=CC6=O)CO)O)N)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Aldoxorubicin

2. Doxo-emch

3. Inno-206

2.2.2 Depositor-Supplied Synonyms

1. Doxo-emch

2. Inno-206

3. Aldoxorubicin

4. C28mv4im0b

5. 151038-96-9

6. Unii-c28mv4im0b

7. Aldoxorubicin [usan:inn]

8. Inno 206

9. Dtxsid301318641

10. 1361644-26-9

2.3 Create Date
2013-04-19
3 Chemical and Physical Properties
Molecular Weight 750.7 g/mol
Molecular Formula C37H42N4O13
XLogP31.3
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count15
Rotatable Bond Count12
Exact Mass750.27483741 g/mol
Monoisotopic Mass750.27483741 g/mol
Topological Polar Surface Area268 Ų
Heavy Atom Count54
Formal Charge0
Complexity1510
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently Bonded Unit Count1

ABOUT THIS PAGE

D00CZL Manufacturers

A D00CZL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of D00CZL, including repackagers and relabelers. The FDA regulates D00CZL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. D00CZL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

D00CZL Suppliers

A D00CZL supplier is an individual or a company that provides D00CZL active pharmaceutical ingredient (API) or D00CZL finished formulations upon request. The D00CZL suppliers may include D00CZL API manufacturers, exporters, distributors and traders.

D00CZL GMP

D00CZL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of D00CZL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right D00CZL GMP manufacturer or D00CZL GMP API supplier for your needs.

D00CZL CoA

A D00CZL CoA (Certificate of Analysis) is a formal document that attests to D00CZL's compliance with D00CZL specifications and serves as a tool for batch-level quality control.

D00CZL CoA mostly includes findings from lab analyses of a specific batch. For each D00CZL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

D00CZL may be tested according to a variety of international standards, such as European Pharmacopoeia (D00CZL EP), D00CZL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (D00CZL USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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