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5 Drugs in Development

5 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 915019-65-7, Nvp-bez235, Bez235, Nvp-bez 235, Bez-235, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1h-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

Molecular Formula

C₃₀H₂₃N₅O

Molecular Weight

469.5 g/mol

InChI Key

JOGKUKXHTYWRGZ-UHFFFAOYSA-N

FDA UNII

RUJ6Z9Y0DT

Dactolisib is an orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. Dactolisib inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase signaling pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

1 2D Structure

Dactolisib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile

2.1.2 InChI

InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3

2.1.3 InChI Key

JOGKUKXHTYWRGZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

2.2 Other Identifiers

2.2.1 UNII

RUJ6Z9Y0DT

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile

2. 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile

3. Bez235

4. Nvp Bez235

5. Nvp-bez235

6. Nvpbez235

2.3.2 Depositor-Supplied Synonyms

1. 915019-65-7

2. Nvp-bez235

3. Bez235

4. Nvp-bez 235

5. Bez-235

6. 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1h-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

7. Nvpbez235

8. Bez 235

9. Nvp-bez-235

10. Nvp Bez235

11. Bez235 (nvp-bez235)

12. Rtb101

13. Rtb-101

14. Ruj6z9y0dt

15. Nsc-751249

16. Bez235 (nvp-bez235, Dactolisib)

17. Chebi:71952

18. 915019-65-7 (free Base)

19. 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile

20. S1009

21. 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile

22. Nvp-bez235-nx

23. 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile

24. 2-methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile.

25. 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1h-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile

26. Dactolisib [usan]

27. Dactolisib [usan:inn]

28. Unii-ruj6z9y0dt

29. Bez235(nvp-bez235)

30. 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

31. 2-methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile

32. Kinome_2911

33. Ct-bez

34. Dactolisib (bez235)

35. Dactolisib; Bez-235

36. Dactolisib [inn]

37. Dactolisib (usan/inn)

38. Nvp-bez235, Free Base

39. Mtor Inhibitor, Bez235

40. Dactolisib [who-dd]

41. Schembl143623

42. Gtpl7950

43. Chembl1879463

44. Bdbm92862

45. Amy2877

46. Dtxsid10238599

47. Ex-a404

48. Bcpp000344

49. Hms3244g21

50. Hms3244g22

51. Hms3244h21

52. Hms3672e19

53. Act04718

54. Bcp00216

55. Bez235 - Nvp-bez235

56. Mfcd10565944

57. Nsc751249

58. Nsc755807

59. Nsc800085

60. Zinc24760115

61. Akos005217097

62. Bcp9000397

63. Ccg-207981

64. Cs-0080

65. Db11651

66. Es-0038

67. Nsc 751249

68. Nsc-755807

69. Nsc-800085

70. Pb26555

71. 2-methyl-2-[3-methyl-2-oxo-8-(3-quinolinyl)-1-imidazo[4,5-c]quinolinyl]propanenitrile

72. Dactolisib (bez235, Nvp-bez235)

73. Ncgc00187481-01

74. Ncgc00187481-02

75. Ncgc00187481-04

76. Ncgc00187481-05

77. Ncgc00187481-06

78. Ncgc00187481-15

79. 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

80. 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile

81. Ac-25486

82. Hy-50673

83. Ft-0658563

84. Ec-000.2325

85. D10552

86. J-509915

87. Q4835503

88. Brd-k12184916-001-01-4

89. 1028385-31-0

90. 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)phenyl)propionitrile

91. 2-methyl-2-[4-[3-methyl-2-oxo-8-(3-quinolyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile

92. 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1h-imidazo[4, 5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethylbenzeneacetonitrile

93. Benzeneacetonitrile, 4-(2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1h-imidazo(4,5-c)quinolin-1-yl)-alpha,alpha-dimethyl-

2.4 Create Date

2007-01-03

3 Chemical and Physical Properties

Molecular Formula	C₃₀H₂₃N₅O
Molecular Weight	469.5 g/mol
XLogP3	5.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	469.19026037 g/mol
Monoisotopic Mass	469.19026037 g/mol
Topological Polar Surface Area	73.1 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	872
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

Drugs in Development

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ABOUT THIS PAGE

Dactolisib Manufacturers

A Dactolisib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dactolisib, including repackagers and relabelers. The FDA regulates Dactolisib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dactolisib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dactolisib Suppliers

A Dactolisib supplier is an individual or a company that provides Dactolisib active pharmaceutical ingredient (API) or Dactolisib finished formulations upon request. The Dactolisib suppliers may include Dactolisib API manufacturers, exporters, distributors and traders.

Dactolisib GMP

Dactolisib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dactolisib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dactolisib GMP manufacturer or Dactolisib GMP API supplier for your needs.

Dactolisib CoA

A Dactolisib CoA (Certificate of Analysis) is a formal document that attests to Dactolisib's compliance with Dactolisib specifications and serves as a tool for batch-level quality control.

Dactolisib CoA mostly includes findings from lab analyses of a specific batch. For each Dactolisib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dactolisib may be tested according to a variety of international standards, such as European Pharmacopoeia (Dactolisib EP), Dactolisib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dactolisib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

Find Dactolisib manufacturers, exporters & distributors on PharmaCompass

Dactolisib

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CHEMISTRY

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5 Drugs in Development

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

5DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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