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Dantrolene

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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ACTIVE PHARMA INGREDIENTS

12 API Suppliers, 8 USDMF, 6 NDC API, 6 Listed Suppliers, $ API Reference Price

12 API Suppliers
8 USDMF
6 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

6 Drugs in Development

FINISHED DOSAGE FORMULATIONS

23 FDF Dossiers, 14 FDA Orange Book, 3 Canada, 1 Australia, 3 South Africa, 2 Listed Dossiers

23 FDF Dossiers
14 FDA Orange Book
3 Canada
1 Australia
3 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 100MG, CAPSULE;ORAL - 25MG, CAPSULE;ORAL - 50MG

drugProductComposition
CAPSULE;ORAL - 100MG
CAPSULE;ORAL - 25MG
CAPSULE;ORAL - 50MG

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 15 SPI Pharma, 6 DKSH, 5 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 9 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 3 Actylis, 1 Aeon Procare, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 BASF, 3 DFE Pharma, 7 Gangwal Chemicals, 4 Ingredion Pharma Solutions, 17 Kerry, 3 Lonza Capsugel, 9 Microlex e.U, 1 Nanjing Bold Chemical, 5 Pluviaendo, 2 Prachin Chemical, 1 Qualicaps, 11 Roquette, 7 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 5 Sigachi Industries, 2 Vasa Pharmachem

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DIGITAL CONTENT

11 NEWS #PharmaBuzz

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11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 3 Finished Drug Prices

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2 US Medicaid Prescriptions
3 Finished Drug Prices

MARKET PLACE

10 APIs, 6 FDF Dossiers

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10 APIs
6 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Patents

patents
1 US Patents

REF. STANDARDS & IMPURITIES

3 USP , 5 Others

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3 USP
5 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,174

MARKET PLACE

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0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

6DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

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Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

4,265,785

Annual Reports (USD Million)

Finished Drug Prices

136 RELATED EXCIPIENT COMPANIES

232EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Dantrolene sodium, 14663-23-1, Tox21_500424, Ccg-221728, Ncgc00261109-01, Ac-25752

Molecular Formula

C₁₄H₉N₄NaO₅

Molecular Weight

336.23 g/mol

InChI Key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.

1 2D Structure

Dantrolene

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidin-3-ide-2,4-dione

2.1.2 InChI

InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

2.1.3 InChI Key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

2.1.4 Canonical SMILES

C1C(=O)[N-]C(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].[Na+]

2.1.5 Isomeric SMILES

C1C(=O)[N-]C(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].[Na+]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Dantrium

2. Dantrolene

3. Dantrolene Sodium

4. Sodium, Dantrolene

2.2.2 Depositor-Supplied Synonyms

1. Dantrolene Sodium

2. 14663-23-1

3. Tox21_500424

4. Ccg-221728

5. Ncgc00261109-01

6. Ac-25752

7. D 9175

2.3 Create Date

2007-02-08

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₉N₄NaO₅
Molecular Weight	336.23 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	336.04706368 g/mol
Monoisotopic Mass	336.04706368 g/mol
Topological Polar Surface Area	110 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	530
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Dantrolene sodium
Drug Label	The chemical formula of dantrolene sodium is hydrated 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2, 4-imidazolidinedione sodium salt. It is an orange powder, slightly soluble in water, but due to its slightly acidic nature the solubility incre...
Active Ingredient	Dantrolene sodium
Dosage Form	Capsule
Route	Oral
Strength	100mg; 25mg; 50mg
Market Status	Prescription
Company	Mikah Pharma; Impax Labs

2 of 2
Drug Name	Dantrolene sodium
Drug Label	The chemical formula of dantrolene sodium is hydrated 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2, 4-imidazolidinedione sodium salt. It is an orange powder, slightly soluble in water, but due to its slightly acidic nature the solubility incre...
Active Ingredient	Dantrolene sodium
Dosage Form	Capsule
Route	Oral
Strength	100mg; 25mg; 50mg
Market Status	Prescription
Company	Mikah Pharma; Impax Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Decreased Striated Muscle Tone [PE]; Skeletal Muscle Relaxant [EPC]; Decreased Striated Muscle Contraction [PE]

API SUPPLIERS

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USDMF

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NDC API

01

Azico Biophore India Private Limite...

India

Medlab Asia & Asia Health

Not Confirmed

02

Catalent Micron Technologies, Inc.

U.S.A

Medlab Asia & Asia Health

Not Confirmed

03

Darmerica, LLC

U.S.A

Medlab Asia & Asia Health

Not Confirmed

04

HAS Healthcare Advanced Synthesis S...

Switzerland

Medlab Asia & Asia Health

Not Confirmed

05

ScinoPharm Taiwan Ltd.

Taiwan

Medlab Asia & Asia Health

Not Confirmed

06

Spectrum Laboratory Products, Inc.

U.S.A

Medlab Asia & Asia Health

Not Confirmed

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Listed Suppliers

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API Reference Price

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ROAD,"},{"dataSource":"API Import","activeIngredients":"DANTROLENE SODIUM","year":"2021","qtr":"Q1","strtotime":1615141800,"product":"DANTROLENE SODIUM (QTY: 2 X 100MG, PRICE: USD-260\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S. PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0002","unit":"KGS","unitRateFc":"2600000","totalValueFC":"546","currency":"USD","unitRateINR":"198738850","date":"08-Mar-2021","totalValueINR":"39747.77","totalValueInUsd":"546","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"3062954","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1646245800,"product":"DANTROLENE SODIUM","address":"Part of Plot No.11 & 87, Sy No.119 Phase - IV, Extension in IP, Pasham","city":"HYDERABAD","supplier":"SCINOPHARM TAIWAN, LTD","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"GLAND PHARMA LIMITED","customerCountry":"INDIA","quantity":"0.12","actualQuantity":"0.12","unit":"KGS","unitRateFc":"4833.3","totalValueFC":"578.7","currency":"USD","unitRateINR":"367575","date":"03-Mar-2022","totalValueINR":"44109","totalValueInUsd":"578.7","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"7716799","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"Part of Plot No.11 & 87, Sy No.119 Phase - IV, Extension in IP, Pasham"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1646332200,"product":"DANTROLENE SODIUM (AS PER TEST LIC.TL\/BDZ\/21\/000310 DT.14\/12\/2021)","address":"VILLAGE THANTHEWAL ROPAR ROAD NALAGARH","city":"DISTT SOLAN","supplier":"SCINOPHARM TAIWAN, LTD","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"IMMACULE LIFESCIENCES P. LTD.","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"5760","totalValueFC":"5792.5","currency":"USD","unitRateINR":"441504","date":"04-Mar-2022","totalValueINR":"441504","totalValueInUsd":"5792.5","indian_port":"DELHI AIR","hs_no":"29419090","bill_no":"7735330","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"VILLAGE THANTHEWAL ROPAR ROAD NALAGARH"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666981800,"product":"DANTROLENE SODIUM CAS NO:24868-20-0","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"BIDDLE SAWYER CORPORATION","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"45.00","actualQuantity":"45","unit":"KGS","unitRateFc":"2200","totalValueFC":"100944","currency":"USD","unitRateINR":"184580","date":"29-Oct-2022","totalValueINR":"8306100","totalValueInUsd":"100944","indian_port":"MADRAS AIR","hs_no":"29349990","bill_no":"3086032","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1681324200,"product":"DANTROLENE SODIUM 3700688 LOT NO. 70330AA134 \/ 70330AA137 CAS.NO.24868-20-0","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"BIDDLE SAWYER CORPORATION","supplierCountry":"TAIWAN","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"59.35","actualQuantity":"59.35","unit":"KGS","unitRateFc":"2300","totalValueFC":"137997.8","currency":"USD","unitRateINR":"190555","date":"13-Apr-2023","totalValueINR":"11309439.25","totalValueInUsd":"137997.8","indian_port":"MADRAS AIR","hs_no":"29349990","bill_no":"5497231","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708885800,"product":"DANTROLENE SODIUM","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"SCINOPHARM TAIWAN, LTD","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"26.00","actualQuantity":"26","unit":"KGS","unitRateFc":"2237","totalValueFC":"58811.8","currency":"USD","unitRateINR":"187685.9","date":"26-Feb-2024","totalValueINR":"4879834","totalValueInUsd":"58811.8","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29349990","bill_no":"1000748","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"N\/A","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715193000,"product":"DANTROLENE SODIUM LOT NO. 70330AA143 CAS.NO.24868-20-0","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"BIDDLE SAWYER CORPORATION","supplierCountry":"TAIWAN","foreign_port":"TAIPEI","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"88.95","actualQuantity":"88.95","unit":"KGS","unitRateFc":"2250","totalValueFC":"202528.5","currency":"USD","unitRateINR":"189787.5","date":"09-May-2024","totalValueINR":"16881598.13","totalValueInUsd":"202528.5","indian_port":"Madras Air","hs_no":"29349990","bill_no":"3396890","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TAIPEI","supplierAddress":"505 EIGHTH AVENUE,NEW YORK NY 10018SDNF UNITED STATES","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"DANTROLENE SODIUM (BATCH NO: 70330AA141) DANTROLENE SODIUM (BATCH NO: 70330AA141)","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"SCINOPHARM TAIWAN, LTD","supplierCountry":"TAIWAN","foreign_port":"KAOHSIUNG","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"50.10","actualQuantity":"50.1","unit":"KGS","unitRateFc":"2250","totalValueFC":"113963.8","currency":"USD","unitRateINR":"191137.5","date":"25-Oct-2024","totalValueINR":"9575988.75","totalValueInUsd":"113963.8","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29349990","bill_no":"6320496","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"KAOHSIUNG","supplierAddress":"NO.1 , NAN KE 8TH ROAD, SHAN HUA TAINAN 741014 TW","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 Norgine

Netherlands

Medlab Asia & Asia Health

Not Confirmed

02 Eagle Pharmaceuticals

U.S.A

Medlab Asia & Asia Health

Not Confirmed

03 Eagle Pharmaceuticals

U.S.A

Medlab Asia & Asia Health

Not Confirmed

04 Eagle Pharmaceuticals

U.S.A

Medlab Asia & Asia Health

Not Confirmed

05 University of Pennsylvania

Country

Medlab Asia & Asia Health

Not Confirmed

06 NorthShore University HealthSystem

Country

Medlab Asia & Asia Health

Not Confirmed

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FDF Dossiers

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FDA Orange Book

01

EUGIA PHARMA SPECLTS

India

Medlab Asia & Asia Health

Not Confirmed

02

EAGLE PHARMS

U.S.A

Medlab Asia & Asia Health

Not Confirmed

03

ELITE LABS INC

U.S.A

Medlab Asia & Asia Health

Not Confirmed

04

ELITE LABS INC

U.S.A

Medlab Asia & Asia Health

Not Confirmed

05

ELITE LABS INC

U.S.A

Medlab Asia & Asia Health

Not Confirmed

06

HIKMA

United Kingdom

Medlab Asia & Asia Health

Not Confirmed

07

IMPAX LABS

U.S.A

Medlab Asia & Asia Health

Not Confirmed

08

IMPAX LABS

U.S.A

Medlab Asia & Asia Health

Not Confirmed

09

USWM

U.S.A

Medlab Asia & Asia Health

Not Confirmed

10

ENDO OPERATIONS

Country

Medlab Asia & Asia Health

Not Confirmed

Only 10 entries up to this point, click to access all

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Canada

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Australia

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South Africa

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE;ORAL - 100MG

USFDA APPLICATION NUMBER - 17443

DOSAGE - CAPSULE;ORAL - 25MG

USFDA APPLICATION NUMBER - 17443

DOSAGE - CAPSULE;ORAL - 50MG

USFDA APPLICATION NUMBER - 17443

Related Excipient Companies

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Excipients by Applications

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Fillers, Diluents & Binders

Direct Compression

Disintegrants & Superdisintegrants

Co-Processed Excipients

Taste Masking

Chewable & Orodispersible Aids

Solubilizers

Parenteral

Granulation

Thickeners and Stabilizers

Lubricants & Glidants

Empty Capsules

Coating Systems & Additives

Film Formers & Plasticizers

Emulsifying Agents

Topical

Controlled & Modified Release

API Stability Enhancers

Surfactant & Foaming Agents

Coloring Agents

Rheology Modifiers

Digital Content

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NEWS #PharmaBuzz

Global Sales Information

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US Medicaid Prescriptions

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Finished Drug Prices

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Market Place

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APIs

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FDF DOSSIERS

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Patents & EXCLUSIVITIES

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US Patents

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REF. STANDARDS & IMPURITIES

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USP

Others

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ABOUT THIS PAGE

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ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

12 API Suppliers

8 USDMF

6 NDC API

6 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

FINISHED DOSAGE FORMULATIONS

23 FDF Dossiers

14 FDA Orange Book

3 Canada

1 Australia

3 South Africa

2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 100MG

CAPSULE;ORAL - 25MG

CAPSULE;ORAL - 50MG

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

15 SPI Pharma

6 DKSH

5 Faran Shimi Pharmaceutical

1 Boai NKY Pharmaceuticals Ltd

9 Gangwal Healthcare

2 Nanjing Well Pharmaceutical

1 Pfanstiehl

4 ACG Worldwide

3 Actylis

1 Aeon Procare

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

2 BASF

3 DFE Pharma

7 Gangwal Chemicals

4 Ingredion Pharma Solutions

17 Kerry

3 Lonza Capsugel

9 Microlex e.U

1 Nanjing Bold Chemical

5 Pluviaendo

2 Prachin Chemical

1 Qualicaps

11 Roquette

7 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

5 Sigachi Industries

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

60 Fillers, Diluents & Binders

26 Direct Compression

16 Disintegrants & Superdisintegrants

14 Co-Processed Excipients

13 Taste Masking

13 Chewable & Orodispersible Aids

11 Solubilizers

11 Parenteral

10 Granulation

10 Thickeners and Stabilizers

10 Lubricants & Glidants

8 Empty Capsules

7 Coating Systems & Additives

5 Film Formers & Plasticizers

4 Emulsifying Agents

3 Topical

3 Controlled & Modified Release

2 API Stability Enhancers

2 Surfactant & Foaming Agents

2 Coloring Agents

2 Rheology Modifiers

DIGITAL CONTENT

11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions