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Chemistry

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Also known as: 69819-86-9, Zinapar, Zio-101, Dmas(iii)g, Sp-02l, Zio 101
Molecular Formula
C12H22AsN3O6S
Molecular Weight
411.31  g/mol
InChI Key
JGDXFQORBMPJGR-YUMQZZPRSA-N
FDA UNII
9XX54M675G

Darinaparsin
Darinaparsin is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low. The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis; in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. Compared to inorganic arsenic compounds such as arsenic trioxide (As2O3), darinaparsin appears to exhibit a wide therapeutic window.
1 2D Structure

Darinaparsin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
2.1.2 InChI
InChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
2.1.3 InChI Key
JGDXFQORBMPJGR-YUMQZZPRSA-N
2.1.4 Canonical SMILES
C[As](C)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
2.1.5 Isomeric SMILES
C[As](C)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
9XX54M675G
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Clarinaparsin

2. Dimethylarsinous Glutathione

3. Dmas(iii)g

4. Dmas(iii)sg

5. S-(dimethylarsino)-glutathione

6. S-(dimethylarsino)glutathione

7. S-dimethylarsino-glutathione

8. Zio 101

9. Zio-101

10. Zio101

2.3.2 Depositor-Supplied Synonyms

1. 69819-86-9

2. Zinapar

3. Zio-101

4. Dmas(iii)g

5. Sp-02l

6. Zio 101

7. 9xx54m675g

8. Glycine, L-gamma-glutamyl-s-(dimethylarsino)-l-cysteinyl-

9. Clarinaparsin

10. (s)-2-amino-5-(((r)-1-((carboxymethyl)amino)-3-((dimethylarsino)thio)-1-oxopropan-2-yl)amino)-5-oxopentanoic Acid

11. Darinaparsin [usan]

12. Dmas(iii)sg

13. Darinaparsin [usan:inn]

14. Dimethylarsinous Glutathione

15. S-dimethylarsino-glutathione

16. S-(dimethylarsino)glutathione

17. S-(dimethylarsino)-glutathione

18. Unii-9xx54m675g

19. Zio101

20. Sglu1

21. Darinaparsin [mi]

22. S-dimethylarsinoglutathione

23. Darinaparsin (jan/usan)

24. Darinaparsin [inn]

25. Darinaparsin [jan]

26. S-dimethylarsino Glutathione

27. Darinaparsin [who-dd]

28. Schembl411358

29. Sp02

30. Chembl3247378

31. Chebi:94295

32. Zio-101-c

33. Dtxsid80220108

34. Bcp15637

35. Db06179

36. Hy-14943

37. Zio 101; Zio101; Zio-101

38. D08898

39. Brd-k35723520-001-01-0

40. Q27166111

41. Glycine, L-gamma-glutamyl-s-(dimethylarsino)-l-cysteinyl

42. L-gamma-glutamyl-s-(dimethylarsanyl)-l-cysteinylglycine

43. L-gamma-glutamyl-s-(dimethylarsino)-l-cysteinyl-glycine

44. Glycine, L-.gamma.-glutamyl-s-(dimethylarsino)-l-cysteinyl-

45. (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic Acid

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 411.31 g/mol
Molecular Formula C12H22AsN3O6S
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Exact Mass411.044526 g/mol
Monoisotopic Mass411.044526 g/mol
Topological Polar Surface Area184 Ų
Heavy Atom Count23
Formal Charge0
Complexity449
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), solid tumors, multiple myeloma, and liver cancer.


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Looking for 69819-86-9 / Darinaparsin API manufacturers, exporters & distributors?

Darinaparsin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Darinaparsin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Darinaparsin manufacturer or Darinaparsin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Darinaparsin manufacturer or Darinaparsin supplier.

PharmaCompass also assists you with knowing the Darinaparsin API Price utilized in the formulation of products. Darinaparsin API Price is not always fixed or binding as the Darinaparsin Price is obtained through a variety of data sources. The Darinaparsin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Darinaparsin

Synonyms

69819-86-9, Zinapar, Zio-101, Dmas(iii)g, Sp-02l, Zio 101

Cas Number

69819-86-9

Unique Ingredient Identifier (UNII)

9XX54M675G

About Darinaparsin

Darinaparsin is a small-molecule organic arsenical with potential antineoplastic activity. Although the exact mechanism of action is unclear, darinaparsin, a highly toxic metabolic intermediate of inorganic arsenicals (iAs) that occurs in vivo, appears to generate volatile cytotoxic arsenic compounds when glutathione (GSH) concentrations are low. The arsenic compounds generated from darinaparsin disrupt mitochondrial bioenergetics, producing reactive oxygen species (ROS) and inducing ROS-mediated tumor cell apoptosis; in addition, this agent or its byproducts may initiate cell death by interrupting the G2/M phase of the cell cycle and may exhibit antiangiogenic effects. Compared to inorganic arsenic compounds such as arsenic trioxide (As2O3), darinaparsin appears to exhibit a wide therapeutic window.

Darinaparsin Manufacturers

A Darinaparsin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Darinaparsin, including repackagers and relabelers. The FDA regulates Darinaparsin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Darinaparsin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Darinaparsin Suppliers

A Darinaparsin supplier is an individual or a company that provides Darinaparsin active pharmaceutical ingredient (API) or Darinaparsin finished formulations upon request. The Darinaparsin suppliers may include Darinaparsin API manufacturers, exporters, distributors and traders.

Darinaparsin GMP

Darinaparsin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Darinaparsin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Darinaparsin GMP manufacturer or Darinaparsin GMP API supplier for your needs.

Darinaparsin CoA

A Darinaparsin CoA (Certificate of Analysis) is a formal document that attests to Darinaparsin's compliance with Darinaparsin specifications and serves as a tool for batch-level quality control.

Darinaparsin CoA mostly includes findings from lab analyses of a specific batch. For each Darinaparsin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Darinaparsin may be tested according to a variety of international standards, such as European Pharmacopoeia (Darinaparsin EP), Darinaparsin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Darinaparsin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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