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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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API

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FDF

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Australia

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Listed Dossiers

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USP

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Chemistry

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Also known as: Lxs196, Lxs-196, 1874276-76-2, Nvp-lxs196, Nvp-lxs-196, Ide196
Molecular Formula
C22H23F3N8O
Molecular Weight
472.5  g/mol
InChI Key
XXJXHXJWQSCNPX-UHFFFAOYSA-N
FDA UNII
E0YF0M8O09

Darovasertib
Darovasertib is an orally available protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Upon oral administration, darovasertib inds to and inhibits PKC, which prevents the activation of PKC-mediated signaling pathways. This may lead to the induction of cell cycle arrest and apoptosis in susceptible tumor cells. PKC, a serine/threonine protein kinase overexpressed in certain types of cancer cells, is involved in tumor cell differentiation, proliferation, invasion and survival.
1 2D Structure

Darovasertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide
2.1.2 InChI
InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
2.1.3 InChI Key
XXJXHXJWQSCNPX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1(CCN(CC1)C2=C(N=CC=C2)NC(=O)C3=NC(=CN=C3N)C4=C(C=CC=N4)C(F)(F)F)N
2.2 Other Identifiers
2.2.1 UNII
E0YF0M8O09
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Lxs196

2. Lxs-196

3. 1874276-76-2

4. Nvp-lxs196

5. Nvp-lxs-196

6. Ide196

7. Ide-196

8. Darovasertib [usan]

9. E0yf0m8o09

10. 3-amino-n-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

11. 3-amino-n-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide

12. 2-pyrazinecarboxamide, 3-amino-n-(3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl)-6-(3-(trifluoromethyl)-2-pyridinyl)-

13. Darovasertib [inn]

14. Unii-e0yf0m8o09

15. Darovasertib [who-dd]

16. Chembl3982723

17. Schembl17506262

18. Gtpl11186

19. Bdbm251460

20. Bcp20781

21. Ex-a2690

22. Zzc27676

23. Nsc800030

24. S6723

25. Zb1591

26. Zinc584641445

27. Cs-7529

28. Nsc-800030

29. Example 9 [wo2016020864a1]

30. Ac-36337

31. Ws-01966

32. Hy-101569

33. D85524

34. Us9452998, 9

35. Q29213686

2.4 Create Date
2016-04-09
3 Chemical and Physical Properties
Molecular Weight 472.5 g/mol
Molecular Formula C22H23F3N8O
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass472.19469187 g/mol
Monoisotopic Mass472.19469187 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count34
Formal Charge0
Complexity702
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Darovasertib Manufacturers

A Darovasertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Darovasertib, including repackagers and relabelers. The FDA regulates Darovasertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Darovasertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Darovasertib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Darovasertib Suppliers

A Darovasertib supplier is an individual or a company that provides Darovasertib active pharmaceutical ingredient (API) or Darovasertib finished formulations upon request. The Darovasertib suppliers may include Darovasertib API manufacturers, exporters, distributors and traders.

click here to find a list of Darovasertib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Darovasertib GMP

Darovasertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Darovasertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Darovasertib GMP manufacturer or Darovasertib GMP API supplier for your needs.

Darovasertib CoA

A Darovasertib CoA (Certificate of Analysis) is a formal document that attests to Darovasertib's compliance with Darovasertib specifications and serves as a tool for batch-level quality control.

Darovasertib CoA mostly includes findings from lab analyses of a specific batch. For each Darovasertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Darovasertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Darovasertib EP), Darovasertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Darovasertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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