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Dasabuvir Sodium

PMC Dasabuvir Sodium

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Fishfa Biogenics: Renowned Manufacturer, & Exporter of Tacrolimus & Mupirocin API.

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Transo-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 Listed Suppliers

2 API Suppliers
2 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers, 2 FDA Orange Book, 3 Europe

5 FDF Dossiers
2 FDA Orange Book
3 Europe

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 250MG BASE;12.5MG, 75MG, 50MG, TABLET, EXTENDED RELEASE;ORAL - EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

drugProductComposition
TABLET;ORAL - EQ 250MG BASE;12.5MG, 75MG, 50MG
TABLET, EXTENDED RELEASE;ORAL - EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

1 Seqens, 1 PMC Isochem, 1 Bioplus Life Sciences

relatedExcipients
1 Seqens
1 PMC Isochem
1 Bioplus Life Sciences

EXCIPIENTS BY APPLICATIONS

2 Emulsifying Agents, 1 Thickeners and Stabilizers, 1 Film Formers & Plasticizers, 1 Solubilizers, 1 Topical, 1 Surfactant & Foaming Agents

excipientsByApplications
2 Emulsifying Agents
1 Thickeners and Stabilizers
1 Film Formers & Plasticizers
1 Solubilizers
1 Topical
1 Surfactant & Foaming Agents

DIGITAL CONTENT

30 NEWS #PharmaBuzz

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30 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 Finished Drug Prices

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3 Finished Drug Prices

PATENTS & EXCLUSIVITIES

37 US Patents

patents
37 US Patents

Dasabuvir Sodium

Synopsis

ACTIVE PHARMA INGREDIENTS

2

API Suppliers

0

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

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EU WC

0

KDMF

0

NDC API

0

VMF

2

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

5

FDF Dossiers

2

FDA Orange Book

FDA (Orange Book)

3

Europe

0

Canada

0

Australia

0

South Africa

0

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

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USP

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JP

0

Others

PATENTS & EXCLUSIVITIES

37

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

30

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

3 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1132940-11-4, Dasabuvir sodium anhydrous, N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide sodium salt, Sodium (6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)(methylsulfonyl)amide, Chebi:85179, Q27158387

Molecular Formula

C₂₆H₂₆N₃NaO₅S

Molecular Weight

515.6 g/mol

InChI Key

VZCGKKLFRJCTFM-UHFFFAOYSA-N

Dasabuvir Sodium

1 2D Structure

Dasabuvir Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]-methylsulfonylazanide

2.1.2 InChI

InChI=1S/C26H26N3O5S.Na/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18;/h6-15H,1-5H3,(H,27,30,31);/q-1;+1

2.1.3 InChI Key

VZCGKKLFRJCTFM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)[N-]S(=O)(=O)C)N4C=CC(=O)NC4=O.[Na+]

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. 1132940-11-4

2. Dasabuvir Sodium Anhydrous

3. N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide Sodium Salt

4. Sodium (6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)(methylsulfonyl)amide

5. Chebi:85179

6. Q27158387

7. Sodium {6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-2-methoxyphenyl]naphthalen-2-yl}(methanesulfonyl)azanide

8. Sodium;[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]-methylsulfonylazanide

2.3 Create Date

2014-12-27

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₂₆N₃NaO₅S
Molecular Weight	515.6 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	515.14908639 g/mol
Monoisotopic Mass	515.14908639 g/mol
Topological Polar Surface Area	102 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	944
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Exviera is indicated in combination with other medicinal products for the treatment of chronic hepatitis C (CHC) in adults.

For hepatitis C virus (HCV) genotype specific activity.

5 Pharmacology and Biochemistry

5.1 ATC Code

J05AP09

API SUPPLIERS

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 250MG BASE;12.5MG, ...DOSAGE - TABLET;ORAL - EQ 250MG BASE;12.5MG, 75MG, 50MG

USFDA APPLICATION NUMBER - 206619

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 2...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - EQ 200MG BASE;8.33MG;50MG;33.33MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 208624

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Emulsifying Agents

Thickeners and Stabilizers

Film Formers & Plasticizers

Solubilizers

Topical

Surfactant & Foaming Agents

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Global Sales Information

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Finished Drug Prices

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Patents & EXCLUSIVITIES

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