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Also known as: 23541-50-6, Daunorubicin hcl, Daunomycin hydrochloride, Cerubidine, Rubidomycin hydrochloride, Rp 13057 hydrochloride
Molecular Formula
C27H30ClNO10
Molecular Weight
564.0  g/mol
InChI Key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
FDA UNII
UD984I04LZ

Daunorubicin HCl
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
1 2D Structure

Daunorubicin HCl

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
2.1.2 InChI
InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
2.1.3 InChI Key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
2.1.4 Canonical SMILES
CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
2.1.5 Isomeric SMILES
C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O.Cl
2.2 Other Identifiers
2.2.1 UNII
UD984I04LZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cerubidine

2. Dauno Rubidomycine

3. Dauno-rubidomycine

4. Daunoblastin

5. Daunoblastine

6. Daunomycin

7. Daunorubicin

8. Hydrochloride, Daunorubicin

9. Nsc 82151

10. Nsc-82151

11. Nsc82151

12. Rubidomycin

13. Rubomycin

2.3.2 Depositor-Supplied Synonyms

1. 23541-50-6

2. Daunorubicin Hcl

3. Daunomycin Hydrochloride

4. Cerubidine

5. Rubidomycin Hydrochloride

6. Rp 13057 Hydrochloride

7. Daunomycin Hcl

8. Ndc 0082-4155

9. Rp-13057 Hydrochloride

10. Daunorubicin (hydrochloride)

11. Daunoblastin

12. Ondena

13. Rubomycin

14. Fi 6339 [as The Base]

15. Daunomycin, Hydrochloride

16. Ud984i04lz

17. Daunorubicin (as Hydrochloride)

18. (8s,10s)-8-acetyl-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

19. Fi 6339 Hydrochloride

20. Fi-6339 Hydrochloride

21. Daunoxome

22. (8s-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride

23. Daunoblastina

24. Nsc-82151

25. Rp 13057 [as The Base]

26. Daunomycin Chlorohydrate

27. Mls000069508

28. Mfcd04974507

29. Rp 13057 [as The Base)

30. Ccris 915

31. Mls001336042

32. Smr000058559

33. Einecs 245-723-4

34. Unii-ud984i04lz

35. C27h29no10.hcl

36. Daunorubicin Hcl (daunomycin Hcl)

37. Ai3-44887

38. Sr-01000000033

39. Sr-05000001600

40. Cerubidine (tn)

41. Daunorubicin,(s)

42. Daunorubicin Hydrochloride(bicins)

43. (8s,10s)-8-acetyl-10-((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

44. (8s,10s)-8-acetyl-10-[[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

45. Smr000768722

46. Daunorubicin Hydrochloride [usan:usp:jan]

47. (7s,9s)-9-acetyl-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione;hydrochloride

48. Daunorubicin Hcl- Bio-x

49. Schembl4444

50. Cas-23541-50-6

51. Chembl1563

52. Dsstox_cid_13382

53. Dsstox_rid_79068

54. Dsstox_gsid_33382

55. (1s,3s)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranoside Hydrochloride

56. Mls002222263

57. Dtxsid0033382

58. Chebi:31456

59. (8s,10s)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-?-l-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride

60. Ex-a2649

61. Tox21_201159

62. Ccg-39942

63. S3035

64. Akos015920259

65. Cs-1271

66. Daunorubicin Hydrochloride (jp17/usp)

67. Daunorubicin Hydrochloride [mi]

68. Ks-5149

69. Daunorubicin Hydrochloride [jan]

70. Daunorubicin Hydrochloride [usan]

71. Ncgc00024246-03

72. Ncgc00258711-01

73. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl))oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8s-cis)-, Hydrochloride

74. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trhydroxy-1-methoxy-, Hydrochloride, (8s,10s)-

75. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8s-cis)-, Hydrochloride

76. Bd164356

77. Daunorubicin Hydrochloride [mart.]

78. Daunorubicin Hydrochloride [vandf]

79. Hy-13062

80. Daunorubicin Hydrochloride [usp-rs]

81. Daunorubicin Hydrochloride [who-dd]

82. Daunorubicin Hydrochloride, >=90% (hplc)

83. D01264

84. Daunorubicin Hydrochloride [orange Book]

85. Wp900 Hydrochloride, >=95% (hplc), Solid

86. Daunorubicin Hydrochloride [ep Monograph]

87. Daunorubicin Hydrochloride [usp Impurity]

88. 541d506

89. A816764

90. Daunorubicin Hydrochloride [usp Monograph]

91. Sr-01000000033-6

92. Sr-05000001600-3

93. Q27291034

94. Daunorubicin Hydrochloride, Meets Usp Testing Specifications

95. Daunorubicin Hydrochloride; Rp 13057 Hydrochloride; Daunomycin

96. Daunorubicin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

97. Daunorubicin Hydrochloride, United States Pharmacopeia (usp) Reference Standard

98. (1s,3s)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranoside Hydrochloride

99. (1s,3s)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-l-lyxo-hexopyranoside Hydrochloride

100. (8s,10s)-8-acetyl-10-(((2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dionehydrochloride

101. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-.alpha.-l-lyxo-hexopyranosyl))oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8s-cis)-, Hydrochloride

102. 5,12-naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, Hydrochloride, (8s,10s)-

103. Daunorubicin Hydrochloride;(8s,10s)-8-acetyl-10-[[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyltetrahydro-2h-pyran-2-yl]oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione Hydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 564.0 g/mol
Molecular Formula C27H30ClNO10
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count4
Exact Mass563.1558238 g/mol
Monoisotopic Mass563.1558238 g/mol
Topological Polar Surface Area186 Ų
Heavy Atom Count39
Formal Charge0
Complexity960
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameDaunorubicin hydrochloride
Drug LabelDaunorubicin Hydrochloride Injection consists of the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus. It is provided as a deep red sterile liquid in vials for intravenous administration...
Active IngredientDaunorubicin hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 5mg base/ml; eq 20mg base/vial; eq 5mg base/vial
Market StatusPrescription
CompanyFresenius Kabi Usa; Teva Pharms Usa; Eurohlth Intl

2 of 2  
Drug NameDaunorubicin hydrochloride
Drug LabelDaunorubicin Hydrochloride Injection consists of the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus. It is provided as a deep red sterile liquid in vials for intravenous administration...
Active IngredientDaunorubicin hydrochloride
Dosage FormInjectable
RouteInjection
Strengtheq 5mg base/ml; eq 20mg base/vial; eq 5mg base/vial
Market StatusPrescription
CompanyFresenius Kabi Usa; Teva Pharms Usa; Eurohlth Intl

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)


Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Anthracyclines [CS]; Topoisomerase Inhibitors [MoA]; Anthracycline Topoisomerase Inhibitor [EPC]

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Looking for 23541-50-6 / Daunorubicin HCl API manufacturers, exporters & distributors?

Daunorubicin HCl manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Daunorubicin HCl API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Daunorubicin HCl manufacturer or Daunorubicin HCl supplier for your needs.

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API | Excipient name

Daunorubicin HCl

Synonyms

23541-50-6, Daunomycin hydrochloride, Cerubidine, Rubidomycin hydrochloride, Rp 13057 hydrochloride, Daunomycin hcl

Cas Number

23541-50-6

Unique Ingredient Identifier (UNII)

UD984I04LZ

About Daunorubicin HCl

A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.

Daunomycin HCl Manufacturers

A Daunomycin HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Daunomycin HCl, including repackagers and relabelers. The FDA regulates Daunomycin HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Daunomycin HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Daunomycin HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Daunomycin HCl Suppliers

A Daunomycin HCl supplier is an individual or a company that provides Daunomycin HCl active pharmaceutical ingredient (API) or Daunomycin HCl finished formulations upon request. The Daunomycin HCl suppliers may include Daunomycin HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Daunomycin HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Daunomycin HCl USDMF

A Daunomycin HCl DMF (Drug Master File) is a document detailing the whole manufacturing process of Daunomycin HCl active pharmaceutical ingredient (API) in detail. Different forms of Daunomycin HCl DMFs exist exist since differing nations have different regulations, such as Daunomycin HCl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Daunomycin HCl DMF submitted to regulatory agencies in the US is known as a USDMF. Daunomycin HCl USDMF includes data on Daunomycin HCl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Daunomycin HCl USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Daunomycin HCl suppliers with USDMF on PharmaCompass.

Daunomycin HCl JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Daunomycin HCl Drug Master File in Japan (Daunomycin HCl JDMF) empowers Daunomycin HCl API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Daunomycin HCl JDMF during the approval evaluation for pharmaceutical products. At the time of Daunomycin HCl JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Daunomycin HCl suppliers with JDMF on PharmaCompass.

Daunomycin HCl KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Daunomycin HCl Drug Master File in Korea (Daunomycin HCl KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Daunomycin HCl. The MFDS reviews the Daunomycin HCl KDMF as part of the drug registration process and uses the information provided in the Daunomycin HCl KDMF to evaluate the safety and efficacy of the drug.

After submitting a Daunomycin HCl KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Daunomycin HCl API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Daunomycin HCl suppliers with KDMF on PharmaCompass.

Daunomycin HCl CEP

A Daunomycin HCl CEP of the European Pharmacopoeia monograph is often referred to as a Daunomycin HCl Certificate of Suitability (COS). The purpose of a Daunomycin HCl CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Daunomycin HCl EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Daunomycin HCl to their clients by showing that a Daunomycin HCl CEP has been issued for it. The manufacturer submits a Daunomycin HCl CEP (COS) as part of the market authorization procedure, and it takes on the role of a Daunomycin HCl CEP holder for the record. Additionally, the data presented in the Daunomycin HCl CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Daunomycin HCl DMF.

A Daunomycin HCl CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Daunomycin HCl CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Daunomycin HCl suppliers with CEP (COS) on PharmaCompass.

Daunomycin HCl WC

A Daunomycin HCl written confirmation (Daunomycin HCl WC) is an official document issued by a regulatory agency to a Daunomycin HCl manufacturer, verifying that the manufacturing facility of a Daunomycin HCl active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Daunomycin HCl APIs or Daunomycin HCl finished pharmaceutical products to another nation, regulatory agencies frequently require a Daunomycin HCl WC (written confirmation) as part of the regulatory process.

click here to find a list of Daunomycin HCl suppliers with Written Confirmation (WC) on PharmaCompass.

Daunomycin HCl NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Daunomycin HCl as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Daunomycin HCl API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Daunomycin HCl as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Daunomycin HCl and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Daunomycin HCl NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Daunomycin HCl suppliers with NDC on PharmaCompass.

Daunomycin HCl GMP

Daunomycin HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Daunomycin HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Daunomycin HCl GMP manufacturer or Daunomycin HCl GMP API supplier for your needs.

Daunomycin HCl CoA

A Daunomycin HCl CoA (Certificate of Analysis) is a formal document that attests to Daunomycin HCl's compliance with Daunomycin HCl specifications and serves as a tool for batch-level quality control.

Daunomycin HCl CoA mostly includes findings from lab analyses of a specific batch. For each Daunomycin HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Daunomycin HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Daunomycin HCl EP), Daunomycin HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Daunomycin HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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