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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 1263774-59-9, Jte-052, Jte-052a, Corectim, Leo 124249a, Leo 124249
Molecular Formula
C16H18N6O
Molecular Weight
310.35  g/mol
InChI Key
LOWWYYZBZNSPDT-ZBEGNZNMSA-N
FDA UNII
9L0Q8KK220

Delgocitinib
Delgocitinib is under investigation in clinical trial NCT03683719 (Phase 2b Dose-ranging Trial to Evaluate Delgocitinib Cream 1, 3, 8, and 20 Mg/g Compared to Delgocitinib Cream Vehicle Over a 16-week Treatment Period in Adult Subjects With Chronic Hand Eczema).
1 2D Structure

Delgocitinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(3S,4R)-3-methyl-7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile
2.1.2 InChI
InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1
2.1.3 InChI Key
LOWWYYZBZNSPDT-ZBEGNZNMSA-N
2.1.4 Canonical SMILES
CC1CN(C12CCN(C2)C3=NC=NC4=C3C=CN4)C(=O)CC#N
2.1.5 Isomeric SMILES
C[C@H]1CN([C@]12CCN(C2)C3=NC=NC4=C3C=CN4)C(=O)CC#N
2.2 Other Identifiers
2.2.1 UNII
9L0Q8KK220
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,6-diazaspiro(3.4)octane-1-propanenitrile, 3-methyl-beta-oxo-6-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-, (3s,4r)-

2. 3-((3s,4r)-3-methyl-6-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1,6-diazaspiro(3.4)octan-1-yl)-3-oxopropanenitrile

3. Jte-052

2.3.2 Depositor-Supplied Synonyms

1. 1263774-59-9

2. Jte-052

3. Jte-052a

4. Corectim

5. Leo 124249a

6. Leo 124249

7. Leo-124249a

8. Leo-124249

9. Delgocitinib [usan]

10. 9l0q8kk220

11. 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile

12. 3-((3s,4r)-3-methyl-6-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1,6-diazaspiro(3.4)octan-1-yl)-3-oxopropanenitrile

13. 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile

14. Delgocitinibum

15. Corectim (tn)

16. 3-((3s,4r)-3-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl)-3-oxopropanenitrile

17. 3-[(3s,4r)-3-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile

18. Ent-60

19. Delgocitinib (jan/usan)

20. Delgocitinib [inn]

21. Delgocitinib [jan]

22. Delgocitinib [who-dd]

23. Unii-9l0q8kk220

24. Gtpl9619

25. Jte052

26. Chembl4297507

27. Schembl12547007

28. Chebi:167600

29. Dtxsid401336933

30. Ex-a5577

31. Bdbm50545650

32. At24880

33. Leo-124249;jte-052

34. Bd178539

35. Hy-109053

36. Cs-0031558

37. D11046

38. A936874

39. 1,6-diazaspiro(3.4)octane-1-propanenitrile, 3-methyl-.beta.-oxo-6-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-, (3s,4r)-

40. 1,6-diazaspiro(3.4)octane-1-propanenitrile, 3-methyl-beta-oxo-6-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-, (3s,4r)-

41. Fhx

2.4 Create Date
2011-03-14
3 Chemical and Physical Properties
Molecular Weight 310.35 g/mol
Molecular Formula C16H18N6O
XLogP31.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass310.15420922 g/mol
Monoisotopic Mass310.15420922 g/mol
Topological Polar Surface Area88.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of dermatitis and eczema


API SUPPLIERS

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01

Excenen PharmaTech

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Duphat
Not Confirmed
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02

FandaChem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Duphat
Not Confirmed
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FandaChem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Duphat
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
blank

03

Conscientia Industrial

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Duphat
Not Confirmed
arrow

04

Sunshine Chemical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Duphat
Not Confirmed
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ABOUT THIS PAGE

Delgocitinib Manufacturers

A Delgocitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Delgocitinib, including repackagers and relabelers. The FDA regulates Delgocitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Delgocitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Delgocitinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Delgocitinib Suppliers

A Delgocitinib supplier is an individual or a company that provides Delgocitinib active pharmaceutical ingredient (API) or Delgocitinib finished formulations upon request. The Delgocitinib suppliers may include Delgocitinib API manufacturers, exporters, distributors and traders.

click here to find a list of Delgocitinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Delgocitinib GMP

Delgocitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Delgocitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Delgocitinib GMP manufacturer or Delgocitinib GMP API supplier for your needs.

Delgocitinib CoA

A Delgocitinib CoA (Certificate of Analysis) is a formal document that attests to Delgocitinib's compliance with Delgocitinib specifications and serves as a tool for batch-level quality control.

Delgocitinib CoA mostly includes findings from lab analyses of a specific batch. For each Delgocitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Delgocitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Delgocitinib EP), Delgocitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Delgocitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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