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Also known as: Tvb-2640, 1399177-37-7, Denifanstat [inn], Denifanstat [usan], Fasn-in-2, 4gf95b2lza

Molecular Formula

C₂₇H₂₉N₅O

Molecular Weight

439.6 g/mol

InChI Key

BBGOSBDSLYHMRA-UHFFFAOYSA-N

FDA UNII

4GF95B2LZA

Denifanstat is an orally bioavailable fatty acid synthase (FASN) inhibitor, with potential antineoplastic activity. Upon administration, denifanstat binds to and blocks FASN, which prevents the synthesis of palmitate needed for tumor cell growth and survival. This leads to a reduction in cell signaling, an induction of tumor cell apoptosis and the inhibition of cell proliferation in susceptible tumor cells. FASN, an enzyme responsible for the de novo synthesis of palmitic acid, is overexpressed in tumor cells and plays a key role in tumor metabolism, lipid signaling, tumor cell survival and drug resistance; tumor cells are dependent on increased fatty acid production for their enhanced metabolic needs and rapid growth.

1 2D Structure

Denifanstat

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile

2.1.2 InChI

InChI=1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31)

2.1.3 InChI Key

BBGOSBDSLYHMRA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5

2.2 Other Identifiers

2.2.1 UNII

4GF95B2LZA

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-1h-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

2. Tvb-2640

2.3.2 Depositor-Supplied Synonyms

1. Tvb-2640

2. 1399177-37-7

3. Denifanstat [inn]

4. Denifanstat [usan]

5. Fasn-in-2

6. 4gf95b2lza

7. Tvb 2640 [who-dd]

8. 4-(1-(4-cyclobutyl-2-methyl-5-(3-methyl-1h-1,2,4-triazol-5-yl)benzoyl)piperidin-4-yl)benzonitrile

9. 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4h-1,2,4-triazol-3- Yl)benzoyl)piperidin-4-yl)benzonitrile

10. 4-(1-(4-cyclobutyl-2-methyl-5-(5-methyl-4h-1,2,4-triazol-3-yl)benzoyl)piperidin-4-yl)benzonitrile

11. Us8871790, 480

12. 4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1h-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile

13. 4-{1-[4-cyclobutyl-2-methyl-5-(5-methyl-1h-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl}benzonitrile

14. Benzonitrile, 4-(1-(4-cyclobutyl-2-methyl-5-(3-methyl-1h-1,2,4-triazol-5-yl)benzoyl)-4-piperidinyl)-

15. Benzonitrile, 4-[1-[4-cyclobutyl-2-methyl-5-(3-methyl-1h-1,2,4-triazol-5-yl)benzoyl]-4-piperidinyl]-

16. Unii-4gf95b2lza

17. Asc-40

18. Chembl3661754

19. Schembl12488853

20. Bdbm137084

21. Bcp30428

22. Ex-a3643

23. S9714

24. Who 11784

25. Zinc150188638

26. Ac-35714

27. Hy-112829

28. Cs-0066310

29. Tvb2640; Tvb 2640;fasn-in-2

30. A937502

31. Us8871790, 152

2.4 Create Date

2012-10-30

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₂₉N₅O
Molecular Weight	439.6 g/mol
XLogP3	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	439.23721057 g/mol
Monoisotopic Mass	439.23721057 g/mol
Topological Polar Surface Area	85.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	728
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

Drugs in Development

01 Ascletis Pharma

China

Pharma, Lab & Chemical Expo

Not Confirmed

02 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

03 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

04 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

05 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

06 Ascletis Pharma

China

Pharma, Lab & Chemical Expo

Not Confirmed

07 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

08 Ascletis Pharma

China

Pharma, Lab & Chemical Expo

Not Confirmed

09 Ascletis Pharma

China

Pharma, Lab & Chemical Expo

Not Confirmed

10 Sagimet Biosciences

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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Denifanstat Manufacturers

A Denifanstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Denifanstat, including repackagers and relabelers. The FDA regulates Denifanstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Denifanstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Denifanstat Suppliers

A Denifanstat supplier is an individual or a company that provides Denifanstat active pharmaceutical ingredient (API) or Denifanstat finished formulations upon request. The Denifanstat suppliers may include Denifanstat API manufacturers, exporters, distributors and traders.

Denifanstat GMP

Denifanstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Denifanstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Denifanstat GMP manufacturer or Denifanstat GMP API supplier for your needs.

Denifanstat CoA

A Denifanstat CoA (Certificate of Analysis) is a formal document that attests to Denifanstat's compliance with Denifanstat specifications and serves as a tool for batch-level quality control.

Denifanstat CoA mostly includes findings from lab analyses of a specific batch. For each Denifanstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Denifanstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Denifanstat EP), Denifanstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Denifanstat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

Find Denifanstat manufacturers, exporters & distributors on PharmaCompass

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