DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers

1 API Suppliers
1 Listed Suppliers

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Wratizolin, 51287-57-1, Itcl, Denotivir [inn], Vratizolin, Polvir

Molecular Formula

C₁₈H₁₄ClN₃O₂S

Molecular Weight

371.8 g/mol

InChI Key

ZPBLNADJHWHOEP-UHFFFAOYSA-N

FDA UNII

W656S9I00W

Denotivir is an isothiazole derivative of 5-amino-3-methylisothiazolocarboxylic acid I with antiviral activity against human herpes simplex viruse types 1 and 2, and varicella zoster virus.

1 2D Structure

Denotivir

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-benzamido-N-(4-chlorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

2.1.2 InChI

InChI=1S/C18H14ClN3O2S/c1-11-15(17(24)20-14-9-7-13(19)8-10-14)18(25-22-11)21-16(23)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,24)(H,21,23)

2.1.3 InChI Key

ZPBLNADJHWHOEP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=NSC(=C1C(=O)NC2=CC=C(C=C2)Cl)NC(=O)C3=CC=CC=C3

2.2 Other Identifiers

2.2.1 UNII

W656S9I00W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(benzoylamino)-n-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide

2. Bacpmi

3. Itcl

4. Wratizolin

2.3.2 Depositor-Supplied Synonyms

1. Wratizolin

2. 51287-57-1

3. Itcl

4. Denotivir [inn]

5. Vratizolin

6. Polvir

7. Vratizolin; Wratizolin

8. 5-benzamido-n-(4-chlorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

9. Denotivir (inn)

10. W656s9i00w

11. 5-benzamido-4'-chloro-3-methyl-4-isothiazolecarboxanilide

12. 5-(benzoylamino)-n-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide

13. 5-benzamido-n-(4-chlorophenyl)-3-methylisothiazole-4-carboxamide

14. Vratizolinum

15. T-15

16. Unii-w656s9i00w

17. P-chlorophenylamide Of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic Acid

18. Polvir (tn)

19. 3-methyl-5-benzoylaminoisothiazole-4-carboxylic Acid P-chlorophenylamide

20. 5-(benzoylamino)-n-(p-chlorophenyl)-3-methyl-4-isothiazolecarboxamide

21. Denotivir [mart.]

22. Denotivir [who-dd]

23. Schembl147338

24. Chembl2104203

25. Dtxsid70199278

26. Zinc608304

27. Stl450987

28. 4-isothiazolecarboxamide, 5-(benzoylamino)-n-(p-chlorophenyl)-3-methyl-

29. Ft-0755612

30. D07789

31. Q11693881

32. N-(4-chlorophenyl)-3-methyl-5-[(phenylcarbonyl)amino]-1,2-thiazole-4-carboxamide

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₄ClN₃O₂S
Molecular Weight	371.8 g/mol
XLogP3	4.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	371.0495256 g/mol
Monoisotopic Mass	371.0495256 g/mol
Topological Polar Surface Area	99.3 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	479
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1