1. 12beta-isomer Deoxycholic Acid
2. 3beta-isomer Deoxycholic Acid
3. 5alpha-isomer Deoxycholic Acid
4. Choleic Acid
5. Deoxycholate
6. Deoxycholate, Sodium
7. Deoxycholic Acid, 12beta Isomer
8. Deoxycholic Acid, 12beta-isomer
9. Deoxycholic Acid, 3beta Isomer
10. Deoxycholic Acid, 3beta-isomer
11. Deoxycholic Acid, 5alpha Isomer
12. Deoxycholic Acid, 5alpha-isomer
13. Deoxycholic Acid, Disodium Salt
14. Deoxycholic Acid, Magnesium (2:1) Salt
15. Deoxycholic Acid, Monoammonium Salt
16. Deoxycholic Acid, Monopotassium Salt
17. Deoxycholic Acid, Monosodium Salt
18. Deoxycholic Acid, Sodium Salt, 12beta-isomer
19. Desoxycholic Acid
20. Dihydroxycholanoic Acid
21. Kybella
22. Lagodeoxycholic Acid
23. Sodium Deoxycholate
1. 83-44-3
2. Deoxycholate
3. Desoxycholic Acid
4. Cholerebic
5. Cholorebic
6. Choleic Acid
7. Degalol
8. Deoxycholatic Acid
9. Droxolan
10. Pyrochol
11. Septochol
12. Desoxycholsaeure
13. 7alpha-deoxycholic Acid
14. 3alpha,12alpha-dihydroxy-5beta-cholanic Acid
15. Cholic Acid, Deoxy-
16. Dihydroxycholanoic Acid
17. Atx-101
18. 7-deoxycholic Acid
19. Kybella
20. (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic Acid
21. 3,12-dihydroxycholanic Acid
22. Deoxy Cholic Acid
23. 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic Acid
24. 5-beta-deoxycholic Acid
25. Desoxycholic Acid [nf]
26. Desoxycholsaeure [german]
27. Nsc8797
28. Nsc 8797
29. Nsc-8797
30. Mfcd00003673
31. (4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoic Acid
32. (r)-4-((3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic Acid
33. 7.alpha.-deoxycholic Acid
34. 3.alpha.,12.alpha.-dihydroxycholanic Acid
35. Dwj211
36. Chebi:28834
37. Cholan-24-oic Acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-
38. Dwj-211
39. 005990whzz
40. 3-alpha,12-alpha-dihydroxycholansaeure [german]
41. 3-alpha,12-alpha-dihydroxy-5-beta-cholanoic Acid
42. Atx-101 (deoxycholic Acid)
43. 5beta-cholan-24-oic Acid, 3alpha,12alpha-dihydroxy-
44. 3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oic Acid
45. Cholan-24-oic Acid, 3,12-dihydroxy-, (3a,5b,12a)-
46. Cholan-24-oic, 3,12-dihydroxy-(3alpha,5beta,12alpha)-
47. 3,12-dihydroxycholan-24-oic Acid, (3alpha,5beta,12alpha)-
48. 17-beta-(1-methyl-3-carboxypropyl)-etiocholane-3-alpha,12-alpha-diol
49. L7-beta-(1-methyl-3-carboxypropyl)-etiocholane-3-alpha,12-alpha-diol
50. 3.alpha.,12.alpha.-dihydroxy-5.beta.-cholanic Acid
51. 3.alpha.,12.alpha.-dihydroxy-5.beta.-cholanoic Acid
52. 3.alpha.,12.alpha.-dihydroxy-5.beta.-cholan-24-oic Acid
53. 5-beta-cholan-24-oic Acid, 3-alpha,12-alpha-dihydroxy-
54. Cholan-24-oic Acid, 3,12-dihydroxy-, (3-alpha,5-beta,12-alpha)-
55. 17.beta.-(1-methyl-3-carboxypropyl)-etiocholane-3.alpha.,12.alpha.-diol
56. Atx 101
57. Dxc
58. Smr000112166
59. Deoxycholatate
60. De-oxycholate
61. 3-hydroxy-polydeoxycholic Acid
62. Deoxy-cholate
63. Unii-005990whzz
64. 3alpha-hydroxy-polydeoxycholate
65. Deoxycholic Acid [usan:inn]
66. Deoxycholic-acid
67. Atx101
68. Ccris 1627
69. Hsdb 293
70. 5b-deoxycholate
71. 3alpha
72. 7-deoxycholate
73. Deoxy-cholic Acid
74. Einecs 201-478-5
75. Kybella (tn)
76. 5b-deoxycholic Acid
77. 7-desoxycholic Acid
78. 3-alpha,12-alpha-dihydroxycholansaeure
79. Brn 3219882
80. 1e3v
81. Deoxycholic Acid [inn]
82. Spectrum5_002007
83. Bmse000833
84. Schembl4300
85. Deoxycholic Acid (nf/inn)
86. Bidd:pxr0198
87. Gtpl610
88. 4-10-00-01608 (beilstein Handbook Reference)
89. Mls001066423
90. Mls001306460
91. Deoxycholic Acid [ii]
92. Deoxycholic Acid [mi]
93. Chembl406393
94. Deoxycholic Acid [hsdb]
95. Deoxycholic Acid [inci]
96. Deoxycholic Acid [usan]
97. Desoxycholic Acid [fcc]
98. 5b-cholanic Acid-3a,12a-diol
99. Dtxsid0042662
100. Desoxycholic Acid [vandf]
101. Deoxycholic Acid [usp-rs]
102. Deoxycholic Acid [who-dd]
103. Hms2270h22
104. Hy-n0593
105. Zinc3914810
106. Deoxycholic Acid, >=98% (hplc)
107. Bbl013877
108. Bdbm50375599
109. Deoxycholic Acid, >=99.0% (t)
110. Lmst04010040
111. S4689
112. Stk801948
113. Akos005622617
114. Deoxycholic Acid [ep Impurity]
115. Deoxycholic Acid [orange Book]
116. Ccg-268565
117. Cs-7613
118. Db03619
119. Deoxycholic Acid [usp Monograph]
120. As-13233
121. Bp-13275
122. Nci60_041946
123. 3-.alpha.,12-.alpha.-dihydroxycholansaeure
124. Deoxycholic Acid, Bioxtra, >=98% (hplc)
125. C04483
126. D10781
127. D85117
128. Q425680
129. Sr-01000765601
130. 5.beta.-cholan-24-oic Acid,12.alpha.-dihydroxy-
131. Sr-01000765601-2
132. 3i+/-,12i+/--dihydroxy-5i(2)-cholansa Currencyure
133. Ursodeoxycholic Acid Impurity E [ep Impurity]
134. Z1945707492
135. 5.beta.-cholan-24-oic Acid, 3.alpha.,12.alpha.-dihydroxy-
136. 3,12-dihydroxycholan-24-oic Acid, (3.alpha.,5.beta.,12.alpha.)- #
137. Cholan-24-oic Acid,12-dihydroxy-, (3.alpha.,5.beta.,12.alpha.)-
138. Deoxycholic Acid, 500 Mug/ml In Methanol, Certified Reference Material
139. (3alpha,5alpha,8alpha,12alpha,14beta,17alpha)-3,12-dihydroxycholan-24-oic Acid
140. Cholan-24-oic Acid, 3,12-dihydroxy-, (3-.alpha., 5-.beta.,12-.alpha.)-
141. Cholan-24-oic Acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-, Homopolymer
142. Deoxycholic Acid (desoxycholic Acid), United States Pharmacopeia (usp) Reference Standard
143. L7-.beta.-(1-methyl-3-carboxypropyl)-etiocholane-3-.alpha.,12-.alpha.-diol
144. (4r)-4-((3r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic Acid
145. (4r)-4-[(1s,2s,5r,7r,10r,11s,14r,15r,16s)-5,16-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic Acid
| Molecular Weight | 392.6 g/mol |
|---|---|
| Molecular Formula | C24H40O4 |
| XLogP3 | 4.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 4 |
| Exact Mass | 392.29265975 g/mol |
| Monoisotopic Mass | 392.29265975 g/mol |
| Topological Polar Surface Area | 77.8 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 605 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 10 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Cholagogues and Choleretics; Detergents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
The useful effects of exogenous bile acids result from their capacity to decrease the cholesterol content of the bile and promote dissolution of cholesterol gallstones. /Bile acids/
Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 935
VET USE: TO INCR VOL OF BILE WITHOUT SIGNIFICANTLY ALTERING PROPORTIONS OF ITS CONSTITUENTS. MOST EFFECTIVE BILE ACID IN AIDING ABSORPTION OF FATS & FAT-SOLUABLE VITAMINS.
Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 154
For improvement in appearance of moderate to severe fullness associated with submental fat in adults.
FDA Label
Investigated for use/treatment in solid tumors.
Treatment of localised fat deposits
Cholagogues and Choleretics
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic). (See all compounds classified as Cholagogues and Choleretics.)
D - Dermatologicals
D11 - Other dermatological preparations
D11A - Other dermatological preparations
D11AX - Other dermatologicals
D11AX24 - Deoxycholic acid
Absorption
Deoxycholic acid is rapidly absorbed after subcutaneous administration. After maximum recommended single treatment dose, 100mg, the post-treatment plasma levels returned to endogenous levels within 24 hours. With the proposed treatment guideline, no accumulation is expected.
Route of Elimination
The exogenous deoxycholic acid joins the endogenous bile acid pool in the enterohepatic circulation and is excreted unchanged in feces along with endogenous deoxycholic acid.
LIVER NORMALLY SECRETES APPROX 24 G OF BILE SALTS IN 700 TO 1000 ML OF BILE IN 24 HR. MOST OF BILE SALTS ARE REABSORBED IN LOWER SMALL INTESTINE & AGAIN BECOME AVAILABLE FOR SECRETION. ... POOL OF BILE SALTS IS APPROX 2 TO 5 G. /BILE SALTS/
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 971
Deoxycholic acid is not metabolized to any significant extent under normal conditions.
As a bile acid, deoxycholic acid emulsifies fat in the gut. Synthetically derived deoxycholic acid, when injected, stimulates a targeted breakdown of adipose cells by disrupting the cell membrane and causing adipocytolysis. This results in an inflammatory reaction and clearing of the adipose tissue remnants by macrophages. Deoxycholic acid's actions are reduced by albumin and tissue-associated proteins, therefore its effect is limited to protein-poor subcutaneous fat tissue. Protein-rich tissues like muscle and skin are unaffected by deoxycholic acid, contributing to its safety profile.
IN SOLN CONJUGATED BILE SALTS FORM MICELLES IN WHICH LIPID MATERIALS MAY BE ENTRAINED. ...ALSO PROMOTE DIGESTION OF FATS BY STIMULATING PANCREATIC SECRETION & BY ACTIVATING PANCREATIC LIPASE. ... DEOXYCHOLIC.../ACID/ PROMOTE/S/ NET EXCRETION OF NA, K, & WATER IN COLON...MAY BE...FACTORS REGULATING COLONIC ABSORPTION.
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 971
DEOXYCHOLATE ADMIN DECR ABSORPTION OF CHOLESTEROL FROM HUMAN INTESTINAL TRACT. IT APPEARED TO INFLUENCE INTESTINAL FLORA AS ASSESSED INDIRECTLY BY ANALYSIS OF TYPES OF NEUTRAL STEROLS ELIM WITH FECES.
PMID:377936 GALLO-TORRES ET AL; AM J CLIN NUTR 32 (7): 1363-1365 (1979)
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