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Chemistry

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Also known as: 1234356-69-4, Arq-087, Arq087, Derazantinib [usan], Arq 087, N9b0h171mj
Molecular Formula
C29H29FN4O
Molecular Weight
468.6  g/mol
InChI Key
KPJDVVCDVBFRMU-AREMUKBSSA-N
FDA UNII
N9B0H171MJ

Derazantinib
Derazantinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. Derazantinib binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.
1 2D Structure

Derazantinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
2.1.2 InChI
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1
2.1.3 InChI Key
KPJDVVCDVBFRMU-AREMUKBSSA-N
2.1.4 Canonical SMILES
COCCNCCC1=CC(=CC=C1)NC2=NC=C3CC(C4=CC=CC=C4C3=N2)C5=CC=CC=C5F
2.1.5 Isomeric SMILES
COCCNCCC1=CC(=CC=C1)NC2=NC=C3C[C@H](C4=CC=CC=C4C3=N2)C5=CC=CC=C5F
2.2 Other Identifiers
2.2.1 UNII
N9B0H171MJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-(2-fluorophenyl)-n-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo(h)quinazolin-2-amine

2. Arq 087

2.3.2 Depositor-Supplied Synonyms

1. 1234356-69-4

2. Arq-087

3. Arq087

4. Derazantinib [usan]

5. Arq 087

6. N9b0h171mj

7. (6r)-6-(2-fluorophenyl)-n-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

8. Benzo(h)quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-n-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-, (6r)-

9. Benzo[h]quinazolin-2-amine, 6-(2-fluorophenyl)-5,6-dihydro-n-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-, (6r)-

10. Derazantinib(arq-087)

11. Derazantinib [inn]

12. Derazantinib (arq 087)

13. Unii-n9b0h171mj

14. Derazantinib [who-dd]

15. Gtpl9785

16. Chembl4297187

17. Schembl13273847

18. Arq-087arq-087

19. Amy16754

20. Bcp29103

21. Ex-a1717

22. S8609

23. Who 10488

24. Akos037648596

25. Cs-7922

26. Db14889

27. Ac-30343

28. Bs-14785

29. Hy-19981

30. A16825

31. C71924

32. (6r)-6-(2-fluorophenyl)-5,6-dihydro-n-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-benzo[h]quinazolin-2-amine

33. (r)-6-(2-fluorophenyl)-n-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

34. 1814961-15-3

2.4 Create Date
2010-08-02
3 Chemical and Physical Properties
Molecular Weight 468.6 g/mol
Molecular Formula C29H29FN4O
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass468.23253972 g/mol
Monoisotopic Mass468.23253972 g/mol
Topological Polar Surface Area59.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Derazantinib Manufacturers

A Derazantinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Derazantinib, including repackagers and relabelers. The FDA regulates Derazantinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Derazantinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Derazantinib Suppliers

A Derazantinib supplier is an individual or a company that provides Derazantinib active pharmaceutical ingredient (API) or Derazantinib finished formulations upon request. The Derazantinib suppliers may include Derazantinib API manufacturers, exporters, distributors and traders.

Derazantinib GMP

Derazantinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Derazantinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Derazantinib GMP manufacturer or Derazantinib GMP API supplier for your needs.

Derazantinib CoA

A Derazantinib CoA (Certificate of Analysis) is a formal document that attests to Derazantinib's compliance with Derazantinib specifications and serves as a tool for batch-level quality control.

Derazantinib CoA mostly includes findings from lab analyses of a specific batch. For each Derazantinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Derazantinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Derazantinib EP), Derazantinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Derazantinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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