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Chemistry

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Also known as: 207679-81-0, (r)-5-hydroxymethyl tolterodine, 5-hydroxymethyl tolterodine, (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol, Pnu-200577, 5-hydroxymethyltolterodine
Molecular Formula
C22H31NO2
Molecular Weight
341.5  g/mol
InChI Key
DUXZAXCGJSBGDW-HXUWFJFHSA-N
FDA UNII
YU871O78GR

Desfesoterodine
Desfesoterodine is a metabolite of [tolterodine].
1 2D Structure

Desfesoterodine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol
2.1.2 InChI
InChI=1S/C22H31NO2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3/t20-/m1/s1
2.1.3 InChI Key
DUXZAXCGJSBGDW-HXUWFJFHSA-N
2.1.4 Canonical SMILES
CC(C)N(CCC(C1=CC=CC=C1)C2=C(C=CC(=C2)CO)O)C(C)C
2.1.5 Isomeric SMILES
CC(C)N(CC[C@H](C1=CC=CC=C1)C2=C(C=CC(=C2)CO)O)C(C)C
2.2 Other Identifiers
2.2.1 UNII
YU871O78GR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (r)-n,n-diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropanamine

2. 5-hydroxymethyl Tolterodine

3. Pnu 200577

4. Pnu-200577

2.3.2 Depositor-Supplied Synonyms

1. 207679-81-0

2. (r)-5-hydroxymethyl Tolterodine

3. 5-hydroxymethyl Tolterodine

4. (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol

5. Pnu-200577

6. 5-hydroxymethyltolterodine

7. Desfesoterodine [inn]

8. 5-hmt

9. Pnu 200577

10. 3-[(1r)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol

11. 5-hydroxymethyl Tolterodine (pnu 200577, 5-hmt, 5-hm)

12. Spm 7605

13. Yu871o78gr

14. (+)-n,n-diisopropyl-3-(2-hydroxy-5-hydroxymethylphenyl)-3-phenylpropylamine

15. 207679-81-0 (free Base)

16. Benzenemethanol, 3-[(1r)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxy-

17. Desfesoterodine (inn)

18. (r)-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

19. Benzenemethanol, 3-((1r)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-hydroxy-

20. 2-[(1r)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenol

21. Unii-yu871o78gr

22. Desfesoterodin

23. R-5-hydroxymethyl Tolterodine

24. 5-hm

25. (r)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol

26. 5-hydroxymethyl-tolterodine

27. Intermediate Of Fesoterodine

28. Schembl209062

29. (r)-5-hydroxymethyltolterodine

30. Zinc6047

31. Chembl3348932

32. Desfesoterodine [who-dd]

33. Dtxsid40431319

34. Chebi:177454

35. Dd 01

36. Hms3884p12

37. Bcp02922

38. Spm-7605

39. Mfcd09264524

40. Pnu200577

41. S2659

42. Akos005146249

43. Akos015841720

44. Ccg-267936

45. Cs-0825

46. Db15578

47. Ncgc00346585-01

48. Ac-23943

49. Bs-15813

50. Hy-76569

51. Bcp0726000296

52. 5-hydroxymethyl Tolterodine (pnu 200577)

53. 5-hydroxymethyl Tolterodine - Pnu 200577

54. Sw219846-1

55. D10853

56. F31141

57. 264h524

58. J-013606

59. Q27294711

60. (r)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy Methyl Phenol

61. (r)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxy Methylphenol

62. (r)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

63. (r)-4-hydroxymethyl-2-(3-diisopropylamino-1-phenylpropyl)-phenol

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 341.5 g/mol
Molecular Formula C22H31NO2
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass341.235479232 g/mol
Monoisotopic Mass341.235479232 g/mol
Topological Polar Surface Area43.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity357
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

G - Genito urinary system and sex hormones

G04 - Urologicals

G04B - Urologicals

G04BD - Drugs for urinary frequency and incontinence

G04BD13 - Desfesoterodine


4.2 Metabolism/Metabolites

5-Hydroxymethyl tolterodine is a known human metabolite of tolterodine.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


API Reference Price

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ABOUT THIS PAGE

Desfesoterodine Manufacturers

A Desfesoterodine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Desfesoterodine, including repackagers and relabelers. The FDA regulates Desfesoterodine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Desfesoterodine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Desfesoterodine Suppliers

A Desfesoterodine supplier is an individual or a company that provides Desfesoterodine active pharmaceutical ingredient (API) or Desfesoterodine finished formulations upon request. The Desfesoterodine suppliers may include Desfesoterodine API manufacturers, exporters, distributors and traders.

click here to find a list of Desfesoterodine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Desfesoterodine USDMF

A Desfesoterodine DMF (Drug Master File) is a document detailing the whole manufacturing process of Desfesoterodine active pharmaceutical ingredient (API) in detail. Different forms of Desfesoterodine DMFs exist exist since differing nations have different regulations, such as Desfesoterodine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Desfesoterodine DMF submitted to regulatory agencies in the US is known as a USDMF. Desfesoterodine USDMF includes data on Desfesoterodine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Desfesoterodine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Desfesoterodine suppliers with USDMF on PharmaCompass.

Desfesoterodine WC

A Desfesoterodine written confirmation (Desfesoterodine WC) is an official document issued by a regulatory agency to a Desfesoterodine manufacturer, verifying that the manufacturing facility of a Desfesoterodine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Desfesoterodine APIs or Desfesoterodine finished pharmaceutical products to another nation, regulatory agencies frequently require a Desfesoterodine WC (written confirmation) as part of the regulatory process.

click here to find a list of Desfesoterodine suppliers with Written Confirmation (WC) on PharmaCompass.

Desfesoterodine GMP

Desfesoterodine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Desfesoterodine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Desfesoterodine GMP manufacturer or Desfesoterodine GMP API supplier for your needs.

Desfesoterodine CoA

A Desfesoterodine CoA (Certificate of Analysis) is a formal document that attests to Desfesoterodine's compliance with Desfesoterodine specifications and serves as a tool for batch-level quality control.

Desfesoterodine CoA mostly includes findings from lab analyses of a specific batch. For each Desfesoterodine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Desfesoterodine may be tested according to a variety of international standards, such as European Pharmacopoeia (Desfesoterodine EP), Desfesoterodine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Desfesoterodine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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