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Chemistry

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Also known as: 1616690-16-4, Desidustat [inn], Zyan-1, Zyan1, Y962pqa4ks, 1,2-dihydroquinoline-3-carbonyl]glycine
Molecular Formula
C16H16N2O6
Molecular Weight
332.31  g/mol
InChI Key
IKRKQQLJYBAPQT-UHFFFAOYSA-N
FDA UNII
Y962PQA4KS

Desidustat
Desidustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, desidustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium.
1 2D Structure

Desidustat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[[1-(cyclopropylmethoxy)-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic acid
2.1.2 InChI
InChI=1S/C16H16N2O6/c19-12(20)7-17-15(22)13-14(21)10-3-1-2-4-11(10)18(16(13)23)24-8-9-5-6-9/h1-4,9,21H,5-8H2,(H,17,22)(H,19,20)
2.1.3 InChI Key
IKRKQQLJYBAPQT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CC1CON2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
2.2 Other Identifiers
2.2.1 UNII
Y962PQA4KS
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic Acid

2. Glycine, N-((1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl)-

3. N-(1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

4. Zyan1 Compound

2.3.2 Depositor-Supplied Synonyms

1. 1616690-16-4

2. Desidustat [inn]

3. Zyan-1

4. Zyan1

5. Y962pqa4ks

6. 1,2-dihydroquinoline-3-carbonyl]glycine

7. N-[1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-

8. 2-(1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic Acid

9. Glycine, N-((1-(cyclopropylmethoxy)-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl)-

10. N-(1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

11. Zyan1 Compound

12. Unii-y962pqa4ks

13. Desidustat [who-dd]

14. Chembl4650314

15. Schembl15846922

16. Dtxsid901337362

17. Bcp29692

18. Ex-a2999

19. S9699

20. Zb1514

21. Akos037515648

22. Cs-8034

23. Ac-36284

24. Bs-16050

25. Hy-103227

26. A16921

27. D80699

28. (1-(cyclopropylmethoxy)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

29. 2-[[1-(cyclopropylmethoxy)-4-hydroxy-2-oxoquinoline-3-carbonyl]amino]acetic Acid

2.4 Create Date
2014-07-14
3 Chemical and Physical Properties
Molecular Weight 332.31 g/mol
Molecular Formula C16H16N2O6
XLogP31.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass332.10083623 g/mol
Monoisotopic Mass332.10083623 g/mol
Topological Polar Surface Area116 Ų
Heavy Atom Count24
Formal Charge0
Complexity583
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

The small molecule hypoxia-inducible factor, desidustat, inhibits the prolyl hydrozylase and stimulates erythropoiesis. It is currently being investigated against anemia of inflammation and COVID-19.


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Looking for 1616690-16-4 / Desidustat API manufacturers, exporters & distributors?

Desidustat manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Desidustat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Desidustat manufacturer or Desidustat supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Desidustat manufacturer or Desidustat supplier.

PharmaCompass also assists you with knowing the Desidustat API Price utilized in the formulation of products. Desidustat API Price is not always fixed or binding as the Desidustat Price is obtained through a variety of data sources. The Desidustat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Desidustat

Synonyms

1616690-16-4, Desidustat [inn], Zyan-1, Zyan1, Y962pqa4ks, 1,2-dihydroquinoline-3-carbonyl]glycine

Cas Number

1616690-16-4

Unique Ingredient Identifier (UNII)

Y962PQA4KS

About Desidustat

Desidustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, desidustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium.

Desidustat Manufacturers

A Desidustat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Desidustat, including repackagers and relabelers. The FDA regulates Desidustat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Desidustat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Desidustat manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Desidustat Suppliers

A Desidustat supplier is an individual or a company that provides Desidustat active pharmaceutical ingredient (API) or Desidustat finished formulations upon request. The Desidustat suppliers may include Desidustat API manufacturers, exporters, distributors and traders.

click here to find a list of Desidustat suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Desidustat GMP

Desidustat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Desidustat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Desidustat GMP manufacturer or Desidustat GMP API supplier for your needs.

Desidustat CoA

A Desidustat CoA (Certificate of Analysis) is a formal document that attests to Desidustat's compliance with Desidustat specifications and serves as a tool for batch-level quality control.

Desidustat CoA mostly includes findings from lab analyses of a specific batch. For each Desidustat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Desidustat may be tested according to a variety of international standards, such as European Pharmacopoeia (Desidustat EP), Desidustat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Desidustat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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