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Also known as: 57773-65-6, Somagard, D-trp lhrh-pea, D-trp-lhrh-pea, Bachem 9022, Tkg3i66tve
Molecular Formula
C64H83N17O12
Molecular Weight
1282.4  g/mol
InChI Key
GJKXGJCSJWBJEZ-XRSSZCMZSA-N
FDA UNII
TKG3I66TVE

Deslorelin
Deslorelin is a synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
1 2D Structure

Deslorelin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
2.1.3 InChI Key
GJKXGJCSJWBJEZ-XRSSZCMZSA-N
2.1.4 Canonical SMILES
CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
2.1.5 Isomeric SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
2.2 Other Identifiers
2.2.1 UNII
TKG3I66TVE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-trp-10-n-et-glynh2-lhrh

2. D-trp(6)-n-et-d-glynh2(10)-lhrh

3. Deslorelin Acetate

4. Gnrh, Trp(6)-n-et-glynh2(10)-

5. Lhrh, Trp(6)-n-et-glynh2(10)-

6. Lhrh, Tryptophyl(6)-n-ethylglycinamide(10)-

7. Ovuplant

8. Somagard

2.3.2 Depositor-Supplied Synonyms

1. 57773-65-6

2. Somagard

3. D-trp Lhrh-pea

4. D-trp-lhrh-pea

5. Bachem 9022

6. Tkg3i66tve

7. 1-9-luteinizing Hormone-releasing Factor (swine),6-d-tryptophan-9-(n-ethyl-l-prolinamide)-

8. 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-d-tryptophyl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide

9. Deslorelina

10. Desloreline

11. Deslorelinum

12. Ncgc00167516-01

13. Unii-tkg3i66tve

14. Desloreline [inn-french]

15. Deslorelinum [inn-latin]

16. Deslorelina [inn-spanish]

17. Gnrh (d-trp6,pro9-net)

18. Deslorelin [usan:inn:ban]

19. (d-trp6,pro9-nhet)lh-rh

20. (d-trp6,des-gly10)-lh-rh Ethylamide

21. (de-gly10,d-trp6,pro-nhet)-lh-rh

22. (des-gly10(d-tro6)-lh-rh Ethylamide

23. Lhrh-t

24. (d-trp(sub 6)-pro(sup 9)-net)-gnrh

25. Deslorelin [mi]

26. Deslorelin [inn]

27. Deslorelin (usan/inn)

28. Deslorelin [usan]

29. (d-trp6,des-gly-nh210)-lh-rh Ethylamide

30. D-trp(sup 6)-pro(sup 9)-n-ethylamide-lhrh

31. (d-trp(sup 6)-pro(sup 9))-lhrh Ethylamide

32. H 4065

33. Deslorelin [mart.]

34. Deslorelin [who-dd]

35. Schembl59413

36. Gtpl9343

37. Chembl2365665

38. Dtxsid2048323

39. Schembl19409316

40. Bdbm84726

41. Chebi:177570

42. (d-trp(sub 6)-pro(sup 9)-net)-gonadotropin Releasing Hormone

43. Gonadotropin Releasing Hormone, (d-trp(sup 6)-pro(sup 9)-net)-

44. Des-gly-10-trp-6-ethylamide-lhrh

45. (d-trp(sup 6)-pro(sup 9))-luteinizing Hormone-releasing Hormone Ethylamide

46. Akos015994649

47. Cs-5746

48. Db11510

49. Hs-2009

50. 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-1-9-luteinizing Hormone-releasing Factor (swine)

51. Gnrh, Trp(6)-n-et-pronh2(9)-

52. Lhrh, Trp(6)-n-et-pronh2(9)-

53. Ncgc00167516-02

54. Ncgc00167516-03

55. Gnrh, Des-gly(10)-trp(6)-ethylamide-

56. Hy-12556

57. Lhrh, Des-gly(10)-trp(6)-ethylamide-

58. 6-trp-9-n-et-pro-10-des-glynh2-lhrh

59. 6-d-phenylalanine-9-(n-ethyl-l-prolinamide)-

60. D03694

61. 773d656

62. Des-gly10,(d-trp6)luteinizing Hormone*releasing H

63. Lhrh, Des-glycyl(10)-tryptophyl(6)-ethylamide-

64. Q5264591

65. (d-trp6-pro9-net)luteinizing Hormone-releasing Factor

66. (d-trp(sup 6),des-gly(sup 10))-lh-rh Ethylamide

67. [des-gly10, D-trp6]-lh-rh Ethylamide, >=97% (hplc)

68. Lhrh, Tryptophyl(6)-n-ethylprolinamide(9)-des-glycinamide(10)-

69. 1-9-luteinizing Hormone-releaasing Factor (swine), 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-

70. Luteinizing Hormone-releasing Factor (pig), 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-10-deglycinamide-

71. Luteinizing Hormone-releasing Factor, 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-10-deglycinamide-

2.4 Create Date
2008-12-10
3 Chemical and Physical Properties
Molecular Weight 1282.4 g/mol
Molecular Formula C64H83N17O12
XLogP31.1
Hydrogen Bond Donor Count16
Hydrogen Bond Acceptor Count14
Rotatable Bond Count32
Exact Mass1281.64071115 g/mol
Monoisotopic Mass1281.64071115 g/mol
Topological Polar Surface Area447 Ų
Heavy Atom Count93
Formal Charge0
Complexity2610
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


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02-Jan-2021
28-Nov-2024
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ABOUT THIS PAGE

Deslorelin Manufacturers

A Deslorelin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Deslorelin, including repackagers and relabelers. The FDA regulates Deslorelin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Deslorelin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Deslorelin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Deslorelin Suppliers

A Deslorelin supplier is an individual or a company that provides Deslorelin active pharmaceutical ingredient (API) or Deslorelin finished formulations upon request. The Deslorelin suppliers may include Deslorelin API manufacturers, exporters, distributors and traders.

click here to find a list of Deslorelin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Deslorelin USDMF

A Deslorelin DMF (Drug Master File) is a document detailing the whole manufacturing process of Deslorelin active pharmaceutical ingredient (API) in detail. Different forms of Deslorelin DMFs exist exist since differing nations have different regulations, such as Deslorelin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Deslorelin DMF submitted to regulatory agencies in the US is known as a USDMF. Deslorelin USDMF includes data on Deslorelin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Deslorelin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Deslorelin suppliers with USDMF on PharmaCompass.

Deslorelin NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Deslorelin as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Deslorelin API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Deslorelin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Deslorelin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Deslorelin NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Deslorelin suppliers with NDC on PharmaCompass.

Deslorelin GMP

Deslorelin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Deslorelin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Deslorelin GMP manufacturer or Deslorelin GMP API supplier for your needs.

Deslorelin CoA

A Deslorelin CoA (Certificate of Analysis) is a formal document that attests to Deslorelin's compliance with Deslorelin specifications and serves as a tool for batch-level quality control.

Deslorelin CoA mostly includes findings from lab analyses of a specific batch. For each Deslorelin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Deslorelin may be tested according to a variety of international standards, such as European Pharmacopoeia (Deslorelin EP), Deslorelin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Deslorelin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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