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Chemistry

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Also known as: 82318-06-7, 82318-06-7 (acetate), 679007nr5c, Deslorelin monoacetate, Oxopyrrolidine-2-carboxamide, (s)-1-((3s,6s,9s,12s,15r,18s,21s)-3-((1h-imidazol-5-yl)methyl)-6,15-bis((1h-indol-3-yl)methyl)-21-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((s)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-n-ethylpyrrolidine-2-carboxamide acetate
Molecular Formula
C66H87N17O14
Molecular Weight
1342.5  g/mol
InChI Key
LYCYLGFSIXIXAB-NUZRHMIVSA-N
FDA UNII
679007NR5C

deslorelin acetate
Deslorelin Acetate is a synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
1 2D Structure

deslorelin acetate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
acetic acid;(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
2.1.2 InChI
InChI=1S/C64H83N17O12.C2H4O2/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45;1-2(3)4/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69);1H3,(H,3,4)/t45-,46-,47-,48-,49+,50-,51-,52-,53-;/m0./s1
2.1.3 InChI Key
LYCYLGFSIXIXAB-NUZRHMIVSA-N
2.1.4 Canonical SMILES
CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8.CC(=O)O
2.1.5 Isomeric SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8.CC(=O)O
2.2 Other Identifiers
2.2.1 UNII
679007NR5C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-trp-10-n-et-glynh2-lhrh

2. D-trp(6)-n-et-d-glynh2(10)-lhrh

3. Deslorelin

4. Gnrh, Trp(6)-n-et-glynh2(10)-

5. Lhrh, Trp(6)-n-et-glynh2(10)-

6. Lhrh, Tryptophyl(6)-n-ethylglycinamide(10)-

7. Ovuplant

8. Somagard

2.3.2 Depositor-Supplied Synonyms

1. 82318-06-7

2. 82318-06-7 (acetate)

3. 679007nr5c

4. Deslorelin Monoacetate

5. Oxopyrrolidine-2-carboxamide

6. (s)-1-((3s,6s,9s,12s,15r,18s,21s)-3-((1h-imidazol-5-yl)methyl)-6,15-bis((1h-indol-3-yl)methyl)-21-(3-((diaminomethylene)amino)propyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((s)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-n-ethylpyrrolidine-2-carboxamide Acetate

7. Ncgc00167516-01

8. Unii-679007nr5c

9. 1h-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1h-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1h-imidazol-4-yl)-1-oxopropan-2-yl]-5-

10. Acetic Acid;(2s)-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2r)-1-[[(2s)-1-[[(2s)-5-carbamimidamido-1-[(2s)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(

11. Suprelorin

12. Bachem 9022 Acetate

13. Dsstox_cid_26683

14. Dsstox_rid_81818

15. Dsstox_gsid_46683

16. Schembl205614

17. Deslorelin Acetate [mi]

18. Chembl2357192

19. Dtxsid1046683

20. Deslorelin Acetate [who-dd]

21. Tox21_112514

22. Mfcd09842868

23. Akos030485982

24. A73d656

25. Deslorelin Acetate [green Book]

26. Cas-82318-06-7

27. Deslorelin Acetate(57773-65-6 Free Base)

28. Deslorelin Acetate [ema Epar Veterinary]

29. Q27264098

30. (des-gly10,d-trp6,pro-nhet9)-lhrh High Acetate Salt

31. Deslorelin Acetate 100 Microg/ml In Acetonitrile:methanol

32. (d-trp(sup 6),des-gly(sup 10))-lh-rh Ethylamide Acetate

33. 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-d-tryptophyl-l-leucyl-l-arginyl-n-ethyl-l-prolinamide Acetate

34. 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-1-9-luteinizing Hormone-releasing Factor (swine) Acetate

35. 6-d-tryptophan-9-(n-ethyl-l-prolinamide)-1-9-luteinizing Hormone-releasing Factor (swine) Monoacetate

36. L-prolinamide, 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-d-tryptophyl-l-leucyl-l-arginyl-n-ethyl-,?acetate (1:1)

2.4 Create Date
2008-12-10
3 Chemical and Physical Properties
Molecular Weight 1342.5 g/mol
Molecular Formula C66H87N17O14
Hydrogen Bond Donor Count17
Hydrogen Bond Acceptor Count16
Rotatable Bond Count32
Exact Mass1341.66184052 g/mol
Monoisotopic Mass1341.66184052 g/mol
Topological Polar Surface Area485 Ų
Heavy Atom Count97
Formal Charge0
Complexity2640
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

For the induction of temporary infertility in healthy, entire, sexually mature male dogs and ferrets.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


5.2 ATC Code

QH01CA93


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02-Jan-2021
28-Nov-2024
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

deslorelin acetate Manufacturers

A deslorelin acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of deslorelin acetate, including repackagers and relabelers. The FDA regulates deslorelin acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. deslorelin acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

deslorelin acetate Suppliers

A deslorelin acetate supplier is an individual or a company that provides deslorelin acetate active pharmaceutical ingredient (API) or deslorelin acetate finished formulations upon request. The deslorelin acetate suppliers may include deslorelin acetate API manufacturers, exporters, distributors and traders.

click here to find a list of deslorelin acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

deslorelin acetate WC

A deslorelin acetate written confirmation (deslorelin acetate WC) is an official document issued by a regulatory agency to a deslorelin acetate manufacturer, verifying that the manufacturing facility of a deslorelin acetate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting deslorelin acetate APIs or deslorelin acetate finished pharmaceutical products to another nation, regulatory agencies frequently require a deslorelin acetate WC (written confirmation) as part of the regulatory process.

click here to find a list of deslorelin acetate suppliers with Written Confirmation (WC) on PharmaCompass.

deslorelin acetate GMP

deslorelin acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of deslorelin acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right deslorelin acetate GMP manufacturer or deslorelin acetate GMP API supplier for your needs.

deslorelin acetate CoA

A deslorelin acetate CoA (Certificate of Analysis) is a formal document that attests to deslorelin acetate's compliance with deslorelin acetate specifications and serves as a tool for batch-level quality control.

deslorelin acetate CoA mostly includes findings from lab analyses of a specific batch. For each deslorelin acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

deslorelin acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (deslorelin acetate EP), deslorelin acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (deslorelin acetate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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