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Desmopressin Acetate

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

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ACTIVE PHARMA INGREDIENTS

35 API Suppliers, 21 USDMF, 15 CEP/COS, 3 JDMF, 5 EU WC, 9 KDMF, 28 NDC API, 17 Listed Suppliers, $ API Reference Price

35 API Suppliers
21 USDMF
15 CEP/COS
3 JDMF
5 EU WC
9 KDMF
28 NDC API
17 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

FINISHED DOSAGE FORMULATIONS

232 FDF Dossiers, 53 FDA Orange Book, 134 Europe, 10 Canada, 12 Australia, 8 South Africa, 15 Listed Dossiers

232 FDF Dossiers
53 FDA Orange Book
134 Europe
10 Canada
12 Australia
8 South Africa
15 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;NASAL - 0.01%, SPRAY, METERED;NASAL - 0.01MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 0.004MG/ML, TABLET;ORAL - 0.1MG, TABLET;ORAL - 0.2MG, SPRAY, METERED;NASAL - 0.00083MG/SPRAY, SPRAY, METERED;NASAL - 0.00166MG/SPRAY, SPRAY, METERED;NASAL - 0.15MG/SPRAY, SPRAY, METERED;NASAL - 0.01MG/SPRAY, TABLET;SUBLINGUAL - 0.0277MG, TABLET;SUBLINGUAL - 0.0553MG

drugProductComposition
SOLUTION;NASAL - 0.01%
SPRAY, METERED;NASAL - 0.01MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - 0.004MG/ML
TABLET;ORAL - 0.1MG
TABLET;ORAL - 0.2MG
SPRAY, METERED;NASAL - 0.00083MG/SPRAY
SPRAY, METERED;NASAL - 0.00166MG/SPRAY
SPRAY, METERED;NASAL - 0.15MG/SPRAY
SPRAY, METERED;NASAL - 0.01MG/SPRAY
TABLET;SUBLINGUAL - 0.0277MG
TABLET;SUBLINGUAL - 0.0553MG

RELATED EXCIPIENT COMPANIES

3 SPI Pharma, 1 DKSH, 4 Faran Shimi Pharmaceutical, 8 Boai NKY Pharmaceuticals Ltd, 9 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 7 Actylis, 1 Aeon Procare, 1 Alcedo Pharmachem, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 15 BASF, 2 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 2 Ingredion Pharma Solutions, 18 Kerry, 10 Microlex e.U, 2 Novo Excipients, 2 Pharmatrans-Sanaq, 4 Pluviaendo, 1 Prachin Chemical, 7 Roquette, 5 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 4 Sigachi Industries, 2 Ulanqab Kema New Material, 1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders, 26 Direct Compression, 19 Disintegrants & Superdisintegrants, 17 Solubilizers, 14 Granulation, 14 Co-Processed Excipients, 13 Lubricants & Glidants, 10 Parenteral, 9 Controlled & Modified Release, 9 Thickeners and Stabilizers, 7 Chewable & Orodispersible Aids, 7 Emulsifying Agents, 4 Taste Masking, 4 Topical, 4 Surfactant & Foaming Agents, 4 Coating Systems & Additives, 3 Film Formers & Plasticizers, 2 API Stability Enhancers

excipientsByApplications
54 Fillers, Diluents & Binders
26 Direct Compression
19 Disintegrants & Superdisintegrants
17 Solubilizers
14 Granulation
14 Co-Processed Excipients
13 Lubricants & Glidants
10 Parenteral
9 Controlled & Modified Release
9 Thickeners and Stabilizers
7 Chewable & Orodispersible Aids
7 Emulsifying Agents
4 Taste Masking
4 Topical
4 Surfactant & Foaming Agents
4 Coating Systems & Additives
3 Film Formers & Plasticizers
2 API Stability Enhancers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 28 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
28 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 123 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
123 Finished Drug Prices

MARKET PLACE

8 APIs, 8 FDF Dossiers

marketPlace
8 APIs
8 FDF Dossiers

PATENTS & EXCLUSIVITIES

13 US Patents, 18 Health Canada Patents

patents
13 US Patents
18 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP , 3 Others

otherSolutions
2 EDQM
1 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 286,769

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

232

FDF Dossiers

FDA Orange Book

134

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

4,970,495

Annual Reports (USD Million)

Finished Drug Prices

128 RELATED EXCIPIENT COMPANIES

220EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Octostim, Minirin, Ddavp, Stimate, Concentraid, Desmopressin acetate anhydrous

Molecular Formula

C₄₈H₆₈N₁₄O₁₄S₂

Molecular Weight

1129.3 g/mol

InChI Key

MLSVJHOYXJGGTR-IFHOVBQLSA-N

FDA UNII

1K12647SFC

A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.

1 2D Structure

Desmopressin Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

2.1.2 InChI

InChI=1S/C46H64N14O12S2.C2H4O2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4)/t28-,29+,30+,31+,32+,33+,34+;/m1./s1

2.1.3 InChI Key

MLSVJHOYXJGGTR-IFHOVBQLSA-N

2.1.4 Canonical SMILES

CC(=O)O.C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N

2.1.5 Isomeric SMILES

CC(=O)O.C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N

2.2 Other Identifiers

2.2.1 UNII

1K12647SFC

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-deamino-8-d-arginine Vasopressin

2. 1-desamino-8-arginine Vasopressin

3. Acetate, Desmopressin

4. Adiuretin

5. Adiuretin Sd

6. Apo-desmopressin

7. Arginine Vasopressin, Deamino

8. Ddavp

9. Deamino Arginine Vasopressin

10. Desmogalen

11. Desmopressin

12. Desmopressin Monoacetate

13. Desmopressin Monoacetate, Trihydrate

14. Desmopressine Ferring

15. Desmospray

16. Desmotabs

17. Ferring, Desmopressine

18. Minirin

19. Minurin

20. Monoacetate, Desmopressin

21. Monoacetate, Trihydrate Desmopressin

22. Nocutil

23. Octim

24. Octostim

25. Trihydrate Desmopressin Monoacetate

26. Vasopressin, 1-deamino-8-d-arginine

27. Vasopressin, 1-desamino-8-arginine

28. Vasopressin, Deamino Arginine

2.3.2 Depositor-Supplied Synonyms

1. Octostim

2. Minirin

3. Ddavp

4. Stimate

5. Concentraid

6. Desmopressin Acetate Anhydrous

7. Noctiva

8. 62288-83-9

9. Ddavp (needs No Refrigeration)

10. Desmospray

11. Anhydrous Desmopressin Acetate

12. Desmopressin Acetate Preservative Free

13. Desmopressin Acetate (needs No Refrigeration)

14. 1k12647sfc

15. Desmopressin Acetate Hydrate

16. Desmotabs

17. Minirine

18. Nocutil

19. Octim

20. Desmopressin Acetate Trihydrate

21. Demopressin Acetate

22. Ddavp Nasal Spray

23. Ddavp Rhinal Tube

24. Stimate Nasal Spray

25. Noqdirna

26. Presinex

27. Desmomelt

28. Unii-1k12647sfc

29. Desmopressin Acetate [usan:jan]

30. Chembl1200556

31. Dtxsid4046864

32. 16679-58-6(free Base)

33. Desmopressin Acetate [mi]

34. Stimate (needs No Refrigeration)

35. Ex-a4285

36. 1-(3-mercaptopropionic Acid)-8-d-arginine Vasopression Monoacetate

37. Bdbm50247923

38. Mfcd00133962

39. Akos025311518

40. Ccg-270644

41. Desmopressin Monoacetate Anhydrous

42. Anhydrous Desmopressin Acetate [mart.]

43. (deamino-cys1,d-arg8)-vasopressin Acetate

44. 789d983

45. Q27252517

46. 1-(3-mercaptopropionic Acid)-8-d-arginine-vasopressin Monoacetate (salt)

47. Vasopressin, 1-(3-mercaptopropanoic Acid)-8-d-arginine-, Monoacetate (salt)

48. Vasopressin,1-(3-mercaptopropanoic Acid)-8-d-arginine-,monoacetate(salt)(9ci)

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₄₈H₆₈N₁₄O₁₄S₂
Molecular Weight	1129.3 g/mol
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	19
Exact Mass	1128.44808525 g/mol
Monoisotopic Mass	1128.44808525 g/mol
Topological Polar Surface Area	526 Å²
Heavy Atom Count	78
Formal Charge	0
Complexity	2070
Isotope Atom Count	0
Defined Atom Stereocenter Count	7
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Desmopressin acetate
Drug Label	Desmopressin Nasal Spray Solution USP, 0.01% is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. The structural formula for the active ingredient is:Mol. w...
Active Ingredient	Desmopressin acetate
Dosage Form	Injectable; Spray, metered; Tablet; Solution
Route	Nasal; oral; Injection; Oral
Strength	0.01mg/spray; 0.004mg/ml; 0.2mg; 0.01%; 0.1mg
Market Status	Tentative Approval; Prescription
Company	Mylan Pharms; Glenmark Generics; Teva Pharms; Hospira; Actavis Labs Fl; Apotex; Bausch And Lomb; Sun Pharm Inds; Teva Pharms Usa; Ferring

2 of 2
Drug Name	Desmopressin acetate
Drug Label	Desmopressin Nasal Spray Solution USP, 0.01% is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. The structural formula for the active ingredient is:Mol. w...
Active Ingredient	Desmopressin acetate
Dosage Form	Injectable; Spray, metered; Tablet; Solution
Route	Nasal; oral; Injection; Oral
Strength	0.01mg/spray; 0.004mg/ml; 0.2mg; 0.01%; 0.1mg
Market Status	Tentative Approval; Prescription
Company	Mylan Pharms; Glenmark Generics; Teva Pharms; Hospira; Actavis Labs Fl; Apotex; Bausch And Lomb; Sun Pharm Inds; Teva Pharms Usa; Ferring

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antidiuretic Agents

Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS. (See all compounds classified as Antidiuretic Agents.)

Hemostatics

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Increased Coagulation Factor VIII Activity [PE]; Increased Coagulation Factor VIII Concentration [PE]; Vasopressin Analog [EPC]; Vasopressins [CS]; Factor VIII Activator [EPC]

API SUPPLIERS

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API Reference Price

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - SOLUTION;NASAL - 0.01%

USFDA APPLICATION NUMBER - 17922

DOSAGE - SPRAY, METERED;NASAL - 0.01MG/SPRAY ...DOSAGE - SPRAY, METERED;NASAL - 0.01MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 17922

DOSAGE - INJECTABLE;INJECTION - 0.004MG/ML

USFDA APPLICATION NUMBER - 18938

DOSAGE - TABLET;ORAL - 0.1MG

USFDA APPLICATION NUMBER - 19955

DOSAGE - TABLET;ORAL - 0.2MG

USFDA APPLICATION NUMBER - 19955

DOSAGE - SPRAY, METERED;NASAL - 0.00083MG/SPR...DOSAGE - SPRAY, METERED;NASAL - 0.00083MG/SPRAY

USFDA APPLICATION NUMBER - 201656

DOSAGE - SPRAY, METERED;NASAL - 0.00166MG/SPR...DOSAGE - SPRAY, METERED;NASAL - 0.00166MG/SPRAY

USFDA APPLICATION NUMBER - 201656

DOSAGE - SPRAY, METERED;NASAL - 0.15MG/SPRAY

USFDA APPLICATION NUMBER - 20355

DOSAGE - SPRAY, METERED;NASAL - 0.01MG/SPRAY

USFDA APPLICATION NUMBER - 21333

DOSAGE - TABLET;SUBLINGUAL - 0.0277MG

USFDA APPLICATION NUMBER - 22517

DOSAGE - TABLET;SUBLINGUAL - 0.0553MG

USFDA APPLICATION NUMBER - 22517

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12 Australia

8 South Africa

15 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;NASAL - 0.01%

SPRAY, METERED;NASAL - 0.01MG/SPRAY **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - 0.004MG/ML

TABLET;ORAL - 0.1MG

TABLET;ORAL - 0.2MG

SPRAY, METERED;NASAL - 0.00083MG/SPRAY

SPRAY, METERED;NASAL - 0.00166MG/SPRAY

SPRAY, METERED;NASAL - 0.15MG/SPRAY

SPRAY, METERED;NASAL - 0.01MG/SPRAY

TABLET;SUBLINGUAL - 0.0277MG

TABLET;SUBLINGUAL - 0.0553MG

RELATED EXCIPIENT COMPANIES

3 SPI Pharma

1 DKSH

4 Faran Shimi Pharmaceutical

8 Boai NKY Pharmaceuticals Ltd

9 Gangwal Healthcare

3 Nanjing Well Pharmaceutical

7 Actylis

1 Aeon Procare

1 Alcedo Pharmachem

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

15 BASF

2 DFE Pharma

1 Finar

7 Gangwal Chemicals

2 Ingredion Pharma Solutions

18 Kerry

10 Microlex e.U

2 Novo Excipients

2 Pharmatrans-Sanaq

4 Pluviaendo

1 Prachin Chemical

7 Roquette

5 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

4 Sigachi Industries

2 Ulanqab Kema New Material

1 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders

26 Direct Compression

19 Disintegrants & Superdisintegrants

17 Solubilizers

14 Granulation

14 Co-Processed Excipients

13 Lubricants & Glidants

10 Parenteral

9 Controlled & Modified Release

9 Thickeners and Stabilizers

7 Chewable & Orodispersible Aids

7 Emulsifying Agents

SPRAY, METERED;NASAL - 0.01MG/SPRAY Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons