Synopsis
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Australia
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1. Desocort
2. Desone
3. Desowen
4. Locapred
5. Locatop
6. Prednacinolone
7. Tridsonit
8. Tridesilon
1. 638-94-8
2. Prednacinolone
3. Locapred
4. Desowen
5. Desonate
6. Topifug
7. Desonida
8. Desonidum
9. Tridesilon
10. Apolar
11. Verdeso
12. D-2083
13. Steroderm
14. Sterax
15. Desfluorotriamcinolone Acetonide
16. 16alpha-hydroxyprednisole-16,17-acetonide
17. Tridesonit
18. D2083
19. Desilux
20. 16alpha,17alpha-isopropylidenedioxyprednisolone
21. Chebi:204734
22. 16alpha-hydroxyprednisolone-16alpha,17-acetonide
23. J280872d1o
24. Nsc-759226
25. Hamiltoderm
26. Flusemidon
27. Reticus
28. Zotinar
29. 11beta,21-dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione
30. 11beta,21-dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
31. 11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione
32. Dsstox_cid_26756
33. Dsstox_rid_81880
34. Dsstox_gsid_46756
35. (1s,2s,4r,8s,9s,11s,12s,13r)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
36. D 2083
37. Desonidum [inn-latin]
38. Desonida [inn-spanish]
39. Desonide [usan:inn:ban]
40. Cas-638-94-8
41. Desowen (tn)
42. Verdeso (tn)
43. Mfcd00866151
44. 16-alpha-hydroxyprednisole-16,17-acetonide
45. Unii-j280872d1o
46. Ncgc00167983-01
47. Ncgc00274065-01
48. Einecs 211-351-6
49. Desonide (usp/inn)
50. Desonide [usan]
51. Desonide [inn]
52. Desonide [mi]
53. Desonide [vandf]
54. Desonide [mart.]
55. Desonide [usp-rs]
56. Desonide [who-dd]
57. Schembl3631
58. 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Acetone
59. Desonide [orange Book]
60. Gtpl7066
61. Desonide [usp Impurity]
62. Chembl1201109
63. Desonide [usp Monograph]
64. Dtxsid7046756
65. Hms3715p20
66. 11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Acetone
67. Bcp04201
68. Hy-b0248
69. Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11.beta.,16.alpha.)-
70. Tridesilon Component Desonide
71. Zinc4212851
72. Tox21_112603
73. 16alpha-hydroxyprednisolone Acetonide
74. S1701
75. Akos037643323
76. Tox21_112603_1
77. Ccg-221279
78. Db01260
79. Desonide Component Of Tridesilon
80. Nsc 759226
81. (4ar,4bs,5s,6as,6bs,9ar,10as,10bs)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2h-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
82. As-13892
83. Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-
84. Budesonide Impurity F [ep Impurity]
85. D5578
86. D03696
87. F20496
88. Ab01274712-01
89. Ab01274712_02
90. 638d948
91. Prednisolone-16,17-acetonide, 16-alpha-hydroxy-
92. Q904011
93. Q-101382
94. Brd-k21528677-001-03-6
95. 16?,17-[1-methylethylidenebis(oxy)]-11?,21-dihydroxypregna-1,4-diene-3,20-dione
96. (11beta,16alpha)-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione
97. (1s,2s,4r,8s,9s,11s,12s,13r)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
98. 16alpha,17-[1-methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (desonide)
| Molecular Weight | 416.5 g/mol |
|---|---|
| Molecular Formula | C24H32O6 |
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 416.21988874 g/mol |
| Monoisotopic Mass | 416.21988874 g/mol |
| Topological Polar Surface Area | 93.1 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 873 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 8 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 8 | |
|---|---|
| Drug Name | Desonate |
| PubMed Health | Desonide (On the skin) |
| Drug Classes | Corticosteroid, Strong |
| Drug Label | Desonate contains desonide [(pregna-1, 4-diene-3, 20-dione,11, 21-dihydroxy-16, 17-[(1-methylethylidene) bis(oxy)]-,(11,16)]- a synthetic nonfluorinated corticosteroid for topical dermatologic use. Chemically, desonide is C24H32O6. It has the fol... |
| Active Ingredient | Desonide |
| Dosage Form | Gel |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Bayer Hlthcare |
| 2 of 8 | |
|---|---|
| Drug Name | Desonide |
| Drug Label | VERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1... |
| Active Ingredient | Desonide |
| Dosage Form | Lotion; Ointment; Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms; Perrigo New York; Taro |
| 3 of 8 | |
|---|---|
| Drug Name | Desowen |
| Drug Label | DesOwen Cream 0.05%, Ointment 0.05%, and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 [(1methylethylidene) bis(oxy)]-,(11,16)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corti... |
| Active Ingredient | Desonide |
| Dosage Form | Lotion; Ointment; Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Galderma Labs |
| 4 of 8 | |
|---|---|
| Drug Name | Verdeso |
| PubMed Health | Desonide (On the skin) |
| Drug Classes | Corticosteroid, Strong |
| Drug Label | VERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1... |
| Active Ingredient | Desonide |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Aqua Pharms |
| 5 of 8 | |
|---|---|
| Drug Name | Desonate |
| PubMed Health | Desonide (On the skin) |
| Drug Classes | Corticosteroid, Strong |
| Drug Label | Desonate contains desonide [(pregna-1, 4-diene-3, 20-dione,11, 21-dihydroxy-16, 17-[(1-methylethylidene) bis(oxy)]-,(11,16)]- a synthetic nonfluorinated corticosteroid for topical dermatologic use. Chemically, desonide is C24H32O6. It has the fol... |
| Active Ingredient | Desonide |
| Dosage Form | Gel |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Bayer Hlthcare |
| 6 of 8 | |
|---|---|
| Drug Name | Desonide |
| Drug Label | VERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1... |
| Active Ingredient | Desonide |
| Dosage Form | Lotion; Ointment; Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Fougera Pharms; Perrigo New York; Taro |
| 7 of 8 | |
|---|---|
| Drug Name | Desowen |
| Drug Label | DesOwen Cream 0.05%, Ointment 0.05%, and Lotion 0.05% contain desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 [(1methylethylidene) bis(oxy)]-,(11,16)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corti... |
| Active Ingredient | Desonide |
| Dosage Form | Lotion; Ointment; Cream |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Galderma Labs |
| 8 of 8 | |
|---|---|
| Drug Name | Verdeso |
| PubMed Health | Desonide (On the skin) |
| Drug Classes | Corticosteroid, Strong |
| Drug Label | VERDESO Foam is a white to off-white petrolatum-based emulsion aerosol foam containing the active ingredient desonide, a low-potency topical corticosteroid.Chemically, desonide is (11,16)-11,21-dihydroxy-16,17-[(1-methylethylidene)-bis(oxy)]-pregna-1... |
| Active Ingredient | Desonide |
| Dosage Form | Aerosol, foam |
| Route | Topical |
| Strength | 0.05% |
| Market Status | Prescription |
| Company | Aqua Pharms |
For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
D07AB08
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
D - Dermatologicals
D07 - Corticosteroids, dermatological preparations
D07A - Corticosteroids, plain
D07AB - Corticosteroids, moderately potent (group ii)
D07AB08 - Desonide
S - Sensory organs
S01 - Ophthalmologicals
S01B - Antiinflammatory agents
S01BA - Corticosteroids, plain
S01BA11 - Desonide
Absorption
Topical corticosteroids can be absorbed from normal intact skin, inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
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DOSAGE - CREAM;TOPICAL - 0.05%
USFDA APPLICATION NUMBER - 17010
DOSAGE - OINTMENT;TOPICAL - 0.05%
USFDA APPLICATION NUMBER - 17426
DOSAGE - GEL;TOPICAL - 0.05% **Federal Regist...DOSAGE - GEL;TOPICAL - 0.05% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
USFDA APPLICATION NUMBER - 21844
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