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    Chemistry

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    Also known as: 382-67-2, Desoxymethasone, Topicort, Desoximetasona, Desoximetasonum, Topicort lp
    Molecular Formula
    C22H29FO4
    Molecular Weight
    376.5  g/mol
    InChI Key
    VWVSBHGCDBMOOT-IIEHVVJPSA-N
    FDA UNII
    4E07GXB7AU
    Desoximetasone
    A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc.
    Desoximetasone is a Corticosteroid. The mechanism of action of desoximetasone is as a Corticosteroid Hormone Receptor Agonist.
    1 2D Structure

    Desoximetasone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
    2.1.2 InChI
    InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
    2.1.3 InChI Key
    VWVSBHGCDBMOOT-IIEHVVJPSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)CO)C)O)F)C
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)F)C
    2.2 Other Identifiers
    2.2.1 UNII
    4E07GXB7AU
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 17 Desoxymethasone

    2. 17-desoxymethasone

    3. A 41304

    4. A-41304

    5. A41304

    6. Deoxydexamethasone

    7. Desoxi

    8. Desoxymethasone

    9. Flubason

    10. Ibaril

    11. Stiedex

    12. Topicort

    13. Topicorte

    14. Topisolon

    2.3.2 Depositor-Supplied Synonyms

    1. 382-67-2

    2. Desoxymethasone

    3. Topicort

    4. Desoximetasona

    5. Desoximetasonum

    6. Topicort Lp

    7. Desoxymetasone

    8. Hoe-304

    9. Hoe 304

    10. A-41-304

    11. Deoxymethasone

    12. 9-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione

    13. R-2113

    14. (8s,9r,10s,11s,13s,14s,16r,17s)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6h-cyclopenta[a]phenanthren-3-one

    15. Chebi:691037

    16. Dexamethasone Impurity F

    17. R 2113

    18. 4e07gxb7au

    19. Esperson

    20. Mls000028654

    21. 17-deoxymethansone

    22. 17-desoximethasone

    23. A-41304

    24. 9alpha-fluoro-16alpha-methyl-delta(1)-corticosterone

    25. Nsc-759189

    26. (8s,9r,10s,11s,13s,14s,16r,17s)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one

    27. 140218-14-0

    28. Ncgc00023648-03

    29. Flubason

    30. J83.644c

    31. Smr000058856

    32. Stiedex

    33. Ibaril

    34. (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

    35. Dsstox_cid_25647

    36. Dsstox_rid_81025

    37. Dsstox_gsid_45647

    38. Desossimetasone

    39. A 41304

    40. Topicort (tn)

    41. Cas-382-67-2

    42. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, Labeled With Tritium, (11beta,16alpha)-

    43. Desossimetasone [dcit]

    44. A 41-304

    45. Desoximetasone (usp/inn)

    46. Unii-4e07gxb7au

    47. Desoximetasonum [inn-latin]

    48. Desoximetasona [inn-spanish]

    49. Einecs 206-845-3

    50. Desoximetasone [usan:usp:inn:ban]

    51. Brn 2228097

    52. Opera_id_52

    53. Desoximetasone [mi]

    54. Schembl4214

    55. Chembl1766

    56. Desoximetasone [inn]

    57. Desoximetasone [jan]

    58. Desoximetasone [usan]

    59. Mls001076073

    60. Mls001424230

    61. Desoximetasone [vandf]

    62. Desoximetasone [mart.]

    63. Gtpl7067

    64. Desoximetasone [usp-rs]

    65. Desoximetasone [who-dd]

    66. Dtxsid3045647

    67. 9-fluoro-11.beta.,21-dihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione

    68. Hms2052c15

    69. Hms2236h07

    70. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-

    71. Zinc4212854

    72. Desoximetasone [orange Book]

    73. Tox21_110889

    74. Bdbm50103622

    75. Desoximetasone [usp Impurity]

    76. Mfcd00083301

    77. S5685

    78. Desoximetasone [usp Monograph]

    79. 9-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione

    80. Akos030254657

    81. Tox21_110889_1

    82. Ccg-101120

    83. Db00547

    84. Nc00370

    85. Nsc 759189

    86. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11beta,16alpha)-

    87. Ncgc00023648-04

    88. As-15787

    89. Hy-17570

    90. D5515

    91. Dexamethasone Impurity F [ep Impurity]

    92. D03697

    93. T72402

    94. 382d672

    95. Q385370

    96. Q-200938

    97. 9alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1.4-pregnadiene-3,20-dione

    98. (1r,2s,10s,11s,13r,14s,15s,17s)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one

    2.4 Create Date
    2005-06-29
    3 Chemical and Physical Properties
    Molecular Weight 376.5 g/mol
    Molecular Formula C22H29FO4
    XLogP32.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass376.20498756 g/mol
    Monoisotopic Mass376.20498756 g/mol
    Topological Polar Surface Area74.6 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity757
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameDesoximetasone
    Drug LabelTopicort (desoximetasone cream USP) 0.05%, Topicort (desoximetasone cream USP) 0.25%, and Topicort (desoximetasone gel USP) 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of prim...
    Active IngredientDesoximetasone
    Dosage FormGel; Ointment; Cream
    RouteTopical
    Strength0.05%; 0.25%
    Market StatusPrescription
    CompanyGlenmark Generics; Fougera Pharms; Versapharm; Perrigo New York

    2 of 4  
    Drug NameTopicort
    PubMed HealthDesoximetasone (On the skin)
    Drug ClassesAnti-Inflammatory, Corticosteroid, Strong, Dermatological Agent
    Drug LabelTopicort (desoximetasone cream USP) 0.05%, Topicort (desoximetasone cream USP) 0.25%, and Topicort (desoximetasone gel USP) 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of prim...
    Active IngredientDesoximetasone
    Dosage FormOintment; Cream; Spray; Gel
    RouteTopical
    Strength0.05%; 0.25%
    Market StatusPrescription
    CompanyTaro; Taro Pharms North

    3 of 4  
    Drug NameDesoximetasone
    Drug LabelTopicort (desoximetasone cream USP) 0.05%, Topicort (desoximetasone cream USP) 0.25%, and Topicort (desoximetasone gel USP) 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of prim...
    Active IngredientDesoximetasone
    Dosage FormGel; Ointment; Cream
    RouteTopical
    Strength0.05%; 0.25%
    Market StatusPrescription
    CompanyGlenmark Generics; Fougera Pharms; Versapharm; Perrigo New York

    4 of 4  
    Drug NameTopicort
    PubMed HealthDesoximetasone (On the skin)
    Drug ClassesAnti-Inflammatory, Corticosteroid, Strong, Dermatological Agent
    Drug LabelTopicort (desoximetasone cream USP) 0.05%, Topicort (desoximetasone cream USP) 0.25%, and Topicort (desoximetasone gel USP) 0.05% contain the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of prim...
    Active IngredientDesoximetasone
    Dosage FormOintment; Cream; Spray; Gel
    RouteTopical
    Strength0.05%; 0.25%
    Market StatusPrescription
    CompanyTaro; Taro Pharms North

    4.2 Drug Indication

    For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Desoximetasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    DESOXIMETASONE
    5.3.2 FDA UNII
    4E07GXB7AU
    5.3.3 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
    5.4 ATC Code

    D - Dermatologicals

    D07 - Corticosteroids, dermatological preparations

    D07A - Corticosteroids, plain

    D07AC - Corticosteroids, potent (group iii)

    D07AC03 - Desoximetasone

    D - Dermatologicals

    D07 - Corticosteroids, dermatological preparations

    D07X - Corticosteroids, other combinations

    D07XC - Corticosteroids, potent, other combinations

    D07XC02 - Desoximetasone

    5.5 Absorption, Distribution and Excretion

    Absorption

    Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

    Route of Elimination

    Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.Pharmacokinetic studies in men with Desoximetasone Cream USP, 0.25% with tagged desoximetasone showed a total of 5.2% 2.9% excretion in urine (4.1% 2.3%) and feces (1.1% 0.6%)

    5.6 Metabolism/Metabolites

    Metabolized, primarily in the liver, and then excreted by the kidneys.

    5.7 Biological Half-Life

    The half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.

    5.8 Mechanism of Action

    The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. This is achieved first by the drug binding to the glucocorticoid receptors which then translocates into the nucleus and binds to DNA causing various activations and repressions of genes. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

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PHARMACEUTICALS","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"12500","totalValueFC":"12611.6","currency":"USD","unitRateINR":"961250","date":"25-Mar-2022","totalValueINR":"961250","totalValueInUsd":"12611.6","indian_port":"DELHI AIR","hs_no":"29372200","bill_no":"8013480","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1658169000,"product":"DESOXIMETASONE USP (DESOXIMETASONE MICRONIZED USP) BATCH NO21320M1 B0032123","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"NA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"0.2","unit":"KGS","unitRateFc":"12500","totalValueFC":"2512.1","currency":"USD","unitRateINR":"998750","date":"19-Jul-2022","totalValueINR":"199750","totalValueInUsd":"2512.1","indian_port":"DELHI AIR","hs_no":"29372200","bill_no":"9613206","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1658169000,"product":"DESOXIMETASONE USP (DESOXIMETASONE MICRONIZED USP) BATCH NO21320M1 B0032123","address":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:","city":"MUMBAI","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"NA","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"12500","totalValueFC":"3768.1","currency":"USD","unitRateINR":"998750","date":"19-Jul-2022","totalValueINR":"299625","totalValueInUsd":"3768.1","indian_port":"DELHI AIR","hs_no":"29372200","bill_no":"9613206","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"B\/2 MAHALAXMI CHAMBERS 22 BHULABHAI DESAI ROAD Contact No:"}]
    02-Jan-2021
    07-Nov-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    ABOUT THIS PAGE

    Desoximetasone Manufacturers

    A Desoximetasone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Desoximetasone, including repackagers and relabelers. The FDA regulates Desoximetasone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Desoximetasone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Desoximetasone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Desoximetasone Suppliers

    A Desoximetasone supplier is an individual or a company that provides Desoximetasone active pharmaceutical ingredient (API) or Desoximetasone finished formulations upon request. The Desoximetasone suppliers may include Desoximetasone API manufacturers, exporters, distributors and traders.

    click here to find a list of Desoximetasone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Desoximetasone USDMF

    A Desoximetasone DMF (Drug Master File) is a document detailing the whole manufacturing process of Desoximetasone active pharmaceutical ingredient (API) in detail. Different forms of Desoximetasone DMFs exist exist since differing nations have different regulations, such as Desoximetasone USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Desoximetasone DMF submitted to regulatory agencies in the US is known as a USDMF. Desoximetasone USDMF includes data on Desoximetasone's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Desoximetasone USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Desoximetasone suppliers with USDMF on PharmaCompass.

    Desoximetasone KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Desoximetasone Drug Master File in Korea (Desoximetasone KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Desoximetasone. The MFDS reviews the Desoximetasone KDMF as part of the drug registration process and uses the information provided in the Desoximetasone KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Desoximetasone KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Desoximetasone API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Desoximetasone suppliers with KDMF on PharmaCompass.

    Desoximetasone NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Desoximetasone as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Desoximetasone API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Desoximetasone as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Desoximetasone and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Desoximetasone NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Desoximetasone suppliers with NDC on PharmaCompass.

    Desoximetasone GMP

    Desoximetasone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Desoximetasone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Desoximetasone GMP manufacturer or Desoximetasone GMP API supplier for your needs.

    Desoximetasone CoA

    A Desoximetasone CoA (Certificate of Analysis) is a formal document that attests to Desoximetasone's compliance with Desoximetasone specifications and serves as a tool for batch-level quality control.

    Desoximetasone CoA mostly includes findings from lab analyses of a specific batch. For each Desoximetasone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Desoximetasone may be tested according to a variety of international standards, such as European Pharmacopoeia (Desoximetasone EP), Desoximetasone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Desoximetasone USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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