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ACTIVE PHARMA INGREDIENTS

12 API Suppliers, 2 NDC API, 12 Listed Suppliers, $ API Reference Price

12 API Suppliers
2 NDC API
12 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

16 Drugs in Development

16 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 1 FDA Orange Book, 1 Canada, 1 Australia, 1 Listed Dossiers

4 FDF Dossiers
1 FDA Orange Book
1 Canada
1 Australia
1 Listed Dossiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 31 NEWS #PharmaBuzz

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2 DATA COMPILATION #PharmaFlow
31 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 2 Annual Reports

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1 US Medicaid Prescriptions
2 Annual Reports

MARKET PLACE

1 APIs, 1 FDF Dossiers

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1 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 US Patents, 1 US Exclusivities

patents
3 US Patents
1 US Exclusivities

Farmhispania Deucravacitinib

Synopsis

ACTIVE PHARMA INGREDIENTS

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FDF Dossiers

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Europe

Canada

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REF. STANDARDS OR IMPURITIES

EDQM

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PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,499,644

Annual Reports (USD Million)

178

Finished Drug Prices

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Chemistry

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Also known as: Bms-986165, 1609392-27-9, Tyk2-in-4, Bms986165, Deucravacitinib [usan], N0a21n6rau

Molecular Formula

C₂₀H₂₂N₈O₃

Molecular Weight

425.5 g/mol

InChI Key

BZZKEPGENYLQSC-FIBGUPNXSA-N

FDA UNII

N0A21N6RAU

Deucravacitinib is under investigation in clinical trial NCT04772079 (A Study to Evaluate the Drug Levels, Efficacy and Safety of BMS-986165 in Adolescent Participants With Moderate to Severe Plaque Psoriasis).

1 2D Structure

Deucravacitinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide

2.1.2 InChI

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4-5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23,24,25,29)/i1D3

2.1.3 InChI Key

BZZKEPGENYLQSC-FIBGUPNXSA-N

2.1.4 Canonical SMILES

CNC(=O)C1=NN=C(C=C1NC2=CC=CC(=C2OC)C3=NN(C=N3)C)NC(=O)C4CC4

2.1.5 Isomeric SMILES

[2H]C([2H])([2H])NC(=O)C1=NN=C(C=C1NC2=CC=CC(=C2OC)C3=NN(C=N3)C)NC(=O)C4CC4

2.2 Other Identifiers

2.2.1 UNII

N0A21N6RAU

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bms-986165

2.3.2 Depositor-Supplied Synonyms

1. Bms-986165

2. 1609392-27-9

3. Tyk2-in-4

4. Bms986165

5. Deucravacitinib [usan]

6. N0a21n6rau

7. 6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-n-(trideuteriomethyl)pyridazine-3-carboxamide

8. Deucravacitinib (usan)

9. Sotyktu

10. Unii-n0a21n6rau

11. Deucravacitinib [inn]

12. Deucravacitinib [jan]

13. Chembl4435170

14. Deucravacitinib [who-dd]

15. Schembl20520348

16. Gtpl10432

17. Ex-a3154

18. Bdbm50507816

19. Mfcd31715455

20. Nsc825520

21. S8879

22. Tyk2-in-4(bms986165)

23. Who 11342

24. At18623

25. Nsc-825520

26. Compound 11 [pmid: 31318208}

27. Ncgc00687789-01

28. Ac-31543

29. Hy-117287

30. Cs-0065044

31. D11817

32. 3-pyridazinecarboxamide, 6-((cyclopropylcarbonyl)amino)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)-

33. 3-pyridazinecarboxamide, 6-((cyclopropylcarbonyl)amino]-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)n-(methyl-d3)-

34. 6-((cyclopropylcarbonyl)amino)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(2h3)methyl-3-pyridazine-carboxamide

35. 6-((cyclopropylcarbonyl)amino]-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-((2h3)methyl)pyridazine-3-carboxamide

36. 6-[(cyclopropylcarbonyl)amino]-4-[[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino]-n-(methyl-d3)-3-pyridazinecarboxamide

2.4 Create Date

2018-10-30

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₂N₈O₃
Molecular Weight	425.5 g/mol
XLogP3	1.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Exact Mass	425.20031683 g/mol
Monoisotopic Mass	425.20031683 g/mol
Topological Polar Surface Area	136 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	648
Isotope Atom Count	3
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of psoriasis

Treatment of Systemic Lupus Erythematosus (SLE)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Dermatologic Agents

Drugs used to treat or prevent skin disorders or for the routine care of skin. (See all compounds classified as Dermatologic Agents.)

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

5.2 ATC Code

L - Antineoplastic and immunomodulating agents

L04 - Immunosuppressants

L04A - Immunosuppressants

L04AA - Selective immunosuppressants

L04AA56 - Deucravacitinib

API SUPPLIERS

01

Farmhispania

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.

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Spain

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

02

Ami Lifesciences Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

AMI Lifesciences is Driven by Chemistry. Powered by People.

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India

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03

Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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India

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04

Dr. Reddy's Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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India

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05

Egis Pharmaceuticals PLC

Hungary

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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Hungary

Virtual Booth

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06

Moehs Iberica

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI WW Frankfurt

Booth #11.0C6

Moehs Group, a reference company in the production of pharmaceutical active ingredients.

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Spain

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07

Changzhou Pharmaceutical Factory

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

08

Curia

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

09

Micro Labs Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

10

Shanghai Hope Chem

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Not Confirmed

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API Reference Price

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