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Chemistry

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Also known as: 1qc36bhi6s, Lyt-100, 1093951-85-9, 2(1h)-pyridinone, 5-(methyl-d3)-1-phenyl-, 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one, Deupirfenidone [usan]
Molecular Formula
C12H11NO
Molecular Weight
188.24  g/mol
InChI Key
ISWRGOKTTBVCFA-FIBGUPNXSA-N
FDA UNII
1QC36BHI6S

Deupirfenidone
Deupirfenidone is an orally bioavailable and deuterated form of the synthetic antifibrotic agent pirfenidone, with potential anti-inflammatory and anti-fibrotic activities. Upon administration, deupirfenidone inhibits a variety of pro-inflammatory mediators, such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a) and transforming growth factor-beta (TGF-b). This may reduce fibrosis, inflammation and infection, and may repair the impaired lymphatic flow, decrease lymphedema and restore lymphatic function. In the lungs, deupirfenidone may abrogate impaired lung function, lymphoedema and pulmonary fibrosis.
1 2D Structure

Deupirfenidone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-phenyl-5-(trideuteriomethyl)pyridin-2-one
2.1.2 InChI
InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3/i1D3
2.1.3 InChI Key
ISWRGOKTTBVCFA-FIBGUPNXSA-N
2.1.4 Canonical SMILES
CC1=CN(C(=O)C=C1)C2=CC=CC=C2
2.1.5 Isomeric SMILES
[2H]C([2H])([2H])C1=CN(C(=O)C=C1)C2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
1QC36BHI6S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one

2. 5-methyl-1-phenyl-2-(1h)-pyridone

3. Deskar

4. Esbriet

5. Pirfenidone

2.3.2 Depositor-Supplied Synonyms

1. 1qc36bhi6s

2. Lyt-100

3. 1093951-85-9

4. 2(1h)-pyridinone, 5-(methyl-d3)-1-phenyl-

5. 1-phenyl-5-(trideuteriomethyl)-1,2-dihydropyridin-2-one

6. Deupirfenidone [usan]

7. Unii-1qc36bhi6s

8. Lyt100

9. Schembl4059454

10. Deupirfenidone [who-dd]

11. Sd-560

12. Who 12460

13. At18410

2.4 Create Date
2009-02-09
3 Chemical and Physical Properties
Molecular Weight 188.24 g/mol
Molecular Formula C12H11NO
XLogP31.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass188.102894212 g/mol
Monoisotopic Mass188.102894212 g/mol
Topological Polar Surface Area20.3 Ų
Heavy Atom Count14
Formal Charge0
Complexity285
Isotope Atom Count3
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)


Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


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ABOUT THIS PAGE

Deupirfenidone Manufacturers

A Deupirfenidone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Deupirfenidone, including repackagers and relabelers. The FDA regulates Deupirfenidone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Deupirfenidone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Deupirfenidone Suppliers

A Deupirfenidone supplier is an individual or a company that provides Deupirfenidone active pharmaceutical ingredient (API) or Deupirfenidone finished formulations upon request. The Deupirfenidone suppliers may include Deupirfenidone API manufacturers, exporters, distributors and traders.

Deupirfenidone GMP

Deupirfenidone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Deupirfenidone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Deupirfenidone GMP manufacturer or Deupirfenidone GMP API supplier for your needs.

Deupirfenidone CoA

A Deupirfenidone CoA (Certificate of Analysis) is a formal document that attests to Deupirfenidone's compliance with Deupirfenidone specifications and serves as a tool for batch-level quality control.

Deupirfenidone CoA mostly includes findings from lab analyses of a specific batch. For each Deupirfenidone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Deupirfenidone may be tested according to a variety of international standards, such as European Pharmacopoeia (Deupirfenidone EP), Deupirfenidone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Deupirfenidone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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