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Chemistry

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Also known as: 103420-77-5, Mk-329, Devazepidum, Mk 329, Devazepida, L-364,718
Molecular Formula
C25H20N4O2
Molecular Weight
408.5  g/mol
InChI Key
NFHRQQKPEBFUJK-HSZRJFAPSA-N
FDA UNII
JE6P7QY7NH

Devazepide
A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.
1 2D Structure

Devazepide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide
2.1.2 InChI
InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
2.1.3 InChI Key
NFHRQQKPEBFUJK-HSZRJFAPSA-N
2.1.4 Canonical SMILES
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=C5
2.1.5 Isomeric SMILES
CN1C2=CC=CC=C2C(=N[C@@H](C1=O)NC(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=C5
2.2 Other Identifiers
2.2.1 UNII
JE6P7QY7NH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. L 364,718

2. L-364,718

3. L364,718

4. Mk 329

5. Mk-329

6. Mk329

2.3.2 Depositor-Supplied Synonyms

1. 103420-77-5

2. Mk-329

3. Devazepidum

4. Mk 329

5. Devazepida

6. L-364,718

7. (s)-n-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl)indole-2-carboxamide

8. L 364718

9. Je6p7qy7nh

10. L-364718

11. Chembl9506

12. Chebi:4460

13. 3(s)-(-)-1,3-dihydro-3-(2-indolecarbonylamino)-1-methyl-5-phenyl-2h-(1,4)benzodiazepin-2-one

14. Ncgc00159551-01

15. Dsstox_cid_26092

16. Dsstox_rid_81331

17. Dsstox_gsid_46092

18. 1h-indole-2-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl)-, (s)-

19. Brn 5156082

20. (s)-n-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-1h-indole-2-carboxamide

21. N-[(3s)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-1,4-benzodiazepin-3-yl]-1h-indole-2-carboxamide

22. Cas-103420-77-5

23. Devazepide [usan:inn]

24. Devazepidum [inn-latin]

25. Unii-je6p7qy7nh

26. Devazepida [inn-spanish]

27. Devacade

28. L 364,718

29. Devazepide [inn]

30. Devazepide (usan/inn)

31. Devazepide [usan]

32. Cck Antagonist Synthetic 17

33. Cck Antagonist Synthetic 18

34. Schembl148766

35. Dtxsid2046092

36. Hms3268j20

37. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide

38. Zinc1847292

39. Tox21_111744

40. Bdbm50005463

41. Nsc778303

42. Pdsp1_000936

43. Pdsp2_000922

44. Akos024457038

45. Devazepide, >=98% (hplc), Powder

46. Tox21_111744_1

47. Nsc-778303

48. N-[(3s)-1-methyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-1h-indole-2-carboxamide

49. Ncgc00159551-02

50. Hy-106301

51. B7008

52. Cs-0025544

53. D02693

54. J-000963

55. Q5266620

56. Brd-k31238592-001-01-6

57. (r)-1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide: 0.1c4h10o

58. (s)-1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide

59. (s,z)-n-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-1h-indole-2-carboxamide

60. (z)-n-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-1h-indole-2-carboxamide

61. 1h-indole-2-carboxylic Acid ((s)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide

62. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide (l-364,718 ((s)-devazepide)

63. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide (mk-329, L-364,718)

64. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide(devazepide Or (r) L364718)

65. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide(devazepide)

66. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide(l-364718)

67. 1h-indole-2-carboxylic Acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-amide: 0.1c4h10o. 0.15ch2cl2

68. N-[(3s)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl]-1h-indole-2-carboxamide

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 408.5 g/mol
Molecular Formula C25H20N4O2
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass408.15862589 g/mol
Monoisotopic Mass408.15862589 g/mol
Topological Polar Surface Area77.6 Ų
Heavy Atom Count31
Formal Charge0
Complexity716
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Hormone Antagonists

Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. (See all compounds classified as Hormone Antagonists.)


ABOUT THIS PAGE

Looking for 103420-77-5 / Devazepide API manufacturers, exporters & distributors?

Devazepide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Devazepide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Devazepide manufacturer or Devazepide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Devazepide manufacturer or Devazepide supplier.

PharmaCompass also assists you with knowing the Devazepide API Price utilized in the formulation of products. Devazepide API Price is not always fixed or binding as the Devazepide Price is obtained through a variety of data sources. The Devazepide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Devazepide

Synonyms

103420-77-5, Mk-329, Devazepidum, Mk 329, Devazepida, L-364,718

Cas Number

103420-77-5

Unique Ingredient Identifier (UNII)

JE6P7QY7NH

About Devazepide

A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.

Devazepide Manufacturers

A Devazepide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Devazepide, including repackagers and relabelers. The FDA regulates Devazepide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Devazepide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Devazepide Suppliers

A Devazepide supplier is an individual or a company that provides Devazepide active pharmaceutical ingredient (API) or Devazepide finished formulations upon request. The Devazepide suppliers may include Devazepide API manufacturers, exporters, distributors and traders.

Devazepide GMP

Devazepide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Devazepide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Devazepide GMP manufacturer or Devazepide GMP API supplier for your needs.

Devazepide CoA

A Devazepide CoA (Certificate of Analysis) is a formal document that attests to Devazepide's compliance with Devazepide specifications and serves as a tool for batch-level quality control.

Devazepide CoA mostly includes findings from lab analyses of a specific batch. For each Devazepide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Devazepide may be tested according to a variety of international standards, such as European Pharmacopoeia (Devazepide EP), Devazepide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Devazepide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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