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    Chemistry

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    Also known as: 50-02-2, Decadron, Maxidex, Dexamethazone, Hexadecadrol, Dexasone
    Molecular Formula
    C22H29FO5
    Molecular Weight
    392.5  g/mol
    InChI Key
    UREBDLICKHMUKA-CXSFZGCWSA-N
    FDA UNII
    7S5I7G3JQL
    Dexamethasone
    An anti-inflammatory 9-fluoro-glucocorticoid.
    Dexamethasone is a Corticosteroid. The mechanism of action of dexamethasone is as a Corticosteroid Hormone Receptor Agonist.
    1 2D Structure

    Dexamethasone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
    2.1.2 InChI
    InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
    2.1.3 InChI Key
    UREBDLICKHMUKA-CXSFZGCWSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
    2.2 Other Identifiers
    2.2.1 UNII
    7S5I7G3JQL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Decaject

    2. Decaject L.a.

    3. Decaject-l.a.

    4. Decameth

    5. Decaspray

    6. Dexasone

    7. Dexpak

    8. Hexadecadrol

    9. Hexadrol

    10. Maxidex

    11. Methylfluorprednisolone

    12. Millicorten

    13. Oradexon

    2.3.2 Depositor-Supplied Synonyms

    1. 50-02-2

    2. Decadron

    3. Maxidex

    4. Dexamethazone

    5. Hexadecadrol

    6. Dexasone

    7. Hexadrol

    8. Decaspray

    9. Millicorten

    10. Oradexon

    11. Prednisolone F

    12. Fluormethylprednisolone

    13. Aeroseb-dex

    14. Cortisumman

    15. Desametasone

    16. Dexacortal

    17. Dexacortin

    18. Fortecortin

    19. Gammacorten

    20. Superprednol

    21. Visumetazone

    22. Auxiron

    23. Calonat

    24. Decaderm

    25. Dexacort

    26. Dexason

    27. Azium

    28. Dexone

    29. Deltafluorene

    30. Desamethasone

    31. Mediamethasone

    32. Aphtasolon

    33. Decasone

    34. Dectancyl

    35. Dekacort

    36. Dergramin

    37. Desadrene

    38. Desameton

    39. Dexadeltone

    40. Dexalona

    41. Dexameth

    42. Dexapolcort

    43. Dextelan

    44. Dinormon

    45. Loverine

    46. Luxazone

    47. Mymethasone

    48. Turbinaire

    49. Corsone

    50. Decalix

    51. Mexidex

    52. Dexa-cortidelt

    53. Dexa-cortisyl

    54. Dexa-scheroson

    55. Prednisolon F

    56. Dexa-sine

    57. Isopto-dex

    58. Aeroseb-d

    59. Sk-dexamethasone

    60. Anaflogistico

    61. Decacortin

    62. Deseronil

    63. Dexafarma

    64. Dexaprol

    65. Dexinolon

    66. Dexinoral

    67. Policort

    68. Spoloven

    69. Decagel

    70. Deronil

    71. Dezone

    72. Sunia Sol D

    73. Bisu Ds

    74. Dexa Mamallet

    75. Hexadrol Elixir

    76. Lokalison F

    77. Ocu-trol

    78. Dex-ide

    79. Hl-dex

    80. Dexamethasonum

    81. Dexone 4

    82. Fluorocort

    83. Decaject

    84. Decameth

    85. Fluormone

    86. Corson

    87. Dexpak

    88. Pet Derm Iii

    89. Dxms

    90. Dexamethasone Alcohol

    91. Hexadrol Tablets

    92. Dexamethasone Intensol

    93. Methylfluorprednisolone

    94. Desametasone [dcit]

    95. Dexone 0.5

    96. Dexone 1.5

    97. Dexone 0.75

    98. Dexametasona

    99. Dexacidin

    100. Maxitrol

    101. Ozurdex

    102. Dexametasona [inn-spanish]

    103. Dexamethasonum [inn-latin]

    104. Dexapos

    105. Decadron Tablets, Elixir

    106. 9alpha-fluoro-16alpha-methylprednisolone

    107. Azium (veterinary)

    108. Dexamethansone

    109. Dextenza

    110. Posurdex

    111. Prodex

    112. Oto-104

    113. Mk 125

    114. (3h)-dexamethasone

    115. Azimycin (veterinary)

    116. Nsc 34521

    117. Dexametasone

    118. Naquasone (veterinary)

    119. Tresaderm (veterinary)

    120. Dexycu

    121. 16alpha-methyl-9alpha-fluoro-1-dehydrocortisol

    122. Dexasite

    123. 16alpha-methyl-9alpha-fluoroprednisolone

    124. 16-alpha-methyl-9-alpha-fluoroprednisolone

    125. 9-alpha-fluoro-16-alpha-methylprednisolone

    126. 1-dehydro-16alpha-methyl-9alpha-fluorohydrocortisone

    127. Delta1-9alpha-fluoro-16alpha-methylcortisol

    128. Decacort

    129. (11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

    130. 16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol

    131. 16-alpha-methyl-9-alpha-fluoro-delta1-hydrocortisone

    132. Delta(sup 1)-9-alpha-fluoro-16-alpha-methylcortisol

    133. Isv-305

    134. 9a-fluoro-16beta-methylprednisolone

    135. 16alpha-methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone

    136. 16-alpha-methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone

    137. Nsc-34521

    138. Dexamethasone (dhap)

    139. 7s5i7g3jql

    140. 16.alpha.-methyl-9.alpha.-fluoroprednisolone

    141. Chebi:41879

    142. [3h]-dexamethasone

    143. Decaject-l.a.

    144. 23495-06-9

    145. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, Labeled With Tritium, (11beta,16alpha)-

    146. Aphthasolone

    147. Dexamonozon

    148. 9.alpha.-fluoro-16.alpha.-methylprednisolone

    149. (1r,2s,10s,11s,13r,14r,15s,17s)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one

    150. (8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

    151. (8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one

    152. C22h29fo5

    153. 16.alpha.-methyl-9.alpha.-fluoro-1-dehydrocortisol

    154. 1-dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone

    155. Osurdex

    156. Dexamethasone Base

    157. Decadron (tn)

    158. (8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]ph

    159. Smr000857119

    160. Dxm [steroid]

    161. Ccris 7067

    162. Hsdb 3053

    163. Dexamethasone (tetramethyl-rhodamine Conjugated )

    164. Prednisolone, 9.alpha.-fluoro-16.alpha.-methyl-

    165. Einecs 200-003-9

    166. Mfcd00064136

    167. Unii-7s5i7g3jql

    168. Solurex

    169. .delta.(sup 1)-9-.alpha.-fluoro-16-.alpha.-methylcortisol

    170. 16.alpha.-methyl-9.alpha.-fluoro-.delta.(sup1)-hydrocortisone

    171. Diodex

    172. Nsc34521

    173. Ai3-50934

    174. .gamma.corten

    175. 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

    176. Apo-dexamethasone

    177. Prednisolone, 9alpha-fluoro-16alpha-methyl-

    178. Dexasone 4mg

    179. Dtxsid3020384

    180. Zema-pak

    181. Phl-dexamethasone

    182. Pms-dexamethasone

    183. 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione

    184. [3h]dexamethasone

    185. Dexamethasone-omega

    186. Ncgc00091019-08

    187. Dexasone 0.5mg

    188. Dexamethasone [usp:inn:ban:jan]

    189. Dexasone 0.75mg

    190. Sandoz Dexamethasone

    191. Hemady

    192. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-

    193. Dexamethasone, Topical

    194. Maxidex Ont 0.1%

    195. Maxidex Sus 0.1%

    196. Dexamethasone-17-acetate

    197. Dsstox_cid_384

    198. Spectrum5_002019

    199. Dexamethasone [mi]

    200. Molmap_000018

    201. 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione

    202. Dexamethasone [inn]

    203. Dexamethasone [jan]

    204. Schembl3774

    205. 16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione

    206. 16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-diene-3,20-dione

    207. 4-alpha-fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-dione

    208. 9-alpha-fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione

    209. Dexamethasone [hsdb]

    210. Dsstox_rid_75557

    211. Bidd:pxr0060

    212. Dsstox_gsid_20384

    213. Bspbio_000995

    214. Dexamethasone [vandf]

    215. Mls001055412

    216. Mls001332507

    217. Mls001332508

    218. Bidd:er0494

    219. Dexamethasone [mart.]

    220. Sustained-release Dexamethasone

    221. Dexamethasone [usp-rs]

    222. Dexamethasone [who-dd]

    223. Dexamethasone [who-ip]

    224. Chembl384467

    225. Gtpl2768

    226. Gtpl3447

    227. Sgcut00126

    228. 9-fluoro-16-methylprednisolone

    229. Ak Dex Oph Otic Soln 0.1%

    230. Dexamethasone [ema Epar]

    231. Bdbm18207

    232. Dexamethasone (jp17/usp/inn)

    233. 1p93

    234. Dexamethasone [green Book]

    235. Hms1792a17

    236. Hms1990a17

    237. Hms2089n13

    238. Hms2235f08

    239. Hms3039l11

    240. Hms3259n11

    241. Hms3403a17

    242. Dexamethasone [orange Book]

    243. Amy28815

    244. To_000038

    245. Zinc3875332

    246. Dexamethasone [ep Monograph]

    247. Tox21_200122

    248. Dexamethasone [usp Monograph]

    249. Dexamethasone, >=97.0% (hplc)

    250. Ibi-10090

    251. Mk-125

    252. S1322

    253. Dexamethasone 1.0 Mg/ml In Methanol

    254. Dexamethasonum [who-ip Latin]

    255. Pms Dexamethasone Elixir 0.5mg/5ml

    256. Akos005259009

    257. Akos015895509

    258. Ciprodex Component Dexamethasone

    259. Decadron Phosphate, Decdan, Dexacort,

    260. Maxitrol Component Dexamethasone

    261. Tobradex Component Dexamethasone

    262. Ccg-264887

    263. Cs-1505

    264. Db01234

    265. Ks-1451

    266. Nc00645

    267. Alpha -fluoro-16-alpha -methylcortisol

    268. Cas-50-02-2

    269. Dexacidin Component Dexamethasone

    270. Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-

    271. Smp1_000092

    272. Dexamethasone 100 Microg/ml In Methanol

    273. Dexamethasone, >=98% (hplc), Powder

    274. Dexasporin Component Dexamethasone

    275. Ncgc00091019-01

    276. Ncgc00091019-02

    277. Ncgc00091019-03

    278. Ncgc00091019-04

    279. Ncgc00091019-05

    280. Ncgc00091019-06

    281. Ncgc00091019-07

    282. Ncgc00091019-23

    283. Ncgc00257676-01

    284. (11beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione Labeled With Tritium

    285. 9alpha-fluoro-16alpha-methyl-prednisolone

    286. Ac-11056

    287. Dexamethasone Component Of Ciprodex

    288. Dexamethasone Component Of Maxitrol

    289. Dexamethasone Component Of Tobradex

    290. Hy-14648

    291. Nci60_003067

    292. Smr001227192

    293. Tobradex St Component Dexamethasone

    294. Dexamethasone 1000 Microg/ml In Methanol

    295. Dexamethasone Component Of Dexacidin

    296. 16alpha -methyl-9alpha -fluoroprednisolone

    297. 9alpha -fluoro-16alpha -methylprednisolone

    298. Dexamethasone Component Of Dexasporin

    299. Dexamethasone, Tested According To Ph.eur.

    300. Dexamethasone 100 Microg/ml In Acetonitrile

    301. Dexamethasone Component Of Tobradex St

    302. Betamethasone Impurity A [ep Impurity]

    303. En300-52607

    304. D00292

    305. Dexamethasone, Meets Usp Testing Specifications

    306. Prednisolone, 9alpha -fluoro-16alpha -methyl-

    307. 9.alpha.-fluoro-16.alpha.-methyl-1,20-dione

    308. Ab00918428-05

    309. Ab00918428-08

    310. Ab00918428-09

    311. Ab00918428_10

    312. 064d136

    313. 16alpha -methyl-9alpha -fluoro-1-dehydrocortisol

    314. Dexamethasone, Vetranal(tm), Analytical Standard

    315. Q422252

    316. Neomycin And Polymyxin B Sulphates And Dexamethasone

    317. Q-200939

    318. Brd-k38775274-001-02-3

    319. Brd-k38775274-001-06-4

    320. Dexamethasone Acetate Impurity A [ep Impurity]

    321. 1-dehydro-16alpha -methyl-9alpha -fluorohydrocortisone

    322. 9-fluoro-11alpha -methylpregna-1,4-diene-3,20-dione

    323. Dexamethasone, British Pharmacopoeia (bp) Assay Standard

    324. Z802671480

    325. Pregna-1,4-diene-3,20-dione, 9-fluoro-11alpha -methyl-

    326. Dexamethasone, European Pharmacopoeia (ep) Reference Standard

    327. Wln: L E5 B666 Ov Ku Mutj A1 Bf Cq E1 Fv1q Fq G1

    328. Dexamethasone, Powder, Bioreagent, Suitable For Cell Culture, >=97%

    329. Dexamethasone, United States Pharmacopeia (usp) Reference Standard

    330. 16-.alpha.-methyl-9-.alpha.-fluoro-1,17-.alpha.,21-triol-3,20-dione

    331. 4.alpha.-fluoro-16.alpha.-methyl-11.beta.-17,4-diene-3,20-dione

    332. Pregna-1,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-

    333. 16.alpha.-methyl-9.alpha.-fluoro-11.beta.-17.alpha.-21-trihydroxypregna-1,20-dione

    334. 9-fluoro-11.beta.,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione

    335. 9-fluoro-16alpha-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione

    336. 9.alpha.-fluoro-11.beta.-17.alpha.- 21-trihydroxy-16.alpha.-methylpregna-1,20-dione

    337. Dexamethasone For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    338. Dexamethasone For System Suitability, European Pharmacopoeia (ep) Reference Standard

    339. Dexamethasone Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

    340. Dexamethasone, Pharmaceutical Secondary Standard; Certified Reference Material

    341. Dexamethasone, Powder, Gamma-irradiated, Bioxtra, Suitable For Cell Culture, >=80% (hplc)

    342. Pregna-1,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.alpha.)-

    343. (11.beta.,16.alpha.)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

    344. (11alpha,14beta,16alpha,17alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

    345. (1r,2s,10s,11s,13r,14r,15s,17s)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo-

    346. (1r,2s,10s,11s,13r,14r,15s,17s)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-3,6-dien-5-one

    347. 1050677-47-8

    348. 9.alpha.-fluoro-16.alpha.-methyl-11.beta.,21.beta.-trihydroxy-pregna-1,4-diene-3,20-dione

    349. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-,(11.beta.,16.alpha.)-9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione

    2.3.3 Other Synonyms

    1. Dexamethasone 9,11-epoxide

    2. Decadronal

    3. Panasone

    4. Dexamethasone Acetate

    5. 33755-46-3

    6. Dexamethasone 17-valerate

    7. Dexamethasone Valerate

    8. Methaderm

    9. 55541-30-5

    10. Dexamethasone Dipropionate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 392.5 g/mol
    Molecular Formula C22H29FO5
    XLogP31.9
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count2
    Exact Mass392.19990218 g/mol
    Monoisotopic Mass392.19990218 g/mol
    Topological Polar Surface Area94.8 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity805
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 10  
    Drug NameDexamethasone
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Drug LabelEach 5 mL (teaspoonful) contains:Dexamethasone, USP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.5 mgAlso contains:Benzoic Acid, USP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.1% (as preservative)Alcohol (% v...
    Active IngredientDexamethasone
    Dosage FormElixir; Tablet; Solution
    RouteOral
    Strength0.5mg/5ml; 4mg; 1.5mg; 0.5mg; 6mg; 2mg; 1mg; 0.75mg
    Market StatusPrescription
    CompanyLyne; Vintage Pharms; Ecr; Sti Pharma; Wockhardt Eu Operatn; Par Pharm; Roxane

    2 of 10  
    Drug NameDexamethasone intensol
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Drug LabelDexamethasone Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Dexamethasone Oral Solution, 0.5 mg per 5 mL and Dexamethasone Intensol Oral Solution (Concentrate), 1 mg per mL are for oral administration.Each tablet contains:Dexamethasone 0.5, 0.75,...
    Active IngredientDexamethasone
    Dosage FormConcentrate
    RouteOral
    Strength1mg/ml
    Market StatusPrescription
    CompanyRoxane

    3 of 10  
    Drug NameMaxidex
    PubMed HealthPolymyxin B/Neomycin/Dexamethasone (Into the eye)
    Drug ClassesAminoglycoside/Corticosteroid Combination
    Drug LabelMAXIDEX 0.1% (dexamethasone ophthalmic suspension) is an adrenocortical steroid prepared as a sterile topical ophthalmic suspension. The active ingredient is represented by the chemical structure:Chemical name: Pregna-1,4-diene-3,20-dione,9-fluoro-...
    Active IngredientDexamethasone
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strength0.1%
    Market StatusPrescription
    CompanyAlcon

    4 of 10  
    Drug NameMaxitrol
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Active IngredientDexamethasone; neomycin sulfate; polymyxin b sulfate
    Dosage FormOintment; Suspension/drops
    RouteOphthalmic
    Strength10,000 units/ml; 0.1%; 10,000 units/gm; eq 3.5mg base/ml; eq 3.5mg base/gm
    Market StatusPrescription
    CompanyAlcon; Falcon Pharms

    5 of 10  
    Drug NameOzurdex
    Drug LabelOZURDEX is an intravitreal implant containing 0.7 mg (700 mcg) dexamethasone in the NOVADUR solid polymer sustained-release drug delivery system. OZURDEX is preloaded into a single-use, DDS applicator to facilitate injection of the rod-shaped...
    Active IngredientDexamethasone
    Dosage FormImplant
    RouteIntravitreal
    Strength0.7mg
    Market StatusPrescription
    CompanyAllergan

    6 of 10  
    Drug NameDexamethasone
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Drug LabelEach 5 mL (teaspoonful) contains:Dexamethasone, USP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.5 mgAlso contains:Benzoic Acid, USP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0.1% (as preservative)Alcohol (% v...
    Active IngredientDexamethasone
    Dosage FormElixir; Tablet; Solution
    RouteOral
    Strength0.5mg/5ml; 4mg; 1.5mg; 0.5mg; 6mg; 2mg; 1mg; 0.75mg
    Market StatusPrescription
    CompanyLyne; Vintage Pharms; Ecr; Sti Pharma; Wockhardt Eu Operatn; Par Pharm; Roxane

    7 of 10  
    Drug NameDexamethasone intensol
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Drug LabelDexamethasone Tablets 0.5, 0.75, 1, 1.5, 2, 4 and 6 mg USP, Dexamethasone Oral Solution, 0.5 mg per 5 mL and Dexamethasone Intensol Oral Solution (Concentrate), 1 mg per mL are for oral administration.Each tablet contains:Dexamethasone 0.5, 0.75,...
    Active IngredientDexamethasone
    Dosage FormConcentrate
    RouteOral
    Strength1mg/ml
    Market StatusPrescription
    CompanyRoxane

    8 of 10  
    Drug NameMaxidex
    PubMed HealthPolymyxin B/Neomycin/Dexamethasone (Into the eye)
    Drug ClassesAminoglycoside/Corticosteroid Combination
    Drug LabelMAXIDEX 0.1% (dexamethasone ophthalmic suspension) is an adrenocortical steroid prepared as a sterile topical ophthalmic suspension. The active ingredient is represented by the chemical structure:Chemical name: Pregna-1,4-diene-3,20-dione,9-fluoro-...
    Active IngredientDexamethasone
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strength0.1%
    Market StatusPrescription
    CompanyAlcon

    9 of 10  
    Drug NameMaxitrol
    PubMed HealthDexamethasone
    Drug ClassesAntiemetic, Corticosteroid, Weak, Diagnostic Agent, Adrenocortical Function, Endocrine-Metabolic Agent, Immune Suppreant, Ophthalmologic Agent
    Active IngredientDexamethasone; neomycin sulfate; polymyxin b sulfate
    Dosage FormOintment; Suspension/drops
    RouteOphthalmic
    Strength10,000 units/ml; 0.1%; 10,000 units/gm; eq 3.5mg base/ml; eq 3.5mg base/gm
    Market StatusPrescription
    CompanyAlcon; Falcon Pharms

    10 of 10  
    Drug NameOzurdex
    Drug LabelOZURDEX is an intravitreal implant containing 0.7 mg (700 mcg) dexamethasone in the NOVADUR solid polymer sustained-release drug delivery system. OZURDEX is preloaded into a single-use, DDS applicator to facilitate injection of the rod-shaped...
    Active IngredientDexamethasone
    Dosage FormImplant
    RouteIntravitreal
    Strength0.7mg
    Market StatusPrescription
    CompanyAllergan

    4.2 Therapeutic Uses

    Anti-Inflammatory Agents, Steroidal; Antiemetics; Antineoplastic Agents, Hormonal; Glucocorticoids, Synthetic; Glucocorticoids, Topical

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Nasal corticosteroids are used in some patients for prophylaxis of seasonal rhinitis. This form of therapy is generally reserved for patients who have consistently demonstrated a need for nasal corticosteroids to control seasonal rhinitis syndromes. Antihistamines and decongestants are considered primary therapies for this disorder. Dexamethasone nasal aerosol is less frequently used because its use results in a significantly higher incidence of systemic adverse effects with no additional benefit over other nasal corticosteroids. /NOT included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 897

    Ophthalmic corticosteroids are indicated in the treatment of corticosteroid-responsive allergic and inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. /Corticosteroids (Ophthalmic); Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 906

    Otic corticosteroids are indicated in the treatment of corticosteroid-responsive inflammatory disorders of the external auditory meatus such as: allergic otitis externa; infective otitis (treatment adjunct); (chronic eczematoid otitis externa or seborrheic otitis externa /NOT included in US product labeling/). Dexamethasone /is/ used in the treatment of these and other corticosteroid-responsive disorders of the external auditory meatus. /Included in US product labeling/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 911

    For more Therapeutic Uses (Complete) data for DEXAMETHASONE (42 total), please visit the HSDB record page.

    4.3 Drug Warning

    Dexamethasone improves the cure rate of childhood acute lymphoblastic leukemia (ALL) but causes physical and behavioral adverse events. The objective of the current study was to determine the effect of dexamethasone exposure on sleep and fatigue in pediatric patients with acute lymphoblastic leukemia. One hundred pediatric patients with low-risk or standard-risk acute lymphoblastic leukemia were enrolled on 1 of 3 protocols (St. Jude Total XV, Children's Oncology Group [COG] 9904, or COG 9905) at 3 institutions. The mean age of the cohort was 9.24 +/- 3.23 years (range, 5.03-18.14 years). The majority of patients were white (79%) males (62%) with standard-risk acute lymphoblastic leukemia (63%). The cohort was divided into 4 subgroups: St. Jude low-risk, St. Jude standard-risk, COG low-risk, and COG standard-risk. Patients wore a wrist actigraph to monitor sleep activity during 2 consecutive 5-day periods: During the first period, they did not receive dexamethasone; and, during the second period, they did. Patients and their parents completed fatigue instruments on Days 2 and 5 of each period, and parents completed sleep diaries. Actual sleep minutes, sleep duration, total daily nap minutes, and fatigue increased significantly during the dexamethasone treatment for 3 to 4 of the subgroups. Total daily nap minutes increased significantly for both standard-risk groups during the dexamethasone treatment. Parents reported significant increases in their child's nighttime awakenings, restless sleep, and nap time during dexamethasone treatment.Dexamethasone treatment during continuation therapy for childhood acute lymphoblastic leukemia significantly and adversely altered sleep and fatigue, confirming that sleep and fatigue are behavioral responses to dexamethasone.

    PMID:17926333 Hinds PS et al; Cancer 110 (10): 2321-30 (2007)

    Excreted in breast milk; nursing by mothers receiving pharmacologic doses not recommended.

    US Pharmacopeial Convention; US Pharmacopeia Dispensing Information (USP DI); Drug Information for the Health Care Professional 12th ed, V.I p.59 (1992)

    /Dexamethasone/ is distributed into breast milk. Nursing while receiving pharmacologic doses of dexamethasone is not recommended.

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 899

    Dexamethasone inhalation is not recommended for use in asthma because it has demonstrated a significantly higher incidence of systemic effects with no additional benefit over other inhaled corticosteroids. The high ratio of systemic glucocorticoid activity to local anti-inflammatory activity of inhaled dexamethasone may be due to its greater water solubility and longer metabolic hal life after absorption relative to the other inhaled corticosteroids.

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 890

    For more Drug Warnings (Complete) data for DEXAMETHASONE (42 total), please visit the HSDB record page.

    4.4 Drug Indication

    Dexamethasone and [ciprofloxacin] otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

    FDA Label

    Treatment of multiple myeloma.

    Ozurdex is indicated for the treatment of adult patients with macular oedema following either branch retinal-vein occlusion (BRVO) or central retinal-vein occlusion (CRVO).

    Ozurdex is indicated for the treatment of adult patients with inflammation of the posterior segment of the eye presenting as noninfectious uveitis.

    Ozurdex is indicated for the treatment of adult patients with visual impairment due to diabetic macular oedema (DME) who are pseudophakic or who are considered insufficiently responsive to, or unsuitable for non-corticosteroid therapy.

    Treatment of postoperative pain and inflammation associated with ophthalmic surgery

    Treatment of diabetic macular oedema

    Chronic non-infectious intermediate or posterior uveitis

    Other retinal vascular occlusion

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Dexamethasone's duration of action varies depending on the route. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

    5.2 MeSH Pharmacological Classification

    Anti-Inflammatory Agents

    Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

    Antineoplastic Agents, Hormonal

    Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079) (See all compounds classified as Antineoplastic Agents, Hormonal.)

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    DEXAMETHASONE
    5.3.2 FDA UNII
    7S5I7G3JQL
    5.3.3 Pharmacological Classes
    Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]
    5.4 ATC Code

    H02AB02

    S01BA01

    H02AB02

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    H02AB02

    S66 | EAWAGTPS | Parent-Transformation Product Pairs from Eawag | DOI:10.5281/zenodo.3754448

    A - Alimentary tract and metabolism

    A01 - Stomatological preparations

    A01A - Stomatological preparations

    A01AC - Corticosteroids for local oral treatment

    A01AC02 - Dexamethasone

    C - Cardiovascular system

    C05 - Vasoprotectives

    C05A - Agents for treatment of hemorrhoids and anal fissures for topical use

    C05AA - Corticosteroids

    C05AA09 - Dexamethasone

    D - Dermatologicals

    D07 - Corticosteroids, dermatological preparations

    D07A - Corticosteroids, plain

    D07AB - Corticosteroids, moderately potent (group ii)

    D07AB19 - Dexamethasone

    D - Dermatologicals

    D07 - Corticosteroids, dermatological preparations

    D07X - Corticosteroids, other combinations

    D07XB - Corticosteroids, moderately potent, other combinations

    D07XB05 - Dexamethasone

    D - Dermatologicals

    D10 - Anti-acne preparations

    D10A - Anti-acne preparations for topical use

    D10AA - Corticosteroids, combinations for treatment of acne

    D10AA03 - Dexamethasone

    H - Systemic hormonal preparations, excl. sex hormones and insulins

    H02 - Corticosteroids for systemic use

    H02A - Corticosteroids for systemic use, plain

    H02AB - Glucocorticoids

    H02AB02 - Dexamethasone

    R - Respiratory system

    R01 - Nasal preparations

    R01A - Decongestants and other nasal preparations for topical use

    R01AD - Corticosteroids

    R01AD03 - Dexamethasone

    S - Sensory organs

    S01 - Ophthalmologicals

    S01B - Antiinflammatory agents

    S01BA - Corticosteroids, plain

    S01BA01 - Dexamethasone

    S - Sensory organs

    S01 - Ophthalmologicals

    S01C - Antiinflammatory agents and antiinfectives in combination

    S01CB - Corticosteroids/antiinfectives/mydriatics in combination

    S01CB01 - Dexamethasone

    S - Sensory organs

    S02 - Otologicals

    S02B - Corticosteroids

    S02BA - Corticosteroids

    S02BA06 - Dexamethasone

    S - Sensory organs

    S03 - Ophthalmological and otological preparations

    S03B - Corticosteroids

    S03BA - Corticosteroids

    S03BA01 - Dexamethasone

    5.5 Absorption, Distribution and Excretion

    Absorption

    Absorption via the intramuscular route is slower than via the intravenous route. A 3mg intramuscular dose reaches a Cmax of 34.66.0ng/mL with a Tmax of 2.01.2h and an AUC of 11338ng\*h/mL. A 1.5mg oral dose reaches a Cmax of 13.96.8ng/mL with a Tmax of 2.00.5h and an AUC of 33150ng\*h/mL. Oral dexamethasone is approximately 70-78% bioavailable in healthy subjects.

    Route of Elimination

    Corticosteroids are generally eliminated predominantly in the urine. However, dexamethasone is <10% elminated in urine.

    Volume of Distribution

    A 1.5mg oral dose of dexamethasone has a volume of distribution of 51.0L, while a 3mg intramuscular dose has a volume of distribution of 96.0L.

    Clearance

    A 20mg oral tablet has a clearance of 15.7L/h. A 1.5mg oral dose of dexamethasone has a clearance of 15.64.9L/h while a 3.0mg intramuscular dose has a clearance of 9.91.4L/h.

    Absorbed into aqueous humor, cornea, iris, choroid ciliary body, and retina. Systemic absorption occurs, but may be significant only at higher dosages or in extended pediatric therapy. /Corticosteroids (Ophthalmic)/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 906

    Dogs (mixed-breed) were administered dexamethasone alcohol or dexamethasone 21-isonicotinate as a solution iv or im (1 mg/kg bw), or dexamethasone 21-isonicotinate as a suspension im (0.1 or 1 mg/kg bw). Plasma concentrations were determined with HPLC up to 120 hours after treatment. The elimination half-life after iv administration was 120-140 minutes for both formulations. Following im administration, absorption was rapid with peak plasma concentrations at 30-40 minutes for both solutions. Bioavailability after im administration was 100% for dexamethasone alcohol but 40% for dexamethasone 21-isonicotinate. After im administration of dexamethasone 21-isonicotinate as a suspension, dexamethasone was not detected in plasma, suggesting a long absorption phase

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    Crl:SD(CD)BR rats were administered a single im dose of 9 ug, (1,2,4-3H)-dexamethasone/kg bw. Radioactivity was measured up to 96 hours after administration in plasma (pre- and post-freeze dried), urine, feces and expired air. Tritium exchange was measured in stored urine. Highest plasma levels were observed 6 hours after dosing (3.7 ug equivalents/g), declining rapidly thereafter to 0.15 ug equivalents/g. Within 24 hours 41% of the radioactivity was excreted in the urine. After 96 hours a mean of 44% of the radio-activity was excreted. Tritium exchange was observed both in plasma and urine. Following freeze-drying, the mean loss of radioactivity 96 hours after dosing was 87% and 37% in plasma and urine, respectively

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    Male Wistar albino rats were administered 0.23 umol (1,2-3H) dexamethasone/kg bw, ip. Urine and feces were collected up to 4 days after treatment. Within 96 hours 74% of the dose was excreted, 30% in the urine and 44% in the feces

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    For more Absorption, Distribution and Excretion (Complete) data for DEXAMETHASONE (11 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Dexamethasone is 6-hydroxylated by CYP3A4 to 6- and 6-hydroxydexamethasone. Dexamethasone is reversibly metabolized to 11-dehydrodexamethasone by corticosteroid 11-beta-dehydrogenase isozyme 2 and can also be converted back to dexamethasone by Corticosteroid 11-beta-dehydrogenase isozyme 1.

    Male Wistar albino rats were administered (3)H-dexamethasone orally at a dose of 1.14 nmol/kg bw. Thirty-one percent of the administered radioactivity was excreted in the urine within 4 days (most of it within the first 24 hours) as unconjugated metabolites. Unchanged dexamethasone accounted for 14%, 6-hydroxydexamethasone for 7.4%, and 20-dihydrodexamethasone for 1.1% of the urine radioactivity.

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    In the urine of rats administered 0.23 umol/kg bw (1,2-3H)- dexamethasone ip, 10% of the administered radioactivity was associated with one polar metabolite of dexamethasone, likely to be 6-hydroxy-dexamethasone

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    No parent compound could be detected in urine of patients after oral administration of a small dose of dexamethasone (<4 mg/day) for a few weeks. However, 60% was recovered as 6-beta-hydroxy-dexamethasone and 5-10% as 6-beta-hydroxy-20-dihydrodexamethasone. After the administration of about 15 mg dexamethasone/day metabolism occurred by an additional route involving epoxidation and subsequent hydrolysis, resulting in glycol formation in ring A

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    Dexamethasone has known human metabolites that include 6-alpha-OH DEXAMETHASONE and 6-beta-OH DEXAMETHASONE.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    The mean terminal half life of a 20mg oral tablet is 4 hours. A 1.5mg oral dose of dexamethasone has a half life of 6.64.3h, while a 3mg intramuscular dose has a half life of 4.21.2h.

    190 minutes (plasma) /Dexamethasone sodium phosphate/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 898

    Dogs (mixed-breed) were administered dexamethasone alcohol or dexamethasone 21-isonicotinate as a solution iv or im (1 mg/kg bw), or dexamethasone 21-isonicotinate as a suspension im (0.1 or 1 mg/kg bw). Plasma concentrations were determined with HPLC up to 120 hours after treatment. The elimination half-life after iv administration was 120-140 minutes for both formulations.

    Joint FAO/WHO Expert Committee on Food Additives; WHO Food Additive Series 33: Toxicological Evaluation of Ceratain Veterinary Drug Residues in Food: Dexamethasone (1994). Available from, as of November 6, 2007: https://www.inchem.org/documents/jecfa/jecmono/v33je09.htm

    5.8 Mechanism of Action

    The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days. Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

    Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA, and stimulate transcription of mRNA and subsequent protein synthesis of enzymes ultimately responsible for anti-inflammatory effects of topical application of corticosteroids to the eye. In high concentrations which may be achieved after topical application, corticosteroids may exert direct membrane effects. Corticosteroids decrease cellular and fibrinous exudation and tissue infiltration, inhibit fibroblastic and collagen-forming activity, retard epithelial regeneration, diminish postinflammatory neovascularization and reduce toward normal levels the excessive permeability of inflamed capillaries. /Corticosteroids (Otic)/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 911

    Glucocorticoids are capable of suppressing the inflammatory process through numerous pathways. They interact with specific intracellular receptor proteins in target tissues to alter the expression of corticosteroid-responsive genes. Glucocorticoid-specific receptors in the cell cytoplasm bind with steroid ligands to form hormone-receptor complexes that eventually translocate to the cell nucleus. There these complexes bind to specific DNA sequences and alter their expression. The complexes may induce the transcription of mRNA leading to synthesis of new proteins. Such proteins include lipocortin, a protein known to inhibit PLA2a and thereby block the synthesis of prostaglandins, leukotrienes, and PAF. Glucocorticoids also inhibit the production of other mediators including AA metabolites such as COX, cytokines, the interleukins, adhesion molecules, and enzymes such as collagenase. /Glucocorticoids/

    Kahn, C.M. (Ed.); The Merck Veterinary Manual 9th ed. Merck & Co. Whitehouse Station, NJ. 2005, p. 2128

    Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids. These anti-inflammatory effects include inhibition of early processes such as edema, fibrin deposition, capillary dilatation, movement of phagocttes into the area, and phagocytic activities. Later processes, such as capillary production, collagen deposition, and keloid formation also are inhibited by corticosteroids. The overall actions of topical corticosteroids are catabolic. /Corticosteroids (topical)/

    Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 919

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CORP.,109 BA WEI ROAD,HEDONG DISTRICT, TIANJIN300 171, CHINA., CHINA","customerAddress":"401, BAANI, 1,,GOLF COURSE ROAD, S"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716402600,"product":"DEXAMETHASONE BP","address":"3-A, SHIV SAGAR ESTATE, NORTH WING,","city":"BOMBAY ,MAHARASHTRA","supplier":"TIANJIN TIANFA PHARMACEUTICALS","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SKANT HEALTHCARE LTD.","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"580","totalValueFC":"29346.5","currency":"USD","unitRateINR":"48923","date":"23-May-2024","totalValueINR":"2446150","totalValueInUsd":"29346.5","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"3629346","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"109 BA WEI ROAD, HEDONG DISTRICT, TIANJIN 300 171, CHINA.SDNF China","customerAddress":"3-A, SHIV SAGAR ESTATE, NORTH WING,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720809000,"product":"DEXAMETHASONE ACETATE (STERILE)","address":"NARBAVI, NO.3,LAKSHMANAN STREET,","city":"CHENNAI\/TAMILNADU","supplier":"M\/S.SYMBIOTICA SPECIALITY INGREDIENT SDN BHD","supplierCountry":"MALAYSIA","foreign_port":"PENANG","customer":"CAPLIN POINT LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"2600","totalValueFC":"1313.4","currency":"USD","unitRateINR":"219570","date":"13-Jul-2024","totalValueINR":"109785","totalValueInUsd":"1313.4","indian_port":"Madras Air","hs_no":"29372200","bill_no":"4492638","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MALAYSIA","selfForZScoreResived":"Sterile","supplierPort":"PENANG","supplierAddress":"NO 518, JALAN WAJA 4TAMAN INDUSTRI WAJA09000 KULIM MY","customerAddress":"NARBAVI, NO.3,LAKSHMANAN STREET,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726770600,"product":"DEXAMETHASONE SODIUM PHOSPHATE USP 2024","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"MICRO LABS LIMITED","customerCountry":"INDIA","quantity":"13.00","actualQuantity":"13","unit":"KGS","unitRateFc":"5000","totalValueFC":"65628.8","currency":"USD","unitRateINR":"423059.2","date":"20-Sep-2024","totalValueINR":"5499769.86","totalValueInUsd":"65628.8","indian_port":"Madras Air","hs_no":"29372200","bill_no":"5701805","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PARQUE TECNOLOGICO DE BOECILLO PARCELA 105, 47151 BOECILLO VALLADOLID, SPAIN","customerAddress":"NO 31, RACE COURSE ROAD,BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728585000,"product":"DEXAMETHASONE IP","address":"110-B,ANDHERI INDUSTRIAL ESTATE","city":"ANDHERI(W),MUMBAI, MAHARASHTRA","supplier":"TIANJIN TIANFA PHARMACEUTICALS","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"ADD BIOTEC","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"505","totalValueFC":"25497.4","currency":"USD","unitRateINR":"42849.3","date":"11-Oct-2024","totalValueINR":"2142462.5","totalValueInUsd":"25497.4","indian_port":"Bombay Air","hs_no":"29372900","bill_no":"6069982","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"109 BA WEI ROAD, HEDONG DISTRICT TI ANJIN Tianjin - 300171, , CHINA SDNF CHINA","customerAddress":"110-B,ANDHERI INDUSTRIAL ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730053800,"product":"DEXAMETHASONE","address":"3-A, SHIV SAGAR ESTATE, NORTH WING,","city":"BOMBAY ,MAHARASHTRA","supplier":"TIANJIN TIANFA PHARMACEUTICALS","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SKANT HEALTHCARE LTD.","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"500","totalValueFC":"25274.7","currency":"USD","unitRateINR":"42475","date":"28-Oct-2024","totalValueINR":"2123750","totalValueInUsd":"25274.7","indian_port":"Bombay Air","hs_no":"29379019","bill_no":"6371349","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"109 BA WEI ROAD, HEDONG DISTRICT, T IANJIN 300 171, CHINA. SDNF China","customerAddress":"3-A, SHIV SAGAR ESTATE, NORTH WING,"}]
    11-Mar-2021
    30-Oct-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SUSPENSION/DROPS;OPHTHALMIC - 0.1%

    USFDA APPLICATION NUMBER - 13422

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    DOSAGE - SUSPENSION/DROPS;OTIC - 0.3%;0.1%

    USFDA APPLICATION NUMBER - 21537

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    DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG ...DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;EQ 3.5MG BASE/GM;10,000 UNITS/GM

    USFDA APPLICATION NUMBER - 50065

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    DOSAGE - SUSPENSION/DROPS;OPHTHALMIC - 0.1%;0...DOSAGE - SUSPENSION/DROPS;OPHTHALMIC - 0.1%;0.3%

    USFDA APPLICATION NUMBER - 50592

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    DOSAGE - OINTMENT;OPHTHALMIC - 0.1%;0.3%

    USFDA APPLICATION NUMBER - 50616

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    DOSAGE - SUSPENSION/DROPS;OPHTHALMIC - 0.05%;...DOSAGE - SUSPENSION/DROPS;OPHTHALMIC - 0.05%;0.3%

    USFDA APPLICATION NUMBER - 50818

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    DOSAGE - TABLET;ORAL - 1.5MG

    USFDA APPLICATION NUMBER - 84610

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    DOSAGE - TABLET;ORAL - 0.5MG

    USFDA APPLICATION NUMBER - 84611

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    DOSAGE - TABLET;ORAL - 4MG

    USFDA APPLICATION NUMBER - 84612

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    DOSAGE - TABLET;ORAL - 0.75MG

    USFDA APPLICATION NUMBER - 84613

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    DOSAGE - TABLET;ORAL - 2MG

    USFDA APPLICATION NUMBER - 87916

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    DOSAGE - SOLUTION;ORAL - 0.5MG/5ML

    USFDA APPLICATION NUMBER - 88248

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    DOSAGE - ELIXIR;ORAL - 0.5MG/5ML

    USFDA APPLICATION NUMBER - 88254

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    DOSAGE - TABLET;ORAL - 1MG

    USFDA APPLICATION NUMBER - 88306

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    DOSAGE - TABLET;ORAL - 6MG

    USFDA APPLICATION NUMBER - 88316

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