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Chemistry

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Also known as: 104632-28-2, (r)-pramipexole, (r)-n6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine, R-(+)-pramipexole, (6r)-6-n-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Wi638gus96
Molecular Formula
C10H17N3S
Molecular Weight
211.33  g/mol
InChI Key
FASDKYOPVNHBLU-SSDOTTSWSA-N
FDA UNII
WI638GUS96

Dexpramipexole
A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.
1 2D Structure

Dexpramipexole

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
2.1.2 InChI
InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m1/s1
2.1.3 InChI Key
FASDKYOPVNHBLU-SSDOTTSWSA-N
2.1.4 Canonical SMILES
CCCNC1CCC2=C(C1)SC(=N2)N
2.1.5 Isomeric SMILES
CCCN[C@@H]1CCC2=C(C1)SC(=N2)N
2.2 Other Identifiers
2.2.1 UNII
WI638GUS96
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2 Amino 6 Propylaminotetrahydrobenzothiazole

2. 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole

3. 2-amino-6-propylaminotetrahydrobenzothiazole

4. 4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine

5. 6,7-tetrahydro-n6-propyl-2,6-benzothiazolediamine Dihydrochloride Monohydrate

6. Kns 760704

7. Kns-760704

8. Kns760704

9. Mirapex

10. Pramipexol

11. Pramipexol Dihydrobromide, (+-)-isomer

12. Pramipexol Dihydrochloride, (s)-isomer

13. Pramipexol, (+-)-isomer

14. Pramipexol, (r)-isomer

15. Pramipexole

16. Pramipexole Dihydrochloride

17. Pramipexole Dihydrochloride Anhydrous

18. Pramipexole Hydrochloride Monohydrate

19. Sifrol

20. Snd 919

21. Snd 919cl2x

22. Snd-919

23. Snd-919cl2x

24. Snd919cl2x

2.3.2 Depositor-Supplied Synonyms

1. 104632-28-2

2. (r)-pramipexole

3. (r)-n6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine

4. R-(+)-pramipexole

5. (6r)-6-n-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

6. Wi638gus96

7. Kns-760704

8. (r)-pramipexole Dihydrochloride

9. Dexpramipexole Dihydrochloride

10. Dexpramipexole [usan:inn]

11. Unii-wi638gus96

12. Dexpramipexole (usan/inn)

13. Dexpramipexole [inn]

14. Schembl74780

15. Dexpramipexole [usan]

16. Mls006011813

17. Chembl249420

18. Dexpramipexole [who-dd]

19. Dtxsid50146624

20. Bcp12512

21. Zinc3831352

22. 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl-, (6r)-

23. Bdbm50568780

24. Hy-17355b

25. Stk621530

26. Akos005555111

27. Cs-1196

28. Db15130

29. Ac-36724

30. As-56557

31. Smr004703492

32. D09886

33. F19514

34. Q5268345

35. (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine

36. (6r)-n6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

37. (6r)-n~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

38. (r)-4,5,6,7-tetrahydro-6-(propylamino)-benzothiazole-2-amine

39. 2,6-benzothiazolediamine, 4,5,6,7-tetrahydro-n6-propyl-, (r)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 211.33 g/mol
Molecular Formula C10H17N3S
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass211.11431873 g/mol
Monoisotopic Mass211.11431873 g/mol
Topological Polar Surface Area79.2 Ų
Heavy Atom Count14
Formal Charge0
Complexity188
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)


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ABOUT THIS PAGE

Dexpramipexole Manufacturers

A Dexpramipexole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dexpramipexole, including repackagers and relabelers. The FDA regulates Dexpramipexole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dexpramipexole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dexpramipexole Suppliers

A Dexpramipexole supplier is an individual or a company that provides Dexpramipexole active pharmaceutical ingredient (API) or Dexpramipexole finished formulations upon request. The Dexpramipexole suppliers may include Dexpramipexole API manufacturers, exporters, distributors and traders.

Dexpramipexole GMP

Dexpramipexole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dexpramipexole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dexpramipexole GMP manufacturer or Dexpramipexole GMP API supplier for your needs.

Dexpramipexole CoA

A Dexpramipexole CoA (Certificate of Analysis) is a formal document that attests to Dexpramipexole's compliance with Dexpramipexole specifications and serves as a tool for batch-level quality control.

Dexpramipexole CoA mostly includes findings from lab analyses of a specific batch. For each Dexpramipexole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dexpramipexole may be tested according to a variety of international standards, such as European Pharmacopoeia (Dexpramipexole EP), Dexpramipexole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dexpramipexole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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