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Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

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Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 5051-22-9, R-(+)-propranolol, (+)-propranolol, D-propranolol, Dextropropranolol, 2r-propranolol

Molecular Formula

C₁₆H₂₁NO₂

Molecular Weight

259.34 g/mol

InChI Key

AQHHHDLHHXJYJD-CQSZACIVSA-N

FDA UNII

PG6KY07UD7

A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.

1 2D Structure

Dexpropranolol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

2.1.2 InChI

InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m1/s1

2.1.3 InChI Key

AQHHHDLHHXJYJD-CQSZACIVSA-N

2.1.4 Canonical SMILES

CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O

2.1.5 Isomeric SMILES

CC(C)NC[C@H](COC1=CC=CC2=CC=CC=C21)O

2.2 Other Identifiers

2.2.1 UNII

PG6KY07UD7

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Anaprilin

2. Anapriline

3. Avlocardyl

4. Ay 20694

5. Ay-20694

6. Ay20694

7. Betadren

8. Dociton

9. Hydrochloride, Propranolol

10. Inderal

11. Obsidan

12. Obzidan

13. Propanolol

14. Propranolol

15. Propranolol Hydrochloride

16. Rexigen

2.3.2 Depositor-Supplied Synonyms

1. 5051-22-9

2. R-(+)-propranolol

3. (+)-propranolol

4. D-propranolol

5. Dextropropranolol

6. 2r-propranolol

7. (r)-(+)-propranolol

8. (r)-propranolol

9. R (+)-propanolol

10. Dexpropranololum

11. (+)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol

12. R(+)-propranolol

13. (2r)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

14. Propranolol, (r)-

15. Pg6ky07ud7

16. Chebi:8736

17. 2-propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, (+)-

18. Ncgc00016429-05

19. 2-propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (r)-

20. 2-propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, (2r)-

21. 2-propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, (r)-

22. Dsstox_cid_25304

23. Dsstox_rid_80790

24. Dsstox_gsid_45304

25. Despropranolo [dcit]

26. Despropranolo

27. (r)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol

28. (2r)-1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol

29. (2r)-3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol

30. Mls001333595

31. Dexpropranolol [inn:ban]

32. Dexpropranololum [inn-latin]

33. Cas-5051-22-9

34. Smr000875288

35. Einecs 225-749-2

36. Unii-pg6ky07ud7

37. R-propanolol

38. Propranolol-(r)

39. Rnp

40. D-(+)-propranolol

41. (r)-(+)-propanolol Hydrochloride

42. (2r)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride

43. Tocris-0624

44. Tocris-0835

45. (+)-(r)-propranolol

46. Prestwick0_001075

47. Prestwick1_001075

48. Prestwick2_001075

49. Lopac-p-0884

50. Lopac-p-8688

51. Cas-318-98-9

52. Dexpropranolol [inn]

53. Schembl25255

54. Cid_66366

55. Bidd:gt0130

56. Spbio_002995

57. Chembl275742

58. Gtpl7596

59. Dtxsid3045304

60. Bdbm60973

61. Zinc20240

62. Tox21_110435

63. Mfcd00066275

64. Pdsp1_000775

65. Pdsp1_001089

66. Pdsp2_000763

67. Pdsp2_001073

68. Akos025212355

69. Tox21_110435_1

70. Cas-839971

71. Db03322

72. Ncgc00015798-01

73. Ncgc00015798-02

74. Ncgc00015798-03

75. Ncgc00015798-11

76. Ncgc00016429-01

77. Ncgc00016429-02

78. Ncgc00016429-03

79. Ncgc00016429-04

80. Ncgc00016429-06

81. Ncgc00024690-01

82. Ncgc00024814-01

83. Ncgc00024814-02

84. Cas-13071-11-9

85. Ab00514691

86. Brd-k92830582-003-04-8

87. Q27088458

88. (+)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol

89. (2r)-1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol

90. 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol, (r)-

91. (2r)-1-(isopropylamino)-3-(1-naphthoxy)propan-2-ol;hydrochloride

92. (2r)-1-(1-naphthalenyloxy)-3-(propan-2-ylamino)-2-propanol;hydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₁NO₂
Molecular Weight	259.34 g/mol
XLogP3	3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	259.157228913 g/mol
Monoisotopic Mass	259.157228913 g/mol
Topological Polar Surface Area	41.5 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	257
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic beta-Antagonists

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

4.2 Metabolism/Metabolites

Dexpropranolol (propranolol) has known human metabolites that include 4-Hydroxypropranolol, 5-Hydroxypropranolol, and N-Desisopropylpropranolol.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

API SUPPLIERS

01

Wyeth Pharmaceuticals Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Duphat

Not Confirmed

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USDMF

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ABOUT THIS PAGE

Dexpropranolol Manufacturers

A Dexpropranolol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dexpropranolol, including repackagers and relabelers. The FDA regulates Dexpropranolol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dexpropranolol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dexpropranolol Suppliers

A Dexpropranolol supplier is an individual or a company that provides Dexpropranolol active pharmaceutical ingredient (API) or Dexpropranolol finished formulations upon request. The Dexpropranolol suppliers may include Dexpropranolol API manufacturers, exporters, distributors and traders.

click here to find a list of Dexpropranolol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Dexpropranolol USDMF

A Dexpropranolol DMF (Drug Master File) is a document detailing the whole manufacturing process of Dexpropranolol active pharmaceutical ingredient (API) in detail. Different forms of Dexpropranolol DMFs exist exist since differing nations have different regulations, such as Dexpropranolol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Dexpropranolol DMF submitted to regulatory agencies in the US is known as a USDMF. Dexpropranolol USDMF includes data on Dexpropranolol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dexpropranolol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Dexpropranolol suppliers with USDMF on PharmaCompass.

Dexpropranolol GMP

Dexpropranolol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dexpropranolol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dexpropranolol GMP manufacturer or Dexpropranolol GMP API supplier for your needs.

Dexpropranolol CoA

A Dexpropranolol CoA (Certificate of Analysis) is a formal document that attests to Dexpropranolol's compliance with Dexpropranolol specifications and serves as a tool for batch-level quality control.

Dexpropranolol CoA mostly includes findings from lab analyses of a specific batch. For each Dexpropranolol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dexpropranolol may be tested according to a variety of international standards, such as European Pharmacopoeia (Dexpropranolol EP), Dexpropranolol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dexpropranolol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.