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Chemistry

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Also known as: L3l3xyp7mp, Lmwd, Schembl206877, Chembl1697742, O-alpha-d-glucopyranosyl-(1.6)-o-alpha-d-glucopyranosyl-(1.6)-d-glucose, Hy-n0913a
Molecular Formula
C18H32O16
Molecular Weight
504.4  g/mol
InChI Key
FZWBNHMXJMCXLU-BLAUPYHCSA-N
FDA UNII
L3L3XYP7MP

Dextrans
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
1 2D Structure

Dextrans

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal
2.1.2 InChI
InChI=1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2/t5-,6+,7+,8+,9+,10+,11+,12+,13-,14-,15+,16+,17-,18-/m0/s1
2.1.3 InChI Key
FZWBNHMXJMCXLU-BLAUPYHCSA-N
2.1.4 Canonical SMILES
C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O
2.1.5 Isomeric SMILES
C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)OC[C@H]([C@H]([C@@H]([C@H](C=O)O)O)O)O)O)O)O)O)O)O)O
2.2 Other Identifiers
2.2.1 UNII
L3L3XYP7MP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dextran

2. Dextran 40000

3. Dextran 70

4. Dextran 75

5. Dextran 80

6. Dextran B 1355

7. Dextran B 1355 S

8. Dextran B-1355

9. Dextran B-1355-s

10. Dextran B1355

11. Dextran B512

12. Dextran Derivatives

13. Dextran M 70

14. Dextran T 40

15. Dextran T 500

16. Dextran T 70

17. Dextran T-40

18. Dextran T-500

19. Dextrans

20. Hemodex

21. Hyskon

22. Infukoll

23. Macrodex

24. Polyglucin

25. Promit

26. Rheodextran

27. Rheoisodex

28. Rheomacrodex

29. Rheopolyglucin

30. Rondex

31. Saviosol

2.3.2 Depositor-Supplied Synonyms

1. L3l3xyp7mp

2. Lmwd

3. Schembl206877

4. Chembl1697742

5. O-alpha-d-glucopyranosyl-(1.6)-o-alpha-d-glucopyranosyl-(1.6)-d-glucose

6. Hy-n0913a

7. Dtxsid701317190

8. 6-.alpha.-isomaltosylglucose

9. Zinc64622163

10. Cs-0109495

11. D-glucose, O-.alpha.-d-glucopyranosyl-(1->6)-o-.alpha.-d-glucopyranosyl-(1->6)-

12. O-alpha-d-glucopyranosyl-(1-->6)-o-alpha-d-glucopyranosyl-(1-->6)-d-glucose

13. Wurcs=2.0/2,3,2/[o2122h][a2122h-1a_1-5]/1-2-2/a6-b1_b6-c1

14. (2r,3s,4r,5r)-2,3,4,5-tetrahydroxy-6-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)methyl)oxan-2-yl)oxy)hexanal

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 504.4 g/mol
Molecular Formula C18H32O16
XLogP3-7.2
Hydrogen Bond Donor Count11
Hydrogen Bond Acceptor Count16
Rotatable Bond Count11
Exact Mass504.16903493 g/mol
Monoisotopic Mass504.16903493 g/mol
Topological Polar Surface Area277 Ų
Heavy Atom Count34
Formal Charge0
Complexity625
Isotope Atom Count0
Defined Atom Stereocenter Count14
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anticoagulants

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)


Plasma Substitutes

Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration. (See all compounds classified as Plasma Substitutes.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Osmotic Activity [MoA]; Plasma Volume Expander [EPC]; Increased Intravascular Volume [PE]

API SUPPLIERS

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Fison

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Pharmacosmos AS

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USDMF

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Fisons Ltd

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Fisons Ltd

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 1183

Submission : 1968-05-07

Status : Inactive

Type : II

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Fisons Ltd

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Fisons Ltd

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 1184

Submission : 1968-05-07

Status : Inactive

Type : II

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Pharmacosmos As

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Rev. Date :

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DMF Number : 19584

Submission : 2006-06-30

Status : Active

Type : II

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Safc Biosciences Inc

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Pharmacia Laboratories Inc

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Pharmacia Laboratories Inc

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DMF Number : 462

Submission : 1962-01-08

Status : Inactive

Type : II

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Pharmacia Laboratories Inc

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Pharmacia Laboratories Inc

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DMF Number : 353

Submission : 1959-11-16

Status : Inactive

Type : II

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Pharmachem Corp

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Pharmachem Corp

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Rev. Date :

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DMF Number : 9447

Submission : 1991-12-05

Status : Inactive

Type : II

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Pfeifer And Langen

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Pfeifer And Langen

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DMF Number : 2573

Submission : 1975-12-03

Status : Inactive

Type : II

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Certificate Number : R1-CEP 2003-165 - Rev 01

Status : Valid

Issue Date : 2022-01-03

Type : Chemical

Substance Number : 1506

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Certificate Number : R1-CEP 1999-065 - Rev 03

Status : Valid

Issue Date : 2022-01-03

Type : Chemical

Substance Number : 1001

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Certificate Number : R1-CEP 1999-064 - Rev 03

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Substance Number : 1000

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Certificate Number : R1-CEP 1999-063 - Rev 03

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Issue Date : 2022-01-03

Type : Chemical

Substance Number : 999

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JDMF

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Dextran sulfate sodium sulfur-18

Registration Number : 218MF10826

Registrant's Address : 2-41 Sasazukacho, Nishi-ku, Nagoya

Initial Date of Registration : 2006-10-20

Latest Date of Registration : 2006-10-20

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Dextran sulfate sodium sulfur 5

Registration Number : 218MF10831

Registrant's Address : 2-41 Sasazukacho, Nishi-ku, Nagoya

Initial Date of Registration : 2006-10-20

Latest Date of Registration : 2006-10-20

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Dextran 40

Registration Number : 217MF11169

Registrant's Address : 2-41 Sasazukacho, Nishi-ku, Nagoya City, Aichi Prefecture

Initial Date of Registration : 2005-12-12

Latest Date of Registration : 2018-10-01

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DEXTRAN 40

NDC Package Code : 49442-5040

Start Marketing Date : 2006-09-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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DEXTRAN 70

NDC Package Code : 49442-5070

Start Marketing Date : 2011-11-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (100g/100g)

Marketing Category : DRUG FOR FURTHER PROCESSING

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DEXTRAN 1

NDC Package Code : 49442-5800

Start Marketing Date : 2015-06-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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DEXTRAN 60

NDC Package Code : 49442-5060

Start Marketing Date : 2011-11-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (100g/100g)

Marketing Category : DRUG FOR FURTHER PROCESSING

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DEXTRAN 1

NDC Package Code : 49442-5001

Start Marketing Date : 2011-11-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (100g/100g)

Marketing Category : DRUG FOR FURTHER PROCESSING

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DEXTRAN 500

NDC Package Code : 49442-5600

Start Marketing Date : 2015-07-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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Dextran 70

About the Company : PT. Cahaya Mandiri Farma is a leading company in the pharmaceutical industry, dedicated to producing high-quality healthcare products for humans. We are committed to excellence thr...

PT. Cahaya Mandiri Farma is a leading company in the pharmaceutical industry, dedicated to producing high-quality healthcare products for humans. We are committed to excellence through the implementation of advanced technology and rigorous production standards that meet both national and international regulations. Our focus is on delivering innovative and reliable solutions to improve health and well-being, while maintaining the highest levels of safety and quality in every product we manufacture.
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Dextran

About the Company : SWATI SPENTOSE PVT. LTD.(SSPL), a pharmaceutical company based in Mumbai, India having 2 manufacturing sites: SSPL Unit 1 and SSPL Unit 2. Please find attached a brief presentation...

SWATI SPENTOSE PVT. LTD.(SSPL), a pharmaceutical company based in Mumbai, India having 2 manufacturing sites: SSPL Unit 1 and SSPL Unit 2. Please find attached a brief presentation on our company. A USFDA inspected & WHO-GMP certified site, with 3 CEP’S as well as UK-MHRA, EDQM and TGA-Australia compliant API manufacture, specializing in manufacture of Polysaccharides.
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Dextran 40

About the Company : Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & ...

Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & DMF available. The company's registered capital reaches CNY 75 million. The building area of company is over 2,000,000 square meters. All the workshops are compliant with GMP requirements. There are more than 700 employees including over 100 RD staffs,20 experienced production management people and 8 senior professional registration specialists. Having a dynamic, high-quality team, which ensures our company sustainable and stable development.
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Cosmoprof India
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Dextrans

About the Company : Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & ...

Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & DMF available. The company's registered capital reaches CNY 75 million. The building area of company is over 2,000,000 square meters. All the workshops are compliant with GMP requirements. There are more than 700 employees including over 100 RD staffs,20 experienced production management people and 8 senior professional registration specialists. Having a dynamic, high-quality team, which ensures our company sustainable and stable development.
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Cosmoprof India
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Dextran 70

About the Company : Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & ...

Xi'an Wanlong Pharmaceutical Co., Ltd was founded in 1995 and it is comprehensive modern pharmaceutical enterprise which mainly produces formulations, API and intermediates, GMP & DMF available. The company's registered capital reaches CNY 75 million. The building area of company is over 2,000,000 square meters. All the workshops are compliant with GMP requirements. There are more than 700 employees including over 100 RD staffs,20 experienced production management people and 8 senior professional registration specialists. Having a dynamic, high-quality team, which ensures our company sustainable and stable development.
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