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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 8 USDMF, 7 NDC API, 4 Listed Suppliers, $ API Reference Price

8 API Suppliers
8 USDMF
7 NDC API
4 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

FINISHED DOSAGE FORMULATIONS

267 FDF Dossiers, 267 FDA Orange Book

267 FDF Dossiers
267 FDA Orange Book

DRUG PRODUCT COMPOSITIONS

CAPSULE, EXTENDED RELEASE;ORAL - 1.25MG;1.25MG;1.25MG;1.25MG, CAPSULE, EXTENDED RELEASE;ORAL - 2.5MG;2.5MG;2.5MG;2.5MG, CAPSULE, EXTENDED RELEASE;ORAL - 3.75MG;3.75MG;3.75MG;3.75MG, CAPSULE, EXTENDED RELEASE;ORAL - 5MG;5MG;5MG;5MG, CAPSULE, EXTENDED RELEASE;ORAL - 6.25MG;6.25MG;6.25MG;6.25MG, CAPSULE, EXTENDED RELEASE;ORAL - 7.5MG;7.5MG;7.5MG;7.5MG

drugProductComposition
CAPSULE, EXTENDED RELEASE;ORAL - 1.25MG;1.25MG;1.25MG;1.25MG
CAPSULE, EXTENDED RELEASE;ORAL - 2.5MG;2.5MG;2.5MG;2.5MG
CAPSULE, EXTENDED RELEASE;ORAL - 3.75MG;3.75MG;3.75MG;3.75MG
CAPSULE, EXTENDED RELEASE;ORAL - 5MG;5MG;5MG;5MG
CAPSULE, EXTENDED RELEASE;ORAL - 6.25MG;6.25MG;6.25MG;6.25MG
CAPSULE, EXTENDED RELEASE;ORAL - 7.5MG;7.5MG;7.5MG;7.5MG

RELATED EXCIPIENT COMPANIES

4 Evonik, 4 Rochem International Inc, 17 SPI Pharma, 2 Seqens, 9 DKSH, 6 Faran Shimi Pharmaceutical, 5 Boai NKY Pharmaceuticals Ltd, 12 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 2 Pfanstiehl, 4 ACG Worldwide, 6 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 29 BASF, 20 Corel Pharma Chem, 5 DFE Pharma, 2 Finar, 9 Gangwal Chemicals, 13 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 31 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 16 Microlex e.U, 2 Nomisma Healthcare, 3 Novo Excipients, 4 Pharmatrans-Sanaq, 6 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 26 Roquette, 8 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 11 Sigachi Industries, 2 The Dow Chemical Company, 2 Ulanqab Kema New Material, 2 Valens Pharmachem, 3 Vasa Pharmachem, 1 Vertellus

relatedExcipients
4 Evonik
4 Rochem International Inc
17 SPI Pharma
2 Seqens
9 DKSH
6 Faran Shimi Pharmaceutical
5 Boai NKY Pharmaceuticals Ltd
12 Gangwal Healthcare
3 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
6 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
29 BASF
20 Corel Pharma Chem
5 DFE Pharma
2 Finar
9 Gangwal Chemicals
13 Ideal Cures Pvt Ltd
4 Ingredion Pharma Solutions
31 Kerry
3 Kima Chemical
6 Lonza Capsugel
16 Microlex e.U
2 Nomisma Healthcare
3 Novo Excipients
4 Pharmatrans-Sanaq
6 Pluviaendo
3 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
26 Roquette
8 Seppic
5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
11 Sigachi Industries
2 The Dow Chemical Company
2 Ulanqab Kema New Material
2 Valens Pharmachem
3 Vasa Pharmachem
1 Vertellus

EXCIPIENTS BY APPLICATIONS

91 Fillers, Diluents & Binders, 66 Coating Systems & Additives, 48 Controlled & Modified Release, 45 Direct Compression, 32 Disintegrants & Superdisintegrants, 32 Thickeners and Stabilizers, 26 Granulation, 24 Taste Masking, 24 Solubilizers, 18 Chewable & Orodispersible Aids, 18 Co-Processed Excipients, 17 Lubricants & Glidants, 15 Film Formers & Plasticizers, 11 Topical, 11 Parenteral, 9 Empty Capsules, 6 API Stability Enhancers, 6 Emulsifying Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 2 Rheology Modifiers, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 24 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
24 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

5 Annual Reports

globalSalesInformation
5 Annual Reports

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

8 US Patents

patents
8 US Patents

REF. STANDARDS & IMPURITIES

1 Others

otherSolutions
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 2,479

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

267

FDF Dossiers

267

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

1,065

Finished Drug Prices

305 RELATED EXCIPIENT COMPANIES

511EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Dextroamphetamine saccharate

Molecular Formula

C₁₅H₂₃NO₈

Molecular Weight

345.34 g/mol

InChI Key

VHKVKWTWHZUFIA-QRPNPIFTSA-N

Dextroamphetamine Saccharate is the saccharate salt form of the dextro-isomer of amphetamine, a synthetic substance related to natural sympathomimetic amines, with CNS stimulating properties. Dextroamphetamine saccharate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from its storage sites in nerve terminals in the brain, and inhibits their uptake within the mesocorticolimbic system, a major component of the brain reward system, thereby resulting in measurable behavioral changes such as euphoria. As a CNS stimulant, this agent may increase blood pressure and reduce appetite. Similar to other amphetamines, dextroamphetamine has a high potential for abuse, dependence, and addiction if used in large doses over extended periods of time.

1 2D Structure

Dextroamphetamine Saccharate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-1-phenylpropan-2-amine;2,3,4,5-tetrahydroxyhexanedioic acid

2.1.2 InChI

InChI=1S/C9H13N.C6H10O8/c1-8(10)7-9-5-3-2-4-6-9;7-1(3(9)5(11)12)2(8)4(10)6(13)14/h2-6,8H,7,10H2,1H3;1-4,7-10H,(H,11,12)(H,13,14)/t8-;/m0./s1

2.1.3 InChI Key

VHKVKWTWHZUFIA-QRPNPIFTSA-N

2.1.4 Canonical SMILES

CC(CC1=CC=CC=C1)N.C(C(C(C(=O)O)O)O)(C(C(=O)O)O)O

2.1.5 Isomeric SMILES

C[C@@H](CC1=CC=CC=C1)N.C(C(C(C(=O)O)O)O)(C(C(=O)O)O)O

2.2 Synonyms

2.2.1 Depositor-Supplied Synonyms

1. Dextroamphetamine Saccharate

2.3 Create Date

2010-12-22

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃NO₈
Molecular Weight	345.34 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	345.14236669 g/mol
Monoisotopic Mass	345.14236669 g/mol
Topological Polar Surface Area	182 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	287
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

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USDMF

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NDC API

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Listed Suppliers

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Drugs in Development

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FDF Dossiers

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FDA Orange Book

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 1.2...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 1.25MG;1.25MG;1.25MG;1.25MG