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Di(morphine) Dihydrogen Sulfate Pentahydrate

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

23 API Suppliers, 12 USDMF, 6 CEP/COS, 4 KDMF, 14 NDC API, 12 Listed Suppliers, $ API Reference Price

23 API Suppliers
12 USDMF
6 CEP/COS
4 KDMF
14 NDC API
12 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

625 FDF Dossiers, 223 FDA Orange Book, 169 Europe, 47 Canada, 106 Australia, 20 South Africa, 60 Listed Dossiers

625 FDF Dossiers
223 FDA Orange Book
169 Europe
47 Canada
106 Australia
20 South Africa
60 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET, EXTENDED RELEASE;ORAL - 100MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 200MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML), INJECTABLE;INJECTION - 10MG/ML, INJECTABLE;INJECTION - 15MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 2MG/ML, INJECTABLE;INJECTION - 4MG/ML, INJECTABLE;INJECTION - 50MG/ML, INJECTABLE;INJECTION - 8MG/ML, CAPSULE, EXTENDED RELEASE;ORAL - 100MG, CAPSULE, EXTENDED RELEASE;ORAL - 10MG, CAPSULE, EXTENDED RELEASE;ORAL - 130MG, CAPSULE, EXTENDED RELEASE;ORAL - 150MG, CAPSULE, EXTENDED RELEASE;ORAL - 200MG, CAPSULE, EXTENDED RELEASE;ORAL - 20MG, CAPSULE, EXTENDED RELEASE;ORAL - 30MG, CAPSULE, EXTENDED RELEASE;ORAL - 40MG, CAPSULE, EXTENDED RELEASE;ORAL - 50MG, CAPSULE, EXTENDED RELEASE;ORAL - 60MG, CAPSULE, EXTENDED RELEASE;ORAL - 70MG, CAPSULE, EXTENDED RELEASE;ORAL - 80MG, TABLET, EXTENDED RELEASE;ORAL - 100MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, SOLUTION;ORAL - 100MG/5ML, SOLUTION;ORAL - 10MG/5ML, SOLUTION;ORAL - 20MG/5ML, TABLET;ORAL - 15MG, TABLET;ORAL - 30MG, CAPSULE, EXTENDED RELEASE;ORAL - 100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

drugProductComposition
TABLET, EXTENDED RELEASE;ORAL - 100MG
TABLET, EXTENDED RELEASE;ORAL - 15MG
TABLET, EXTENDED RELEASE;ORAL - 200MG
TABLET, EXTENDED RELEASE;ORAL - 30MG
TABLET, EXTENDED RELEASE;ORAL - 60MG
INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML)
INJECTABLE;INJECTION - 10MG/ML
INJECTABLE;INJECTION - 15MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - 2MG/ML
INJECTABLE;INJECTION - 4MG/ML
INJECTABLE;INJECTION - 50MG/ML
INJECTABLE;INJECTION - 8MG/ML
CAPSULE, EXTENDED RELEASE;ORAL - 100MG
CAPSULE, EXTENDED RELEASE;ORAL - 10MG
CAPSULE, EXTENDED RELEASE;ORAL - 130MG
CAPSULE, EXTENDED RELEASE;ORAL - 150MG
CAPSULE, EXTENDED RELEASE;ORAL - 200MG
CAPSULE, EXTENDED RELEASE;ORAL - 20MG
CAPSULE, EXTENDED RELEASE;ORAL - 30MG
CAPSULE, EXTENDED RELEASE;ORAL - 40MG
CAPSULE, EXTENDED RELEASE;ORAL - 50MG
CAPSULE, EXTENDED RELEASE;ORAL - 60MG
CAPSULE, EXTENDED RELEASE;ORAL - 70MG
CAPSULE, EXTENDED RELEASE;ORAL - 80MG
TABLET, EXTENDED RELEASE;ORAL - 100MG
TABLET, EXTENDED RELEASE;ORAL - 15MG
TABLET, EXTENDED RELEASE;ORAL - 30MG
TABLET, EXTENDED RELEASE;ORAL - 60MG
TABLET, EXTENDED RELEASE;ORAL - 15MG
TABLET, EXTENDED RELEASE;ORAL - 30MG
TABLET, EXTENDED RELEASE;ORAL - 60MG
SOLUTION;ORAL - 100MG/5ML
SOLUTION;ORAL - 10MG/5ML
SOLUTION;ORAL - 20MG/5ML
TABLET;ORAL - 15MG
TABLET;ORAL - 30MG
CAPSULE, EXTENDED RELEASE;ORAL - 100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
CAPSULE, EXTENDED RELEASE;ORAL - 80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

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relatedExcipients
3 Evonik
4 Rochem International Inc
17 SPI Pharma
2 Seqens
20 DKSH
1 Jai Radhe Sales
2 Pharm-RX Chemical
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4 Boai NKY Pharmaceuticals Ltd
13 Gangwal Healthcare
10 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
15 Actylis
1 Aeon Procare
1 Alcedo Pharmachem
7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
1 Avesta Pharma
36 BASF
1 Bioplus Life Sciences
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4 Kima Chemical
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1 Qianhao Chemical (Hebei) Co., Ltd
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2 Shijiazhuang Huaxu Pharmaceutical
10 Sigachi Industries
3 The Dow Chemical Company
2 Ulanqab Kema New Material
2 Valens Pharmachem
2 Vasa Pharmachem
1 Vertellus
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

110 Fillers, Diluents & Binders, 78 Coating Systems & Additives, 52 Controlled & Modified Release, 42 Direct Compression, 39 Thickeners and Stabilizers, 35 Solubilizers, 35 Topical, 33 Parenteral, 28 Taste Masking, 27 Granulation, 27 Film Formers & Plasticizers, 22 Lubricants & Glidants, 22 Co-Processed Excipients, 16 Chewable & Orodispersible Aids, 14 Disintegrants & Superdisintegrants, 11 Emulsifying Agents, 9 API Stability Enhancers, 9 Rheology Modifiers, 9 Empty Capsules, 6 Surfactant & Foaming Agents, 5 Coloring Agents, 4 Vegetarian Capsules, 1 Soft Gelatin

DIGITAL CONTENT

5 DATA COMPILATION #PharmaFlow, 119 NEWS #PharmaBuzz

media
5 DATA COMPILATION #PharmaFlow
119 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 186 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
186 Finished Drug Prices

MARKET PLACE

15 APIs, 19 FDF Dossiers

marketPlace
15 APIs
19 FDF Dossiers

PATENTS & EXCLUSIVITIES

88 US Patents, 4 US Exclusivities, 26 Health Canada Patents

patents
88 US Patents
4 US Exclusivities
26 Health Canada Patents

REF. STANDARDS & IMPURITIES

2 EDQM , 4 USP , 7 Others

otherSolutions
2 EDQM
4 USP
7 Others

Veranova Morphine Sulfate

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 15,454

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

625

FDF Dossiers

223

FDA Orange Book

169

Europe

Canada

106

Australia

South Africa

Listed Dossiers

2DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

119

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

1,320,832

Annual Reports (USD Million)

Finished Drug Prices

371 RELATED EXCIPIENT COMPANIES

634EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Morphine sulfate, Schembl29317, Morphinesulfatenarcoticanalgesic

Molecular Formula

C₁₇H₂₁NO₇S

Molecular Weight

383.4 g/mol

InChI Key

OOZBZVAQKFGLOL-VYKNHSEDSA-N

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

1 2D Structure

Morphine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;sulfuric acid

2.1.2 InChI

InChI=1S/C17H19NO3.H2O4S/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t10-,11+,13-,16-,17-;/m0./s1

2.1.3 InChI Key

OOZBZVAQKFGLOL-VYKNHSEDSA-N

2.1.4 Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Chloride, Morphine

2. Contin, Ms

3. Duramorph

4. Morphia

5. Morphine

6. Morphine Chloride

7. Morphine Sulfate

8. Morphine Sulfate (2:1), Anhydrous

9. Morphine Sulfate (2:1), Pentahydrate

10. Ms Contin

11. Oramorph Sr

12. Sdz 202 250

13. Sdz 202-250

14. Sdz 202250

15. Sdz202 250

16. Sdz202-250

17. Sdz202250

18. Sulfate, Morphine

2.2.2 Depositor-Supplied Synonyms

1. Morphine Sulfate

2. Schembl29317

3. Morphinesulfatenarcoticanalgesic

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₁NO₇S
Molecular Weight	383.4 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	0
Exact Mass	383.10387318 g/mol
Monoisotopic Mass	383.10387318 g/mol
Topological Polar Surface Area	136 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	576
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Astramorph pf
PubMed Health	Morphine (Injection)
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa

2 of 6
Drug Name	Duramorph pf
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Hikma Maple

3 of 6
Drug Name	Morphine sulfate
PubMed Health	Morphine Sulfate Liposome (Injection)
Drug Classes	Analgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug Label	DESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active Ingredient	Morphine sulfate
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
Route	Intramuscular, intravenous; oral; Injection; Oral
Strength	2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market Status	Prescription
Company	Clonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

4 of 6
Drug Name	Astramorph pf
PubMed Health	Morphine (Injection)
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa

5 of 6
Drug Name	Duramorph pf
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Hikma Maple

6 of 6
Drug Name	Morphine sulfate
PubMed Health	Morphine Sulfate Liposome (Injection)
Drug Classes	Analgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug Label	DESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active Ingredient	Morphine sulfate
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
Route	Intramuscular, intravenous; oral; Injection; Oral
Strength	2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market Status	Prescription
Company	Clonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

API SUPPLIERS

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USDMF

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CEP/COS

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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LOUIS MO 63147 , UNITED STATES UNITED STATES","customerAddress":"A-43, G.T.KARNAL ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 100M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 100MG

USFDA APPLICATION NUMBER - 19516

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 15MG

USFDA APPLICATION NUMBER - 19516

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 200M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 200MG

USFDA APPLICATION NUMBER - 19516

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 30MG

USFDA APPLICATION NUMBER - 19516

DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 60MG

USFDA APPLICATION NUMBER - 19516

DOSAGE - INJECTABLE;INJECTION - 1MG/ML **Fede...DOSAGE - INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19916

DOSAGE - INJECTABLE;INJECTION - 5MG/ML **Fede...DOSAGE - INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19916

DOSAGE - SOLUTION;INTRAMUSCULAR - 10MG/0.7ML ...DOSAGE - SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML)

USFDA APPLICATION NUMBER - 19999

DOSAGE - INJECTABLE;INJECTION - 10MG/ML

USFDA APPLICATION NUMBER - 202515

DOSAGE - INJECTABLE;INJECTION - 15MG/ML **Fed...DOSAGE - INJECTABLE;INJECTION - 15MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 202515

DOSAGE - INJECTABLE;INJECTION - 2MG/ML

USFDA APPLICATION NUMBER - 202515

DOSAGE - INJECTABLE;INJECTION - 4MG/ML

USFDA APPLICATION NUMBER - 202515

DOSAGE - INJECTABLE;INJECTION - 50MG/ML

USFDA APPLICATION NUMBER - 202515

DOSAGE - INJECTABLE;INJECTION - 8MG/ML

USFDA APPLICATION NUMBER - 202515

DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100MG