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    Chemistry

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    Also known as: Morphine sulfate, Schembl29317, Morphinesulfatenarcoticanalgesic
    Molecular Formula
    C17H21NO7S
    Molecular Weight
    383.4  g/mol
    InChI Key
    OOZBZVAQKFGLOL-VYKNHSEDSA-N
    Morphine Sulfate
    The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
    1 2D Structure

    Morphine Sulfate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;sulfuric acid
    2.1.2 InChI
    InChI=1S/C17H19NO3.H2O4S/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t10-,11+,13-,16-,17-;/m0./s1
    2.1.3 InChI Key
    OOZBZVAQKFGLOL-VYKNHSEDSA-N
    2.1.4 Canonical SMILES
    CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.OS(=O)(=O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Chloride, Morphine

    2. Contin, Ms

    3. Duramorph

    4. Morphia

    5. Morphine

    6. Morphine Chloride

    7. Morphine Sulfate

    8. Morphine Sulfate (2:1), Anhydrous

    9. Morphine Sulfate (2:1), Pentahydrate

    10. Ms Contin

    11. Oramorph Sr

    12. Sdz 202 250

    13. Sdz 202-250

    14. Sdz 202250

    15. Sdz202 250

    16. Sdz202-250

    17. Sdz202250

    18. Sulfate, Morphine

    2.2.2 Depositor-Supplied Synonyms

    1. Morphine Sulfate

    2. Schembl29317

    3. Morphinesulfatenarcoticanalgesic

    2.3 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 383.4 g/mol
    Molecular Formula C17H21NO7S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count0
    Exact Mass383.10387318 g/mol
    Monoisotopic Mass383.10387318 g/mol
    Topological Polar Surface Area136 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity576
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameAstramorph pf
    PubMed HealthMorphine (Injection)
    Active IngredientMorphine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml; 0.5mg/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    2 of 6  
    Drug NameDuramorph pf
    Active IngredientMorphine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml; 0.5mg/ml
    Market StatusPrescription
    CompanyHikma Maple

    3 of 6  
    Drug NameMorphine sulfate
    PubMed HealthMorphine Sulfate Liposome (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
    Drug LabelDESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
    Active IngredientMorphine sulfate
    Dosage FormTablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
    RouteIntramuscular, intravenous; oral; Injection; Oral
    Strength2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
    Market StatusPrescription
    CompanyClonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

    4 of 6  
    Drug NameAstramorph pf
    PubMed HealthMorphine (Injection)
    Active IngredientMorphine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml; 0.5mg/ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    5 of 6  
    Drug NameDuramorph pf
    Active IngredientMorphine sulfate
    Dosage FormInjectable
    RouteInjection
    Strength1mg/ml; 0.5mg/ml
    Market StatusPrescription
    CompanyHikma Maple

    6 of 6  
    Drug NameMorphine sulfate
    PubMed HealthMorphine Sulfate Liposome (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct, Central Nervous System Agent
    Drug LabelDESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
    Active IngredientMorphine sulfate
    Dosage FormTablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
    RouteIntramuscular, intravenous; oral; Injection; Oral
    Strength2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
    Market StatusPrescription
    CompanyClonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Analgesics, Opioid

    Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

    Narcotics

    Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

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    01-Mar-2021
    30-Dec-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 100M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 100MG

    USFDA APPLICATION NUMBER - 19516

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 15MG

    USFDA APPLICATION NUMBER - 19516

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 200M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 200MG

    USFDA APPLICATION NUMBER - 19516

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 30MG

    USFDA APPLICATION NUMBER - 19516

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 60MG

    USFDA APPLICATION NUMBER - 19516

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    DOSAGE - INJECTABLE;INJECTION - 1MG/ML **Fede...DOSAGE - INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19916

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    DOSAGE - INJECTABLE;INJECTION - 5MG/ML **Fede...DOSAGE - INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 19916

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    DOSAGE - SOLUTION;INTRAMUSCULAR - 10MG/0.7ML ...DOSAGE - SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML)

    USFDA APPLICATION NUMBER - 19999

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    DOSAGE - INJECTABLE;INJECTION - 10MG/ML

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - INJECTABLE;INJECTION - 15MG/ML **Fed...DOSAGE - INJECTABLE;INJECTION - 15MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - INJECTABLE;INJECTION - 2MG/ML

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - INJECTABLE;INJECTION - 4MG/ML

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - INJECTABLE;INJECTION - 50MG/ML

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - INJECTABLE;INJECTION - 8MG/ML

    USFDA APPLICATION NUMBER - 202515

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 100MG

    USFDA APPLICATION NUMBER - 20616

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 10M...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 10MG

    USFDA APPLICATION NUMBER - 20616

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    DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 130...DOSAGE - CAPSULE, EXTENDED RELEASE;ORAL - 130MG

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    ABOUT THIS PAGE

    Looking for 64-31-3 / Morphine Sulfate API manufacturers, exporters & distributors?

    Morphine Sulfate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Morphine Sulfate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Morphine Sulfate manufacturer or Morphine Sulfate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Morphine Sulfate manufacturer or Morphine Sulfate supplier.

    PharmaCompass also assists you with knowing the Morphine Sulfate API Price utilized in the formulation of products. Morphine Sulfate API Price is not always fixed or binding as the Morphine Sulfate Price is obtained through a variety of data sources. The Morphine Sulfate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Morphine Sulfate

    Synonyms

    Schembl29317, Morphinesulfatenarcoticanalgesic

    Cas Number

    64-31-3

    About Morphine Sulfate

    The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

    Di(morphine) dihydrogen sulfate pentahydrate Manufacturers

    A Di(morphine) dihydrogen sulfate pentahydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Di(morphine) dihydrogen sulfate pentahydrate, including repackagers and relabelers. The FDA regulates Di(morphine) dihydrogen sulfate pentahydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Di(morphine) dihydrogen sulfate pentahydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate Suppliers

    A Di(morphine) dihydrogen sulfate pentahydrate supplier is an individual or a company that provides Di(morphine) dihydrogen sulfate pentahydrate active pharmaceutical ingredient (API) or Di(morphine) dihydrogen sulfate pentahydrate finished formulations upon request. The Di(morphine) dihydrogen sulfate pentahydrate suppliers may include Di(morphine) dihydrogen sulfate pentahydrate API manufacturers, exporters, distributors and traders.

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate USDMF

    A Di(morphine) dihydrogen sulfate pentahydrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Di(morphine) dihydrogen sulfate pentahydrate active pharmaceutical ingredient (API) in detail. Different forms of Di(morphine) dihydrogen sulfate pentahydrate DMFs exist exist since differing nations have different regulations, such as Di(morphine) dihydrogen sulfate pentahydrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Di(morphine) dihydrogen sulfate pentahydrate DMF submitted to regulatory agencies in the US is known as a USDMF. Di(morphine) dihydrogen sulfate pentahydrate USDMF includes data on Di(morphine) dihydrogen sulfate pentahydrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Di(morphine) dihydrogen sulfate pentahydrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate suppliers with USDMF on PharmaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Di(morphine) dihydrogen sulfate pentahydrate Drug Master File in Korea (Di(morphine) dihydrogen sulfate pentahydrate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Di(morphine) dihydrogen sulfate pentahydrate. The MFDS reviews the Di(morphine) dihydrogen sulfate pentahydrate KDMF as part of the drug registration process and uses the information provided in the Di(morphine) dihydrogen sulfate pentahydrate KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Di(morphine) dihydrogen sulfate pentahydrate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Di(morphine) dihydrogen sulfate pentahydrate API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate suppliers with KDMF on PharmaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate CEP

    A Di(morphine) dihydrogen sulfate pentahydrate CEP of the European Pharmacopoeia monograph is often referred to as a Di(morphine) dihydrogen sulfate pentahydrate Certificate of Suitability (COS). The purpose of a Di(morphine) dihydrogen sulfate pentahydrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Di(morphine) dihydrogen sulfate pentahydrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Di(morphine) dihydrogen sulfate pentahydrate to their clients by showing that a Di(morphine) dihydrogen sulfate pentahydrate CEP has been issued for it. The manufacturer submits a Di(morphine) dihydrogen sulfate pentahydrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Di(morphine) dihydrogen sulfate pentahydrate CEP holder for the record. Additionally, the data presented in the Di(morphine) dihydrogen sulfate pentahydrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Di(morphine) dihydrogen sulfate pentahydrate DMF.

    A Di(morphine) dihydrogen sulfate pentahydrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Di(morphine) dihydrogen sulfate pentahydrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate suppliers with CEP (COS) on PharmaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Di(morphine) dihydrogen sulfate pentahydrate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Di(morphine) dihydrogen sulfate pentahydrate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Di(morphine) dihydrogen sulfate pentahydrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Di(morphine) dihydrogen sulfate pentahydrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Di(morphine) dihydrogen sulfate pentahydrate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Di(morphine) dihydrogen sulfate pentahydrate suppliers with NDC on PharmaCompass.

    Di(morphine) dihydrogen sulfate pentahydrate GMP

    Di(morphine) dihydrogen sulfate pentahydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Di(morphine) dihydrogen sulfate pentahydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Di(morphine) dihydrogen sulfate pentahydrate GMP manufacturer or Di(morphine) dihydrogen sulfate pentahydrate GMP API supplier for your needs.

    Di(morphine) dihydrogen sulfate pentahydrate CoA

    A Di(morphine) dihydrogen sulfate pentahydrate CoA (Certificate of Analysis) is a formal document that attests to Di(morphine) dihydrogen sulfate pentahydrate's compliance with Di(morphine) dihydrogen sulfate pentahydrate specifications and serves as a tool for batch-level quality control.

    Di(morphine) dihydrogen sulfate pentahydrate CoA mostly includes findings from lab analyses of a specific batch. For each Di(morphine) dihydrogen sulfate pentahydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Di(morphine) dihydrogen sulfate pentahydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Di(morphine) dihydrogen sulfate pentahydrate EP), Di(morphine) dihydrogen sulfate pentahydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Di(morphine) dihydrogen sulfate pentahydrate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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