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Chemistry

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Also known as: 1,2:5,6-diepoxydulcitol, Dianhydromannitol, 23261-20-3, 1,2-bis(oxiran-2-yl)ethane-1,2-diol, Nsc 132313, 5,6-diepoxydulcitol
Molecular Formula
C6H10O4
Molecular Weight
146.14  g/mol
InChI Key
AAFJXZWCNVJTMK-UHFFFAOYSA-N

Dianhydrogalactitol
One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
1 2D Structure

Dianhydrogalactitol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,2-bis(oxiran-2-yl)ethane-1,2-diol
2.1.2 InChI
InChI=1S/C6H10O4/c7-5(3-1-9-3)6(8)4-2-10-4/h3-8H,1-2H2
2.1.3 InChI Key
AAFJXZWCNVJTMK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1C(O1)C(C(C2CO2)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 1,2,5,6-dianhydrogalactitol

2. 1,2-5,6-dianhydrogalactitol

3. Dianhydrogalactitol

4. Diepoxydulcitol

5. Diepoxygalactitol

6. Nsc 132313

7. Nsc-132313

8. Nsc132313

2.2.2 Depositor-Supplied Synonyms

1. 1,2:5,6-diepoxydulcitol

2. Dianhydromannitol

3. 23261-20-3

4. 1,2-bis(oxiran-2-yl)ethane-1,2-diol

5. Nsc 132313

6. 5,6-diepoxydulcitol

7. 1,2-5,6-dianhydro-dulcitol

8. 1,2:5,6-dianhydrodulcitol

9. Galactitol, 1,2:5,6-dianhydro-

10. Dianhydrodulcitol;dianhydrogalactitol

11. Nsc132313

12. 19895-66-0

13. Nsc-133129

14. 1,6-diepoxydulcitol

15. 1,6-dianhydrodulcitol

16. 1,6-dianhydromannitol

17. 1,6-dianhydrogalactitol

18. 1,6-diepoxy-d-mannitol

19. 1,6-dianhydro-d-mannitol

20. 1,2:5,6-dianhydrohexitol

21. 1,6-di-anhydro-d-mannitol

22. Galactitol,2:5,6-dianhydro-

23. Schembl8375579

24. D-mannitol,2:5,6-dianhydro-

25. Chembl1987719

26. Dtxsid60941768

27. Mannitol,2:5,6-dianhydro-, D-

28. Nsc133129

29. Akos025396866

30. Nci60_000711

31. Ft-0667810

32. 261d203

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 146.14 g/mol
Molecular Formula C6H10O4
XLogP3-1.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass146.05790880 g/mol
Monoisotopic Mass146.05790880 g/mol
Topological Polar Surface Area65.5 Ų
Heavy Atom Count10
Formal Charge0
Complexity122
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents, Alkylating

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) (See all compounds classified as Antineoplastic Agents, Alkylating.)


ABOUT THIS PAGE

Dianhydrogalactitol Manufacturers

A Dianhydrogalactitol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dianhydrogalactitol, including repackagers and relabelers. The FDA regulates Dianhydrogalactitol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dianhydrogalactitol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dianhydrogalactitol Suppliers

A Dianhydrogalactitol supplier is an individual or a company that provides Dianhydrogalactitol active pharmaceutical ingredient (API) or Dianhydrogalactitol finished formulations upon request. The Dianhydrogalactitol suppliers may include Dianhydrogalactitol API manufacturers, exporters, distributors and traders.

Dianhydrogalactitol GMP

Dianhydrogalactitol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dianhydrogalactitol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dianhydrogalactitol GMP manufacturer or Dianhydrogalactitol GMP API supplier for your needs.

Dianhydrogalactitol CoA

A Dianhydrogalactitol CoA (Certificate of Analysis) is a formal document that attests to Dianhydrogalactitol's compliance with Dianhydrogalactitol specifications and serves as a tool for batch-level quality control.

Dianhydrogalactitol CoA mostly includes findings from lab analyses of a specific batch. For each Dianhydrogalactitol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dianhydrogalactitol may be tested according to a variety of international standards, such as European Pharmacopoeia (Dianhydrogalactitol EP), Dianhydrogalactitol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dianhydrogalactitol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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