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SOLUTION;ORAL, RECTAL - 66%;10%, INJECTABLE;INJECTION - 66%;10%

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SOLUTION;ORAL, RECTAL - 66%;10%
INJECTABLE;INJECTION - 66%;10%

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Chemistry

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Also known as: Sodium diatrizoate, 737-31-5, Sodium amidotrizoate, Triombrine, Hypaque sodium, Diatrizoic acid sodium salt

Molecular Formula

C₁₁H₈I₃N₂NaO₄

Molecular Weight

635.89 g/mol

InChI Key

ZEYOIOAKZLALAP-UHFFFAOYSA-M

FDA UNII

V5403H8VG7

Diatrizoate Sodium is an iodinated radiopaque X-ray contrast medium. Diatrizoate sodium blocks X-rays, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine and allowing visualization of these areas. This contrast agent is used as a diagnostic aid in angiography, urography and radiography. (NCI05)

1 2D Structure

Diatrizoate Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;3,5-diacetamido-2,4,6-triiodobenzoate

2.1.2 InChI

InChI=1S/C11H9I3N2O4.Na/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;/h1-2H3,(H,15,17)(H,16,18)(H,19,20);/q;+1/p-1

2.1.3 InChI Key

ZEYOIOAKZLALAP-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CC(=O)NC1=C(C(=C(C(=C1I)C(=O)[O-])I)NC(=O)C)I.[Na+]

2.2 Other Identifiers

2.2.1 UNII

V5403H8VG7

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Sodium Diatrizoate

2. 737-31-5

3. Sodium Amidotrizoate

4. Triombrine

5. Hypaque Sodium

6. Diatrizoic Acid Sodium Salt

7. Sodium 3,5-diacetamido-2,4,6-triiodobenzoate

8. Triombrin

9. Natrii Amidotrizoas

10. Vascoray

11. Conray 35

12. Hypaque Cysto

13. Hpaque - Cysto

14. Amidotrizoato Sodico

15. Histopaque

16. Hypaque Sodium 20%

17. Urovist Sodium

18. Diatrizoate Sodium Salt

19. Amidotrizoate De Sodium

20. Benzoic Acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, Monosodium Salt

21. Hypaque 50

22. Md 50

23. Sodium Diacetyldiaminetriiodobenzoate

24. Sodium Amidotrizoate (inn)

25. Urographing 370

26. Monosodium 3,5-diacetamido-2,4,6-triiodobenzoate

27. Urografic Acid, Sodium Salt

28. Diatrizoate Sodium [usp]

29. Sodium Amidotrizoate [inn]

30. Ml 216

31. Win 8308-3

32. 3,5-diacetamido-2,4,6-triiodobenzoic Acid Sodium Salt

33. Md-50

34. Mls000069526

35. Chebi:53692

36. V5403h8vg7

37. Gastrografin

38. 3,5-diacetylamino-2,4,6-trijodbenzosaeure Natrium

39. Nsc-61815

40. Smr000058586

41. Diatrizoate Sodium (usp)

42. Sodium;3,5-diacetamido-2,4,6-triiodobenzoate

43. Diatrizoic Acid Sodium Salt;sodium Amidotrizoate

44. Benzoic Acid, 3,5-diacetamido-2,4,6-triiodo-, Monosodium Salt

45. Urovist Sodium 300

46. Radioselectan

47. Urovist 300

48. Natrii Amidotrizoas [inn-latin]

49. Amidotrizoato Sodico [inn-spanish]

50. Einecs 212-004-1

51. Nsc 61815

52. Amidotrizoate De Sodium [inn-french]

53. Renografin 76 Injectable (veterinary)

54. Unii-v5403h8vg7

55. Hsdb 8078

56. 3,5-diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt

57. Urovist Sodium (tn)

58. 3,5-diacetylamino-2,4,6-trijodbenzosaeure Natrium [german]

59. Benzoic Acid, 3,5-diacetamido-2,4,6-triiodo-, Sodium Salt

60. Opera_id_214

61. Dsstox_cid_2912

62. Sodium Diatrizoate [ban]

63. Dsstox_rid_76785

64. Dsstox_gsid_22912

65. Schembl37116

66. Chembl1200581

67. Dtxsid7022912

68. Hy-b0926a

69. Diatrizoate Sodium [vandf]

70. Diatrizoate Sodium [who-ip]

71. Tox21_301439

72. Diatrizoic Acid Sodium Salt Dihydrate

73. Sodium Amidotrizoate [mart.]

74. Sodium Amidotrizoate [who-dd]

75. Sodium Amidotrizoate [who-ip]

76. Akos024371067

77. Ccg-270302

78. Diatrizoate Sodium [green Book]

79. Diatrizoate Sodium [orange Book]

80. Diatrizoic Acid Sodium Salt [mi]

81. Ncgc00255327-01

82. Cas-737-31-5

83. Diatrizoate Sodium [usp Monograph]

84. Sodium Amidotrizoate [ep Impurity]

85. Natrii Amidotrizoas [who-ip Latin]

86. Renocal Component Diatrizoate Sodium

87. Sodium Amidotrizoate [ep Monograph]

88. Renovist Component Diatrizoate Sodium

89. Angiovist Component Diatrizoate Sodium

90. Cs-0013563

91. Ft-0603095

92. Diatrizoate Sodium Component Of Renocal

93. Gastrovist Component Diatrizoate Sodium

94. Renografin Component Diatrizoate Sodium

95. Sodium3,5-diacetamido-2,4,6-triiodobenzoate

96. A17075

97. D01013

98. D97593

99. Diatrizoate Sodium Component Of Renovist

100. Gastrografin Component Diatrizoate Sodium

101. Diatrizoate Sodium Component Of Angiovist

102. Diatrizoate Sodium Component Of Gastrovist

103. Diatrizoate Sodium Component Of Renografin

104. Md-gastroview Component Diatrizoate Sodium

105. Diatrizoate Sodium Component Of Gastrografin

106. Diatrizoate Sodium Component Of Md-gastroview

107. Sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate

108. 3,5-diacetamido-2,4,6-tiiodobenzoic Acid Sodium Salt

109. Q27104811

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₈I₃N₂NaO₄
Molecular Weight	635.89 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	635.7516 g/mol
Monoisotopic Mass	635.7516 g/mol
Topological Polar Surface Area	98.3 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	396
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

GLOFIL-125 (Sodium Iothalamate I-125 Injection) is indicated for evaluation of glomerular filtration in the diagnosis or monitoring of patients with renal disease.

US Natl Inst Health; DailyMed. Current Medication Information for Glofil-125 (iothalamate sodium, I-125) Injection (June 2007). Available from, as of July 23, 2012: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c07ce91-cc83-45e3-bd2b-f923a9c8286c

4.2 Drug Warning

Contrast Media

National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)

As in the use of any radioactive material, care should be taken to minimize radiation exposure to the patient, consistent with proper patient management, and to insure minimum radiation exposure to occupational workers.

Rapid or bolus-like injections should be avoided.

Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe use and handling of radionuclides.

For more Drug Warnings (Complete) data for Iothalamate (8 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

Radioiodine is excreted in human milk during lactation. It is not known whether GLOFIL-125 is excreted in human milk.

The renal clearance of sodium iothalamate in man closely approximates that of inulin. The compound is cleared by glomerular filtration without tubular secretion or reabsorption.

5.2 Biological Half-Life

Following infusion administration of I-125 iothalamate, the effective half-life is about 0.07 days.

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