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    Chemistry

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    Also known as: 364-98-7, Proglycem, Hyperstat, Hypertonalum, Eudemine, Proglicem
    Molecular Formula
    C8H7ClN2O2S
    Molecular Weight
    230.67  g/mol
    InChI Key
    GDLBFKVLRPITMI-UHFFFAOYSA-N
    FDA UNII
    O5CB12L4FN
    Diazoxide
    A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
    1 2D Structure

    Diazoxide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-chloro-3-methyl-4H-16,2,4-benzothiadiazine 1,1-dioxide
    2.1.2 InChI
    InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
    2.1.3 InChI Key
    GDLBFKVLRPITMI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    O5CB12L4FN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hyperstat

    2. Proglycem

    2.3.2 Depositor-Supplied Synonyms

    1. 364-98-7

    2. Proglycem

    3. Hyperstat

    4. Hypertonalum

    5. Eudemine

    6. Proglicem

    7. Dizoxide

    8. Mutabase

    9. 7-chloro-3-methyl-2h-1,2,4-benzothiadiazine 1,1-dioxide

    10. Sch 6783

    11. Sch-6783

    12. Diazossido

    13. Diazoxidum

    14. Srg 95213

    15. Srg-95213

    16. Diazoxido

    17. 2h-1,2,4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

    18. Eudemine Injection

    19. Nsc-64198

    20. Nsc 76130

    21. Chebi:4495

    22. Mfcd00078578

    23. Nsc-76130

    24. O5cb12l4fn

    25. 3-methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide

    26. Mls000028459

    27. 7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido

    28. 364-98-7 (free)

    29. 7-chloro-3-methyl-4h-1$l^{6},2,4-benzothiadiazine 1,1-dioxide

    30. Diazossido [italian]

    31. Nsc64198

    32. Nsc76130

    33. 7-chloro-3-methyl-2h-1,2,4-benzothiadiazine1,1-dioxide

    34. C8h7cln2o2s

    35. Diazossido [dcit]

    36. Ncgc00015380-09

    37. Cas-364-98-7

    38. Smr000058392

    39. 7-chloro-3-methyl-2h-benzo[e][1,2,4]thiadiazine 1,1-dioxide

    40. Dsstox_cid_2914

    41. Diazoxidum [inn-latin]

    42. Dsstox_rid_76786

    43. Diazoxido [inn-spanish]

    44. Dsstox_gsid_22914

    45. 7-chloro-3-methyl-4h-1,2,4-benzothiadiazine 1,1-dioxide

    46. Aroglycem

    47. 7-chloro-3-methyl-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide

    48. Hyperstat (tn)

    49. Sr-01000075314

    50. Einecs 206-668-1

    51. Nsc 64198

    52. Unii-o5cb12l4fn

    53. 7-chloro-3-methyl-2h-1,4-benzothiadiazine 1,1-dioxide

    54. Diazoxide (jan/usp/inn)

    55. Eudimine

    56. 2h-1,4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

    57. 7-chloro-3-methyl-2h-1?^{6},2,4-benzothiadiazine 1,1-dioxide

    58. 7-cloro-3-metil-2h-1,2,4-benzotiodiazina-1,1-diossido [italian]

    59. Proglycem (tn)

    60. Prestwick_163

    61. Diazoxide [usan:usp:inn:ban:jan]

    62. Tocris-0964

    63. Diazoxide [inn]

    64. Diazoxide [jan]

    65. Opera_id_608

    66. Diazoxide [mi]

    67. Diazoxide [usan]

    68. Prestwick0_000087

    69. Prestwick1_000087

    70. Prestwick2_000087

    71. Prestwick3_000087

    72. Spectrum3_000735

    73. Spectrum4_001248

    74. Diazoxide [vandf]

    75. Lopac-d-9035

    76. Chembl181

    77. Diazoxide [mart.]

    78. D 9035

    79. Diazoxide [usp-rs]

    80. Diazoxide [who-dd]

    81. Diazoxide [who-ip]

    82. Cbiol_001750

    83. Lopac0_000404

    84. Schembl41254

    85. Bspbio_000014

    86. Bspbio_001307

    87. Bspbio_002290

    88. Kbiogr_000027

    89. Kbiogr_001776

    90. Kbioss_000027

    91. Mls001076071

    92. Mls001424164

    93. Spectrum2300206

    94. Spbio_001953

    95. Bpbio1_000016

    96. Gtpl2409

    97. Diazoxide [orange Book]

    98. Chembl1518123

    99. Diazoxide [ep Monograph]

    100. Dtxsid7022914

    101. Bdbm86248

    102. Kbio2_000027

    103. Kbio2_002595

    104. Kbio2_005163

    105. Kbio3_000053

    106. Kbio3_000054

    107. Kbio3_001510

    108. Diazoxide [usp Monograph]

    109. Diazoxidum [who-ip Latin]

    110. Bio1_000036

    111. Bio1_000525

    112. Bio1_001014

    113. Bio2_000027

    114. Bio2_000507

    115. Hms1361b09

    116. Hms1568a16

    117. Hms1791b09

    118. Hms1922l22

    119. Hms1989b09

    120. Hms2051p20

    121. Hms2089l04

    122. Hms2093n12

    123. Hms2095a16

    124. Hms2234b23

    125. Hms3261a10

    126. Hms3267i11

    127. Hms3371l13

    128. Hms3393p20

    129. Hms3402b09

    130. Hms3411l18

    131. Hms3675l18

    132. Hms3712a16

    133. Hms3885h12

    134. Pharmakon1600-02300206

    135. 2h-1,2, 4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

    136. 7-chloro-3-methyl-1lambda~4~,2,4-benzothiadiazin-1-ol 1-oxide

    137. 7-chloro-3-methyl-4h-1lambda6,2,4-benzothiadiazine 1,1-dioxide

    138. Bcp26107

    139. Hy-b1140

    140. Nsc_3019

    141. Zinc3872277

    142. Tox21_110132

    143. Tox21_500404

    144. Bdbm50237612

    145. Kc-115

    146. Nsc759574

    147. S4630

    148. Akos015896340

    149. Akos024458715

    150. Tox21_110132_1

    151. Ccg-101062

    152. Ccg-204497

    153. Cs-4745

    154. Db01119

    155. Ks-1444

    156. Lp00404

    157. Nc00312

    158. Nsc-759574

    159. Sdccgsbi-0050390.p002

    160. Idi1_033777

    161. Diazoxide 100 Microg/ml In Acetonitrile

    162. Ncgc00015380-01

    163. Ncgc00015380-02

    164. Ncgc00015380-03

    165. Ncgc00015380-04

    166. Ncgc00015380-05

    167. Ncgc00015380-06

    168. Ncgc00015380-07

    169. Ncgc00015380-08

    170. Ncgc00015380-10

    171. Ncgc00015380-11

    172. Ncgc00015380-12

    173. Ncgc00015380-13

    174. Ncgc00015380-20

    175. Ncgc00022882-03

    176. Ncgc00024907-01

    177. Ncgc00024907-02

    178. Ncgc00024907-03

    179. Ncgc00024907-04

    180. Ncgc00024907-05

    181. Ncgc00024907-06

    182. Ncgc00024907-07

    183. Ncgc00024907-08

    184. Ncgc00261089-01

    185. Cas_364-98-7

    186. Sy066792

    187. Db-048966

    188. B6526

    189. D5402

    190. Eu-0100404

    191. Ft-0603087

    192. Vu0239714-6

    193. C06949

    194. D00294

    195. F12855

    196. 364d987

    197. A823275

    198. Q420009

    199. Sr-01000075314-1

    200. Sr-01000075314-3

    201. Sr-01000075314-4

    202. Sr-01000075314-6

    203. 3-methyl-7-chloro-1,2,4-benzothiadiazine1,1-dioxide

    204. Brd-k73109821-001-05-2

    205. Brd-k73109821-001-10-2

    206. Diazoxide, European Pharmacopoeia (ep) Reference Standard

    207. 4h-1,2,4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

    208. 7-chloro-3-methyl-4h-1

    209. E?,2,4-benzothiadiazine-1,1-dione

    210. 7-chloro-3-methyl-4h-1

    211. E6,2,4-benzothiadiazine 1,1-dioxide

    212. Diazoxide, United States Pharmacopeia (usp) Reference Standard

    213. 7-chloro-3-methyl-2h-1$l^{6},2,4-benzothiadiazine 1,1-dioxide

    214. 7-chloro-3-methyl-4h-1$l^{6},2,4-benzothiadiazine-1,1-dione

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 230.67 g/mol
    Molecular Formula C8H7ClN2O2S
    XLogP31.2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count0
    Exact Mass229.9916763 g/mol
    Monoisotopic Mass229.9916763 g/mol
    Topological Polar Surface Area66.9 Ų
    Heavy Atom Count14
    Formal Charge0
    Complexity360
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameProglycem
    PubMed HealthDiazoxide (By mouth)
    Drug ClassesGastrointestinal Agent, Glucose Regulation, Antihypoglycemic
    Drug LabelPROGLYCEM (diazoxide) is a nondiuretic benzothiadiazine derivative taken orally for the management of symptomatic hypoglycemia. PROGLYCEM Capsules contain 50 mg diazoxide, USP. The Suspension contains 50 mg of diazoxide, USP in each milliliter an...
    Active IngredientDiazoxide
    Dosage FormSuspension
    RouteOral
    Strength50mg/ml
    Market StatusPrescription
    CompanyTeva Branded Pharm

    2 of 2  
    Drug NameProglycem
    PubMed HealthDiazoxide (By mouth)
    Drug ClassesGastrointestinal Agent, Glucose Regulation, Antihypoglycemic
    Drug LabelPROGLYCEM (diazoxide) is a nondiuretic benzothiadiazine derivative taken orally for the management of symptomatic hypoglycemia. PROGLYCEM Capsules contain 50 mg diazoxide, USP. The Suspension contains 50 mg of diazoxide, USP in each milliliter an...
    Active IngredientDiazoxide
    Dosage FormSuspension
    RouteOral
    Strength50mg/ml
    Market StatusPrescription
    CompanyTeva Branded Pharm

    4.2 Drug Indication

    Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Diazoxide is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.

    5.2 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    5.3 ATC Code

    C - Cardiovascular system

    C02 - Antihypertensives

    C02D - Arteriolar smooth muscle, agents acting on

    C02DA - Thiazide derivatives

    C02DA01 - Diazoxide

    V - Various

    V03 - All other therapeutic products

    V03A - All other therapeutic products

    V03AH - Drugs for treatment of hypoglycemia

    V03AH01 - Diazoxide

    5.4 Absorption, Distribution and Excretion

    Absorption

    Readily absorbed following oral administration.

    Route of Elimination

    Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.

    5.5 Metabolism/Metabolites

    Hepatic.

    5.6 Biological Half-Life

    28 ±8.3 hours in normal adults.

    5.7 Mechanism of Action

    Diazoxide inhibits insulin release from the pancreas, by opening potassium channels in the beta cell membrane. Diazoxide is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance.

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LTD","supplierCountry":"INDIA","foreign_port":"BOGOTA","customer":"LIMINAL THERAPEUTIC SAS","customerCountry":"COLOMBIA","quantity":"0.40","actualQuantity":"0.4","unit":"KGS","unitRateFc":"2000","totalValueFC":"792.5","currency":"USD","unitRateINR":167200,"date":"28-Nov-2024","totalValueINR":"66880","totalValueInUsd":"792.5","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"5987631","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COLOMBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"425\/3RT, D.NO.7-1-621\/328,, HYDERABAD, AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733855400,"product":"ACTIVE PHARMACEUTICAL INGREDIENT(API)DIAZOXIDE USP BATCH NODAZM240003\/4 MFG DTNOV-2024\/DEC-2024\/EXP RETEST-OCT-29\/NOV-29","address":"25","city":"CHENNAI, TAMILNADU","supplier":"NURAY CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"THE PURCHASE MANAGER","customerCountry":"UNITED STATES","quantity":"70.00","actualQuantity":"70","unit":"KGS","unitRateFc":"2992","totalValueFC":"206806.4","currency":"USD","unitRateINR":251030.41428571427,"date":"11-Dec-2024","totalValueINR":"17572129","totalValueInUsd":"206806.4","indian_port":"Madras Air","hs_no":"29270090","bill_no":"6369748","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"25, CHENNAI, TAMILNADU","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734892200,"product":"ACTIVE PHARMACEUTICAL INGREDIENT(API) PACKED IN 50 LTR HDPE DRUM NAME OF API:DIAZOXIDE USP","address":"25","city":"CHENNAI, TAMILNADU","supplier":"NURAY CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"THE PURCHASE MANAGER","customerCountry":"UNITED STATES","quantity":"13.15","actualQuantity":"13.15","unit":"KGS","unitRateFc":"3000","totalValueFC":"39133","currency":"USD","unitRateINR":252858.91634980988,"date":"23-Dec-2024","totalValueINR":"3325094.75","totalValueInUsd":"39133","indian_port":"Madras Air","hs_no":"29270090","bill_no":"6689607","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"25, CHENNAI, TAMILNADU","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1664562600,"product":"DIAZOXIDE (FOR R&D PURPOSE)","address":"34TH KM TUMKUR ROAD,TEPPADA BEGUR NELAMANGALA","city":"BANGALORE,KARNATAKA","supplier":"TAPI TECHNOLOGY & API SERVICES","supplierCountry":"ITALY","foreign_port":"NA","customer":"RECIPHARM AB","customerCountry":"INDIA","quantity":"10.03","actualQuantity":"10.03","unit":"KGS","unitRateFc":"5000","totalValueFC":"49001.6","currency":"USD","unitRateINR":"402000","date":"01-Oct-2022","totalValueINR":"4032060","totalValueInUsd":"49001.6","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"2694042","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"34TH KM TUMKUR ROAD,TEPPADA BEGUR NELAMANGALA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1680201000,"product":"DIAZOXIDE BP LUNDBECK","address":"34TH KM TUMKUR ROAD,TEPPADA BEGUR NELAMANGALA","city":"BANGALORE,KARNATAKA","supplier":"TAPI TECHNOLOGY & API SERVICES","supplierCountry":"ITALY","foreign_port":"NA","customer":"RECIPHARM AB","customerCountry":"INDIA","quantity":"19.95","actualQuantity":"19.95","unit":"KGS","unitRateFc":"5000","totalValueFC":"101508.1","currency":"USD","unitRateINR":"418500","date":"31-Mar-2023","totalValueINR":"8349075","totalValueInUsd":"101508.1","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"5314298","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"34TH KM TUMKUR ROAD,TEPPADA BEGUR NELAMANGALA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695925800,"product":"DIAZOXIDE BP LUNDBECK","address":"34TH KM TUMKUR ROAD,TEPPADA BEGUR","city":"BANGALORE,KARNATAKA","supplier":"TAPI TECHNOLOGY & API SERVICES","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"RECIPHARM AB","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"5000","totalValueFC":"151882.6","currency":"USD","unitRateINR":"420250","date":"29-Sep-2023","totalValueINR":"12607500","totalValueInUsd":"151882.6","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"8064238","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1 07, 1019 GM AMSTERDAM, THE NETHERLA","customerAddress":"34TH KM TUMKUR ROAD,TEPPADA BEGUR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702578600,"product":"DIAZOXIDE BP LUNDBECK","address":"34TH KM TUMKUR ROAD,TEPPADA BEGUR","city":"BANGALORE,KARNATAKA","supplier":"TAPI TECHNOLOGY & API SERVICES","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"RECIPHARM AB","customerCountry":"INDIA","quantity":"32.00","actualQuantity":"32","unit":"KGS","unitRateFc":"5000","totalValueFC":"162031.3","currency":"USD","unitRateINR":"421500","date":"15-Dec-2023","totalValueINR":"13488000","totalValueInUsd":"162031.3","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"9252326","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Amsterdam, , Netherlands Netherlands","customerAddress":"34TH KM TUMKUR ROAD,TEPPADA BEGUR"}]
    22-Jan-2021
    23-Dec-2024
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    ABOUT THIS PAGE

    Diazoxide Manufacturers

    A Diazoxide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diazoxide, including repackagers and relabelers. The FDA regulates Diazoxide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diazoxide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Diazoxide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Diazoxide Suppliers

    A Diazoxide supplier is an individual or a company that provides Diazoxide active pharmaceutical ingredient (API) or Diazoxide finished formulations upon request. The Diazoxide suppliers may include Diazoxide API manufacturers, exporters, distributors and traders.

    click here to find a list of Diazoxide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Diazoxide USDMF

    A Diazoxide DMF (Drug Master File) is a document detailing the whole manufacturing process of Diazoxide active pharmaceutical ingredient (API) in detail. Different forms of Diazoxide DMFs exist exist since differing nations have different regulations, such as Diazoxide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Diazoxide DMF submitted to regulatory agencies in the US is known as a USDMF. Diazoxide USDMF includes data on Diazoxide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diazoxide USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Diazoxide suppliers with USDMF on PharmaCompass.

    Diazoxide JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Diazoxide Drug Master File in Japan (Diazoxide JDMF) empowers Diazoxide API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Diazoxide JDMF during the approval evaluation for pharmaceutical products. At the time of Diazoxide JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Diazoxide suppliers with JDMF on PharmaCompass.

    Diazoxide CEP

    A Diazoxide CEP of the European Pharmacopoeia monograph is often referred to as a Diazoxide Certificate of Suitability (COS). The purpose of a Diazoxide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Diazoxide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Diazoxide to their clients by showing that a Diazoxide CEP has been issued for it. The manufacturer submits a Diazoxide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Diazoxide CEP holder for the record. Additionally, the data presented in the Diazoxide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Diazoxide DMF.

    A Diazoxide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Diazoxide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Diazoxide suppliers with CEP (COS) on PharmaCompass.

    Diazoxide WC

    A Diazoxide written confirmation (Diazoxide WC) is an official document issued by a regulatory agency to a Diazoxide manufacturer, verifying that the manufacturing facility of a Diazoxide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Diazoxide APIs or Diazoxide finished pharmaceutical products to another nation, regulatory agencies frequently require a Diazoxide WC (written confirmation) as part of the regulatory process.

    click here to find a list of Diazoxide suppliers with Written Confirmation (WC) on PharmaCompass.

    Diazoxide NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Diazoxide as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Diazoxide API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Diazoxide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Diazoxide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Diazoxide NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Diazoxide suppliers with NDC on PharmaCompass.

    Diazoxide GMP

    Diazoxide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Diazoxide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diazoxide GMP manufacturer or Diazoxide GMP API supplier for your needs.

    Diazoxide CoA

    A Diazoxide CoA (Certificate of Analysis) is a formal document that attests to Diazoxide's compliance with Diazoxide specifications and serves as a tool for batch-level quality control.

    Diazoxide CoA mostly includes findings from lab analyses of a specific batch. For each Diazoxide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Diazoxide may be tested according to a variety of international standards, such as European Pharmacopoeia (Diazoxide EP), Diazoxide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diazoxide USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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