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    Also known as: 7789-77-7, Calcium hydrogenphosphate dihydrate, Dicalcium phosphate dihydrate, Calcium monohydrogen phosphate dihydrate, 14567-92-1, Dibasic calcium phosphate dihydrate
    Molecular Formula
    CaH5O6P
    Molecular Weight
    172.09  g/mol
    InChI Key
    XAAHAAMILDNBPS-UHFFFAOYSA-L
    FDA UNII
    O7TSZ97GEP
    Dibasic Calcium Phosphate Dihydrate
    1 2D Structure

    Dibasic Calcium Phosphate Dihydrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;hydrogen phosphate;dihydrate
    2.1.2 InChI
    InChI=1S/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-2
    2.1.3 InChI Key
    XAAHAAMILDNBPS-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    O.O.OP(=O)([O-])[O-].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    O7TSZ97GEP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Brushite

    2. Calcium Monohydrogen Phosphate Dihydrate

    3. Calcium Phosphate, Dibasic

    4. Calcium Phosphate, Dibasic, Dihydrate

    5. Calcium Phosphate, Dihydrate (1:1)

    6. Dibasic Calcium Phosphate Dihydrate

    7. Dicalcium Phosphate

    8. Dicalcium Phosphate Anhydrous

    9. Dicalcium Phosphate Dihydrate

    2.3.2 Depositor-Supplied Synonyms

    1. 7789-77-7

    2. Calcium Hydrogenphosphate Dihydrate

    3. Dicalcium Phosphate Dihydrate

    4. Calcium Monohydrogen Phosphate Dihydrate

    5. 14567-92-1

    6. Dibasic Calcium Phosphate Dihydrate

    7. Calcium Phosphate, Dibasic, Dihydrate

    8. Calciumhydrogenphosphatedihydrate

    9. D.c.p.

    10. Calcium Phosphate Dibasic Dihydrate

    11. Calcium;hydrogen Phosphate;dihydrate

    12. Calcium Phosphate Dihydrate, Dibasic

    13. O7tsz97gep

    14. Phosphoric Acid, Calcium Salt (1:1), Dihydrate

    15. Dibasic Calcium Phosphate Hydrate

    16. Calcium Phosphate Dibasic, Hydrous

    17. Calcium Phosphate, Dibasic, Hydrous

    18. Brushite

    19. Aksepillen

    20. Eunova

    21. Unii-o7tsz97gep

    22. Brushite (ca(hpo4).2h2o)

    23. Calcium-hydrogenphosphat-2-wasser

    24. Calster (tn)

    25. Cahpo4.2h2o

    26. Calcium Phosphate Dihydrate, Dibasic [usp:jan]

    27. Calcium Phosphate, Gel (aged)

    28. Chebi:4496

    29. Dibasic Calcium Phosphate (tn)

    30. Dtxsid90872536

    31. Mfcd00149621

    32. Akos015855298

    33. Db14481

    34. Calcium Hydrogenphosphate Dihydrate,(s)

    35. Calcium Hydrogenphosphate--water (1/2)

    36. Calcium Hydrogenphosphate Dihydrate, 98%

    37. Dibasic Calcium Phosphate Hydrate (jp17)

    38. Dicalcium Phosphate Dihydrate [inci]

    39. Calcium Phosphate Dihydrate [who-dd]

    40. Calcium Phosphate, Dihydrate (1:1)

    41. Calcium Phosphate, Dihydrate, Dibasic (usp)

    42. Ft-0623398

    43. D00937

    44. Dibasic Calcium Phosphate Hydrate [jan]

    45. Calcium Phosphate, Dibasic, Dihydrate [ii]

    46. Calcium Hydrogen Phosphate Dehydrate [who-ip]

    47. Calcii Hydrogenophosphas Dihydrate [who-ip Latin]

    48. Calcium Hydrogen Phosphate Dihydrate [ep Monograph]

    49. Calcium Hydrogenphosphate Dihydrate, P.a., 98.0-105.0%

    50. Calcium Hydrogenphosphate Dihydrate, Vetec(tm) Reagent Grade

    51. Calcium Phosphate Dihydrate, Dibasic [usp Impurity]

    52. Dibasic Calcium Phosphate Dihydrate [usp Monograph]

    53. Calcium Phosphate Dibasic Dihydrate, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 98-102.5%

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 172.09 g/mol
    Molecular Formula CaH5O6P
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count0
    Exact Mass171.9449657 g/mol
    Monoisotopic Mass171.9449657 g/mol
    Topological Polar Surface Area85.4 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity46.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Drug and Medication Information
    4.1 Drug Indication

    For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Calcium phosphate reacts with acid in the stomach to raise the pH. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

    5.2 Mechanism of Action

    The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

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