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1. Methylene Bromide
2. Methylene Bromide Ion (1+)
3. Methylene Bromide, 79br2-labeled
4. Methylene Bromide, 80br-labeled
5. Methylene Bromide, 80br2-labeled
6. Methylene Bromide, 82br-labeled
7. Methylene Bromide, 82br2-labeled
8. Methylene Dibromide
1. 74-95-3
2. Methylene Bromide
3. Methane, Dibromo-
4. Methylene Dibromide
5. Ch2br2
6. Dibrommethan
7. Dibromomethylene
8. Rcra Waste Number U068
9. Methylenbromid
10. Dibromo-methane
11. 1,1-dibromomethane
12. Chebi:47077
13. Nsc-7293
14. Mfcd00000168
15. V69b659w01
16. Ccris 939
17. Hsdb 1334
18. Nsc 7293
19. Einecs 200-824-2
20. Un2664
21. Rcra Waste No. U068
22. Brn 0969143
23. Dibromo Methane
24. Ai3-52311
25. Unii-v69b659w01
26. Dibromomethane, 99%
27. Dibromomethane, >=99%
28. Dsstox_cid_1557
29. Ec 200-824-2
30. Wln: E1e
31. Dsstox_rid_76209
32. Dsstox_gsid_21557
33. Schembl20033
34. 4-01-00-00078 (beilstein Handbook Reference)
35. Methylene Bromide [mi]
36. Chembl1229889
37. Dtxsid4021557
38. Nsc7293
39. Dibromomethane, Analytical Standard
40. Amy11088
41. Tox21_200410
42. Stl282729
43. Akos009031545
44. Dibromomethane [un2664] [poison]
45. Un 2664
46. Cas-74-95-3
47. Ncgc00248598-01
48. Ncgc00257964-01
49. 2bm
50. 4371-77-1
51. Db-029642
52. Dibromomethane, Puriss., >=98.5% (gc)
53. D0192
54. Ft-0624675
55. S0636
56. Q421736
57. J-520238
58. F1908-0088
59. Dibromomethane Solution, 2000 Mug/ml In Methanol, Analytical Standard
60. Dibromomethane Solution, 5000 Mug/ml In Methanol, Analytical Standard
| Molecular Weight | 173.83 g/mol |
|---|---|
| Molecular Formula | CH2Br2 |
| XLogP3 | 1.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 173.85028 g/mol |
| Monoisotopic Mass | 171.85233 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 3 |
| Formal Charge | 0 |
| Complexity | 2.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)
IT ... DOES NOT APPEAR TO BE ABSORBED SIGNIFICANTLY EVEN WHEN APPLIED REPEATEDLY /TO EYES AND SKIN OF RABBITS/.
Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 4052
IT IS METABOLIZED TO CARBON MONOXIDE AND BROMIDE.
Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 4052
MASS SPECTRAL STUDIES USING (18)O2 SHOWED THAT (18)O-CO WAS PRODUCED INDICATING THAT OXYGEN WAS INCORPORATED DURING THE REACTION. A PRIMARY DEUTERIUM ISOTOPE EFFECT WAS OBSERVED FOR CONVERSION OF DICHLOROMETHANE TO CARBON MONOXIDE BOTH BY LONG-EVANS RAT HEPATIC MICROSOMAL FRACTIONS & BY STANNOUS PHOSPHATE MODEL SYSTEM. INCUBATION OF DIBROMOMETHANE IN THE MODEL SYSTEM IN THE PRESENCE OF 3,4-DIMETHYLANILINE RESULTED IN FORMATION OF 3,4-FORMOXYLIDIDE, SUPPORTING THE INTERMEDIACY OF A FORMYL HALIDE. A MECHANISM FOR THE METABOLISM OF DIHALOMETHANES TO CARBON MONOXIDE IS PROPOSED.
PMID:728186 KUBIC VL, ANDERS MW; BIOCHEM PHARMACOL 27 (19): 2349-55 (1978)
Halogenated methanes, in particular the brominated homologs, including dibromomethane and tribromomethane were subjected to biochemical decomposition in vitro by the cytochrome p450 rich fraction of the monooxygenase liver system. No significant contribution of GSH addition to the overall rate of metabolism of the halogenated methanes could be observed.
Buether H et al; Chemosphere 15 (8): 1043-62 (1986)
Treatment of Sprague-Dawley rats with sodium phenobarbital (50 mg/kg in 0.9% saline for 4 days) or 3-methylcholanthrene (20 mg/kg in corn oil for 2 days) resulted in increased metabolism of dibromomethane (3 m mol/kg) to carbon monoxide.
PMID:7434361 Stevens JL et al; Toxicol Appl Pharmacol 55 (3): 484-89 (1980)
Biotransformation of dihalomethanes leads to dehalogenation & end product is carbon monoxide. In the case of dichloromethane the carbon monoxide appears to arise from formyl halide. This intermediate, as an alternative to losing carbon monoxide, can covalently bind to cellular protein or lipid. The involvement of nonmicrosomal enzymes in dihalomethane biotransformation leads to prodn of formaldehyde & halide. A necessary step is the reaction of dihalomethane with glutathione, which results in loss of one halide. The resulting halomethylglutathione is postulated to undergo nonenzymatic hydrolytic dehalogenation leaving hydroxymethylglutathione. The next step would result in the release of the hydroxymethyl group as formaldehyde. Alternatively it has been shown that in the presence of formaldehyde dehydrogenase & NAD /nicotinamide-adenine dinucleotide/ formic acid can be formed. /Dichloromethane/
Doull, J., C.D.Klassen, and M.D. Amdur (eds.). Casarett and Doull's Toxicology. 3rd ed., New York: Macmillan Co., Inc., 1986., p. 647
... REPEATED 6 HR EXPOSURES /OF DOGS/ TO EITHER 25, 75, OR 150 PPM /METHYLENE BROMIDE/ FOR 90 DAYS. PLASMA CLEARANCE WAS AT LEAST BIPHASIC WITH ILL DEFINED ALPHA PHASE & A TERMINAL PHASE (HALF LIFE 103 + OR - 14 MIN) @ ALL 3 CONCN.
Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 4052
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ABOUT THIS PAGE
A Dibromomethane manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dibromomethane, including repackagers and relabelers. The FDA regulates Dibromomethane manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dibromomethane API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Dibromomethane manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Dibromomethane supplier is an individual or a company that provides Dibromomethane active pharmaceutical ingredient (API) or Dibromomethane finished formulations upon request. The Dibromomethane suppliers may include Dibromomethane API manufacturers, exporters, distributors and traders.
click here to find a list of Dibromomethane suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Dibromomethane DMF (Drug Master File) is a document detailing the whole manufacturing process of Dibromomethane active pharmaceutical ingredient (API) in detail. Different forms of Dibromomethane DMFs exist exist since differing nations have different regulations, such as Dibromomethane USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Dibromomethane DMF submitted to regulatory agencies in the US is known as a USDMF. Dibromomethane USDMF includes data on Dibromomethane's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dibromomethane USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Dibromomethane suppliers with USDMF on PharmaCompass.
Dibromomethane Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Dibromomethane GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dibromomethane GMP manufacturer or Dibromomethane GMP API supplier for your needs.
A Dibromomethane CoA (Certificate of Analysis) is a formal document that attests to Dibromomethane's compliance with Dibromomethane specifications and serves as a tool for batch-level quality control.
Dibromomethane CoA mostly includes findings from lab analyses of a specific batch. For each Dibromomethane CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Dibromomethane may be tested according to a variety of international standards, such as European Pharmacopoeia (Dibromomethane EP), Dibromomethane JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dibromomethane USP).
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