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    Chemistry

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    Also known as: 1777-82-8, (2,4-dichlorophenyl)methanol, Dybenal, 2,4-dichlorobenzenemethanol, Rapidosept, Benzenemethanol, 2,4-dichloro-
    Molecular Formula
    C7H6Cl2O
    Molecular Weight
    177.02  g/mol
    InChI Key
    DBHODFSFBXJZNY-UHFFFAOYSA-N
    FDA UNII
    1NKX3648J9
    Dichlorobenzyl Alcohol
    Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.
    1 2D Structure

    Dichlorobenzyl Alcohol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2,4-dichlorophenyl)methanol
    2.1.2 InChI
    InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
    2.1.3 InChI Key
    DBHODFSFBXJZNY-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=C(C=C1Cl)Cl)CO
    2.2 Other Identifiers
    2.2.1 UNII
    1NKX3648J9
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dichlorobenzyl Alcohol

    2.3.2 Depositor-Supplied Synonyms

    1. 1777-82-8

    2. (2,4-dichlorophenyl)methanol

    3. Dybenal

    4. 2,4-dichlorobenzenemethanol

    5. Rapidosept

    6. Benzenemethanol, 2,4-dichloro-

    7. Myacide Sp

    8. Benzyl Alcohol, 2,4-dichloro-

    9. Chebi:48220

    10. Mfcd00004606

    11. Nsc-15635

    12. 1nkx3648j9

    13. Ncgc00181337-01

    14. Dsstox_cid_21362

    15. Dsstox_rid_79699

    16. Dsstox_gsid_41362

    17. Cas-1777-82-8

    18. 2,4-dichlorobenzylalcohol

    19. Einecs 217-210-5

    20. Nsc 15635

    21. 2,4-dichlorobenzoyl Alcohol

    22. Brn 1448652

    23. Unii-1nkx3648j9

    24. Ai3-20619

    25. Schembl41323

    26. Oxiconazole Related Compound D

    27. Chembl3184437

    28. Dtxsid9041362

    29. (2,4-dichlorophenyl)methanol #

    30. Dalc2-h_000039

    31. Zinc157458

    32. 2,4-dichlorobenzyl Alcohol, 99%

    33. Dichlorobenzyl Alcohol [ii]

    34. Dichlorobenzyl Alcohol [mi]

    35. Nsc15635

    36. Tox21_112796

    37. Tox21_300895

    38. Bdbm50498198

    39. Dichlorobenzyl Alcohol [inci]

    40. S6067

    41. Stl480884

    42. Dichlorobenzyl Alcohol [vandf]

    43. Akos000248902

    44. Dichlorobenzyl Alcohol [mart.]

    45. Tox21_112796_1

    46. Am81457

    47. Db13269

    48. Dichlorobenzyl Alcohol [who-dd]

    49. Hy-w039454

    50. Ps-5315

    51. Ncgc00181337-02

    52. Ncgc00181337-03

    53. Ncgc00254799-01

    54. Ac-10679

    55. Sy015811

    56. Db-015914

    57. Cs-0097299

    58. D1837

    59. Ft-0610050

    60. Ft-0674330

    61. 77d828

    62. Oxiconazole Related Compound D [usp-rs]

    63. 2,4-dichlorobenzyl Alcohol [ep Monograph]

    64. Q209202

    65. Sr-01000944729

    66. Sr-01000944729-1

    67. W-107827

    68. (2,4-dichlorophenyl)methanol;2,4-dichlorobenzyl Alcohol

    69. Z111479786

    70. 2,4-dichlorobenzyl Alcohol, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 177.02 g/mol
    Molecular Formula C7H6Cl2O
    XLogP32.5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count1
    Exact Mass175.9795702 g/mol
    Monoisotopic Mass175.9795702 g/mol
    Topological Polar Surface Area20.2 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity108
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Dichlorobenzyl alcohol in combination with [DB13908] is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    In vitro studies with the combination of dichlorobenzyl alcohol and amylmetacresol have shown a virucidal against a number of viruses associated with the common cold which is observed by a reduction in the viral load. In clinical trials, administration of dichlorobenzyl alcohol lozenges has been shown to generate a reduced throat soreness and to provide pain relief and relief from difficulty in swallowing 5 minutes after administration. This effect can last for even 2 hours. The relief effect was shown to reach a steady-state after 45 minutes.

    5.2 ATC Code

    R - Respiratory system

    R02 - Throat preparations

    R02A - Throat preparations

    R02AA - Antiseptics

    R02AA03 - Dichlorobenzyl alcohol

    5.3 Absorption, Distribution and Excretion

    Absorption

    Dichlorobenzyl alcohol is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes. The concentration in saliva after 120 minutes represents about 50% of the administered dose.

    Route of Elimination

    In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose. After metabolism, dichlorobenzyl alcohol is excreted in the urine.

    Volume of Distribution

    This pharmacokinetic property has not been fully studied.

    Clearance

    This pharmacokinetic property has not been fully studied.

    5.4 Metabolism/Metabolites

    Dichlorobenzyl alcohol is metabolized in the liver to form hippuric acid.

    5.5 Biological Half-Life

    This pharmacokinetic property has not been fully studied.

    5.6 Mechanism of Action

    The use of dichlorobenzyl alcohol has been related to its antibacterial, antiviral and local anesthetic properties. The local anesthetic action of dichlorobenzyl alcohol is thought to be due to a reduced sodium channel blockade. The antiseptic mechanism of action of dichlorobenzyl alcohol is not fully understood but it is thought to be related to a denaturation of external proteins and rearrangement of the tertiary structure proteins.

    API Reference Price

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    16-Aug-2021
    19-Apr-2022
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    ABOUT THIS PAGE

    Dichlorobenzyl Alcohol Manufacturers

    A Dichlorobenzyl Alcohol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dichlorobenzyl Alcohol, including repackagers and relabelers. The FDA regulates Dichlorobenzyl Alcohol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dichlorobenzyl Alcohol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Dichlorobenzyl Alcohol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Dichlorobenzyl Alcohol Suppliers

    A Dichlorobenzyl Alcohol supplier is an individual or a company that provides Dichlorobenzyl Alcohol active pharmaceutical ingredient (API) or Dichlorobenzyl Alcohol finished formulations upon request. The Dichlorobenzyl Alcohol suppliers may include Dichlorobenzyl Alcohol API manufacturers, exporters, distributors and traders.

    click here to find a list of Dichlorobenzyl Alcohol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Dichlorobenzyl Alcohol CEP

    A Dichlorobenzyl Alcohol CEP of the European Pharmacopoeia monograph is often referred to as a Dichlorobenzyl Alcohol Certificate of Suitability (COS). The purpose of a Dichlorobenzyl Alcohol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Dichlorobenzyl Alcohol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Dichlorobenzyl Alcohol to their clients by showing that a Dichlorobenzyl Alcohol CEP has been issued for it. The manufacturer submits a Dichlorobenzyl Alcohol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Dichlorobenzyl Alcohol CEP holder for the record. Additionally, the data presented in the Dichlorobenzyl Alcohol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Dichlorobenzyl Alcohol DMF.

    A Dichlorobenzyl Alcohol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Dichlorobenzyl Alcohol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Dichlorobenzyl Alcohol suppliers with CEP (COS) on PharmaCompass.

    Dichlorobenzyl Alcohol WC

    A Dichlorobenzyl Alcohol written confirmation (Dichlorobenzyl Alcohol WC) is an official document issued by a regulatory agency to a Dichlorobenzyl Alcohol manufacturer, verifying that the manufacturing facility of a Dichlorobenzyl Alcohol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Dichlorobenzyl Alcohol APIs or Dichlorobenzyl Alcohol finished pharmaceutical products to another nation, regulatory agencies frequently require a Dichlorobenzyl Alcohol WC (written confirmation) as part of the regulatory process.

    click here to find a list of Dichlorobenzyl Alcohol suppliers with Written Confirmation (WC) on PharmaCompass.

    Dichlorobenzyl Alcohol GMP

    Dichlorobenzyl Alcohol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Dichlorobenzyl Alcohol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dichlorobenzyl Alcohol GMP manufacturer or Dichlorobenzyl Alcohol GMP API supplier for your needs.

    Dichlorobenzyl Alcohol CoA

    A Dichlorobenzyl Alcohol CoA (Certificate of Analysis) is a formal document that attests to Dichlorobenzyl Alcohol's compliance with Dichlorobenzyl Alcohol specifications and serves as a tool for batch-level quality control.

    Dichlorobenzyl Alcohol CoA mostly includes findings from lab analyses of a specific batch. For each Dichlorobenzyl Alcohol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Dichlorobenzyl Alcohol may be tested according to a variety of international standards, such as European Pharmacopoeia (Dichlorobenzyl Alcohol EP), Dichlorobenzyl Alcohol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dichlorobenzyl Alcohol USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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