Synopsis
Synopsis
0
CEP/COS
0
JDMF
0
EU WC
0
KDMF
0
NDC API
0
VMF
0
Listed Suppliers
0
API
0
FDF
0
FDF Dossiers
0
FDA Orange Book
0
Europe
0
Canada
0
Australia
0
South Africa
0
Listed Dossiers
DRUG PRODUCT COMPOSITIONS
0
EDQM
0
USP
0
JP
0
Others
0
US Patents
0
US Exclusivities
0
Health Canada Patents
0
Data Compilation #PharmaFlow
0
Stock Recap #PipelineProspector
0
Weekly News Recap #Phispers
0
News #PharmaBuzz
US Medicaid
NA
Annual Reports
NA
Finished Drug Prices
NA
1. Cryosthesia -60c
2. Fc 12
3. Fluorocarbon-12
4. Freon 12
5. Freon 12, 18f-labeled
6. Freon-12
7. Genetron 12
8. Refrigerant 12
1. 75-71-8
2. Difluorodichloromethane
3. Dichloro(difluoro)methane
4. Genetron 12
5. Freon 12
6. Refrigerant 12
7. Halon
8. Eskimon 12
9. Frigen 12
10. Electro-cf 12
11. Chlorofluorocarbon 12
12. Algofrene Type 2
13. Isotron 2
14. Propellant 12
15. Arcton 6
16. Isotron 12
17. Arcton 12
18. Forane 12
19. Kaiser Chemicals 12
20. Methane, Dichlorodifluoro-
21. Cfc-12
22. Dymel 12
23. Ledon 12
24. Isceon 122
25. Freon F-12
26. Halon 122
27. Ucon 12
28. Halocarbon 12
29. Refrigerant R 12
30. Ucon 12/halocarbon 12
31. Dwuchlorodwufluorometan
32. R 12 (refrigerant)
33. Ccl2f2
34. Diclorodifluometano
35. Refrigerant R12
36. Propellent 12
37. Rcra Waste Number U075
38. Fc 12
39. Cfc 12
40. Fcc 12
41. Fkw 12
42. Cf2cl2
43. R 12, Refrigerant
44. F 12
45. Ofm06sg1ko
46. Dichlorodifluoromethane (nf)
47. Dichlorodifluoromethane [nf]
48. Chlorofluoromethane (ccl2f2)
49. Fluorocarbon-12
50. Freon-12
51. Fluorocarbon 12
52. Caswell No. 304
53. Diclorodifluometano [spanish]
54. Isot Ron 2
55. Ccris 3501
56. Hsdb 139
57. Dwuchlorodwufluorometan [polish]
58. Dichloro-difluoro-methane
59. Einecs 200-893-9
60. Unii-ofm06sg1ko
61. Un1028
62. Rcra Waste No. U075
63. Epa Pesticide Chemical Code 000014
64. Sterethox
65. Dichlorodifluoromethane Solution
66. Ai3-01708
67. Dichlorodifluormethane
68. R12 [un1028] [nonflammable Gas]
69. Dichlorodifluoro-methane
70. Fron 12
71. Schembl485
72. Ec 200-893-9
73. Schembl9459323
74. Methane, Dichlorodifluoro
75. Chembl2106634
76. Dtxsid6020436
77. Pxbrqckwgahehs-uhfffaoysa-
78. Dichlorodifluoromethane [r12] [un1028] [nonflammable Gas]
79. Dichlorodifluoromethane [ii]
80. Dichlorodifluoromethane [mi]
81. Zinc8214541
82. Mfcd00000781
83. Dichlorodifluoromethane [hsdb]
84. Akos006228770
85. Dichlorodifluoromethane [vandf]
86. Dichlorodifluoromethane [mart.]
87. Un 1028
88. Dichlorodifluoromethane [who-dd]
89. R12 [un1028] [nonflammable Gas]
90. R 12
91. Db-055985
92. Ft-0624709
93. D03789
94. Dichlorodifluoromethane 100 Microg/ml In Methanol
95. Q423021
96. Dichlorodifluoromethane 5000 Microg/ml In Methanol
97. Dichlorodifluoromethane [r12] [un1028] [nonflammable Gas]
| Molecular Weight | 120.91 g/mol |
|---|---|
| Molecular Formula | CCl2F2 |
| XLogP3 | 2.3 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 119.9345117 g/mol |
| Monoisotopic Mass | 119.9345117 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 5 |
| Formal Charge | 0 |
| Complexity | 30.6 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Elimination of CFC-12 from the body is rapid. Dogs exhaled within 1 hr essentially all the CFC-12 inhaled during 6- to 20-minute exposure to 8000 to 12000 ppm. Inhaled CFC-12 rapidly appeared in blood, bile, cerebrospinal fluid, and urine of anesthetized rabbits and dogs. Unanesthetized dogs exposed to 1000 to 100,000 ppm for 10 min showed rapid rise in blood concentrations of CFC-12 during the first 3 to 5 minutes, which was paralleled by a rapid decline for first 5 min after exposure.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Dichlorodifluoromethane p.2 CD-ROM Cincinnati, OH 45240-4148 2012.
Blood levels of CFC-12 were below detection limits in normal subjects using household aerosols; in asthmatic subjects using aerosol inhaler, blood levels were much lower than in dogs exposed at threshold for cardiac sensitization. Radiolabeled tests showed essentially all the dose of CFC-12 (95-103%) exhaled within the first hour after a 12- or 17-minute inhalation at 1000 ppm; total metabolites were < 0.2% of the administed dose. At 30 minutes, retention of the labeled dose inhaled in a single breath was 10% vesus 23%, 20%, and 12% for comparable doses of trichlorofluoromethane (FC-11), 1,1,2-trichloro-1,2,2,-trifluoroethane (FC-113), and 1,2-dichloro-1,1,2,2-tetrafluoroethane (FC-114), respectively. For an eight hr inhalation at 1000 ppm, a pharmacokinetic model based on analyses in dogs and humans gave an estimate of 55% absorption of the inhaled CFC-12.
American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Dichlorodifluoromethane p.2 CD-ROM Cincinnati, OH 45240-4148 2012.
At 1000 ppm ... level in /human/ venous blood was 1.2 ug/mL.
National Research Council. Drinking Water and Health. Volume 3. Washington, DC: National Academy Press, 1980., p. 101
Absorption and elimination are dynamic processes involving equilibria among air, blood, and various tissues. Upon absorption, a biphasic blood-level pattern occurs, with an initial rapid then slower rise in blood levels, during which the material is absorbed from blood into tissue.
USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-26 (1980) EPA 440/5-80-051
For more Absorption, Distribution and Excretion (Complete) data for DICHLORODIFLUOROMETHANE (10 total), please visit the HSDB record page.
The distribution half-life of the common fluorocarbons (Freon 11, Freon 12) averages 13 to 14 seconds; the elimination half-life is longer (1.5 hours) because of slower release from fat stores.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 884
Freons are toxic to humans by several mechanisms. Inhaled fluorocarbons sensitized the myocardium to catecholamines, frequently resulting in lethal ventricular arrhythmias. Because they are gases heavier than air, fluorocarbons can displace atmospheric oxygen, thus resulting in asphyxiation. These compounds also have a central nervous system (CNS) anesthetic effect analogous to a structurally similar general anesthetic, halothane. Pressurized refrigerant or liquid fluorocarbons with a low boiling point have a cryogenic effect on exposed tissues, causing frostbite, laryngeal or pulmonary edema, and gastrointestinal perforation. Certain fluorocarbons degrade at high temperatures into toxic products of chlorine, hydrofluoric acid, or phosgene gases. /Freons/
Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 1281
ABOUT THIS PAGE
LOOKING FOR A SUPPLIER?
