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Chemistry

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Also known as: 75-71-8, Difluorodichloromethane, Dichloro(difluoro)methane, Genetron 12, Freon 12, Refrigerant 12
Molecular Formula
CCl2F2
Molecular Weight
120.91  g/mol
InChI Key
PXBRQCKWGAHEHS-UHFFFAOYSA-N
FDA UNII
OFM06SG1KO

Dichlorodifluoromethane
1 2D Structure

Dichlorodifluoromethane

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dichloro(difluoro)methane
2.1.2 InChI
InChI=1S/CCl2F2/c2-1(3,4)5
2.1.3 InChI Key
PXBRQCKWGAHEHS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(F)(F)(Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
OFM06SG1KO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cryosthesia -60c

2. Fc 12

3. Fluorocarbon-12

4. Freon 12

5. Freon 12, 18f-labeled

6. Freon-12

7. Genetron 12

8. Refrigerant 12

2.3.2 Depositor-Supplied Synonyms

1. 75-71-8

2. Difluorodichloromethane

3. Dichloro(difluoro)methane

4. Genetron 12

5. Freon 12

6. Refrigerant 12

7. Halon

8. Eskimon 12

9. Frigen 12

10. Electro-cf 12

11. Chlorofluorocarbon 12

12. Algofrene Type 2

13. Isotron 2

14. Propellant 12

15. Arcton 6

16. Isotron 12

17. Arcton 12

18. Forane 12

19. Kaiser Chemicals 12

20. Methane, Dichlorodifluoro-

21. Cfc-12

22. Dymel 12

23. Ledon 12

24. Isceon 122

25. Freon F-12

26. Halon 122

27. Ucon 12

28. Halocarbon 12

29. Refrigerant R 12

30. Ucon 12/halocarbon 12

31. Dwuchlorodwufluorometan

32. R 12 (refrigerant)

33. Ccl2f2

34. Diclorodifluometano

35. Refrigerant R12

36. Propellent 12

37. Rcra Waste Number U075

38. Fc 12

39. Cfc 12

40. Fcc 12

41. Fkw 12

42. Cf2cl2

43. R 12, Refrigerant

44. F 12

45. Ofm06sg1ko

46. Dichlorodifluoromethane (nf)

47. Dichlorodifluoromethane [nf]

48. Chlorofluoromethane (ccl2f2)

49. Fluorocarbon-12

50. Freon-12

51. Fluorocarbon 12

52. Caswell No. 304

53. Diclorodifluometano [spanish]

54. Isot Ron 2

55. Ccris 3501

56. Hsdb 139

57. Dwuchlorodwufluorometan [polish]

58. Dichloro-difluoro-methane

59. Einecs 200-893-9

60. Unii-ofm06sg1ko

61. Un1028

62. Rcra Waste No. U075

63. Epa Pesticide Chemical Code 000014

64. Sterethox

65. Dichlorodifluoromethane Solution

66. Ai3-01708

67. Dichlorodifluormethane

68. R12 [un1028] [nonflammable Gas]

69. Dichlorodifluoro-methane

70. Fron 12

71. Schembl485

72. Ec 200-893-9

73. Schembl9459323

74. Methane, Dichlorodifluoro

75. Chembl2106634

76. Dtxsid6020436

77. Pxbrqckwgahehs-uhfffaoysa-

78. Dichlorodifluoromethane [r12] [un1028] [nonflammable Gas]

79. Dichlorodifluoromethane [ii]

80. Dichlorodifluoromethane [mi]

81. Zinc8214541

82. Mfcd00000781

83. Dichlorodifluoromethane [hsdb]

84. Akos006228770

85. Dichlorodifluoromethane [vandf]

86. Dichlorodifluoromethane [mart.]

87. Un 1028

88. Dichlorodifluoromethane [who-dd]

89. R12 [un1028] [nonflammable Gas]

90. R 12

91. Db-055985

92. Ft-0624709

93. D03789

94. Dichlorodifluoromethane 100 Microg/ml In Methanol

95. Q423021

96. Dichlorodifluoromethane 5000 Microg/ml In Methanol

97. Dichlorodifluoromethane [r12] [un1028] [nonflammable Gas]

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 120.91 g/mol
Molecular Formula CCl2F2
XLogP32.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass119.9345117 g/mol
Monoisotopic Mass119.9345117 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count5
Formal Charge0
Complexity30.6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

Elimination of CFC-12 from the body is rapid. Dogs exhaled within 1 hr essentially all the CFC-12 inhaled during 6- to 20-minute exposure to 8000 to 12000 ppm. Inhaled CFC-12 rapidly appeared in blood, bile, cerebrospinal fluid, and urine of anesthetized rabbits and dogs. Unanesthetized dogs exposed to 1000 to 100,000 ppm for 10 min showed rapid rise in blood concentrations of CFC-12 during the first 3 to 5 minutes, which was paralleled by a rapid decline for first 5 min after exposure.

American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Dichlorodifluoromethane p.2 CD-ROM Cincinnati, OH 45240-4148 2012.


Blood levels of CFC-12 were below detection limits in normal subjects using household aerosols; in asthmatic subjects using aerosol inhaler, blood levels were much lower than in dogs exposed at threshold for cardiac sensitization. Radiolabeled tests showed essentially all the dose of CFC-12 (95-103%) exhaled within the first hour after a 12- or 17-minute inhalation at 1000 ppm; total metabolites were < 0.2% of the administed dose. At 30 minutes, retention of the labeled dose inhaled in a single breath was 10% vesus 23%, 20%, and 12% for comparable doses of trichlorofluoromethane (FC-11), 1,1,2-trichloro-1,2,2,-trifluoroethane (FC-113), and 1,2-dichloro-1,1,2,2-tetrafluoroethane (FC-114), respectively. For an eight hr inhalation at 1000 ppm, a pharmacokinetic model based on analyses in dogs and humans gave an estimate of 55% absorption of the inhaled CFC-12.

American Conference of Governmental Industrial Hygienists. Documentation of the TLV's and BEI's 7th Edition. Dichlorodifluoromethane p.2 CD-ROM Cincinnati, OH 45240-4148 2012.


At 1000 ppm ... level in /human/ venous blood was 1.2 ug/mL.

National Research Council. Drinking Water and Health. Volume 3. Washington, DC: National Academy Press, 1980., p. 101


Absorption and elimination are dynamic processes involving equilibria among air, blood, and various tissues. Upon absorption, a biphasic blood-level pattern occurs, with an initial rapid then slower rise in blood levels, during which the material is absorbed from blood into tissue.

USEPA; Ambient Water Quality Criteria Doc: Halomethanes p.C-26 (1980) EPA 440/5-80-051


For more Absorption, Distribution and Excretion (Complete) data for DICHLORODIFLUOROMETHANE (10 total), please visit the HSDB record page.


4.2 Biological Half-Life

The distribution half-life of the common fluorocarbons (Freon 11, Freon 12) averages 13 to 14 seconds; the elimination half-life is longer (1.5 hours) because of slower release from fat stores.

Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 884


4.3 Mechanism of Action

Freons are toxic to humans by several mechanisms. Inhaled fluorocarbons sensitized the myocardium to catecholamines, frequently resulting in lethal ventricular arrhythmias. Because they are gases heavier than air, fluorocarbons can displace atmospheric oxygen, thus resulting in asphyxiation. These compounds also have a central nervous system (CNS) anesthetic effect analogous to a structurally similar general anesthetic, halothane. Pressurized refrigerant or liquid fluorocarbons with a low boiling point have a cryogenic effect on exposed tissues, causing frostbite, laryngeal or pulmonary edema, and gastrointestinal perforation. Certain fluorocarbons degrade at high temperatures into toxic products of chlorine, hydrofluoric acid, or phosgene gases. /Freons/

Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 1281


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