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    Chemistry

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    Also known as: 7778-50-9, Potassium bichromate, Kaliumdichromat, Potassium dichromate(vi), Dipotassium bichromate, Dipotassium dichromate
    Molecular Formula
    Cr2K2O7
    Molecular Weight
    294.18  g/mol
    InChI Key
    KMUONIBRACKNSN-UHFFFAOYSA-N
    FDA UNII
    T4423S18FM
    Potassium Dichromate
    Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.
    1 2D Structure

    Potassium Dichromate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dipotassium;oxido-(oxido(dioxo)chromio)oxy-dioxochromium
    2.1.2 InChI
    InChI=1S/2Cr.2K.7O/q;;2*+1;;;;;;2*-1
    2.1.3 InChI Key
    KMUONIBRACKNSN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    [O-][Cr](=O)(=O)O[Cr](=O)(=O)[O-].[K+].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    T4423S18FM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bichromate, Potassium

    2. Dichromate, Potassium

    3. K2cr2o7

    4. Potassium Bichromate

    2.3.2 Depositor-Supplied Synonyms

    1. 7778-50-9

    2. Potassium Bichromate

    3. Kaliumdichromat

    4. Potassium Dichromate(vi)

    5. Dipotassium Bichromate

    6. Dipotassium Dichromate

    7. Dichromic Acid Dipotassium Salt

    8. Dipotassium Dichromium Heptaoxide

    9. Chromium Potassium Oxide

    10. Iopezite

    11. Chebi:53444

    12. T4423s18fm

    13. Mfcd00011367

    14. Dipotassium;oxido-(oxido(dioxo)chromio)oxy-dioxochromium

    15. Dsstox_cid_5948

    16. Dsstox_rid_77973

    17. Dsstox_gsid_25948

    18. Caswell No. 690

    19. Kaliumdichromat [german]

    20. Chromium, Reference Standard Solution

    21. Kalium Bichromicum

    22. Srm 935a

    23. Cas-7778-50-9

    24. Ccris 2409

    25. Hsdb 1238

    26. Einecs 231-906-6

    27. Nsc 77372

    28. K2cr2o7

    29. Epa Pesticide Chemical Code 068302

    30. Unii-t4423s18fm

    31. Kali Bichromicum

    32. Potassium Dichromate(2-)

    33. Epitope Id:119680

    34. Ec 231-906-6

    35. Chromic Acid (h2cr2o7) Potassium Salt (1:2)

    36. Potassium Dichromate Solution

    37. Potassium Dichromate Acs Grade

    38. Potassium Dichromate [chromium And Chromium Compounds]

    39. Kali Bichromicum [hpus]

    40. Dtxsid5025948

    41. Potassium Dichromate [hsdb]

    42. Potassium Dichromate [vandf]

    43. Tox21_111009

    44. Tox21_202307

    45. Potassium Dichromate [mart.]

    46. Potassium Dichromate, Puriss., 99%

    47. Potassium Dichromate [who-dd]

    48. Akos024418771

    49. Potassium Dichromate(vi) [mi]

    50. Potassium Dichromate, Ar, >=99.9%

    51. Potassium Dichromate, Lr, >=99.5%

    52. Potassium Dichromate Solution, 1/60 M

    53. Ncgc00090755-01

    54. Ncgc00259856-01

    55. Potassium Dichromate, Bioxtra, >=99.5%

    56. Ft-0698964

    57. Potassium Dichromate, Acs Reagent, >=99.0%

    58. Potassium Dichromate, 0.1n Standardized Solution

    59. Potassium Dichromate, Bioultra, >=99.5% (rt)

    60. Potassium Dichromate, Reagentplus(r), >=99.5%

    61. Chromic Acid (h2cr2o7), Potassium Salt (1:2)

    62. Potassium Dichromate, 0.25n Standardized Solution

    63. Potassium Dichromate, 99.99% Trace Metals Basis

    64. Potassium Dichromate, Saj First Grade, >=99.5%

    65. Q239729

    66. Potassium Dichromate, 0.025n Standardized Solution

    67. Potassium Dichromate, Jis Special Grade, >=99.5%

    68. Potassium Dichromate, Yanagishima Pharmaceutical Co. Ltd.

    69. Potassium Dichromate, Nist(r) Srm(r) 136f, Oxidimetric Standard

    70. Potassium Dichromate, Nist(r) Srm(r) 935a, Uv Absorbance Standard

    71. Potassium Dichromate, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.8%

    72. Chromium Standard Solution, Suitable For Atomic Absorption Spectrometry, 1 Mg/ml Cr, 1000 Ppm Cr

    73. Potassium Dichromate, Certified Reference Material For Titrimetry, Certified By Bam According To Iso 17025, >=99.5%

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 294.18 g/mol
    Molecular Formula Cr2K2O7
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count0
    Exact Mass293.772825 g/mol
    Monoisotopic Mass293.772825 g/mol
    Topological Polar Surface Area124 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity194
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Anti-Infective Agents, Local; Astringents; Caustics; Dyes

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Potassium dichromate is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of March 17, 2016: https://clinicaltrials.gov/ct2/results?term=potassium+dichromate&Search=Search

    Medication (vet): caustic

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1419

    MEDICATION (VET): HAS BEEN USED IN ANTITUSSIVE & LYMPHANGITIS MIXTURES; 20 PPM IN FISH TANK WATER TO CONTROL PROTOZOA & FLUKES

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 473

    4.2 Minimum/Potential Fatal Human Dose

    4 OR 5. 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG; BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB); 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG; BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB)

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-76

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Caustics

    Strong alkaline chemicals that destroy soft body tissues resulting in a deep, penetrating type of burn, in contrast to corrosives, that result in a more superficial type of damage via chemical means or inflammation. Caustics are usually hydroxides of light metals. SODIUM HYDROXIDE and potassium hydroxide are the most widely used caustic agents in industry. Medically, they have been used externally to remove diseased or dead tissues and destroy warts and small tumors. The accidental ingestion of products (household and industrial) containing caustic ingredients results in thousands of injuries per year. (See all compounds classified as Caustics.)

    Coloring Agents

    Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)

    5.2 Absorption, Distribution and Excretion

    The acute and subacute toxicities of several Cr(III) and Cr(VI) compounds (chromium(3+) chloride, chromium(3+) nitrate, chromium(3+) sulfate, chromium trioxide, potassium dichromate) were determined in NZC and (CxO) mice injected ip. The distal median lethal doses (> 10 days after treatment) averaged (17.9 + or - 1.8) X 10(-6) g chromium/g body wt regardless of the oxidation state of the Cr compound injected (chromium(3+) sulfate may be an exception), but acute toxicity (3 days) was much greater with Cr(VI) compounds. Acid digests of entire male mice that were administered ip 1/6 of the distal LD50, either once or repeatedly at weekly intervals, were analyzed to determine the whole body persistence and clearance kinetics of Cr. Mice dosed once with Cr(III) retained 6.5 times more chromium at 21 days than mice treated with Cr(VI). When Cr(III) was given at weekly intervals mice accumulated 6 times more Cr by 8 wk than Cr(VI)-treated mice, though only the latter showed symptoms of chromic toxicity. Whole body Cr concentrations continued to rise with further Cr(III) treatments, but slowly declined with Cr(VI). Analyses of fecal and urinary excretion confirmed that most of the urinary Cr excretion from Cr(VI)-treated animals was much faster in both urine and feces than from mice given Cr(III). The differential storage and clearance kinetics of Cr(III) and Cr(VI) compounds may be significant in experimental Cr carcinogenesis studies and in the toxicology of Cr in workers exposed industrially to potentially carcinogenic chromium-containing dusts or aerosols.

    PMID:6652867 Bryson WG, Goodall CM; Carcinogenesis 4 (12): 1535-40 (1983)

    The interaction of potassium dichromate (Cr(VI)) with bovine serum albumin (BSA) was investigated by fluorescence, synchronous fluorescence, resonance light scattering (RLS), ultraviolet-visible absorption, and circular dichroism (CD) spectroscopies under simulated physiological conditions. The experimental results showed that Cr(VI) could quench the intrinsic fluorescence of BSA following a static quenching process, which indicates the formation of a Cr(VI)-BSA complex. The binding constant (KA) and binding site (n) were measured at different temperatures. The spectroscopic results also revealed that the binding of Cr(VI) to BSA can lead to the loosening of the protein conformation and can change the microenvironment and skeleton of BSA.

    PMID:22095857 Zhang P et al; J Biochem Mol Toxicol 26 (2): 54-9 (2012)

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    PharmaCompass offers a list of Potassium Dichromate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Potassium Dichromate manufacturer or Potassium Dichromate supplier for your needs.

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    API | Excipient name

    Potassium Dichromate

    Synonyms

    7778-50-9, Potassium bichromate, Kaliumdichromat, Potassium dichromate(vi), Dipotassium bichromate, Dipotassium dichromate

    Cas Number

    7778-50-9

    Unique Ingredient Identifier (UNII)

    T4423S18FM

    About Potassium Dichromate

    Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) Manufacturers

    A Dichromic acid (H2Cr2O7), dipotassium salt (8CI) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dichromic acid (H2Cr2O7), dipotassium salt (8CI), including repackagers and relabelers. The FDA regulates Dichromic acid (H2Cr2O7), dipotassium salt (8CI) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dichromic acid (H2Cr2O7), dipotassium salt (8CI) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) Suppliers

    A Dichromic acid (H2Cr2O7), dipotassium salt (8CI) supplier is an individual or a company that provides Dichromic acid (H2Cr2O7), dipotassium salt (8CI) active pharmaceutical ingredient (API) or Dichromic acid (H2Cr2O7), dipotassium salt (8CI) finished formulations upon request. The Dichromic acid (H2Cr2O7), dipotassium salt (8CI) suppliers may include Dichromic acid (H2Cr2O7), dipotassium salt (8CI) API manufacturers, exporters, distributors and traders.

    click here to find a list of Dichromic acid (H2Cr2O7), dipotassium salt (8CI) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) USDMF

    A Dichromic acid (H2Cr2O7), dipotassium salt (8CI) DMF (Drug Master File) is a document detailing the whole manufacturing process of Dichromic acid (H2Cr2O7), dipotassium salt (8CI) active pharmaceutical ingredient (API) in detail. Different forms of Dichromic acid (H2Cr2O7), dipotassium salt (8CI) DMFs exist exist since differing nations have different regulations, such as Dichromic acid (H2Cr2O7), dipotassium salt (8CI) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Dichromic acid (H2Cr2O7), dipotassium salt (8CI) DMF submitted to regulatory agencies in the US is known as a USDMF. Dichromic acid (H2Cr2O7), dipotassium salt (8CI) USDMF includes data on Dichromic acid (H2Cr2O7), dipotassium salt (8CI)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Dichromic acid (H2Cr2O7), dipotassium salt (8CI) USDMF is kept confidential to protect the manufacturer’s intellectual property.

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    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) GMP

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Dichromic acid (H2Cr2O7), dipotassium salt (8CI) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dichromic acid (H2Cr2O7), dipotassium salt (8CI) GMP manufacturer or Dichromic acid (H2Cr2O7), dipotassium salt (8CI) GMP API supplier for your needs.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) CoA

    A Dichromic acid (H2Cr2O7), dipotassium salt (8CI) CoA (Certificate of Analysis) is a formal document that attests to Dichromic acid (H2Cr2O7), dipotassium salt (8CI)'s compliance with Dichromic acid (H2Cr2O7), dipotassium salt (8CI) specifications and serves as a tool for batch-level quality control.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) CoA mostly includes findings from lab analyses of a specific batch. For each Dichromic acid (H2Cr2O7), dipotassium salt (8CI) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Dichromic acid (H2Cr2O7), dipotassium salt (8CI) may be tested according to a variety of international standards, such as European Pharmacopoeia (Dichromic acid (H2Cr2O7), dipotassium salt (8CI) EP), Dichromic acid (H2Cr2O7), dipotassium salt (8CI) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dichromic acid (H2Cr2O7), dipotassium salt (8CI) USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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