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Diclofenac Epolamine

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 6 USDMF, 1 EU WC, 2 KDMF, 4 NDC API, 3 Listed Suppliers, $ API Reference Price

8 API Suppliers
6 USDMF
1 EU WC
2 KDMF
4 NDC API
3 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 2 FDA Orange Book, 2 South Africa

4 FDF Dossiers
2 FDA Orange Book
2 South Africa

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 3 SPI Pharma, 7 DKSH, 1 Faran Shimi Pharmaceutical, 4 Boai NKY Pharmaceuticals Ltd, 2 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Capital Farma, 4 ACG Worldwide, 2 Actylis, 1 Aeon Procare, 11 BASF, 1 Finar, 5 Gangwal Chemicals, 1 Kima Chemical, 3 Lonza Capsugel, 4 Microlex e.U, 1 Nanjing Bold Chemical, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo, 1 Qualicaps, 11 Roquette, 6 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries, 1 The Dow Chemical Company, 1 Ulanqab Kema New Material, 1 Valens Pharmachem, 1 Zhejiang Huakang Pharmaceutical

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24 Solubilizers, 20 Fillers, Diluents & Binders, 15 Film Formers & Plasticizers, 14 Thickeners and Stabilizers, 10 Coating Systems & Additives, 10 Parenteral, 8 Empty Capsules, 7 Topical, 6 Direct Compression, 5 Co-Processed Excipients, 5 Granulation, 5 Taste Masking, 5 Rheology Modifiers, 4 Emulsifying Agents, 4 Controlled & Modified Release, 2 Chewable & Orodispersible Aids, 2 Disintegrants & Superdisintegrants, 2 API Stability Enhancers, 2 Surfactant & Foaming Agents, 2 Coloring Agents, 1 Lubricants & Glidants, 1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 3 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions

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3 US Medicaid Prescriptions

MARKET PLACE

2 APIs

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2 APIs

PATENTS & EXCLUSIVITIES

2 US Patents

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2 US Patents

ANALYTICAL

1 BioAnalytical Methods

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1 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

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CEP/COS

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KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 391

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

8DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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PATENTS & EXCLUSIVITIES

US Patents

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Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

168,362,416

Annual Reports (USD Million)

Finished Drug Prices

85 RELATED EXCIPIENT COMPANIES

154EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Flector, Diclofenac hydroxyethylpyrrolidine, Diep, Dhep, Diclofenac epolaminum, Diclofenac-epolamine

Molecular Formula

C₂₀H₂₄Cl₂N₂O₃

Molecular Weight

411.3 g/mol

InChI Key

DCERVXIINVUMKU-UHFFFAOYSA-N

FDA UNII

X5F8EKL9ZG

1 2D Structure

Diclofenac Epolamine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-(2,6-dichloroanilino)phenyl]acetic acid;2-pyrrolidin-1-ylethanol

2.1.2 InChI

InChI=1S/C14H11Cl2NO2.C6H13NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;8-6-5-7-3-1-2-4-7/h1-7,17H,8H2,(H,18,19);8H,1-6H2

2.1.3 InChI Key

DCERVXIINVUMKU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1CCN(C1)CCO.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

2.2 Other Identifiers

2.2.1 UNII

X5F8EKL9ZG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dhep

2. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

3. Diclofenac Hydroxyethylpyrrolidine

4. Diclofenac-epolamine

5. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

6. Diep

7. Flector

8. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

2.3.2 Depositor-Supplied Synonyms

1. Flector

2. Diclofenac Hydroxyethylpyrrolidine

3. Diep

4. Dhep

5. Diclofenac Epolaminum

6. Diclofenac-epolamine

7. X5f8ekl9zg

8. 2-[2-(2,6-dichloroanilino)phenyl]acetic Acid;2-pyrrolidin-1-ylethanol

9. N-(2-hydroxyethyl)pyrrolidinium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

10. 2-((2,6-dichlorophenyl)amino)benzeneacetic Acid, Compd. With 1-pyrrolidineethanol (1:1)

11. Diclofenac 1-(2-hydroxyethyl)pyrrolidinium Salt

12. Dhep Plaster

13. Benzeneacetic Acid, 2-((2,6-dichlorophenyl)amino)-, Compd. With 1-pyrrolidineethanol (1:1)

14. Chebi:48296

15. Unii-x5f8ekl9zg

16. Flector (tn)

17. Licart

18. Diclofenac-n-(2-hydroxyethyl) Pyrrolidine

19. Schembl1006944

20. Chembl1201180

21. Dtxsid80152531

22. Diclofenac Epolamine [vandf]

23. Diclofenac Epolamine [mart.]

24. S5737

25. Diclofenac Epolamine [who-dd]

26. Diclofenac Hydroxyethylpirrolidine

27. Diclofenac Epolamine [orange Book]

28. D07818

29. 528d502

30. Diclofenac Acid N-(2-hydroxyetheyl) Pyrrolidine Salt

31. Q27121125

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₄Cl₂N₂O₃
Molecular Weight	411.3 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	410.1163980 g/mol
Monoisotopic Mass	410.1163980 g/mol
Topological Polar Surface Area	72.8 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	363
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Flector
PubMed Health	Diclofenac
Drug Classes	Analgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug Label	Flector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
Active Ingredient	Diclofenac epolamine
Dosage Form	Patch
Route	Topical
Strength	1.3%
Market Status	Prescription
Company	Inst Biochem

2 of 2
Drug Name	Flector
PubMed Health	Diclofenac
Drug Classes	Analgesic, Anti-Inflammatory, Antimigraine, Antirheumatic, Central Nervous System Agent, Musculoskeletal Agent, Ophthalmologic Agent
Drug Label	Flector Patch (10 cm x 14 cm) is comprised of an adhesive material containing 1.3% diclofenac epolamine which is applied to a non-woven polyester felt backing and coveredwith a polypropylene film release liner. The release liner is emoved prior to...
Active Ingredient	Diclofenac epolamine
Dosage Form	Patch
Route	Topical
Strength	1.3%
Market Status	Prescription
Company	Inst Biochem

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cyclooxygenase Inhibitors [MoA]; Decreased Prostaglandin Production [PE]; Nonsteroidal Anti-inflammatory Drug [EPC]; Anti-Inflammatory Agents, Non-Steroidal [CS]

API SUPPLIERS

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USDMF

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Coating Systems & Additives

Parenteral

Empty Capsules

Topical

Direct Compression

Co-Processed Excipients

Granulation

Taste Masking

Rheology Modifiers

Emulsifying Agents

Controlled & Modified Release

Chewable & Orodispersible Aids

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API Stability Enhancers

Surfactant & Foaming Agents

Coloring Agents

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Soft Gelatin

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers

6 USDMF

1 EU WC

2 KDMF

4 NDC API

3 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

8 Drugs in Development

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers

2 FDA Orange Book

2 South Africa

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2 Rochem International Inc

3 SPI Pharma

7 DKSH

1 Faran Shimi Pharmaceutical

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2 Gangwal Healthcare

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1 Capital Farma

4 ACG Worldwide

2 Actylis

1 Aeon Procare

11 BASF

1 Finar

5 Gangwal Chemicals

1 Kima Chemical

3 Lonza Capsugel

4 Microlex e.U

1 Nanjing Bold Chemical

1 Novo Excipients

1 Pharmatrans-Sanaq

1 Pluviaendo

1 Qualicaps

11 Roquette

6 Seppic

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shanghai Welltone Material Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Sigachi Industries

1 The Dow Chemical Company

1 Ulanqab Kema New Material

1 Valens Pharmachem

1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

24 Solubilizers

20 Fillers, Diluents & Binders

15 Film Formers & Plasticizers

14 Thickeners and Stabilizers

10 Coating Systems & Additives

10 Parenteral

8 Empty Capsules

7 Topical

6 Direct Compression

5 Co-Processed Excipients

5 Granulation

5 Taste Masking

5 Rheology Modifiers

4 Emulsifying Agents

4 Controlled & Modified Release

2 Chewable & Orodispersible Aids

2 Disintegrants & Superdisintegrants

2 API Stability Enhancers

2 Surfactant & Foaming Agents

2 Coloring Agents

1 Lubricants & Glidants

1 Soft Gelatin

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow

3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION