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Chemistry

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Also known as: 0kc57i4unb, Azane, 1-carboxycyclobutane-1-carboxylate, platinum(2+), 287402-09-9, Platinum(2+) 1-carboxycyclobutanecarboxylate ammoniate (1:2:2), Unii-0kc57i4unb, Dicycloplatin [who-dd]
Molecular Formula
C12H20N2O8Pt
Molecular Weight
515.38  g/mol
InChI Key
IIJQICKYWPGJDT-UHFFFAOYSA-L
FDA UNII
0KC57I4UNB

Dicycloplatin
Dicycloplatin is a third-generation, supramolecular platinum-based compound composed of carboplatin linked, by a strong hydrogen bond, to 1,1-cyclobutane dicarboxylate (CBDCA), with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, dicycloplatin appears to have a mechanism of action similar to that of other platinum-based compounds, which involves both DNA binding and the formation of DNA crosslinks. This mechanism results in the induction of apoptosis and cell growth inhibition. Compared to carboplatin alone, dicycloplatin shows enhanced solubility and stability in aqueous solution and appears to have a more favorable toxicity profile.
1 2D Structure

Dicycloplatin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
2.1.2 InChI
InChI=1S/2C6H8O4.2H3N.Pt/c2*7-4(8)6(5(9)10)2-1-3-6;;;/h2*1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;;+2/p-2
2.1.3 InChI Key
IIJQICKYWPGJDT-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C1CC(C1)(C(=O)O)C(=O)O.C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]
2.2 Other Identifiers
2.2.1 UNII
0KC57I4UNB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Cis-diammine(1,1-cyclobutanedicarboxylate)platinum(ii)

2. Diammine(1,1-cyclobutanedicarboxylate)platinum(ii)

2.3.2 Depositor-Supplied Synonyms

1. 0kc57i4unb

2. Azane, 1-carboxycyclobutane-1-carboxylate, Platinum(2+)

3. 287402-09-9

4. Platinum(2+) 1-carboxycyclobutanecarboxylate Ammoniate (1:2:2)

5. Unii-0kc57i4unb

6. Dicycloplatin [who-dd]

7. 1,1-cyclobutanedicarboxylic Acid, Compd. With (sp-4-2)-diammine(1,1-cyclobutanedi(carboxylato-kappao)(2-))platinum (1:1)

8. Platinum, Diammine(1,1-cyclobutanedi(carboxylato-kappao)(2-))-, (sp-4-2)-, 1,1-cyclobutanedicarboxylate (1:1)

9. Platinum, Diammine(1,1-cyclobutanedicarboxylato(2-)-kappao,kappao'')-, (sp-4-2)-, 1,1-cyclobutanedicarboxylate (1:1)

10. Db-119035

11. Cis-diammine(1,1-cyclobutanedicarboxylate)platinum(ii)

12. Q19776556

13. Azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic Acid;platinum(2+)

14. 1,1-cyclobutanedicarboxylic Acid, Compd. With (sp-4-2)-diammine(1,1-cyclobutanedi(carboxylato-.kappa.o)(2-))platinum (1:1)

15. Platinum, Diammine(1,1-cyclobutanedi(carboxylato-.kappa.o)(2-))-, (sp-4-2)-, 1,1-cyclobutanedicarboxylate (1:1)

16. Platinum, Diammine(1,1-cyclobutanedicarboxylato(2-)-.kappa.o,.kappa.o'')-, (sp-4-2)-, 1,1-cyclobutanedicarboxylate (1:1)

2.4 Create Date
2009-12-07
3 Chemical and Physical Properties
Molecular Weight 515.38 g/mol
Molecular Formula C12H20N2O8Pt
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Exact Mass515.086760 g/mol
Monoisotopic Mass515.086760 g/mol
Topological Polar Surface Area157 Ų
Heavy Atom Count23
Formal Charge0
Complexity317
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5

ABOUT THIS PAGE

Dicycloplatin Manufacturers

A Dicycloplatin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dicycloplatin, including repackagers and relabelers. The FDA regulates Dicycloplatin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dicycloplatin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dicycloplatin Suppliers

A Dicycloplatin supplier is an individual or a company that provides Dicycloplatin active pharmaceutical ingredient (API) or Dicycloplatin finished formulations upon request. The Dicycloplatin suppliers may include Dicycloplatin API manufacturers, exporters, distributors and traders.

Dicycloplatin GMP

Dicycloplatin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dicycloplatin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dicycloplatin GMP manufacturer or Dicycloplatin GMP API supplier for your needs.

Dicycloplatin CoA

A Dicycloplatin CoA (Certificate of Analysis) is a formal document that attests to Dicycloplatin's compliance with Dicycloplatin specifications and serves as a tool for batch-level quality control.

Dicycloplatin CoA mostly includes findings from lab analyses of a specific batch. For each Dicycloplatin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dicycloplatin may be tested according to a variety of international standards, such as European Pharmacopoeia (Dicycloplatin EP), Dicycloplatin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dicycloplatin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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