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Chemistry

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Also known as: Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl
Molecular Formula
C13H20ClNO
Molecular Weight
241.76  g/mol
InChI Key
ICFXZZFWRWNZMA-UHFFFAOYSA-N
FDA UNII
19V2PL39NG

Diethylpropion Hydrochloride
A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
1 2D Structure

Diethylpropion Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)-1-phenylpropan-1-one;hydrochloride
2.1.2 InChI
InChI=1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H
2.1.3 InChI Key
ICFXZZFWRWNZMA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)C(C)C(=O)C1=CC=CC=C1.Cl
2.2 Other Identifiers
2.2.1 UNII
19V2PL39NG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-diethylaminopropiophenone

2. Amfepramon

3. Amfepramone

4. Anorex

5. Delgamer

6. Diethylpropion

7. Dietil Retard

8. Dietil-retard

9. Dietilretard

10. Hydrochloride, Diethylpropion

11. Ifa Norex

12. Lipomin

13. Maruate

14. Modratan

15. Neobes

16. Nobesine

17. Norex, Ifa

18. Phepranon

19. Prfamone

20. Propion

21. Regenon

22. Regibon

23. Tenuate

24. Tepanil

2.3.2 Depositor-Supplied Synonyms

1. Amfepramone Hydrochloride

2. 134-80-5

3. Moderatan

4. Dobesin

5. Tenuate

6. Diethylpropion Hcl

7. Tepanil

8. Anorex

9. Tenuate Dospan

10. Regenon Hydrochloride

11. 2-(diethylamino)propiophenone Hydrochloride

12. Amfepramone (hydrochloride)

13. Prefamone

14. Regenon

15. Amphepramonum Hydrochloride

16. 1-propanone, 2-(diethylamino)-1-phenyl-, Hydrochloride

17. 19v2pl39ng

18. Diethylpropion Hydrochloride Civ

19. Alpha-benzoyltriethylammonium Chloride

20. Alpha-benzoyltriethylamine Hydrochloride

21. D03801

22. Diethylpropion Hydrochloride [usp]

23. Menutil

24. 1-phenyl-2-diethylaminopropanone-1 Hydrochloride

25. Magrex Retard

26. Tenuate-dospan

27. Amfepramon Hydrochloride

28. Lineal-rivo

29. Tepanil Ten-tab

30. Nu-dispoz

31. Dsstox_cid_27816

32. Dsstox_rid_82580

33. Dsstox_gsid_47838

34. Propiophenone, 2-(diethylamino)-, Hydrochloride

35. Diethylpropion Hydrochloride (usp)

36. 2-(diethylamino)-1-phenylpropan-1-one Hydrochloride

37. Cas-134-80-5

38. Chebi:643703

39. 2-diethylaminopropiophenone Hydrochloride

40. Sr-01000220674

41. Ncgc00167475-01

42. Einecs 205-156-5

43. Unii-19v2pl39ng

44. Tenuate (tn)

45. Rac Diethylpropion-d10 Hydrochloride

46. Diethylproion Hydrochloride

47. Cambridge Id 5809497

48. Chembl1693

49. Schembl15483

50. 2-(diethylamino)-1-phenyl-1-propanone Hydrochloride

51. 2-(diethylamino)-1-phenylpropan-1-one;hydrochloride

52. Dtxsid4047838

53. Hy-b0981

54. Tox21_112479

55. Akos015962206

56. Tox21_112479_1

57. Ccg-220122

58. Cs-4472

59. Diethylpropion Hydrochloride [mi]

60. Ncgc00167475-02

61. Ac-16025

62. Amfepramone Hydrochloride [who-dd]

63. As-16865

64. Diethylpropion Hydrochloride [mart.]

65. Diethylpropion Hydrochloride [vandf]

66. Diethylpropion Hydrochloride [usp-rs]

67. .alpha.-benzoyltriethylamine Hydrochloride

68. 090d846

69. Diethylpropion Hydrochloride [orange Book]

70. Diethylpropion Hydrochloride [usp Monograph]

71. Sr-01000220674-1

72. Sr-01000220674-2

73. Q27105182

74. Diethylpropion Hydrochloride Solution, 1.0 Mg/ml In Methanol (with 1% 1 M Hcl; As Free Base), Certified Reference Material

2.4 Create Date
2005-07-29
3 Chemical and Physical Properties
Molecular Weight 241.76 g/mol
Molecular Formula C13H20ClNO
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass241.1233420 g/mol
Monoisotopic Mass241.1233420 g/mol
Topological Polar Surface Area20.3 Ų
Heavy Atom Count16
Formal Charge0
Complexity193
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameDiethylpropion hydrochloride
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strength75mg; 25mg
Market StatusPrescription
CompanyLannett Holdings; Corepharma; Avanthi

2 of 6  
Drug NameTenuate
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet
RouteOral
Strength25mg
Market StatusPrescription
CompanyWatson Pharms

3 of 6  
Drug NameTenuate dospan
PubMed HealthDiethylpropion (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength75mg
Market StatusPrescription
CompanyWatson Pharms

4 of 6  
Drug NameDiethylpropion hydrochloride
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strength75mg; 25mg
Market StatusPrescription
CompanyLannett Holdings; Corepharma; Avanthi

5 of 6  
Drug NameTenuate
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet
RouteOral
Strength25mg
Market StatusPrescription
CompanyWatson Pharms

6 of 6  
Drug NameTenuate dospan
PubMed HealthDiethylpropion (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength75mg
Market StatusPrescription
CompanyWatson Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]

API Reference Price

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ADD: NO.36, LONGMEN ROAD, HAICANG XINYANG INDUSTRIAL ZONE, X IAMEN 361026., CHINA CHINA","customerAddress":"DIAMOND CHAMBERS,BLOCK-II"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739817000,"product":"ALLYL CYCLO HEXYL PROPIONATE (AROMATICAL PRODUTS FOR INDUSTRIAL PURPOSE)(COO:01251113410000626)ALLYL CYCLO HEXYL PROPIONATE (AROMATICAL PRODUTS FOR INDUSTR","address":"27\/1,NEW 2ND CROSS,NEHRU ROAD,,KUV","city":"BANGALORE,KARNATAKA","supplier":"JIAXING SHENGYUAN IMP&EXP.CO.LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"KAROMAS AROMATICS","customerCountry":"INDIA","quantity":"380.00","actualQuantity":"380","unit":"KGS","unitRateFc":"7.8","totalValueFC":"2993.6","currency":"USD","unitRateINR":"685.1","date":"18-Feb-2025","totalValueINR":"260338","totalValueInUsd":"2993.6","indian_port":"JM FTZ SEZ\/MANNUR","hs_no":"29161990","bill_no":"8420423","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ZHONGHUAN EAST PLAZA A\/1802 JIAXING ZHEJIANG SDNF CHINA","customerAddress":"27\/1,NEW 2ND CROSS,NEHRU ROAD,,KUV"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739817000,"product":"3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YLAMINO]-PROPIONIC ACID ETHYL ESTERIUPAC NAME: ETHYL 3-[[3-AMINO-4-(MO-BENZOTRIAZOL-1-YL-N,N,N,N-T ETRAMETHYLURONIUM TETRAFLUOROB","address":"101\/2RT,S.R.NAGAR,","city":"ANDHRA PRADESH","supplier":"NANJING JOYIN PHARMACHEM CO, LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SRI CHAVADI PHARMA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"650.00","actualQuantity":"650","unit":"KGS","unitRateFc":"42","totalValueFC":"27750.8","currency":"USD","unitRateINR":"3712.8","date":"18-Feb-2025","totalValueINR":"2413320","totalValueInUsd":"27750.8","indian_port":"Hyderabad Air","hs_no":"29339990","bill_no":"8421967","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ROOMS 1201, 1202, AND 1212, 12TH FLOOR, PHASE I OF SUNNY WORLD CENTE R NO. 188 LUSHAN ROAD, JIANYE DISTR CN","customerAddress":"101\/2RT,S.R.NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739989800,"product":"PURESTAB 1098 (N,N-HEXANE-1,6-DIYLBIS(3-(3,5-DI-TERT.-BUTYL-4-HYDROXYPHENYLPROPIONAMIDE))PURESTAB 1098 (N,N-HEXANE-1,6-DIYLBIS(3-(3,5-DI-TERT.-BUTYL-","address":"FANTREE BLDG,PLOT NO.369,SARLA PARK","city":"MUMBAI,MAHARASHTRA","supplier":"POLYGEL ORGANOMETALLIC BRUNEI ","supplierCountry":"BRUNEI DARUSSALAM","foreign_port":"MUARA","customer":"DKSH","customerCountry":"INDIA","quantity":"2000.00","actualQuantity":"2000","unit":"KGS","unitRateFc":"6.2","totalValueFC":"12604.7","currency":"USD","unitRateINR":"548.1","date":"20-Feb-2025","totalValueINR":"1096160","totalValueInUsd":"12604.7","indian_port":"JNPT","hs_no":"29242990","bill_no":"8469548","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRUNEI","selfForZScoreResived":"Pharma Grade","supplierPort":"MUARA","supplierAddress":"PLOT NO. 5C1B SALAMBIGAR INDUSTRIAL PARK, BRUNEI DARUSSALAM BU-1129 BRUNEI","customerAddress":"FANTREE BLDG,PLOT NO.369,SARLA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739989800,"product":"3-MERCAPTOPROPIONIC ACID (CAS NO.107-96-0) 3-MERCAPTOPROPIONIC ACID","address":"208, OKHLA INDUSTRIAL ESTAT,PHASE-","city":"NEW DELHI,DELHI","supplier":"NINGBO SANGER MEDTECH CO.LTD.","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"SHREE JEE LABORATORY ","customerCountry":"INDIA","quantity":"177.50","actualQuantity":"177.5","unit":"KGS","unitRateFc":"35","totalValueFC":"6315.1","currency":"USD","unitRateINR":"3094","date":"20-Feb-2025","totalValueINR":"549185","totalValueInUsd":"6315.1","indian_port":"Delhi Air","hs_no":"29309099","bill_no":"8455302","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"7-1-20 NO.666 SANGTIAN ROAD NINGBO SDNF CHINA","customerAddress":"208, OKHLA INDUSTRIAL ESTAT,PHASE-"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740076200,"product":"PROPIONYL BROMIDE PROPIONYL BROMIDE","address":"PLOT NO.43, , TTC MIDC INDL. 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SDNF Switzerland","customerAddress":"PLOT NO.26,2ND CROSS,JIGANI"}]
01-Jan-2021
28-Feb-2025
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DOSAGE - TABLET;ORAL - 25MG **Federal Registe...DOSAGE - TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 11722

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 12546

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ABOUT THIS PAGE

Looking for 134-80-5 / Diethylpropion Hydrochloride API manufacturers, exporters & distributors?

Diethylpropion Hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Diethylpropion Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Diethylpropion Hydrochloride manufacturer or Diethylpropion Hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Diethylpropion Hydrochloride manufacturer or Diethylpropion Hydrochloride supplier.

PharmaCompass also assists you with knowing the Diethylpropion Hydrochloride API Price utilized in the formulation of products. Diethylpropion Hydrochloride API Price is not always fixed or binding as the Diethylpropion Hydrochloride Price is obtained through a variety of data sources. The Diethylpropion Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Diethylpropion Hydrochloride

Synonyms

Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl

Cas Number

134-80-5

Unique Ingredient Identifier (UNII)

19V2PL39NG

About Diethylpropion Hydrochloride

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Diethylpropion HCl Manufacturers

A Diethylpropion HCl manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diethylpropion HCl, including repackagers and relabelers. The FDA regulates Diethylpropion HCl manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diethylpropion HCl API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Diethylpropion HCl manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Diethylpropion HCl Suppliers

A Diethylpropion HCl supplier is an individual or a company that provides Diethylpropion HCl active pharmaceutical ingredient (API) or Diethylpropion HCl finished formulations upon request. The Diethylpropion HCl suppliers may include Diethylpropion HCl API manufacturers, exporters, distributors and traders.

click here to find a list of Diethylpropion HCl suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Diethylpropion HCl USDMF

A Diethylpropion HCl DMF (Drug Master File) is a document detailing the whole manufacturing process of Diethylpropion HCl active pharmaceutical ingredient (API) in detail. Different forms of Diethylpropion HCl DMFs exist exist since differing nations have different regulations, such as Diethylpropion HCl USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Diethylpropion HCl DMF submitted to regulatory agencies in the US is known as a USDMF. Diethylpropion HCl USDMF includes data on Diethylpropion HCl's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diethylpropion HCl USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Diethylpropion HCl suppliers with USDMF on PharmaCompass.

Diethylpropion HCl KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Diethylpropion HCl Drug Master File in Korea (Diethylpropion HCl KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Diethylpropion HCl. The MFDS reviews the Diethylpropion HCl KDMF as part of the drug registration process and uses the information provided in the Diethylpropion HCl KDMF to evaluate the safety and efficacy of the drug.

After submitting a Diethylpropion HCl KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Diethylpropion HCl API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Diethylpropion HCl suppliers with KDMF on PharmaCompass.

Diethylpropion HCl NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Diethylpropion HCl as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Diethylpropion HCl API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Diethylpropion HCl as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Diethylpropion HCl and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Diethylpropion HCl NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Diethylpropion HCl suppliers with NDC on PharmaCompass.

Diethylpropion HCl GMP

Diethylpropion HCl Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Diethylpropion HCl GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diethylpropion HCl GMP manufacturer or Diethylpropion HCl GMP API supplier for your needs.

Diethylpropion HCl CoA

A Diethylpropion HCl CoA (Certificate of Analysis) is a formal document that attests to Diethylpropion HCl's compliance with Diethylpropion HCl specifications and serves as a tool for batch-level quality control.

Diethylpropion HCl CoA mostly includes findings from lab analyses of a specific batch. For each Diethylpropion HCl CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Diethylpropion HCl may be tested according to a variety of international standards, such as European Pharmacopoeia (Diethylpropion HCl EP), Diethylpropion HCl JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diethylpropion HCl USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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