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Chemistry

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Also known as: Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl
Molecular Formula
C13H20ClNO
Molecular Weight
241.76  g/mol
InChI Key
ICFXZZFWRWNZMA-UHFFFAOYSA-N
FDA UNII
19V2PL39NG

Diethylpropion Hydrochloride
A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
1 2D Structure

Diethylpropion Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(diethylamino)-1-phenylpropan-1-one;hydrochloride
2.1.2 InChI
InChI=1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H
2.1.3 InChI Key
ICFXZZFWRWNZMA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)C(C)C(=O)C1=CC=CC=C1.Cl
2.2 Other Identifiers
2.2.1 UNII
19V2PL39NG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-diethylaminopropiophenone

2. Amfepramon

3. Amfepramone

4. Anorex

5. Delgamer

6. Diethylpropion

7. Dietil Retard

8. Dietil-retard

9. Dietilretard

10. Hydrochloride, Diethylpropion

11. Ifa Norex

12. Lipomin

13. Maruate

14. Modratan

15. Neobes

16. Nobesine

17. Norex, Ifa

18. Phepranon

19. Prfamone

20. Propion

21. Regenon

22. Regibon

23. Tenuate

24. Tepanil

2.3.2 Depositor-Supplied Synonyms

1. Amfepramone Hydrochloride

2. 134-80-5

3. Moderatan

4. Dobesin

5. Tenuate

6. Diethylpropion Hcl

7. Tepanil

8. Anorex

9. Tenuate Dospan

10. Regenon Hydrochloride

11. 2-(diethylamino)propiophenone Hydrochloride

12. Amfepramone (hydrochloride)

13. Prefamone

14. Regenon

15. Amphepramonum Hydrochloride

16. 1-propanone, 2-(diethylamino)-1-phenyl-, Hydrochloride

17. 19v2pl39ng

18. Diethylpropion Hydrochloride Civ

19. Alpha-benzoyltriethylammonium Chloride

20. Alpha-benzoyltriethylamine Hydrochloride

21. D03801

22. Diethylpropion Hydrochloride [usp]

23. Menutil

24. 1-phenyl-2-diethylaminopropanone-1 Hydrochloride

25. Magrex Retard

26. Tenuate-dospan

27. Amfepramon Hydrochloride

28. Lineal-rivo

29. Tepanil Ten-tab

30. Nu-dispoz

31. Dsstox_cid_27816

32. Dsstox_rid_82580

33. Dsstox_gsid_47838

34. Propiophenone, 2-(diethylamino)-, Hydrochloride

35. Diethylpropion Hydrochloride (usp)

36. 2-(diethylamino)-1-phenylpropan-1-one Hydrochloride

37. Cas-134-80-5

38. Chebi:643703

39. 2-diethylaminopropiophenone Hydrochloride

40. Sr-01000220674

41. Ncgc00167475-01

42. Einecs 205-156-5

43. Unii-19v2pl39ng

44. Tenuate (tn)

45. Rac Diethylpropion-d10 Hydrochloride

46. Diethylproion Hydrochloride

47. Cambridge Id 5809497

48. Chembl1693

49. Schembl15483

50. 2-(diethylamino)-1-phenyl-1-propanone Hydrochloride

51. 2-(diethylamino)-1-phenylpropan-1-one;hydrochloride

52. Dtxsid4047838

53. Hy-b0981

54. Tox21_112479

55. Akos015962206

56. Tox21_112479_1

57. Ccg-220122

58. Cs-4472

59. Diethylpropion Hydrochloride [mi]

60. Ncgc00167475-02

61. Ac-16025

62. Amfepramone Hydrochloride [who-dd]

63. As-16865

64. Diethylpropion Hydrochloride [mart.]

65. Diethylpropion Hydrochloride [vandf]

66. Diethylpropion Hydrochloride [usp-rs]

67. .alpha.-benzoyltriethylamine Hydrochloride

68. 090d846

69. Diethylpropion Hydrochloride [orange Book]

70. Diethylpropion Hydrochloride [usp Monograph]

71. Sr-01000220674-1

72. Sr-01000220674-2

73. Q27105182

74. Diethylpropion Hydrochloride Solution, 1.0 Mg/ml In Methanol (with 1% 1 M Hcl; As Free Base), Certified Reference Material

2.4 Create Date
2005-07-29
3 Chemical and Physical Properties
Molecular Weight 241.76 g/mol
Molecular Formula C13H20ClNO
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass241.1233420 g/mol
Monoisotopic Mass241.1233420 g/mol
Topological Polar Surface Area20.3 Ų
Heavy Atom Count16
Formal Charge0
Complexity193
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameDiethylpropion hydrochloride
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strength75mg; 25mg
Market StatusPrescription
CompanyLannett Holdings; Corepharma; Avanthi

2 of 6  
Drug NameTenuate
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet
RouteOral
Strength25mg
Market StatusPrescription
CompanyWatson Pharms

3 of 6  
Drug NameTenuate dospan
PubMed HealthDiethylpropion (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength75mg
Market StatusPrescription
CompanyWatson Pharms

4 of 6  
Drug NameDiethylpropion hydrochloride
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release; Tablet
RouteOral
Strength75mg; 25mg
Market StatusPrescription
CompanyLannett Holdings; Corepharma; Avanthi

5 of 6  
Drug NameTenuate
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet
RouteOral
Strength25mg
Market StatusPrescription
CompanyWatson Pharms

6 of 6  
Drug NameTenuate dospan
PubMed HealthDiethylpropion (By mouth)
Drug ClassesAppetite Suppressant, Centrally Acting
Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
Active IngredientDiethylpropion hydrochloride
Dosage FormTablet, extended release
RouteOral
Strength75mg
Market StatusPrescription
CompanyWatson Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]

API Reference Price

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C-24,","city":"HYDERABAD. AP","supplier":"NANJING JOYIN PHARMACHEM CO, LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MSN LABORATORIES","customerCountry":"INDIA","quantity":"2550.00","actualQuantity":"2550","unit":"KGS","unitRateFc":"33","totalValueFC":"85074.8","currency":"USD","unitRateINR":"2803.4","date":"24-Oct-2024","totalValueINR":"7148542.5","totalValueInUsd":"85074.8","indian_port":"Madras Sea","hs_no":"29339990","bill_no":"6303309","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 1201, 1202, & 1212, 12TH FLOOR PHASE 1 OF SUNNY WORLD CENTER, NO.188 LUSHAN ROAD, JIANYE ROAD, CN","customerAddress":"MSN HOUSE, PLOT NO. C-24,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"BOURGEONAL (LILIONAL) (AS PER INVOICE NO:COR24\/0906) (CAS NO:18127-01-0 & IUPAC NAME:3-(4-TERT-BUTYLPHENYL)PROPION-ALDEH","address":"NOVELL HOUSE RD NO 13 MIDC MAROL","city":"MUMBAI, MAHARASHTRA","supplier":"O LAUGHLIN CORPORATION ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"FIRMENICH","customerCountry":"INDIA","quantity":"195.00","actualQuantity":"195","unit":"KGS","unitRateFc":"41.8","totalValueFC":"8240.6","currency":"USD","unitRateINR":"3550.9","date":"25-Oct-2024","totalValueINR":"692427","totalValueInUsd":"8240.6","indian_port":"Dahez-SEZ","hs_no":"29122990","bill_no":"1005276","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"NOVELL HOUSE RD NO 13 MIDC MAROL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"ALLYL CYCLOHEXYL PROPIONATE","address":"49, SDA ANNEX. LASUDIA MORI,","city":"INDORE (M.P.)","supplier":"HANGZHOU DASHAN CHEMICAL ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"MYSORE DEEP PERFUMERY ","customerCountry":"INDIA","quantity":"900.00","actualQuantity":"900","unit":"KGS","unitRateFc":"7.8","totalValueFC":"7175.5","currency":"USD","unitRateINR":"669.9","date":"25-Oct-2024","totalValueINR":"602929.37","totalValueInUsd":"7175.5","indian_port":"JNPT","hs_no":"29162090","bill_no":"6321392","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"MAMU-NANFENG HI-TECH INDUSTRIALZONE , MEICHENG TOWN, JIANDE CITY,HANGZH OU, ZHEJIANG PROVINCE, CHINA","customerAddress":"49, SDA ANNEX. LASUDIA MORI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"(R)-(+)-2-(4-HYDROXYPHENOXY)PROPIONIC ACID (DHPPA) 99 %","address":"19-A,NEW MANDI","city":"MUZAFFARNAGAR,UTTAR PRADESH","supplier":"HENGDIAN GROUP","supplierCountry":"CHINA","foreign_port":"SHANGHAI PT","customer":"ROL AGRICHEM PRIVATE ","customerCountry":"INDIA","quantity":"16000.00","actualQuantity":"16000","unit":"KGS","unitRateFc":"9.7","totalValueFC":"156905.6","currency":"USD","unitRateINR":"824","date":"25-Oct-2024","totalValueINR":"13184240","totalValueInUsd":"156905.6","indian_port":"JNPT","hs_no":"29189990","bill_no":"6339272","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI PT","supplierAddress":"LTD. 16F, T1, HENGDIAN CENTER, NO. 136 FUCHUN ROAD, SHANGCHENG DISTRIC T, HANGZHOU, CHINA","customerAddress":"19-A,NEW MANDI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"LAL-29C AMINOPROPIONIC ACID 15X5KG","address":"GALA NO.11,12,AMBICA COMMERCIAL","city":"DIST. THANE, MAHARASHTRA.","supplier":"SORACHIM SA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"ANALYTICA","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"16","totalValueFC":"1337.6","currency":"EUR","unitRateINR":"1498.6","date":"25-Oct-2024","totalValueINR":"112395.84","totalValueInUsd":"1337.6","indian_port":"Bombay Air","hs_no":"29224990","bill_no":"6329297","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CHEMIN DE PRE- FLEURI 6, 1006 LAUSA NNE, SWITZERLAND Lausanne, , Switze rland Switzerland","customerAddress":"GALA NO.11,12,AMBICA COMMERCIAL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"ACETYLPROPIONIC ACID LEVULINIC ACID CAS NO:123-76-2","address":"OLD NO.1\/63, NEW NO.1\/58,PUDUPAKKAM","city":"ROAD, KELAMBAKKAM \/CHENNAI\/ TAMILNA","supplier":"CHANGZHOU JOYOUS CHEMICAL CO.,LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"PAR ACTIVE TECHNOLOGIES ","customerCountry":"INDIA","quantity":"45.00","actualQuantity":"45","unit":"KGS","unitRateFc":"40","totalValueFC":"1819.8","currency":"USD","unitRateINR":"3398","date":"25-Oct-2024","totalValueINR":"152910","totalValueInUsd":"1819.8","indian_port":"Madras Air","hs_no":"29339990","bill_no":"6322896","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"CO. LTD., 1201, BLGD 2, FUCHEN COMMERCIAL PLAZA, XINBEI DIST CHANGZHOU, JIANGSU 213022 CHINA","customerAddress":"OLD NO.1\/63, NEW NO.1\/58,PUDUPAKKAM"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"975180 AMYL PROPIONATE (RAW MATERIAL)","address":"NOVELL HOUSE RD NO 13 MIDC MAROL","city":"MUMBAI, MAHARASHTRA","supplier":"FIRMENICH","supplierCountry":"SWITZERLAND","foreign_port":"GENEVA","customer":"FIRMENICH","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"30.8","totalValueFC":"801.2","currency":"USD","unitRateINR":"2692.9","date":"30-Oct-2024","totalValueINR":"67322.46","totalValueInUsd":"801.2","indian_port":"Bombay Air","hs_no":"29155000","bill_no":"6426010","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"GENEVA","supplierAddress":"RUE DE LA BERGERE 7SATIGNY 1242 GEN EVA SDNF SWITZERLAND","customerAddress":"NOVELL HOUSE RD NO 13 MIDC MAROL"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"ETHYL 2,3-DICYANO PROPIONATE","address":"8-2-269\/S\/3\/A, PLOT.NO.3, SAGAR","city":"HYDERABAD","supplier":"HEBEI CHENGXIN CO., LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"BHAGIRADHA CHEMICALS AND ","customerCountry":"INDIA","quantity":"16000.00","actualQuantity":"16000","unit":"KGS","unitRateFc":"6","totalValueFC":"97055","currency":"USD","unitRateINR":"509.7","date":"30-Oct-2024","totalValueINR":"8155200","totalValueInUsd":"97055","indian_port":"Madras Sea","hs_no":"29269000","bill_no":"6416224","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"YUANZHAO ROAD, YUANSHI COUNTRY, HEBEI PROVINCE, CHINA CN","customerAddress":"8-2-269\/S\/3\/A, PLOT.NO.3, SAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"CLOBETASOL PROPIONATE MICRONIZED USP","address":"UNIT NO.24 STEEL MADE INDL.ESTATE","city":"MUMBAI","supplier":"AXPLORA","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ENCUBE ETHICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"5250","totalValueFC":"31846.2","currency":"USD","unitRateINR":"445987.5","date":"30-Oct-2024","totalValueINR":"2675925","totalValueInUsd":"31846.2","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"6415521","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"MILAN - MALPENSA","supplierAddress":"VIA PAVIA - 1,,27027,GROPE P CAIROLI (PV) SDNF IT","customerAddress":"UNIT NO.24 STEEL MADE INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730313000,"product":"IR3535 (INSECT REPELLENT 3535) 3-[N-N-BUTYL-N-ACETYL] AMINOPROPIONIC ACID ETHYLESTER 1PCS X 25KG","address":"1505-1506, KESAR SOLITAIRE, PLOT","city":"SANPADA, NAVI MUMBAI (M.S.)","supplier":"MERCK ELECTRONICS KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK PERFORMANCE MATERIALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"2540.1","totalValueFC":"755.8","currency":"INR","unitRateINR":"2540.4","date":"31-Oct-2024","totalValueINR":"63510.57","totalValueInUsd":"755.8","indian_port":"Bombay Air","hs_no":"29241900","bill_no":"6435600","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 25064293 Darmst adt,(BENEFICIARY MERCK FINANCIALS S ERVICES GMBH) GERMANY","customerAddress":"1505-1506, KESAR SOLITAIRE, PLOT"}]
02-Jan-2021
31-Oct-2024
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DOSAGE - TABLET;ORAL - 25MG **Federal Registe...DOSAGE - TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 11722

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 12546

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