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    Also known as: Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl
    Molecular Formula
    C13H20ClNO
    Molecular Weight
    241.76  g/mol
    InChI Key
    ICFXZZFWRWNZMA-UHFFFAOYSA-N
    FDA UNII
    19V2PL39NG
    Diethylpropion Hydrochloride
    A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
    1 2D Structure

    Diethylpropion Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(diethylamino)-1-phenylpropan-1-one;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H
    2.1.3 InChI Key
    ICFXZZFWRWNZMA-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C(C)C(=O)C1=CC=CC=C1.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    19V2PL39NG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-diethylaminopropiophenone

    2. Amfepramon

    3. Amfepramone

    4. Anorex

    5. Delgamer

    6. Diethylpropion

    7. Dietil Retard

    8. Dietil-retard

    9. Dietilretard

    10. Hydrochloride, Diethylpropion

    11. Ifa Norex

    12. Lipomin

    13. Maruate

    14. Modratan

    15. Neobes

    16. Nobesine

    17. Norex, Ifa

    18. Phepranon

    19. Prfamone

    20. Propion

    21. Regenon

    22. Regibon

    23. Tenuate

    24. Tepanil

    2.3.2 Depositor-Supplied Synonyms

    1. Amfepramone Hydrochloride

    2. 134-80-5

    3. Moderatan

    4. Dobesin

    5. Tenuate

    6. Diethylpropion Hcl

    7. Tepanil

    8. Anorex

    9. Tenuate Dospan

    10. Regenon Hydrochloride

    11. 2-(diethylamino)propiophenone Hydrochloride

    12. Amfepramone (hydrochloride)

    13. Prefamone

    14. Regenon

    15. Amphepramonum Hydrochloride

    16. 1-propanone, 2-(diethylamino)-1-phenyl-, Hydrochloride

    17. 19v2pl39ng

    18. Diethylpropion Hydrochloride Civ

    19. Alpha-benzoyltriethylammonium Chloride

    20. Alpha-benzoyltriethylamine Hydrochloride

    21. D03801

    22. Diethylpropion Hydrochloride [usp]

    23. Menutil

    24. 1-phenyl-2-diethylaminopropanone-1 Hydrochloride

    25. Magrex Retard

    26. Tenuate-dospan

    27. Amfepramon Hydrochloride

    28. Lineal-rivo

    29. Tepanil Ten-tab

    30. Nu-dispoz

    31. Dsstox_cid_27816

    32. Dsstox_rid_82580

    33. Dsstox_gsid_47838

    34. Propiophenone, 2-(diethylamino)-, Hydrochloride

    35. Diethylpropion Hydrochloride (usp)

    36. 2-(diethylamino)-1-phenylpropan-1-one Hydrochloride

    37. Cas-134-80-5

    38. Chebi:643703

    39. 2-diethylaminopropiophenone Hydrochloride

    40. Sr-01000220674

    41. Ncgc00167475-01

    42. Einecs 205-156-5

    43. Unii-19v2pl39ng

    44. Tenuate (tn)

    45. Rac Diethylpropion-d10 Hydrochloride

    46. Diethylproion Hydrochloride

    47. Cambridge Id 5809497

    48. Chembl1693

    49. Schembl15483

    50. 2-(diethylamino)-1-phenyl-1-propanone Hydrochloride

    51. 2-(diethylamino)-1-phenylpropan-1-one;hydrochloride

    52. Dtxsid4047838

    53. Hy-b0981

    54. Tox21_112479

    55. Akos015962206

    56. Tox21_112479_1

    57. Ccg-220122

    58. Cs-4472

    59. Diethylpropion Hydrochloride [mi]

    60. Ncgc00167475-02

    61. Ac-16025

    62. Amfepramone Hydrochloride [who-dd]

    63. As-16865

    64. Diethylpropion Hydrochloride [mart.]

    65. Diethylpropion Hydrochloride [vandf]

    66. Diethylpropion Hydrochloride [usp-rs]

    67. .alpha.-benzoyltriethylamine Hydrochloride

    68. 090d846

    69. Diethylpropion Hydrochloride [orange Book]

    70. Diethylpropion Hydrochloride [usp Monograph]

    71. Sr-01000220674-1

    72. Sr-01000220674-2

    73. Q27105182

    74. Diethylpropion Hydrochloride Solution, 1.0 Mg/ml In Methanol (with 1% 1 M Hcl; As Free Base), Certified Reference Material

    2.4 Create Date
    2005-07-29
    3 Chemical and Physical Properties
    Molecular Weight 241.76 g/mol
    Molecular Formula C13H20ClNO
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass241.1233420 g/mol
    Monoisotopic Mass241.1233420 g/mol
    Topological Polar Surface Area20.3 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity193
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameDiethylpropion hydrochloride
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength75mg; 25mg
    Market StatusPrescription
    CompanyLannett Holdings; Corepharma; Avanthi

    2 of 6  
    Drug NameTenuate
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyWatson Pharms

    3 of 6  
    Drug NameTenuate dospan
    PubMed HealthDiethylpropion (By mouth)
    Drug ClassesAppetite Suppressant, Centrally Acting
    Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength75mg
    Market StatusPrescription
    CompanyWatson Pharms

    4 of 6  
    Drug NameDiethylpropion hydrochloride
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet, extended release; Tablet
    RouteOral
    Strength75mg; 25mg
    Market StatusPrescription
    CompanyLannett Holdings; Corepharma; Avanthi

    5 of 6  
    Drug NameTenuate
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet
    RouteOral
    Strength25mg
    Market StatusPrescription
    CompanyWatson Pharms

    6 of 6  
    Drug NameTenuate dospan
    PubMed HealthDiethylpropion (By mouth)
    Drug ClassesAppetite Suppressant, Centrally Acting
    Drug LabelDiethylpropion hydrochloride, USPis available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: corn starch, lactose monohydrate, magne...
    Active IngredientDiethylpropion hydrochloride
    Dosage FormTablet, extended release
    RouteOral
    Strength75mg
    Market StatusPrescription
    CompanyWatson Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Appetite Depressants

    Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Increased Sympathetic Activity [PE]; Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]

    API Reference Price

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LTD.","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"STYLAM INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"13.4","totalValueFC":"6901.4","currency":"USD","unitRateINR":"1172.8","date":"23-Dec-2024","totalValueINR":"586404","totalValueInUsd":"6901.4","indian_port":"Delhi PPG ICD","hs_no":"29309099","bill_no":"7417574","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"112 ROBINSON ROAD 03-01 ROBINSON 112 SINGAPORE SDNF SDNF","customerAddress":"SCO 14 SECTOR 7 C,MADHYA MARG"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735151400,"product":"ETHYL 2,3-DICYANO PROPIONATE CHEMICAL","address":"8-2-269\/S\/3\/A, PLOT.NO.3, SAGAR","city":"HYDERABAD","supplier":"HEBEI CHENGXIN CO., LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"BHAGIRADHA CHEMICALS AND ","customerCountry":"INDIA","quantity":"8000.00","actualQuantity":"8000","unit":"KGS","unitRateFc":"5.9","totalValueFC":"47989.3","currency":"USD","unitRateINR":"509.7","date":"26-Dec-2024","totalValueINR":"4077600","totalValueInUsd":"47989.3","indian_port":"Madras Sea","hs_no":"29269000","bill_no":"7456158","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"QINGDAO","supplierAddress":"YUANZHAO ROAD, YUANSHI COUNTRY, HEBEI PROVINCE, CHINA CN","customerAddress":"8-2-269\/S\/3\/A, PLOT.NO.3, SAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735237800,"product":"ETHYL R-2-(4-HYDROXYPHENOXY) PROPIONATE 99 % MIN ETHYL R-2-(4-HYDROXYPHENOXY) PROPIONATE 99 % MIN","address":"GI\/17, INDUSTRIAL AREA, G.T. 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    01-Jan-2021
    31-Dec-2024
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    Adcock Ingram Limited

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    Regulatory Info : Generic

    Registration Country : South Africa

    Diethylpropion Hcl

    Brand Name : Tenuate Dospan

    Dosage Form : TAB

    Dosage Strength : 75mg

    Packaging : 30X1mg

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : South Africa

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    DOSAGE - TABLET;ORAL - 25MG **Federal Registe...DOSAGE - TABLET;ORAL - 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 11722

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 75MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 12546

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    PharmaCompass offers a list of Diethylpropion Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Diethylpropion Hydrochloride manufacturer or Diethylpropion Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Diethylpropion Hydrochloride manufacturer or Diethylpropion Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Diethylpropion Hydrochloride API Price utilized in the formulation of products. Diethylpropion Hydrochloride API Price is not always fixed or binding as the Diethylpropion Hydrochloride Price is obtained through a variety of data sources. The Diethylpropion Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Diethylpropion Hydrochloride

    Synonyms

    Amfepramone hydrochloride, 134-80-5, Moderatan, Dobesin, Tenuate, Diethylpropion hcl

    Cas Number

    134-80-5

    Unique Ingredient Identifier (UNII)

    19V2PL39NG

    About Diethylpropion Hydrochloride

    A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

    Diethylpropion Hydrochloride Manufacturers

    A Diethylpropion Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Diethylpropion Hydrochloride, including repackagers and relabelers. The FDA regulates Diethylpropion Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Diethylpropion Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Diethylpropion Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Diethylpropion Hydrochloride Suppliers

    A Diethylpropion Hydrochloride supplier is an individual or a company that provides Diethylpropion Hydrochloride active pharmaceutical ingredient (API) or Diethylpropion Hydrochloride finished formulations upon request. The Diethylpropion Hydrochloride suppliers may include Diethylpropion Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Diethylpropion Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Diethylpropion Hydrochloride USDMF

    A Diethylpropion Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Diethylpropion Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Diethylpropion Hydrochloride DMFs exist exist since differing nations have different regulations, such as Diethylpropion Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Diethylpropion Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Diethylpropion Hydrochloride USDMF includes data on Diethylpropion Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Diethylpropion Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Diethylpropion Hydrochloride suppliers with USDMF on PharmaCompass.

    Diethylpropion Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Diethylpropion Hydrochloride Drug Master File in Korea (Diethylpropion Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Diethylpropion Hydrochloride. The MFDS reviews the Diethylpropion Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Diethylpropion Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Diethylpropion Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Diethylpropion Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Diethylpropion Hydrochloride suppliers with KDMF on PharmaCompass.

    Diethylpropion Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Diethylpropion Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Diethylpropion Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Diethylpropion Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Diethylpropion Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Diethylpropion Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Diethylpropion Hydrochloride suppliers with NDC on PharmaCompass.

    Diethylpropion Hydrochloride GMP

    Diethylpropion Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Diethylpropion Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Diethylpropion Hydrochloride GMP manufacturer or Diethylpropion Hydrochloride GMP API supplier for your needs.

    Diethylpropion Hydrochloride CoA

    A Diethylpropion Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Diethylpropion Hydrochloride's compliance with Diethylpropion Hydrochloride specifications and serves as a tool for batch-level quality control.

    Diethylpropion Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Diethylpropion Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Diethylpropion Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Diethylpropion Hydrochloride EP), Diethylpropion Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Diethylpropion Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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