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Chemistry

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Also known as: 98106-17-3, Difloxacin [inn], 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Dicural, 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid, Pulsaflox
Molecular Formula
C21H19F2N3O3
Molecular Weight
399.4  g/mol
InChI Key
NOCJXYPHIIZEHN-UHFFFAOYSA-N
FDA UNII
5Z7OO9FNFD

Difloxacin
Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials.
1 2D Structure

Difloxacin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
2.1.2 InChI
InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
2.1.3 InChI Key
NOCJXYPHIIZEHN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
2.2 Other Identifiers
2.2.1 UNII
5Z7OO9FNFD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(4-fluorophenyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid

2. 1-ffmpoc

3. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-quinolone-3-carboxylic Acid

4. A 56619

5. A-56619

6. Dicural

7. Difloxacin Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 98106-17-3

2. Difloxacin [inn]

3. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

4. Dicural

5. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid

6. Pulsaflox

7. Difloxacin (inn)

8. 5z7oo9fnfd

9. Chebi:4537

10. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

11. Difloxacin (hydrochloride)

12. A 56619

13. 3-quinolinecarboxylic Acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

14. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic Acid

15. A-56619

16. Difloxacin Hydrochloride Salt

17. 3-quinolinecarboxylic Acid,6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

18. Ncgc00166308-01

19. Unii-5z7oo9fnfd

20. Difloxacin [mi]

21. Chembl6259

22. Schembl148765

23. Dtxsid5048348

24. Gtpl10801

25. Bcp33408

26. Rkl10076

27. Zinc4099034

28. Bbl010805

29. Stk618168

30. Zinc04099034

31. Akos005551754

32. Db11511

33. Difloxacin [ema Epar Veterinary]

34. Ac-12060

35. Ls-14845

36. Db-057711

37. Hy-121272

38. Cs-0081346

39. Ft-0624916

40. D07828

41. Ab00923781_02

42. Ab00923781_04

43. 106d173

44. A843794

45. A845811

46. A858583

47. Q5275450

48. 4-(4-hydroxy-4-p-tolylpiperidin-1-yl)-1-phenylbutan-1-one

49. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

50. 3-quinolinecarboxylic Acid, 6-fluoro-1-(4-fluorophenyl) 1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

51. 6-fluoranyl-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinoline-3-carboxylic Acid

52. 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4- Methyl-1- Piperazinyl)-4-oxo-3- Quinolinecarboxylic Acid

53. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic Acid;difluoxacin Hydrochloride

54. 6-fluoro-1-(p-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 399.4 g/mol
Molecular Formula C21H19F2N3O3
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass399.13944780 g/mol
Monoisotopic Mass399.13944780 g/mol
Topological Polar Surface Area64.1 Ų
Heavy Atom Count29
Formal Charge0
Complexity672
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

* Chickens: :

for the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

* Turkeys: :

- For the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

- Also for the treatment of infections caused by Pasteurella multocida.

* Dogs: :

- For the treatment of acute uncomplicated urinary-tract infections caused by Escherichia coli or Staphylococcus spp. and superficial pyoderma caused by Staphylococcus intermedius.

* Cattle: :

- For the treatment of bovine respiratory disease (shipping fever, calf pneumonia) caused by single or mixed infections with Pasteurella haemolytica, Pasteurella multocida and / or Mycoplasma spp.


In chickens and turkeys Pulsaflox oral solution is indicated for treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

In turkeys Pulsaflox oral solution is also indicated for the treatment of infections caused by Pasteurella multocida.

Pulsaflox oral solution should only be used based on susceptibility testing.


5 Pharmacology and Biochemistry
5.1 ATC Code

QJ01MA94


QJ01MA


API Reference Price

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07-Jun-2022
06-Oct-2024
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ABOUT THIS PAGE

Difloxacin Manufacturers

A Difloxacin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Difloxacin, including repackagers and relabelers. The FDA regulates Difloxacin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Difloxacin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Difloxacin Suppliers

A Difloxacin supplier is an individual or a company that provides Difloxacin active pharmaceutical ingredient (API) or Difloxacin finished formulations upon request. The Difloxacin suppliers may include Difloxacin API manufacturers, exporters, distributors and traders.

Difloxacin GMP

Difloxacin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Difloxacin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Difloxacin GMP manufacturer or Difloxacin GMP API supplier for your needs.

Difloxacin CoA

A Difloxacin CoA (Certificate of Analysis) is a formal document that attests to Difloxacin's compliance with Difloxacin specifications and serves as a tool for batch-level quality control.

Difloxacin CoA mostly includes findings from lab analyses of a specific batch. For each Difloxacin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Difloxacin may be tested according to a variety of international standards, such as European Pharmacopoeia (Difloxacin EP), Difloxacin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Difloxacin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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