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    Chemistry

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    Also known as: 98106-17-3, Difloxacin [inn], 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Dicural, 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid, Pulsaflox
    Molecular Formula
    C21H19F2N3O3
    Molecular Weight
    399.4  g/mol
    InChI Key
    NOCJXYPHIIZEHN-UHFFFAOYSA-N
    FDA UNII
    5Z7OO9FNFD
    Difloxacin
    Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials.
    1 2D Structure

    Difloxacin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
    2.1.2 InChI
    InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
    2.1.3 InChI Key
    NOCJXYPHIIZEHN-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
    2.2 Other Identifiers
    2.2.1 UNII
    5Z7OO9FNFD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(4-fluorophenyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid

    2. 1-ffmpoc

    3. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-quinolone-3-carboxylic Acid

    4. A 56619

    5. A-56619

    6. Dicural

    7. Difloxacin Hydrochloride

    2.3.2 Depositor-Supplied Synonyms

    1. 98106-17-3

    2. Difloxacin [inn]

    3. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid

    4. Dicural

    5. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic Acid

    6. Pulsaflox

    7. Difloxacin (inn)

    8. 5z7oo9fnfd

    9. Chebi:4537

    10. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic Acid

    11. Difloxacin (hydrochloride)

    12. A 56619

    13. 3-quinolinecarboxylic Acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

    14. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic Acid

    15. A-56619

    16. Difloxacin Hydrochloride Salt

    17. 3-quinolinecarboxylic Acid,6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

    18. Ncgc00166308-01

    19. Unii-5z7oo9fnfd

    20. Difloxacin [mi]

    21. Chembl6259

    22. Schembl148765

    23. Dtxsid5048348

    24. Gtpl10801

    25. Bcp33408

    26. Rkl10076

    27. Zinc4099034

    28. Bbl010805

    29. Stk618168

    30. Zinc04099034

    31. Akos005551754

    32. Db11511

    33. Difloxacin [ema Epar Veterinary]

    34. Ac-12060

    35. Ls-14845

    36. Db-057711

    37. Hy-121272

    38. Cs-0081346

    39. Ft-0624916

    40. D07828

    41. Ab00923781_02

    42. Ab00923781_04

    43. 106d173

    44. A843794

    45. A845811

    46. A858583

    47. Q5275450

    48. 4-(4-hydroxy-4-p-tolylpiperidin-1-yl)-1-phenylbutan-1-one

    49. 6-fluoro-1-(4-fluorophenyl)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

    50. 3-quinolinecarboxylic Acid, 6-fluoro-1-(4-fluorophenyl) 1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-

    51. 6-fluoranyl-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinoline-3-carboxylic Acid

    52. 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4- Methyl-1- Piperazinyl)-4-oxo-3- Quinolinecarboxylic Acid

    53. 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic Acid;difluoxacin Hydrochloride

    54. 6-fluoro-1-(p-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 399.4 g/mol
    Molecular Formula C21H19F2N3O3
    XLogP31.6
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count3
    Exact Mass399.13944780 g/mol
    Monoisotopic Mass399.13944780 g/mol
    Topological Polar Surface Area64.1 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity672
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    * Chickens: :

    for the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

    * Turkeys: :

    - For the treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

    - Also for the treatment of infections caused by Pasteurella multocida.

    * Dogs: :

    - For the treatment of acute uncomplicated urinary-tract infections caused by Escherichia coli or Staphylococcus spp. and superficial pyoderma caused by Staphylococcus intermedius.

    * Cattle: :

    - For the treatment of bovine respiratory disease (shipping fever, calf pneumonia) caused by single or mixed infections with Pasteurella haemolytica, Pasteurella multocida and / or Mycoplasma spp.

    In chickens and turkeys Pulsaflox oral solution is indicated for treatment of chronic respiratory infections caused by sensitive strains of Escherichia coli and Mycoplasma gallisepticum.

    In turkeys Pulsaflox oral solution is also indicated for the treatment of infections caused by Pasteurella multocida.

    Pulsaflox oral solution should only be used based on susceptibility testing.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    QJ01MA94

    QJ01MA

    API Reference Price

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    31-Mar-2021
    06-Oct-2024
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