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Chemistry

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Also known as: 483-15-8, Dihydroberbine, Dihydroumbellatine, 9,10-dimethoxy-6,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline, Lambertine, 7,8-dihydroberberine
Molecular Formula
C20H19NO4
Molecular Weight
337.4  g/mol
InChI Key
FZAGOOYMTPGPGF-UHFFFAOYSA-N

Dihydroberberine
16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0,.0,.0,]henicosa-1(21),2,4(8),9,15,17,19-heptaene is a natural product found in Thalictrum foliolosum, Berberis vulgaris, and Chelidonium majus with data available.
1 2D Structure

Dihydroberberine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaene
2.1.2 InChI
InChI=1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
2.1.3 InChI Key
FZAGOOYMTPGPGF-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=C(C2=C(C=C1)C=C3C4=CC5=C(C=C4CCN3C2)OCO5)OC
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Dihydroberberine Hydrochloride

2.2.2 Depositor-Supplied Synonyms

1. 483-15-8

2. Dihydroberbine

3. Dihydroumbellatine

4. 9,10-dimethoxy-6,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

5. Lambertine

6. 7,8-dihydroberberine

7. Berberine, Dihydro-

8. 9,10-dimethoxy-2,3-(methylenedioxy)-13,13a-didehydroberbine

9. Dihydroberberine/dihydroumbellatine

10. Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-

11. 6h-benzo(g)-1,3-benzodioxolo(5,6-a)quinolizine, 5,8-dihydro-9,10-dimethoxy-

12. Nsc331264

13. 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,15(20),16,18-heptaene

14. 9,10-dimethoxy-5,8-dihydro-6h-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

15. Nsc 331264

16. Brn 0344128

17. Lambertin

18. 3bti

19. 4-27-00-06505 (beilstein Handbook Reference)

20. Chembl11848

21. Schembl299738

22. Dtxsid70197476

23. Chebi:192073

24. Hy-n1934

25. Zinc1575028

26. Bdbm50480308

27. Mfcd00022312

28. Akos016010627

29. Nsc-331264

30. Ac-34205

31. Cs-0018246

32. Ft-0701465

33. A14704

34. A871933

35. 9,10-dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob

36. 9,10-dimethoxy-5,8-dihydro-6h-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline

37. 9,10-dimethoxy-5,8-dihydro-6h-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline #

38. 9,10-dimethoxy-6,8-dihydro-5h-1,3-dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

39. 16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,15,17,19-heptaene

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 337.4 g/mol
Molecular Formula C20H19NO4
XLogP33.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass337.13140809 g/mol
Monoisotopic Mass337.13140809 g/mol
Topological Polar Surface Area40.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity538
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Dihydroberberine Manufacturers

A Dihydroberberine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Dihydroberberine, including repackagers and relabelers. The FDA regulates Dihydroberberine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Dihydroberberine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Dihydroberberine Suppliers

A Dihydroberberine supplier is an individual or a company that provides Dihydroberberine active pharmaceutical ingredient (API) or Dihydroberberine finished formulations upon request. The Dihydroberberine suppliers may include Dihydroberberine API manufacturers, exporters, distributors and traders.

Dihydroberberine GMP

Dihydroberberine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Dihydroberberine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Dihydroberberine GMP manufacturer or Dihydroberberine GMP API supplier for your needs.

Dihydroberberine CoA

A Dihydroberberine CoA (Certificate of Analysis) is a formal document that attests to Dihydroberberine's compliance with Dihydroberberine specifications and serves as a tool for batch-level quality control.

Dihydroberberine CoA mostly includes findings from lab analyses of a specific batch. For each Dihydroberberine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Dihydroberberine may be tested according to a variety of international standards, such as European Pharmacopoeia (Dihydroberberine EP), Dihydroberberine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Dihydroberberine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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